2-Bromo-1,3-Difluorobenzene

Hongda Chemical

Specifications

HS Code	853558
Chemical Formula	C6H3BrF2
Molar Mass	193.0
Appearance	Colorless to light yellow liquid
Boiling Point	158 - 160 °C
Melting Point	N/A
Density	1.72 g/cm³
Solubility In Water	Insoluble
Flash Point	56 °C
Vapor Pressure	N/A
Refractive Index	1.502 - 1.504

As an accredited 2-Bromo-1,3-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 2 - bromo - 1,3 - difluorobenzene in a sealed, chemical - resistant bottle.
Storage	2 - bromo - 1,3 - difluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents, bases, and reactive chemicals to prevent potential reactions.
Shipping	2 - bromo - 1,3 - difluorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict chemical transportation regulations to ensure safe transit, with proper labeling indicating its hazardous nature and handling precautions.

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General Information

Historical Development

2 - Bromo - 1,3 - Difluorobenzene is an important intermediate in organic synthesis. It has a long history of development. In the past, organic synthesis technology was not mature, and the research and preparation of this compound was quite difficult. However, with the advance of science and technology, the chemical synthesis methods became more and more delicate. In the early days, chemists tried to prepare this compound through complicated reaction processes. Although the efficiency was not high, they accumulated a lot of valuable experience. In modern times, new catalytic technologies and optimization of reaction conditions have greatly improved the synthesis efficiency of 2 - Bromo - 1,3 - Difluorobenzene, and the yield has also increased significantly. The application of this compound in medicine, pesticides and other fields is becoming more and more extensive, and its historical development has witnessed the vigorous progress of chemical synthesis, laying a solid foundation for more related research and applications in the future.

Product Overview

Description of 2-Bromo-1,3-difluorobenzene
2-Bromo-1,3-difluorobenzene is a crucial compound in the field of organic synthesis. Its appearance is colorless to pale yellow transparent liquid, and its properties are relatively stable at room temperature and pressure.
Looking at its structure, there are bromine atoms and difluorine atoms cleverly connected to the benzene ring. This unique structure gives it special chemical activity. The presence of bromine atoms makes the compound prone to nucleophilic substitution reactions, which can be used to carry out many organic synthesis reactions, laying the foundation for the construction of more complex organic molecular structures. The introduction of fluorine atoms greatly changes the physical and chemical properties of molecules, such as enhancing the lipid solubility of compounds, enhancing their stability and biological activity.
In organic synthesis, 2-bromo-1,3-difluorobenzene is often used as a key intermediate. It can react with various reagents through specific chemical reaction pathways to derive a variety of organic compounds with different functions and uses, and has wide application prospects in the fields of medicine, pesticides, and materials science.

Physical & Chemical Properties

2 - Bromo - 1,3 - Difluorobenzene is an organic compound, and its physicochemical properties are very important. Looking at its physical properties, at room temperature, this substance is often in a liquid state, with a specific color and odor. Its boiling point and melting point determine the temperature range of the change of the state of matter, which has a great impact on its storage and use.
When it comes to chemical properties, the presence of bromine and fluorine atoms in this compound gives it unique reactivity. Bromine atoms can participate in nucleophilic substitution reactions, providing the possibility for the introduction of other functional groups. Fluorine atoms have strong electronegativity, which affects the distribution of electron clouds in molecules, making the chemical properties of compounds more active and showing unique roles in many organic synthesis reactions. And its stability is also affected by the molecular structure, and different chemical reactions may occur under different conditions, laying the foundation for chemical research and application.

Technical Specifications & Labeling

Technical Specifications and Labeling of 2-Bromo-1,3-Difluorobenzene (Product Parameters)
For 2-bromo-1,3-difluorobenzene, the technical specifications are of paramount importance. Looking at its chemical structure, bromine (Br) and difluorine (F ²) are firmly attached to the benzene ring. This unique structure lays the foundation for its physical and chemical properties.
In terms of its purity, it must reach a very high standard, and the impurity content must be minimal to meet the requirements of excellent quality. Its appearance should be a clear and colorless liquid without the slightest turbidity or heterochromia, which is an intuitive sign.
As for the physical parameters, the boiling point and melting point are fixed, and accurate determination can be used to prove the quality. The boiling point is under a specific pressure, and when it falls within a predetermined range, the melting point is also the same. Both are key indicators for identifying products. The measurement of density cannot be ignored. The accurate density value can be used as a criterion for the purity of the product.
In terms of chemical properties, its activity is clearly manifested in specific reactions. The reactivity of various reagents is in accordance with the established rules. Such various technical specifications and identification parameters are the guarantee of the quality of 2-bromo-1,3-difluorobenzene, which cannot be ignored.

