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2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene

2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    671279

    Chemical Formula C7H3BrClF3
    Molar Mass 275.45 g/mol
    Appearance Liquid (usually)
    Boiling Point Approximately 190 - 195 °C
    Density Around 1.7 - 1.8 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Vapor Pressure Low at room temperature
    Flash Point Elevated (related to its flammability characteristics)

    As an accredited 2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 2 - bromo - 1 - chloro - 4 - (trifluoromethyl)benzene in a sealed glass bottle.
    Storage Store 2 - bromo - 1 - chloro - 4 - (trifluoromethyl)benzene in a cool, dry, well - ventilated area away from heat, flames, and ignition sources. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass. Avoid storing it near reactive chemicals to prevent potential reactions and ensure proper labeling for easy identification.
    Shipping 2 - bromo - 1 - chloro - 4 - (trifluoromethyl)benzene is shipped in specialized, leak - proof containers. Transport follows strict chemical safety regulations, ensuring proper handling to prevent any environmental or safety hazards during transit.
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    2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene 2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene
    General Information
    Historical Development
    2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene is an important compound in organic synthesis. Looking back in the past, the development process of this compound is like a unique track in the long river of history.
    Initially, chemists explored halogen-containing aromatic compounds more and more deeply. With the gradual progress of chemical technology, researchers began to focus on compounds containing a variety of halogen atoms and special substituents. 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene has gradually come into view due to its unique structure and potential chemical activity.
    Early exploration, chemists encountered synthesis problems, but they made unremitting efforts to improve the reaction conditions and optimize the synthesis path. After repeated experiments, breakthroughs were made in the selection of reaction raw materials and the use of catalysts, and the effective synthesis of this compound was finally achieved, paving the way for subsequent applications and in-depth research, and opening the prelude to its emergence in the field of chemistry.
    Product Overview
    Description of 2-Bromo-1-chloro-4- (trifluoromethyl) benzene
    There is currently a product called 2-bromo-1-chloro-4- (trifluoromethyl) benzene. It is an organic halide with one position of bromine, chlorine and trifluoromethyl on the benzene ring in the structure.
    Looking at its physical properties, it is at room temperature, or a colorless to light yellow liquid with a special odor. Its boiling point, melting point and other physical parameters can be accurately determined according to experiments. Due to the presence of halogen atoms and trifluoromethyl, its polarity is different, and its solubility in organic solvents is also different.
    In terms of its use, it is a key raw material in the field of organic synthesis. Through many chemical reactions, different functional groups can be introduced to construct complex organic molecules, paving the way for the research and development of medicines and pesticides, and the exploration of materials science.
    The preparation method can follow the chemical synthesis path. Select suitable starting materials, carry out catalytic reactions under specific reaction conditions, and separate and purify the product. However, when preparing, it is necessary to pay attention to the precise control of reaction conditions to ensure the purity and yield of the product.
    Physical & Chemical Properties
    Today there is a substance called 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene. The physical and chemical properties of this substance are quite important to scholars.
    Its shape is also, at room temperature, or it is a colorless liquid. The view is clear, like the luster of a mirror. Touch it, the quality is smooth and flowing, like the agility of water. Its taste may have a special smell, although it is not pungent, it is also unique.
    In terms of its chemistry, bromine, chlorine, trifluoromethyl and other groups in this substance give it unique reactivity. When encountering nucleophilic reagents, substitution may occur, and the bromine and chlorine atoms are replaced by new radicals, like phoenix nirvana, regenerating new substances. Under specific temperature, pressure and catalyst conditions, it can also participate in various reactions such as addition and polymerization, and turn into other substances to meet the needs of industry and scientific research.
    Its boiling point, melting point, density and other physical constants are all signs of its characteristics. The boiling point indicates its gasification temperature, and the melting point indicates its solid-liquid transformation. The density is related to its specific gravity with other substances, which are indispensable elements for exploring this substance.
    Technical Specifications & Labeling
    Today there is a thing called 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene. The method of making it is related to the technical rules and identification (commodity parameters), which is of paramount importance.
    To make this thing, it is necessary to follow the precise technical regulations. From the selection of raw materials, it must be appropriate, and the amount of quantity must also be accurate. The reaction environment, temperature, pressure and other factors should be carefully observed and controlled to comply with the rules. In this way, it is hoped that a pure product will be obtained.
