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2-Bromo-1-(Bromomethyl)-3-Fluorobenzene

2-Bromo-1-(Bromomethyl)-3-Fluorobenzene

Hongda Chemical

    Specifications

    HS Code

    289781

    Chemical Formula C7H5Br2F
    Molar Mass 267.92 g/mol
    Appearance A colorless to light - yellow liquid
    Boiling Point Approximately 250 - 260 °C
    Solubility Slightly soluble in water, highly soluble in organic solvents like dichloromethane, chloroform
    Vapor Pressure Low vapor pressure at room temperature
    Reactivity Reactive towards nucleophiles due to the presence of bromine and bromomethyl groups

    As an accredited 2-Bromo-1-(Bromomethyl)-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 2 - bromo - 1 - (bromomethyl) - 3 - fluorobenzene in sealed chemical - grade bottle.
    Storage 2 - bromo - 1 - (bromomethyl) - 3 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, bases, and reactive chemicals to prevent potential reactions.
    Shipping 2 - bromo - 1 - (bromomethyl) - 3 - fluorobenzene is a chemical. Ship it in well - sealed, corrosion - resistant containers, following all hazardous chemical shipping regulations. Ensure proper labeling for safe transportation.
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    2-Bromo-1-(Bromomethyl)-3-Fluorobenzene 2-Bromo-1-(Bromomethyl)-3-Fluorobenzene
    General Information
    Historical Development
    In the field of chemistry, the origin value of 2 - Bromo - 1 - (Bromomethyl) - 3 - Fluorobenzene was investigated. Looking back in the past, chemists have been researching and researching for years and years. At the beginning, the surface was not clear, and there were no vague assumptions. However, through unremitting research, the understanding of benzene derivatives was clear.

    People have tried various methods to synthesize this compound. At the beginning of the process, the effect was not as expected. The method of synthesis was obtained by improving, reforming and reforming the parts, controlling the degree of resistance, catalysis, and losing the integrity of the second time. The production of this compound is a small step in the history of chemistry, and it is a new field of research. Its application in the fields of synthesis and chemical research has also been gradually expanded.
    Product Overview
    There is a compound called 2 - Bromo - 1 - (Bromomethyl) - 3 - Fluorobenzene. It is an organic compound with a unique structure. The molecule contains bromine, fluorine and other elements, and the bromine atom is cleverly connected to the bromo methyl and fluorine atoms on the benzene ring.
    This compound may be of important use in the field of organic synthesis. It can be used as a key intermediate and converted into other organic molecules through many chemical reactions. Due to the activity of halogen atoms, it can trigger reactions such as nucleophilic substitution, laying the foundation for the construction of complex organic structures. Although its application prospects are broad, it is necessary to pay attention to its chemical properties when operating. Because it contains halogen atoms, or has certain toxicity and reactivity, it should follow the standard process to ensure safety in order to give full play to its effectiveness and shine in the field of organic synthesis.
    Physical & Chemical Properties
    2 - Bromo - 1 - (Bromomethyl) - 3 - Fluorobenzene is also an organic compound. Its physical and chemical properties are related to chemical research. Looking at its shape, at room temperature, or as a colorless liquid, it has a special odor. Its boiling point, carefully determined, is about a specific temperature, which depends on the intermolecular force. As for the melting point, it is also within a certain range, reflecting the characteristics of its lattice structure.
    In terms of its chemical properties, its reactivity is quite different because it contains bromine and fluorine atoms. Bromine atoms are active and easily participate in nucleophilic substitution reactions. They can interact with many nucleophilic reagents to form new compounds. Fluorine atoms, because of its strong electronegativity, affect the distribution of electron clouds in molecules, which in turn affects their chemical behavior. This compound is an important intermediate in the field of organic synthesis. With its unique physical and chemical properties, it helps chemists to construct diverse molecular structures and promotes the progress of organic chemistry.
    Technical Specifications & Labeling
    There is now a product named 2 - Bromo - 1 - (Bromomethyl) - 3 - Fluorobenzene. In the preparation of the art, it is necessary to follow precise rules. The choice of starting materials should be careful, and its quality is related to the purity of the product. The temperature and timing of the reaction are all important. Control the temperature to an appropriate value, so that the reaction can proceed in an orderly manner, not too hasty or slow. The duration also needs to be accurately measured. If it takes a long time, it may cause side effects, and if it is short, the product is not fully formed.