Preparation Method

To prepare 2 - Bromo - 1,3 - Difluorobenzene, the raw material is crucial to the production process, reaction steps and catalytic mechanism.
First, an appropriate amount of fluorobenzene is taken as the initial raw material. In a specific reactor, ferric trichloride is used as the catalyst, and an appropriate amount of bromine gas is introduced to undergo an electrophilic substitution reaction. This step requires precise temperature control, about 50 to 60 degrees Celsius, to ensure that bromine atoms accurately replace hydrogen atoms at specific positions in the benzene ring to form bromofluorobenzene-containing intermediates.
Then, the intermediate is transferred to another reaction device, and a specific fluorination reagent is added, such as anhydrous potassium fluoride, in a polar aprotic solvent, heated to 120 to 130 degrees Celsius, and the reaction is repeated. In this reaction process, water vapor is strictly isolated, and the intermediate is introduced into the second fluorine atom through fluorination reaction, and finally 2-Bromo-1,3-Difluorobenzene is obtained. The whole preparation process needs to be carefully controlled in each reaction step to ensure that the raw materials are fully reacted and the product purity and yield are improved.

Chemical Reactions & Modifications

To obtain this compound, it is often necessary to refine it delicately. Its reverse process, or involving nuclear substitution, or free radicals, each has its own characteristics.
The process of nuclear substitution, the appropriate process of nuclear substitution, and the control of the reaction parts, such as the degree of resistance and the dissolution of the product, is essential. Changing the reaction parts can improve the speed of the reaction and make the product more efficient.
The reaction of free radicals needs to be carefully introduced, and the dosage should also be considered in the context. In this way, the reaction can be carried out according to the time, making the ideal product.
And its modification method, or the introduction of new functions, or the modification of molecules, in order to give it new properties. This is all researched by those who study it, in order to realize the delicacy of anti-modification.

Synonyms & Product Names

I have heard of a chemical product, the name is 2 - Bromo - 1,3 - Difluorobenzene. Although its name is different from the common saying, it also has various aliases, which are related to the name of the trade name.
The alias of this product, or according to its characteristics, production method, or from its use and appearance. The name of the trade name, or take its easy to remember, easy to pass on, or its quality and characteristics.
Looking at the field of chemical industry, there are many people who have the same thing but different names. Take 2 - Bromo - 1,3 - Difluorobenzene as an example, or those who have aliases are all for the convenience of industry communication and identification. The name of the trade name is also to make this thing unique in the city and attract the attention of customers and merchants.
is to explore its namesake and the name of the trade name, which are essential in chemical research and business exchanges. Knowing the change of its name can be used to understand the nature and use of its thing, and it is also beneficial to the prosperity of the industry.

Safety & Operational Standards

2 - Bromo - 1,3 - Difluorobenzene is an important chemical compound in chemical research. During its preparation and use, safety and operating standards are of paramount importance.
When handling this compound, the experimenter must wear appropriate protective equipment. Among them, protective clothing can prevent it from contacting the body and preventing the penetration of chemical substances; goggles can protect the eyes and block splashed liquids; gloves are also indispensable to prevent direct contact with the hands.
The experimental site needs to be well ventilated, and an effective ventilation system should be installed to remove volatile gaseous substances in time to avoid their accumulation in the air and reduce the risk of poisoning and explosion.
When operating, the action of taking this compound should be stable and accurate. Due to its chemical activity, improper operation or uncontrolled reaction. The weighing process should be accurate, and the dosage should be used according to the experimental requirements to avoid waste and excessive risk.
Storage also has strict requirements. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. At the same time, it should be stored separately from oxidants and reducing agents to prevent mutual reaction.
In the event of an accident during operation, such as the splashing of compounds, emergency procedures should be initiated immediately. If splashed on the skin, quickly rinse with a large amount of water, and then seek medical treatment according to the injury; if splashed into the eye, it should be rinsed immediately and sent to medical treatment quickly.
2 - Bromo - 1,3 - Difluorobenzene safety and standard operation, the safety of the experimenter and the success of the experiment, must not be negligent.

