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2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene

2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene

Hongda Chemical

Specifications

HS Code

789225

Chemical Formula C7H3BrClF3O
Molar Mass 275.45 g/mol
Appearance Colorless to light yellow liquid
Boiling Point Around 190 - 195 °C
Density Approx. 1.7 - 1.8 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Purity Typically available in high purity, e.g., 95%+ in commercial products
Packing & Storage
Packing 500g of 2 - bromo - 1 - chloro - 4 - (trifluoromethoxy)benzene in a sealed glass bottle.
Storage Store 2 - bromo - 1 - chloro - 4 - (trifluoromethoxy)benzene in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. As it's a chemical, store it separately from oxidizing agents, reducing agents, and other incompatible substances to avoid potential reactions.
Shipping 2 - bromo - 1 - chloro - 4 - (trifluoromethoxy)benzene is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transportation regulations, ensuring proper handling to prevent spills and maintain safety during transit.
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2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene 2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene
General Information
Historical Development
2 - Bromo - 1 - Chloro - 4 - (Trifluoromethoxy) Benzene is an important compound. Its historical development can be traced back to the past. In the initial stage, chemists became increasingly interested in benzene compounds containing halogenated and special alkoxy groups when exploring the field of organic synthesis. At that time, many scholars devoted their energy to studying related synthesis paths.
Early attempts to synthesize this compound went through many twists and turns. Due to the precise connection of halogen atoms and specific alkoxy groups to benzene rings, the reaction conditions were harsh and the yield was poor. However, scientists were unyielding and improved the reaction medium, temperature and catalyst conditions through repeated experiments.
With the passage of time, the synthesis technology gradually matured. The advent of a new type of catalyst has greatly improved the selectivity of the reaction and increased the yield significantly. The historical development of this compound is like a small boat in the long river of scientific exploration. It continues to move forward in waves and turns, adding a strong color to the development of organic chemistry.
Product Overview
Description of 2-Bromo-1-chloro-4- (trifluoromethoxy) benzene
Now there is a product called 2-bromo-1-chloro-4- (trifluoromethoxy) benzene. It is an organic halide with a delicate structure. On the benzene ring, bromine, chlorine and trifluoromethoxy are arranged in an orderly manner.
This product has unique properties. It is a colorless to light yellow liquid at room temperature, and has a slight odor when it is pure. It is volatile to a certain extent, but slightly slower than common low-boiling point solvents. In organic solvents, it has good solubility, such as ethanol, ether, dichloromethane, etc., which can be fused with it, just like fish and water.
In the chemical industry, this product is like a cornerstone. Often a key intermediate in the synthesis of complex organic compounds. With its lively chemical properties, it can participate in a variety of chemical reactions. With ingenious design and operation, it can derive many substances with special properties and uses. It has its place in the pharmaceutical, pesticide and other industries. It is just like a good material in the hands of skilled craftsmen. It can turn decay into magic and contribute to the development of various industries.
Physical & Chemical Properties
2 - Bromo - 1 - Chloro - 4 - (Trifluoromethoxy) Benzene is an organic compound, and its physical and chemical properties are very important. Looking at its physical properties, it is liquid at room temperature and has a specific color, taste and phase state. Its boiling point may vary due to intermolecular forces, which affects the energy required for its gasification. In terms of solubility, it may have different manifestations in organic solvents, depending on the principle that its molecular polarity is similar to that of solvents.
In terms of chemical properties, bromine, chlorine and trifluoromethoxy functional groups in this compound give it unique reactivity. Bromine and chlorine atoms can participate in nucleophilic substitution reactions. Due to the high activity of halogen atoms, they are easily replaced by nucleophilic reagents. The strong electron-absorbing property of trifluoromethoxy may affect the electron cloud density of the benzene ring and change its electrophilic substitution reactivity. The physicochemical properties of this compound lay the foundation for its application in organic synthesis and other fields.
Technical Specifications & Labeling
The global market size of 2-bromo-1-chloro-4- (trifluoromethoxy) benzene in 2024 is about [X] million US dollars, and it is expected to reach [X] million US dollars by 2031, with a compound annual growth rate of [X]% from 2024 to 2031.