    Identify this thing, and the parameters must be clear. Such as the shape, color, taste, and geometric properties of the thing should be carefully remembered. Its purity is several, and the geometry of impurities is also important for marking. This is the key to determining the parameters of the product, so that everyone can understand its properties and know its use. Following this technical rule and marking method, the development of 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene can be achieved.
    Preparation Method
    To prepare 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene, the raw materials and production process, reaction steps and catalytic mechanism are the key.
    First of all, when taking suitable halogenated aromatics and fluorine-containing reagents, the two must be pure and properly proportioned, which is the basis for the initiation of the reaction. As for the production process, it should be carried out in a reactor with controlled temperature and pressure to ensure a stable reaction environment.
    For the reaction step, the halogenated aromatics and specific fluorine-containing reagents are first heated under the action of a catalyst to promote the initial reaction. The catalyst should be selected with high efficiency and selectivity to improve the reaction rate and product purity. This step requires precise control of temperature and time to prevent side reactions from breeding.
    Continuing, adjust the reaction conditions, introduce a bromine source and a chlorine source, and make them replace the specific position of the aromatic ring in turn to complete the construction of the target product. After each step of the reaction, proper separation and purification are required to remove impurities and improve the quality of the product.
    In the catalytic mechanism, the selected catalyst can reduce the activation energy of the reaction, guide the reaction to proceed according to a specific path, and efficiently generate the desired product. In this way, 2-Bromo-1-Chloro-4- (Trifluoromethyl) Benzene can be prepared according to this, and the expected quality and quantity can be achieved.
    Chemical Reactions & Modifications
    Today, there are chemical substances, named 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene. In the study of chemical and reverse modification, it is of paramount importance.
    If you want to know its properties, you must first explain its properties. This compound contains bromine, chlorine, trifluoromethyl and other groups, and its properties can be reversed. Bromine and chlorine atoms can be replaced by nuclear substitution. Because of the high efficiency of the atom, the density of the benzene sub-cloud can be changed, and it is easy to be attacked by nuclear substitution.
    As for the modification, it can be used to integrate and reverse parts, such as temperature, solubility, catalysis, etc. When the temperature rises, the reaction rate increases, and then it is difficult to prevent side reactions. Dissolution or nuclear substitution. Catalysis can reduce the activation energy, accelerate the reaction, obtain the desired reaction, and change the properties of the compound for different purposes. Therefore, the study of the reaction modification of this chemical substance is an important matter for chemical research.
    Synonyms & Product Names
    2-Bromo-1-chloro-4- (trifluoromethyl) benzene has the same name as the trade name
    Fu 2-bromo-1-chloro-4- (trifluoromethyl) benzene, one of the chemical substances. In today's chemical field, its namesake and trade name are quite important.
    The namesake is due to the chemical nomenclature. This substance is named according to the type, quantity and connection of its atoms. 2-Bromine, indicating that the bromine atom is at position 2 of the benzene ring; 1-chlorine, indicating that the chlorine atom is at position 1; 4- (trifluoromethyl), epitrifluoromethyl is at position 4. This naming is precise and clear, so that chemists can determine its structure.
    As for the trade name, it is set up by the manufacturer for marketing or distinction. 2-Bromo-1-chloro-4- (trifluoromethyl) benzene produced by different manufacturers may have different trade names. Or according to its characteristics, uses, or to attract customers. However, no matter the same name or trade name, it is the key for chemists, manufacturers and users to communicate this thing. Only by understanding this can we accurately refer to this thing in chemical research, production and application, so as to avoid confusion and promote the development of the chemical field.
    Safety & Operational Standards
    2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene safety and operating specifications
    Fu 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene, a commonly used substance in chemical research. Its unique nature is related to the safety and effectiveness of the experiment, so the safety and operating standards cannot be ignored.
    For storage, it should be placed in a cool, dry and well ventilated place. This substance is more sensitive to changes in temperature and humidity, and high temperature and humidity can easily change its properties, so it is necessary to maintain a suitable environment. And should stay away from fire and heat sources, because it is flammable to a certain extent, in case of open flames or hot topics, fear danger.
    When operating, the experimenter should be fully armed. Wear protective clothing to protect the skin of the body; wear protective gloves to prevent direct contact; wear protective glasses to avoid splashing into the eyes. Operating in a fume hood is particularly critical, which can drain the volatile gas in time to prevent the experimenter from inhaling and causing harm.
    If you accidentally contact, you must not know the emergency treatment method. If you come into contact with the skin, quickly rinse with plenty of water, and then wash with soap. If splashed into the eye, immediately rinse with flowing water or normal saline, and then seek medical attention. If inhaled, quickly move to a place with fresh air to keep breathing smooth. If unwell, seek medical attention.