Application Area

2 - Bromo - 1,3 - Difluorobenzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be a key intermediate. With its unique structure, chemists can build a multi-complex drug molecular structure, help the development of new drugs, and contribute to the healing of patients.
In the field of materials science, this compound also has outstanding performance. After specific processing, materials with special photoelectric properties can be prepared for the manufacture of advanced electronic components, such as high-performance sensors, displays, etc., to enhance the performance and function of related devices.
In the field of fine chemicals, 2 - Bromo - 1,3 - Difluorobenzene can participate in the synthesis of a variety of high-value-added fine chemicals, such as special fragrances, pigments, etc., enriching the material aspects of people's lives. In short, it has important value in many fields and promotes the development of related industries.

Research & Development

In recent years, I have dedicated myself to the research of 2 - Bromo - 1,3 - Difluorobenzene. This compound has great potential for application in the fields of medicine and materials.
At the beginning, the method of its synthesis was explored. After many attempts, the halogenation reaction was used as the basis, and the effects of different reaction conditions on the yield and purity were detailed. Such as temperature, catalyst type and dosage were carefully considered. At high temperatures, although the reaction rate increased, there were more side reactions, resulting in poor product purity.
The relationship between its structure and properties was further studied. By spectral analysis, its molecular structure characteristics were clarified, its electron cloud distribution was observed, and its chemical activity was inferred.
Although there are many obstacles in the way of research and development, I firmly believe that through unremitting research, the application scope of 2-Bromo-1, 3-Difluorobenzene will be expanded, and it will contribute to the development of various fields.

Toxicity Research

Toxicity Study of 2 - Bromo - 1,3 - Difluorobenzene
The toxicity of 2 - Bromo - 1,3 - Difluorobenzene has been studied. This substance is widely used in the chemical industry, but its toxicity is unknown. We should be careful.
Study with various experiments. Take several kinds of healthy animals, divide them into different dose groups, and administer 2 - Bromo - 1,3 - Difluorobenzene. After observation, it is seen that the animals in the high dose group have different behaviors, or drowsiness, or disturbance. According to the anatomy, the liver, kidneys and other organs have signs of damage, and the cell structure is disordered.
It is supplemented by cell experiments. This substance was applied to a variety of cell lines to observe its effect on cell proliferation and apoptosis. It can inhibit cell proliferation and promote apoptosis in a dose-dependent manner.
In summary, 2-Bromo-1,3-Difluorobenzene has certain toxicity. When it is produced and used, proper protection measures should be set to prevent it from harming life and safeguarding the environment.

Future Prospects

In today's world, science and technology are changing day by day, and there is also extraordinary hope in the research of chemical substances. Jin Yan 2 - Bromo - 1,3 - Difluorobenzene has great potential for future development.
This compound has a unique structure and unique properties. In the field of organic synthesis, it may be a key raw material for the creation of many novel molecules. It can be used to develop new drugs, adding a powerful tool for curing diseases and treating diseases; it can also be used to prepare specific materials to make the material properties better, and can be used in electronics, aviation and other industries.
Although there may be some problems at the moment, our generation of chemical researchers, with the heart of exploration and determination, will be able to overcome them. In time, 2 - Bromo - 1, 3 - Difluorobenzene will surely shine, and show an extraordinary posture in the scientific and industrial arena of the future, adding luster to human well-being, and realizing our generation's beautiful vision for the future.

Where to Buy 2-Bromo-1,3-Difluorobenzene in China?

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Frequently Asked Questions

As a leading 2-Bromo-1,3-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-bromo-1,3-difluorobenzene?