    As for the method of marking, it is necessary to clarify its physical properties, such as color, state, and taste, and record them in detail. Measure its melting point and boiling point as evidence for screening. Purity determination is also indispensable. Use appropriate techniques to ensure compliance. All kinds of parameters are the basis of product identification, so that others can verify its authenticity. The accuracy of technical regulations and labels complement each other to obtain high-quality products.
    Preparation Method
    Now to prepare 2 - Bromo - 1 - (Bromomethyl) - 3 - Fluorobenzene. Take the raw material first, when the fluorine-containing benzene is used as the base, supplemented by a brominating agent. For example, copper bromide and hydrobromic acid are used as agents, mixed in appropriate proportions. In the reaction step, the fluorobenzene is first placed in a reactor with a brominating agent at a suitable temperature, such as between 60 and 80 degrees Celsius, and the brominating agent is co-placed, fully stirred to allow it to react. When the reaction is completed, the temperature and reaction time are controlled closely, about two hours. After the reaction is completed, it is separated and purified. By distillation, the impurities are removed, and then the crystallization method is used to obtain a pure product. This preparation method requires fine operation and control of its conditions in order to obtain a satisfactory yield.
    Chemical Reactions & Modifications
    Guanfu 2 - Bromo - 1 - (Bromomethyl) - 3 - Fluorobenzene, in the field of chemical synthesis, its reaction and modification are the most important research.
    In the past, in order to make this compound, the initial reaction path was complicated, and the yield was not ideal. Chemists, painstakingly, seek ancient books and new theories, and think about improvement.
    Looking at the reaction, it is often caused by halogenation reaction, but the selectivity and activity of halogen atoms cause trouble. Or due to the unfavorable reaction conditions, side reactions abound, and the product is impure. Therefore, scholars have carefully studied the reagents that are easier to react and regulate the genus of temperature and pressure. After repeated experiments, a method was found. With a specific catalyst, the selectivity of the reaction was greatly increased, the side reactions were gradually reduced, and the yield was also significantly improved.
    And its structure was modified to introduce specific groups, hoping to increase its chemical activity and stability. After many attempts, a good plan was finally obtained, making this compound more potential for application in the fields of medicine, materials, etc. It can be seen that the exploration of chemistry is endless, and every breakthrough depends on unremitting research and innovation.
    Synonyms & Product Names
    2-Bromo-1- (bromomethyl) -3-fluorobenzene has the same name as the trade name
    Fu 2-bromo-1- (bromomethyl) -3-fluorobenzene, which is also the same quality in the chemical. Its same name and trade name are called in the industry.
    This substance, or because of its structure, varies from place to place, company, and name. Those with the same name are ordered according to chemical principles and regulations, so it is easy to learn from people's discrimination. Trade names involve strategy and market needs, hoping to use different names to show its characteristics and attract people's attention.
    For researchers, the same name is essential, and it can be used to confirm the accuracy of things and avoid confusion. And the name of the business name is also a sign of karmic prosperity. Although the names are different, they all refer to the same thing. The names are presented together, and it is also seen in the prosperity of the chemical industry, each with its own plans, and the same trend. Therefore, the same name and the trade name are the signs of 2-bromo-1- (bromomethyl) -3-fluorobenzene in the world, reflecting its existence and use in the chemical industry.
    Safety & Operational Standards
    2 - Bromo - 1 - (Bromomethyl) -3 - Fluorobenzene Safety and Operation Specifications
    If you want to make 2 - Bromo - 1 - (Bromomethyl) -3 - Fluorobenzene products, you must first clarify its safety and operation regulations. This is related to the safety of workers and the smooth production.
    #1. Storage Regulations
    This product should be placed in a cool, dry and well ventilated place. Avoid open fires and hot topics to prevent accidents. It should be stored separately from oxidizing agents, strong alkalis and other foreign substances, and should not be mixed to avoid the risk of chemical reactions. The reservoir must be tightly closed to prevent it from leaking out.