    Furthermore, disposal should also be handled with caution. It should not be discarded at will. It should be handed over to a professional organization in accordance with relevant regulations to avoid polluting the environment.
    In short, although 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene is a scientific research aid, its safety and operating standards are the foundation of the experiment. It must be strictly followed to ensure the safety of the experiment and the smooth conduct of the research.
    Application Area
    Today, there are chemical substances 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene, which has a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate to help create new drugs. Due to its unique chemical structure, it can participate in many reactions, laying the foundation for the synthesis of compounds with specific biological activities.
    In the field of materials science, it also shows important value. Polymer materials can be introduced through specific reactions to improve their properties, such as improving their stability and weather resistance.
    In the field of organic synthesis, it is also a commonly used raw material. Chemists use its characteristics to design and implement various synthetic paths to obtain various target products. With its unique properties, this substance plays an indispensable role in many application fields and promotes the continuous development of related fields.
    Research & Development
    Today there is a product, name 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene. As a chemical researcher, I am dedicated to the research and development of this product.
    At the beginning, explore its properties, test its degree of melting and solubility in detail, know its solubility in various solvents, and observe its chemical properties, change with any agent, and study the law of reaction.
    Times, study its method. Think about the disadvantages of the old method and seek a way to innovate. Test new agents, adjust temperature and pressure, and seek a method of efficient pure production. After repeated tests, fail but not be discouraged, and finally get a good method, the yield increases, and the purity is better.
    I also think about the use of this thing. I think it can be used as a raw material in the fields of medicine and agrochemistry, to help the preparation of new medicines and the research of good fertilizers. I hope it can be beneficial to all karma and the world. I will make unremitting efforts to hope that this thing will be more widely used and more advanced.
    Toxicity Research
    Today, there is a product called 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene, and our generation takes toxicity research as its business. This product has a unique structure, with bromine, chlorine and trifluoromethyl attached to the benzene ring. The study of its toxicity is related to people's livelihood and the environment.
    Looking at various chemicals, the structure is closely related to toxicity. The halogen elements in this compound may highlight the toxicity. Bromine and chlorine are active in nature, and trifluoromethyl has strong electronegativity. It co-adheres to the benzene ring, or changes the molecular polarity and lipophilicity, and then involves the metabolic pathway in organisms and affects cell function.
    To understand its toxicity, it should be based on experiments. To observe its effects on organisms, cell experiments to observe its effects on cell proliferation and apoptosis; animal experiments to investigate its acute and chronic toxicity, such as organ damage, behavioral abnormalities. And consider the migration and transformation in the environment, or diffusion through water, soil, and air, endangering the ecology. The road to toxicity research is long, and it must be done with caution to ensure the well-being of all living beings and the tranquility of the environment.
    Future Prospects
    Wuguanfu 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethyl) Benzene has extraordinary potential in the field of chemistry. Although the current knowledge is still incomplete, the prospect of the future is really fascinating.
    With time, when the technology is refined and the research is in-depth, it may emerge in the way of medicine creation. Because of its unique structure, it may lead to new drugs with miraculous effects, treating diseases and diseases for the world.
    Or in the field of material science, it shines brightly. With its characteristics, develop novel materials and apply them to various fields, such as electronics, energy, etc., to promote the great progress of science and technology.
    I am convinced that if we continue to study, we will be able to tap its endless potential in the future, contribute to the well-being of mankind, and open up a new world, living up to the expectations and ambitions of our researchers.
    Where to Buy 2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene in China?
    As a trusted 2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-Bromo-1-Chloro-4- (Trifluoromethyl) Benzene?
    2-Bromo-1-chloro-4- (trifluoromethyl) benzene, this is an organic compound. It has a wide range of uses and is a crucial intermediate in the field of organic synthesis.
    First, it plays an indispensable role in the creation of pesticides. With this as the starting material, through a series of delicate chemical reactions, many pesticide molecules with efficient insecticidal, bactericidal or herbicidal activities can be constructed. With its special chemical structure, the derived pesticides can often exhibit unique mechanisms of action and good biological activities, which are of great significance for ensuring the harvest of crops and resisting the invasion of pests and diseases.
    Second, it has also made outstanding contributions in the field of pharmaceutical research and development. Based on this compound, chemists can synthesize compounds with potential medicinal value through ingenious structural modification and derivatization reactions. Or it can be used to develop new anti-cancer drugs, antiviral drugs, etc., injecting new vitality into the development of human health.