This compound is an organohalogenated aromatic hydrocarbon, which is widely used in the fields of pesticides, medicine and material synthesis. Its preparation is often made of benzene derivatives containing corresponding substituents, which are achieved by reactions such as halogenation and etherification.
Quality Standard, the appearance should be colorless to light yellow liquid, with purity ≥ 99% and moisture ≤ 0.1%. The identification method can be used to confirm the structure by nuclear magnetic resonance hydrogen spectroscopy, carbon spectroscopy and mass spectrometry, and the purity can be determined by gas chromatography.
The packaging is mainly sealed galvanized iron drums or plastic drums, with a net weight of 250kg per barrel. Storage should be in a cool, dry and ventilated warehouse, away from fire and heat sources, and stored separately from oxidants and alkalis. Transportation is in accordance with relevant regulations on hazardous chemicals to ensure complete packaging and safe loading.
Preparation Method
2 - Bromo - 1 - Chloro - 4 - (Trifluoromethoxy) Benzene is an important compound in organic synthesis. The method of its preparation is related to the raw materials and production process, reaction steps and catalytic mechanism.
In the selection of raw materials, it is necessary to choose bromine, chlorine and trifluoromethoxy related reagents. Usually a specific halogenated benzene derivative is used as the starting point, such as p-chlorobromobenzene. In the production process, the starting material is first reacted with a trifluoromethoxy reagent under specific conditions. This reaction may require a specific solvent, such as an aprotic solvent, to facilitate the reaction.
The first reaction step conditions are precisely controlled, and temperature, pressure and reaction time are all critical. Usually, the reaction is initiated at low temperature first, and then heated to make the reaction sufficient. For example, stirring at 0-10 ° C first, and then gradually rising to 40-60 ° C. The catalytic mechanism of
cannot be ignored, or metal catalysts, such as copper catalysts, can be selected to reduce the activation energy of the reaction, accelerate the reaction process, and improve the yield of the product. In this way, 2-Bromo-1-Chloro-4 - (Trifluoromethoxy) Benzene can be efficiently prepared.
Chemical Reactions & Modifications
The beauty of chemistry lies in the variety of changes, the change of substances, and the migration of properties. Now on 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethoxy) Benzene. Its chemical reaction is related to the clutch of atoms and the tension of valence bonds. To seek its variability, when examining its structure, know the atomic system and the distribution of electrons.
Look at this compound, bromine, chlorine, and trifluoromethoxy are in their respective positions, which affect the polarity and activity of the molecule. Or when encountering a nucleophilic reagent, the halogen atom leaves, and a new bond is formed, which is often the nucleophilic substitution. And the way to modify it can be modified by the group to adjust its electrical properties and retardation. Or introduce specific groups to change their physical and chemical properties, such as solubility and stability.
However, the change of chemistry cannot be achieved overnight. It is necessary to pay attention to the conditions of the reaction, including temperature, pressure and catalyst. Only with detailed investigation and careful handling can we understand the mechanism of the reaction and improve the change of its performance, which will be beneficial to the study of chemistry.
Synonyms & Product Names
2 - Bromo - 1 - Chloro - 4 - (Trifluoromethoxy) Benzene, which is an important raw material for organic synthesis. Its synonymous name, the academic name may be different from the commercial trade name. In the academic world, or because of its structural characteristics, it has the name of the detailed description of the chemical structure, such as "o-bromo-p-chlorotrifluoromethoxy benzene", to accurately express its atomic connection and substituent position.
And the market trade name, for easy memory and marketing activities, or more concise and easy to remember, such as "bromochlorofluoroether benzene". Although the names are different, they all refer to this specific chemical substance. In the field of synthesis, whether it is the name of the academic community or the name of the product, it is well known to researchers and practitioners, making it easy to communicate, study and apply this compound in various synthetic reactions, in order to promote the development and innovation of chemical synthesis technology.
Safety & Operational Standards
2 - Bromo - 1 - Chloro - 4 - (Trifluoromethoxy) Benzene Safety and Operating Specifications
Fu 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethoxy) Benzene, the product of transformation. When used, safety comes first, and the operation must follow the rules to ensure safety.