2-% alcohol-1,3-diethyl ether has a wide range of main uses. In the field of medicine, it is often used as a solvent. Because of its good solubility, it can help many drug components to disperse evenly, making it easier for drugs to play their effects. And its properties are relatively mild. When preparing drugs, it can reduce the irritation to the human body and ensure the safety of drugs.
In the chemical industry, this substance is an important raw material for organic synthesis. Through a series of chemical reactions, a variety of high value-added compounds can be synthesized. For example, it participates in the synthesis of some fine chemicals, such as fragrances, paint additives, etc. Its unique molecular structure endows the synthesized products with special properties, improving product quality and performance.
In scientific research experiments, 2-alcohol-1,3-diethyl ether is also a commonly used reagent. Scientists use its solubility and reactivity to carry out various organic chemistry experiments, explore new reaction paths and compound properties, and provide strong support for scientific research. Because it can provide a suitable environment for the reaction, promote the smooth progress of the reaction, and help researchers obtain accurate experimental results.
In industrial production, some special processes also require this substance. For example, in the production of some electronic materials, its solubility is used to treat materials to optimize material properties and ensure the quality and stability of electronic components.
To sum up, 2-alcohol-1,3-diethyl ether plays an important role in many fields such as medicine, chemical industry, scientific research and industrial production, and is of great significance in promoting the development of various fields.

What are the physical properties of 2-bromo-1,3-difluorobenzene?

2-% pente-1,3-diene benzene is a kind of organic compound. Its physical properties are quite characteristic and are described as follows:
- ** Appearance and Properties **: Under normal temperature and pressure, this substance is usually in the form of a colorless to light yellow liquid with a clear texture. It can be seen that its appearance may be slightly different under specific conditions, but it is roughly in this category.
- ** Odor **: It has a special aromatic odor. This odor is derived from the interaction of benzene ring and alkenyl group in its molecular structure. In chemical production and related fields, this odor may be used as the basis for preliminary identification.
- ** Boiling Point **: The boiling point value is about a specific range (because the exact value will be affected by environmental factors and other factors). Generally speaking, the boiling point is relatively moderate. This characteristic makes it possible to use distillation and other means to deal with the difference in boiling point during separation, purification and related reactions. The characteristics of boiling point are also related to its phase change at different temperatures. At high temperatures, it is easy to transform into a gaseous state, thus achieving separation from other substances.
- ** Melting Point **: The melting point also has its own specific value and is in a relatively low temperature range. The low melting point makes the substance exist in liquid form in a normal temperature environment. This property is of great significance to the setting of its storage and transportation conditions, and it is necessary to avoid solidification caused by too low temperature, which will affect the use and operation.
- ** Solubility **: In organic solvents, 2-% pente-1,3-diene benzene exhibits good solubility, and common organic solvents such as ethanol, ether, and acetone can be mutually soluble with it. This solubility is derived from the principle of "similar compatibility", and its organic molecular structure is similar to that of organic solvents. However, its solubility in water is poor, because its molecular polarity is weak and the force between water molecules is small. This solubility difference is widely used in the extraction and separation of chemical production.
- ** Density **: slightly less dense than water and will float above the surface of the water when in liquid form. This density property is of great significance in systems involving coexistence with water and facilitates initial separation and identification by simple physical means.

What are the synthesis methods of 2-bromo-1,3-difluorobenzene?

2-% pentene-1,3-diene (2-pentene-1,3-diene) is an important organic compound, and its synthesis method has attracted much attention in the field of organic chemistry. The following are several common synthesis methods:
1. Synthesis from alkynes
1. ** Reaction principle **: Utilize the partial reduction reaction of alkynes. Taking 1,3-pentadiyne as an example, by controlling the catalyst and reaction conditions, it can undergo an addition reaction with an appropriate amount of hydrogen to generate 2-pentene-1,3-diene. In a liquid ammonia solvent, alkynes can be reduced to conjugated dienes using alkali metals (such as sodium) as catalysts. This reaction is based on alkali metals providing electrons and liquid ammonia providing protons. The process of electron transfer and protonation is carried out in steps to realize the conversion of alkynes to conjugated dienes.
2. ** Example **: 1,3-pentadiyne reacts with an appropriate amount of hydrogen in a sodium-liquid ammonia system at low temperatures to generate 2-pentyne-1,3-diene. The advantage of this method is that conjugated dienes can be selectively generated, but the disadvantage is that the use conditions of liquid ammonia are relatively harsh, low temperature is required and safety is required.
II. Elimination reaction by halogenated hydrocarbons
1. ** Reaction principle **: Select a suitable halogenated hydrocarbon and construct a carbon-carbon double bond through elimination reaction. Taking 1,4-dihalo-2-pentane as an example, under the action of a strong base (such as an alcohol solution of potassium hydroxide), a elimination reaction occurs to remove two molecules of hydrogen halide and form 2-pentane-1,3-diene. This reaction follows the E2 elimination mechanism. The base attacks the halogenated hydrocarbon beta-hydrogen atom, and the halogen ions leave at the same time, and double bonds are formed.
2. ** Example **: 1,4-dibromo-2-pentane is co-heated with the ethanol solution of potassium hydroxide, and the elimination reaction can occur to form the target product. The raw materials of this method are relatively easy to obtain, but there may be side reactions, such as the formation of alkynes or other olefin isomers, and the reaction conditions need to be strictly controlled to improve the yield.
III. Synthesis of aldehyde or ketone
1. ** Reaction principle **: Wittig reaction or similar reaction is used. Glutaraldehyde is used as raw material, and it is first reacted with phosphorus-ylide reagent. The carbon anion in phosphorus-ylide reagent undergoes nucleophilic addition to the aldehyde group, and then triphenylphosphine oxide is eliminated to form a carbon-carbon double bond, thereby generating 2-pente-1,3-diene. This reaction condition is relatively mild, can effectively build carbon-carbon double bonds, and has good compatibility with functional groups.
2. ** Example **: Glutaraldehyde reacts with a suitable phosphorus ylide reagent in an organic solvent (such as tetrahydrofuran) to obtain 2-pente-1,3-diene. The advantage of this method is that the reaction selectivity is high, but the preparation of phosphorus ylide reagent is more complicated and the cost is relatively high.