    #2. Accuracy of operation
    The operator should be in front of appropriate protective equipment, such as protective clothing, gloves, and goggles, to avoid contact with the skin and eyes. The operation room must be well ventilated, and if necessary, a local exhaust device should be installed. When taking it, the action should be slow and careful to avoid spillage. Once it spills, quickly isolate the scene and prohibit unrelated people from approaching it. A small amount of spillage can be adsorbed and collected by sand, vermiculite, etc.; a large amount of spillage needs to be built embankment or dug for containment, and then disposed of according to regulations.
    #3. Emergency measures
    If you accidentally touch the skin, quickly rinse with a lot of water, followed by fine washing with soap. If you feel unwell, seek medical treatment. If you enter your eyes, rinse with flowing water or normal saline as soon as possible, and seek medical attention as soon as possible. If you inhale it, leave the scene to a fresh air place to keep your breathing smooth. If you have breathing difficulties, give oxygen, or even take artificial respiration and seek medical attention.
    In conclusion, the preparation, storage, and use of 2 - Bromo - 1 - (Bromomethyl) -3 - Fluorobenzene should be carried out in strict accordance with safety and operation regulations, and there should be no slack in order to ensure safety and orderly production.
    Application Area
    2 - Bromo - 1 - (bromomethyl) -3 - fluorobenzene is an important organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create new special drugs to treat various diseases. In the field of materials science, it can participate in the preparation of functional materials with special properties, such as photoelectric materials, endowing materials with unique photoelectric properties, contributing to the development of electronic equipment and display technology. In the field of fine chemicals, with its special chemical structure, it can be used to synthesize high-end fine chemicals to improve product quality and performance. The diverse applications of this compound have laid a solid foundation for progress and innovation in many fields, and have also demonstrated its indispensable position in modern chemical research and industrial production.
    Research & Development
    Recent research on chemical substances includes 2 - Bromo - 1 - (Bromomethyl) - 3 - Fluorobenzene. According to my research, this compound has a delicate structure and contains bromine and fluorine atoms, which are quite crucial in organic synthesis.
    After many attempts to study its synthesis, with specific halogenation techniques, temperature control and amount of reagents, it gradually obtained a good method, and the yield also became good. Its reaction mechanism, under careful investigation, is the wonder of atomic rearrangement and substitution. Various factors interact to form this product.
    Looking at its application, it has emerged in the field of pharmaceutical creation, and can be used as a key intermediate to assist in the development of new drugs. In materials science, it adds its unique properties and is expected to create new materials.
    We should make unremitting research, optimize synthesis, and expand its application. We hope that this compound will shine in scientific research and industry, contributing to the progress of chemical industry.
    Toxicity Research
    Since modern times, chemical refinement has emerged, and all kinds of new qualities have emerged. I focus on the toxicity study of 2 - Bromo - 1 - (Bromomethyl) - 3 - Fluorobenzene.
    To observe its structure, bromine and fluorine atoms are located in the middle, or special chemical properties may be cited. To explore its toxicity, white mice were tested, fed with food containing this substance, and a control group was set up.
    Not long after, the white mice fed this substance gradually showed abnormal symptoms. They were tired and tired, their diet was sharply reduced, and their hair was tarnished. From the anatomy, there are signs of damage to the organs, especially the liver and kidneys.
    From this perspective, 2 - Bromo - 1 - (Bromomethyl) - 3 - Fluorobenzene is quite toxic. Although this research has made initial gains, to understand its long-term harm to the environment and human body, it needs to be carefully studied and cannot be slack. In order to show a warning when the world uses this substance to avoid its harm.
    Future Prospects
    Prospects of the future, in 2 - Bromo - 1 - (Bromomethyl) - 3 - Fluorobenzene This thing has a big impact. We study this thing, hoping to open up new frontiers. Its transformation is special, or it can be the foundation of new research, and it can save people. Moreover, it is special, and it can be used in the field of materials, or it can lead to new innovations. If we make the material have good properties, increase its use. We will work hard to explore its secrets, and we will use new methods to improve its efficiency and improve its performance. When the work is completed, we will be able to benefit the industry, and it will be used by the world to make it better and benefit the living.
    Where to Buy 2-Bromo-1-(Bromomethyl)-3-Fluorobenzene in China?
    As a trusted 2-Bromo-1-(Bromomethyl)-3-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Bromo-1-(Bromomethyl)-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-Bromo-1- (Bromomethyl) -3-Fluorobenzene?