Store in a cool, dry and well-ventilated place. Avoid open flames and hot topics to prevent accidents. Cover this thing or have the risk of explosion. If it is near the source of fire, it is afraid of disaster. Its container must be well sealed to prevent contact with air and moisture to prevent deterioration and damage to its quality.
When operating, take appropriate protective gear. Such as a gas mask, which can prevent its gas from entering the body and prevent breathing; protective gloves, which can prevent it from touching the skin and prevent skin damage. And the operation is suitable for ventilation cabinets, so that the exhaust gas can be discharged quickly and the harm can be reduced invisibly.
When taking it, the action should be slow and careful. Measure it with a clean appliance, and do not sprinkle it. If there is a sprinkle, take emergency measures as soon as possible. Cut off the fire source first to prevent it from exploding; then cover it with sand, vermiculite, etc., collect it properly, and do not discard it at will.
If you accidentally touch the body, rinse it with a lot of water quickly, and then wash it with soap. If it enters the eye, rinse it quickly with water and seek medical treatment. If inhaling its gas, leave the scene quickly and go to a place with fresh air. If necessary, apply artificial respiration and seek medical first aid.
Furthermore, the disposal of this waste should not be ignored. When treated in accordance with environmental protection regulations, it should not be mixed with regular waste. In this way, it can ensure safe operation, harmless environment, and beneficial to people and things.
Application Area
2-Bromo-1-chloro-4- (trifluoromethoxy) benzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often a key intermediate. With its special structure, it can participate in many reactions, help create new drugs, and cure various diseases.
In the field of materials science, it also has its uses. It can be integrated into polymer materials through special processes to give the material unique properties, such as enhancing its chemical stability and improving its electrical properties.
Furthermore, in the field of fine chemicals, it can be used as a raw material to prepare high-end fine chemicals to meet the strict needs of various industries for special chemicals. Its application in various fields has broad prospects, and it is a substance that cannot be ignored in chemical research and industrial production.
Research & Development
In recent years, in the field of chemistry, I have studied a strange product named 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethoxy) Benzene. The properties of this product are worth studying. Its structure is exquisite, and bromine, chlorine and trifluoromethoxy are listed in the benzene ring, giving it a specific quality.
Study its synthesis, select several routes. Or from benzene derivatives, after halogenation and etherification, it gradually became this product. However, the advantages and disadvantages of each method are mutually different, and there are strict rules that need to be strict, and the yield is not ideal.
As for the application, the prospect is also wide. In the production of medicine, it can be used as a key intermediate to help innovate drugs and treat various diseases in the world. In the field of materials, or to build the foundation of special materials, to develop unique properties.
We should do our best to explore its principles and expand its uses, hoping that this compound will shine in scientific research and industry, and become the achievement of our generation's efforts, benefiting the country and the people, and promoting the vigorous and prosperous chemical industry.
Toxicity Research
Recently, I have focused on the toxicity study of 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethoxy) Benzene. This substance has a unique structure and contains groups such as bromine, chlorine and trifluoromethoxy, or has special chemical activities and toxic effects.
After repeated experiments, it has a significant impact on the tested organisms. At low concentrations, some biological behaviors change slightly or are disturbed by the nervous system. At high concentrations, the biological physiological functions are seriously abnormal, growth and development are blocked, and even death.
Investigate the mechanism of its toxicity, or because its structure is in line with key molecules in organisms, it interferes with normal biochemical reactions. Although the research is still shallow, the preliminary conclusions show that this chemical has irreversible toxicity. The follow-up should study its mechanism of action in order to provide a solid basis for prevention and treatment, and protect the ecology and human well-being.
Future Prospects
The future exhibition is about 2 - Bromo - 1 - Chloro - 4 - (Trifluoromethoxy) Benzene. Our generation researches it, hoping that it will bloom in various domains. The road of viewing chemical industry, or the cornerstone of new materials, with its unique structure, builds strong and corrosion-resistant new materials, adding innovation to aviation and automobiles. The path of medicine is also expected to be the source of special effects and miracles, with precise targeting and disease removal. The field of electronics can be used as a high-quality substrate to help chips be efficient and circuits run smoothly. Although the road ahead is long, but we uphold the heart of research, fearless and difficult, with wisdom and sweat, lead this thing to the glorious state, for the benefit of future generations, and create endless possibilities.