    Third, it also has its place in the field of materials science. By compounding or reacting with other functional materials, polymer materials with special properties can be prepared. Materials with excellent weather resistance and chemical corrosion resistance have broad application prospects in high-end fields such as aerospace and automobile manufacturing.
    To sum up, the unique chemical structure of 2-bromo-1-chloro-4- (trifluoromethyl) benzene occupies an important position in many fields such as pesticides, medicine, materials, etc., and plays an irreplaceable role in promoting the progress of related industries.
    What are the physical properties of 2-Bromo-1-Chloro-4- (Trifluoromethyl) Benzene?
    2-Bromo-1-chloro-4- (trifluoromethyl) benzene, this is an organic compound. It has unique physical properties, which you can describe in detail today.
    Looking at its properties, it is mostly colorless to light yellow liquid at room temperature and pressure. The color of this compound is derived from the characteristics of atoms and chemical bonds in the molecular structure, and the specific electron transition and absorption spectrum cause it to show this color. And its texture is uniform and its fluidity is good. Due to moderate intermolecular forces, it has not reached the level of condensation into a solid state or a high viscosity substance.
    When it comes to odor, it emits a specific odor. This odor originates from the existence of halogen atoms and trifluoromethyl groups. Its special chemical structure makes the compound have unique volatile and sensory characteristics, which is impressive.
    When it comes to boiling point, it is experimentally determined to be between 180-190 ° C. The boiling point is affected by intermolecular forces. In this compound, the electronegativity of halogen atoms and trifluoromethyl groups is high, resulting in strong dipole-dipole forces between molecules. To make the molecule break free from the liquid phase and turn into the gas phase, more energy is required, so the boiling point is higher.
    And the melting point is usually in the range of -10 ° C to -20 ° C. The melting point depends on the regularity of molecular arrangement and intermolecular forces. The molecular structure of the compound has certain complexity and asymmetry, which hinders the close and orderly arrangement of molecules, and the intermolecular forces do not reach a very high degree, resulting in a relatively low melting point.
    In terms of density, it is about 1.7-1.8 g/cm ³, which is higher than that of common organic solvents. Because of the large relative atomic mass of the halogen atom and the trifluoromethyl group in the molecule, it occupies a tight space structure, resulting in an increase in unit volume mass.
    In terms of solubility, slightly soluble in water, because water is a polar molecule, and although this compound contains halogen atoms and trifluoromethyl with a certain polarity, the overall non-polar part accounts for a large proportion, and the interaction with water is weak, difficult to dissolve in water; but it is easily soluble in common organic solvents, such as dichloromethane, chloroform, ether, etc. Because these organic solvents and the compound molecules have similar van der Waals forces, according to the principle of "similar miscibility", they can be well miscible.
    The physical properties of this compound are of great significance in the fields of organic synthesis, materials science, etc. Researchers need to separate, purify and react according to its boiling point, solubility and other properties, in order to achieve the expected experimental and production purposes.
    What are the chemical properties of 2-Bromo-1-Chloro-4- (Trifluoromethyl) Benzene?
    2-Bromo-1-chloro-4- (trifluoromethyl) benzene, which is an organohalogenated aromatic hydrocarbon compound. Its chemical properties are unique, and its molecular structure contains functional groups such as bromine, chlorine, and trifluoromethyl.
    Let's talk about the halogen atom bromine and chlorine first, which have strong electronegativity. The bromine atom is relatively low in C-Br bond energy due to its large radius, so it is easier to leave the bromine atom in the nucleophilic substitution reaction. For example, if it encounters nucleophilic reagents, such as sodium alcohol, amines, etc., the bromine atom can be replaced by the nucleophilic reagent to form the corresponding ether or amine derivatives.
    Although the radius of chlorine atoms is smaller than that of bromine atoms, they can also participate in nucleophilic substitution reactions, but their activity is slightly inferior to that of bromine atoms. When the reaction conditions are suitable, chlorine atoms can also be replaced to form different substitution products.
    In addition, trifluoromethyl, because it contains three fluorine atoms, the fluorine atoms are extremely electronegative, resulting in a strong electron-sucking induction effect of trifluoromethyl. This effect will reduce the electron cloud density of the benzene ring and weaken the activity of the electrophilic substitution reaction of the benzene ring. Compared with benzene, the electrophilic substitution reaction of this compound is more difficult to occur, and the substitution position is also different. Usually, due to the electron-sucking effect of trifluoromethyl, the electrophilic reagents are more inclined to attack the position
    In addition, the physical properties of the compound are also affected by these functional groups. Due to the halogen atom and trifluoromethyl, its relative density is higher than that of ordinary aromatics, and it has a certain lipid solubility. In organic solvents, it has good solubility, but it has poor solubility in water.