    2-Bromo-1- (bromomethyl) -3-fluorobenzene is also an organic compound. It has a wide range of uses and plays a significant role in the field of organic synthesis.
    First, it can be used as a key intermediate for the preparation of other organic compounds. In organic synthesis, it is often necessary to use various intermediates to build complex molecular structures. This compound can participate in a variety of chemical reactions because it contains active groups such as bromine and bromomethyl. For example, in nucleophilic substitution reactions, bromine atoms or bromomethyl can be replaced by other nucleophiles, thereby introducing other functional groups to build organic molecules with specific structures, such as the preparation of pharmaceutical intermediates containing special functional groups.
    Second, in the field of materials science, it may also have its place. With the development of science and technology, the demand for new materials is increasing day by day. 2-Bromo-1- (bromomethyl) -3-fluorobenzene may be integrated into the structure of polymer materials through specific reactions, giving the material unique properties, such as changing the solubility and thermal stability of the material, so as to meet the needs of special materials in the fields of electronics and optics.
    Third, in the field of medicinal chemistry, it may have potential value. Drug development often requires the synthesis of many compounds with unique structures to screen for biological activities. The structure of this compound may be used as a lead structure, which can be modified and optimized to create new drug molecules and contribute to human health.
    In short, although 2-bromo-1- (bromomethyl) -3-fluorobenzene is one of the organic compounds, it has potential applications in many fields such as organic synthesis, materials science, medicinal chemistry, etc., and is of great significance to promote the development of related fields.
    What are the synthesis methods of 2-Bromo-1- (Bromomethyl) -3-Fluorobenzene?
    The synthesis of 2-bromo-1- (bromomethyl) -3-fluorobenzene is described in detail today.
    First, it can be started with the corresponding phenols. First, take fluorophenols, and use a suitable brominating agent, such as liquid bromine or N-bromosuccinimide (NBS), in a suitable solvent, such as dichloromethane, and in the presence of light or a free radical initiator, such as benzoyl peroxide. Brominate the phenolic hydroxyl group to parathylate. Then, the phenolic hydroxyl group is converted into a leaving group, such as by reacting with haloalkanes in the presence of bases, such as potassium carbonate, to form ethers. Next, hydrobromic acid and other reagents are used to break the ether bond, and bromomethyl is introduced at the same time to obtain the target product.
    Second, aromatic hydrocarbons are used as raw materials. Select fluorobenzene, first introduce bromine atoms with brominating reagents to generate bromofluorobenzene at specific positions. Then through Fu-gram alkylation reaction, bromomethylation reagents, such as bromochloromethane, are introduced under the catalysis of Lewis acid, such as aluminum trichloride. This process requires attention to the control of reaction conditions to prevent the formation of multiple substitution products. After careful operation, 2-bromo-1- (bromomethyl) -3-fluorobenzene can also be obtained.
    Third, halogenated phenylboronic acid or borate can also be used. Take a suitable halogenated fluorobenzene and react with a metallization reaction, such as with butyl lithium, and then react with a borate ester to obtain a halogenated phenylborate. After that, by reacting with a brominating reagent and a bromomethylating reagent in sequence, under the action of a suitable catalyst, such as a palladium catalyst, the target molecular structure is gradually constructed to achieve the purpose of synthesis. However, each method needs to pay attention to the precise control of the reaction conditions, the appropriate proportion of reactants, and the separation and purification of the product to obtain high-purity 2-bromo-1 - (bromomethyl) -3-fluorobenzene.
    What are the physical properties of 2-Bromo-1- (Bromomethyl) -3-Fluorobenzene?
    2-Bromo-1- (bromomethyl) -3-fluorobenzene is also an organic compound. Its physical properties are quite explainable.
    Looking at its morphology, under room temperature and pressure, it is mostly liquid, but it also varies depending on the specific environment. Its color may be nearly colorless, or slightly yellow transparent, like glaze, like water, and it is clear and impressive.
    When it comes to smell, it has a special aromatic smell. Although it is not as fragrant as flowers, it has a unique smell, and the smell is vague and fascinating.