Frequently Asked Questions
What are the physical properties of 2-Bromo-1-Chloro-4- (Trifluoromethoxy) Benzene?
2-Bromo-1-chloro-4- (trifluoromethoxy) benzene, this is an organic compound. Its physical properties, let me explain in detail.
Looking at its properties, under room temperature and pressure, it is mostly colorless to pale yellow liquid, which is caused by the interaction of various atoms in its molecular structure, resulting in its aggregated state. Its odor may have a certain irritation, which is caused by halogen atoms and specific functional groups, and its volatile substances stimulate olfactory receptors.
When it comes to melting point and boiling point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. The values of melting point and boiling point are closely related to the intermolecular forces. The presence of halogen atoms and trifluoromethoxy in the molecule enhances the intermolecular force, so a higher temperature is required to change its physical state.
In addition, the density is about [X] g/cm ³, which is greater than the density of water. Due to the large number of atoms in the molecule, the mass is large, and the structure is relatively compact, which increases the mass of the substance per unit volume.
In terms of solubility, it has good solubility in organic solvents such as ethanol and ether. Because the compound is an organic molecule, it follows the principle of "similar compatibility" with organic solvents, and van der Waals forces or other weak interactions can be formed between molecules to promote dissolution. However, the solubility in water is poor, because water is a polar molecule, the intermolecular force with the organic compound is weak, making it difficult to overcome its intramolecular and intermolecular forces to dissolve it.
Volatility, has a certain volatility. Because the intermolecular force is not extremely strong, some molecules can obtain enough energy to escape the liquid surface and enter the gas phase at room temperature.
The physical properties of 2-bromo-1-chloro-4- (trifluoromethoxy) benzene are determined by their unique molecular structure, and these properties play a key role in various chemical reactions and practical applications.
What are the chemical properties of 2-Bromo-1-Chloro-4- (Trifluoromethoxy) Benzene?
2-Bromo-1-chloro-4- (trifluoromethoxy) benzene is one of the organic compounds, and its chemical properties are profound and have attracted the attention of many chemistry researchers.
In this compound, bromine atoms, chlorine atoms and trifluoromethoxy groups each show unique properties. Bromine atoms have a certain nucleophilic substitution activity. When encountering nucleophilic reagents, they can often break their carbon-bromine bonds and be replaced by nucleophilic reagents. For example, if encountering nucleophiles such as hydroxyl negative ions, nucleophilic substitution reactions may occur to generate derivatives containing hydroxyl groups.
Chlorine atoms also have a similar tendency to nucleophilic substitution, but because of their different atomic properties from bromine atoms, the reactivity is also slightly different. Usually under specific reaction conditions, chlorine atoms can be replaced by other groups to participate in the construction of novel organic molecular structures.
As for trifluoromethoxy groups, due to their large number of fluorine atoms, this compound has unique electronic and spatial effects. Fluorine atoms are extremely electronegative, making trifluoromethoxy groups strong electron absorbers, which can affect the electron cloud distribution of the benzene ring. In this way, the reaction check point and reaction activity on the benzene ring will change. For example, in the electrophilic substitution reaction, this electron-withdrawing group will reduce the electron cloud density of the benzene ring, the reactivity is lower than that of the benzene itself, and the reaction check point is mostly concentrated in the meta position.
In addition, in some reduction reactions of 2-bromo-1-chloro-4- (trifluoromethoxy) benzene, bromine and chlorine atoms may be reduced to form hydrogenated benzene products. In the field of organic synthesis, chemists often rely on the properties of this compound to construct complex and diverse organic molecules through various reactions, providing important intermediates for drug development, materials science and other fields.
What is the main use of 2-Bromo-1-Chloro-4- (Trifluoromethoxy) Benzene?
2-Bromo-1-chloro-4- (trifluoromethoxy) benzene is widely used. In the field of organic synthesis, it is often a key raw material for the construction of many complex and functional organic compounds.
In the field of pharmaceutical research and development, it can be used as a starting material to introduce specific functional groups through a series of chemical reactions, and then synthesize bioactive molecules, or can be used to create new drugs and contribute to human health.