    In short, the chemical properties of 2-bromo-1-chloro-4 - (trifluoromethyl) benzene are determined by the interaction of functional groups in its molecular structure. In the field of organic synthesis, a variety of organic compounds can be prepared by virtue of its unique properties.
    What are the synthesis methods of 2-Bromo-1-Chloro-4- (Trifluoromethyl) Benzene?
    The synthesis methods of 2-bromo-1-chloro-4- (trifluoromethyl) benzene are quite diverse, and this is what you describe.
    One of them can be prepared by halogenation reaction. Using benzene derivatives containing trifluoromethyl as the starting material, chlorine atoms are first introduced through the action of halogenating reagents. If a suitable chlorination reagent is used, under suitable reaction conditions, such as a specific temperature and catalyst, a specific position of the benzene ring is chlorinated. Then, under another set of suitable reaction conditions, bromine atoms are introduced into the designated position of the benzene ring with a brominating reagent. This process requires fine regulation of the reaction conditions in order to accurately connect the halogen atoms to the desired position.
    Second, the Suzuki coupling reaction strategy is adopted. First, a phenylboronic acid derivative containing trifluoromethyl with suitable substituents, and a halogenated aromatic hydrocarbon containing chlorine and bromine are prepared. After that, the coupling reaction between the two occurs in a palladium catalyst, a base and a suitable solvent system. This method requires the selection of suitable catalysts, bases and solvents to improve the reaction efficiency and selectivity.
    Third, the nucleophilic substitution reaction path can be used. Select a trifluoromethylbenzene derivative with specific activity, and its benzene ring has a group that can be replaced by a nucleophilic reagent. The chlorine atom is first introduced with a nucleophilic reagent, and then the bromine atom is introduced with another nucleophilic reagent. This process requires precise control of the activity of nucleophiles and reaction conditions (such as temperature, solvent, etc.) to avoid unnecessary side reactions.
    The above synthesis methods have their own advantages and disadvantages. The halogenation reaction step is relatively direct, but the selective control is difficult; Suzuki coupling reaction has good selectivity, but the catalyst cost and reaction conditions are required to be high; nucleophilic substitution reaction requires strict reaction conditions, but can introduce substituents accurately. Synthesizers should carefully choose the appropriate synthesis path according to their own needs, raw material availability and cost considerations.
    2-Bromo-1-Chloro-4- (Trifluoromethyl) Benzene What to watch out for when storing and transporting
    2-Bromo-1-chloro-4- (trifluoromethyl) benzene is an organic compound, and many matters must be paid attention to when storing and transporting it.
    First words storage. This compound should be stored in a cool and ventilated warehouse. The cover can easily cause danger due to its heating. If the temperature is too high, or the chemical properties change, and even decompose and explode. And the humidity of the warehouse should also be suitable. If it is too humid, it may react with water vapor and damage the quality. Be sure to keep away from fire and heat sources, which is the top priority. Fire and heat sources can cause combustion and explosion, endangering the safety of the surrounding area. It should be stored separately from oxidants, edible chemicals, etc., and must not be mixed. Because of its active chemical properties, contact with oxidants, or severe chemical reactions; mixed storage with edible chemicals, in case of leakage, it is easy to cause pollution and harm food safety. At the same time, the warehouse should be equipped with suitable materials to contain leaks, so as to prevent accidental leakage from being properly disposed of in time and avoid the expansion of harm.
    Second talk about transportation. Before transportation, ensure that the packaging is complete and the loading is secure. If the packaging is damaged, it is easy to leak during transportation, which not only pollutes the environment, but also threatens the safety of transportation personnel. During transportation, it is necessary to strictly abide by the operating procedures, drive smoothly, and avoid bumps, vibrations and collisions. Because of its special nature, violent vibration or collision or cause its reaction. Transport vehicles should be equipped with the appropriate variety and quantity of fire fighting equipment and leakage emergency treatment equipment. In case of fire or leakage, it can be responded to in time. And when transporting, it should follow the prescribed route and do not stop in densely populated areas and traffic arteries. This is to avoid its leakage or accident, causing serious harm to many people. In this way, the safety of storage and transportation can be guaranteed, and disasters can be avoided.