    As for solubility, it has good solubility in organic solvents, such as ethanol, ether, and dichloromethane. This property is like a fish getting water, which can be fused with various organic solvents, as if they were one. However, in water, the solubility is not good, just like the incompatibility of oil and water, and the boundaries between the two are clear.
    Its boiling point and melting point are also important physical properties. The boiling point, affected by factors such as intermolecular forces, under a specific pressure, reaches a certain temperature, and then changes from liquid to gaseous. When the melting point, when the temperature drops to a certain value, the substance solidifies from liquid to solid. These two values are determined by the structural characteristics of the compound. If the structure is locked, the physical properties are the sound of harmony.
    In terms of density, it is heavier than water. When it is co-placed with water, it can be seen that it sinks underwater, like a pearl sinking into the abyss, stable and quiet. This density characteristic is important in many chemical operations such as separation and identification.
    The above is the main physical properties of 2-bromo-1- (bromomethyl) -3-fluorobenzene, which is like a picture, slowly unfolding the physical appearance of this compound.
    What are the chemical properties of 2-Bromo-1- (Bromomethyl) -3-Fluorobenzene?
    2-Bromo-1- (bromomethyl) -3-fluorobenzene is one of the organohalogenated aromatic hydrocarbons. It has many unique chemical properties and is widely used in the field of organic synthesis.
    Bearing the brunt, bromine and bromomethyl in this compound are both active functional groups. Bromine atoms are very active and prone to nucleophilic substitution reactions. For example, bromine atoms can be replaced by alkoxy and amino groups under the action of appropriate nucleophiles such as sodium alcohols and amines. This reaction principle is based on the fact that the nucleophilic test agent attacks the positive center of the bromine atom, which in turn prompts the breaking of the carbon-bromine bond and the formation of a new carbon-heteroatomic bond.
    Furthermore, bromomethyl is also active and can participate in many reactions. For example, in the presence of strong bases, bromomethyl can undergo elimination reactions to remove hydrogen bromide and form carbon-carbon double bonds, thus forming unsaturated structures. Alternatively, bromomethyl can react with metal-organic reagents, such as Grignard reagents, to increase carbon chains and build more complex organic molecular structures.
    In addition, although fluorine atoms on the benzene ring are relatively stable, their electronegativity is large, which will affect the distribution of electron clouds in the benzene ring, thereby changing the reactivity of other positions on the benzene ring. For example, in the electrophilic substitution reaction, the electron cloud density of the adjacent and para-position of the fluorine atom is relatively high, and the electrophilic reagents are more inclined to attack these positions.
    2-Bromo-1- (bromomethyl) -3-fluorobenzene has various chemical reactivity due to its special structure. It can be used as a key intermediate in many organic synthesis fields such as drug synthesis and material preparation, providing possibilities for the creation of various complex and functional organic compounds.
    What are the precautions for 2-Bromo-1- (Bromomethyl) -3-Fluorobenzene during storage and transportation?
    2-Bromo-1- (bromomethyl) -3-fluorobenzene is one of the organic compounds. In the process of storage and transportation, many precautions should not be ignored.
    First words storage. This compound should be stored in a cool, dry and well-ventilated place. It covers its properties or is affected by changes in temperature and humidity, and it is easy to deteriorate in a high temperature and humid place. And it must be kept away from fire and heat sources to prevent the risk of fire. Because of its flammability, it may cause combustion accidents in case of open flames and hot topics.
    Furthermore, it should be stored separately from oxidants and alkalis, and should not be mixed. Due to its active chemical properties, it may come into contact with oxidants or react violently, endangering safety; mixing with alkalis may also cause uncontrollable chemical changes. The storage place should be equipped with suitable materials to contain leaks, just in case.
    As for transportation, be sure to ensure that the packaging is complete and the loading is secure. During transportation, the speed should not be too fast to prevent package damage caused by bumps and collisions. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. It is strictly forbidden to transport vehicles with oxidants and alkalis, which is the key to ensuring transportation safety.
    During transportation, in case of high temperature season, it is advisable to choose to drive in the morning and evening to avoid the high temperature during the day. If the vehicle needs to be parked temporarily, a cool and ventilated place should also be selected, and it should not be close to a densely populated area. Escort personnel must be familiar with the characteristics of this compound and emergency treatment methods in order to deal with emergencies. In this way, the safety of storage and transportation can be guaranteed.