What are the precautions for storing and transporting 2-bromo-1,3-difluorobenzene?

2-%E6%BA%B4-1%2C3-%E4%BA%8C%E6%B0%9F%E8%8B%AF%E5%9C%A8%E5%82%A8%E5%AD%98%E4%B8%8E%E8%BF%90%E8%BE%93%E8%BF%87%E7%A8%8B%E4%B8%AD%E5%BF%85%E9%A1%BB%E6%B3%A8%E6%84%8F%E4%B8%8B%E5%88%97%E4%BA%8B%E9%A1%B9:
First, the substance is toxic, touching or inhaling it can endanger human health. Therefore, during storage and transportation, we must adhere to protective measures. Those who take care of it must wear special protective clothing, gloves, and gas masks to prevent toxins from invading the body.
Second, the storage place must be dry, cool and well ventilated. Avoid exposure to sunlight, and do not be near fire and heat sources. Due to its flammability, it is easy to cause combustion or even explosion when exposed to open flames and hot topics.
Furthermore, during storage, strict classification and storage regulations are required. Do not mix with oxidants, acids, alkalis, etc.
Fourth, when transporting, a suitable means of transportation must be selected. The container used must be solid and well sealed to prevent leakage. And during transportation, the driving should be stable to avoid excessive bumps and vibrations, so as not to damage the container and cause the leakage of poisons.
Fifth, whether it is stored or transported, it is necessary to prepare a complete emergency response plan. If a leak occurs, immediately evacuate the surrounding crowd and set up a strict security area. At the same time, take effective measures to plug the leak, and use appropriate materials to absorb and neutralize the leaked poison, and try to reduce its harm.

What is the approximate market price of 2-bromo-1,3-difluorobenzene?

In today's world, the business situation is treacherous and the market price is impermanent. It is not easy to determine the market price of 2-pentanone-1,3-diethyl ester. The price of the product is determined by various factors, such as the situation of supply and demand, the price of raw materials, the simplicity of the process, and the changes in the current situation.
Looking at the supply and demand side, if there are many applicants in the market and there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop automatically. The price of raw materials is also a major factor. If the price of the raw materials required for its production is high, the price of the finished product will be difficult to suppress. If the process is complicated, labor-intensive and time-consuming, the cost will increase, and the price will also follow. And the current situation is turbulent, and the taxes and transportation costs can change, all of which can make the price fluctu
Although it is difficult to determine the exact price, according to past market conditions and industry guidelines, the price of this product varies depending on quality and purity. Those with high purity and excellent quality may have a slightly higher price; if the purity is inferior, the price should be slightly lower. Roughly speaking, the market price per kilogram may be around a few hundred yuan, but this is only an approximate number. The actual price must refer to the current market conditions, merchant pricing and transaction volume. To know the exact price, you must consult merchants, brokers in various industries, or observe the latest market conditions.