In the field of materials science, compounds derived from it may have unique physical and chemical properties, and can be prepared such as high-performance polymers, special coating materials, etc. Such materials may be used in electronics, aerospace and other fields to demonstrate excellent properties, such as excellent heat resistance, chemical stability, etc.
Furthermore, in the field of pesticides, the organic compounds they participate in the synthesis may have good insecticidal and bactericidal activities, and can be developed into new pesticides, providing effective means for pest control in agricultural production, and ensuring crop yield and quality.
In addition, in the fine chemical industry, it is also commonly used in the synthesis of various fine chemicals, such as fragrances, dye intermediates, etc., to provide support for the diverse needs of people's daily life. Overall, 2-bromo-1-chloro-4- (trifluoromethoxy) benzene plays an important role in many fields, promoting the development and progress of various industries.
What are the synthesis methods of 2-Bromo-1-Chloro-4- (Trifluoromethoxy) Benzene?
There are several ways to synthesize 2-bromo-1-chloro-4- (trifluoromethoxy) benzene.
First, it can be obtained by electrophilic substitution reaction from the starting material containing the benzene ring. First take the appropriate benzene derivative, and introduce the bromine atom with a brominating reagent under specific reaction conditions. If liquid bromine is used as the bromine source, under the catalysis of Lewis acid (such as iron tribromide), bromine can selectively replace the hydrogen atom at a specific position on the benzene ring. Subsequently, the chlorine atom is introduced with a chlorination reagent. During chlorination, the reaction conditions, such as temperature, ratio of reactants, etc., need to be precisely adjusted to achieve the desired substitution position. Finally, trifluoromethoxy is introduced by a specific method. The nucleophilic substitution reaction can be used to react the reagent containing trifluoromethoxy with the intermediate to obtain the target product.
Second, it can also be synthesized by the strategy of gradually constructing the benzene ring. First, a simple compound containing a partial substituent, such as a monomer containing bromine or chlorine, is prepared and converted into a suitable intermediate through a multi-step reaction. Subsequently, the benzene ring is constructed through a cyclization reaction, and the remaining substituents are introduced at the same time. In this process, each step of the reaction needs to be carefully designed to ensure the selectivity and yield of the reaction.
Furthermore, the coupling reaction catalyzed by transition metals can also be considered. Using benzene derivatives containing bromine and chlorine as substrates, under the action of transition metal catalysts (such as palladium catalysts), the coupling reaction occurs with reagents containing trifluoromethoxy groups. Such reaction conditions are mild and highly selective, which can effectively synthesize the target product. However, it is necessary to pay attention to the selection of suitable ligands and reaction solvents to optimize the reaction conditions and improve the reaction efficiency.
All synthesis methods have their own advantages and disadvantages. In practice, the appropriate synthesis route should be carefully selected according to the availability of starting materials, reaction costs, product purity requirements and many other factors.
What are the precautions for storing and transporting 2-Bromo-1-Chloro-4- (Trifluoromethoxy) Benzene?
2-Bromo-1-chloro-4- (trifluoromethoxy) benzene is also an organic compound. When storing and transporting, all precautions must be kept in mind.
First storage, this compound should be placed in a cool, dry and well ventilated place. To cover its properties or be unstable due to changes in temperature and humidity, avoid hot topics and humid places to prevent deterioration. And keep away from fire and heat sources to prevent the danger of open flames, because it may be flammable, a little carelessness will lead to disaster. Furthermore, it is appropriate to store it separately from oxidizing agents, acids, alkalis and other substances. Due to its active chemical properties, it is easy to react with various substances and cause accidents.
As for transportation, there are also many precautions. When handling, be sure to pack and unload lightly to prevent damage to the packaging container. If the packaging is damaged, the compound will escape, which may cause environmental pollution and endanger personal safety. Transportation vehicles should also ensure that the vehicle is in good condition and has corresponding fire protection and emergency treatment equipment. When driving on the way, drive slowly to avoid bumps and vibrations, so as to avoid the danger caused by the shock of the compound. Transportation personnel must also undergo professional training and be familiar with the characteristics of the compound and emergency response methods. In case of emergencies, they can properly deal with it and avoid danger.
All of these are essential for the storage and transportation of 2-bromo-1-chloro-4- (trifluoromethoxy) benzene, and they should not be slack to ensure that everything goes smoothly and is safe.