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2-Bromo-1,3,4-Trifluorobenzene

2-Bromo-1,3,4-Trifluorobenzene

Hongda Chemical

Specifications

HS Code

507098

Chemical Formula C6H2BrF3
Molecular Weight 211.98
Appearance Colorless to light yellow liquid
Boiling Point 148 - 150 °C
Melting Point N/A
Density 1.739 g/mL at 25 °C
Vapor Pressure N/A
Flash Point 45 °C
Solubility Insoluble in water, soluble in organic solvents
Refractive Index 1.4905 - 1.4925
Stability Stable under normal conditions

As an accredited 2-Bromo-1,3,4-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 250 - gram bottle of 2 - bromo - 1,3,4 - trifluorobenzene with tight - sealed packaging.
Storage 2 - bromo - 1,3,4 - trifluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass. Avoid storing it near oxidizing agents and reactive chemicals. Store in a dedicated chemical storage cabinet to prevent spills and ensure safety.
Shipping 2 - bromo - 1,3,4 - trifluorobenzene is shipped in properly labeled, tightly sealed containers. It adheres to hazardous chemical shipping regulations, ensuring secure transport to prevent spills and exposure during transit.
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2-Bromo-1,3,4-Trifluorobenzene 2-Bromo-1,3,4-Trifluorobenzene
General Information
Historical Development
2 - Bromo - 1,3,4 - Trifluorobenzene is an important chemical in organic synthesis. Tracing its historical development, the study of organic chemistry in the past was still in its infancy, and chemists paid attention to it when exploring the synthesis path of halogen-containing aromatic compounds. At that time, the synthesis methods were limited, and the preparation of this compound was difficult.
With the passage of time, chemical technology has continued to evolve, and many new reaction mechanisms have been revealed. After countless experiments and explorations, scientists have found more efficient synthesis methods, which has gradually increased the yield of 2 - Bromo - 1,3,4 - Trifluorobenzene. From a complex and inefficient process in the early days to a relatively simple and mature process today, this compound has become increasingly widely used in the field of organic synthesis, laying a key foundation for the development of many fine chemicals and drugs. Its historical development has witnessed the vigorous progress of the chemical discipline.
Product Overview
Today there is a substance called 2 - Bromo - 1, 3, 4 - Trifluorobenzene. It is an organic compound with an exquisite molecular structure, containing one bromine atom and three fluorine atoms. Bromine, the element of the halogen group, is active; fluorine is also a halogen group, with strong electronegativity. These three are arranged in an orderly manner on the benzene ring, giving this substance its unique properties.
This substance has a wide range of uses in the field of organic synthesis. It can be used as a key intermediate, through various reactions, to breed a variety of organic products. It can play an important role in either nucleophilic substitution or coupling reactions, contributing to the creation of new substances and contributing to the development of organic chemistry. It is actually a weapon for organic synthesis.
Physical & Chemical Properties
2 - Bromo - 1,3,4 - Trifluorobenzene is an organic compound, and its physicochemical properties are particularly important. Looking at its physical properties, it is mostly liquid at room temperature, with a color close to colorless and transparent, and a unique odor. Its boiling point is suitable, which is conducive to separation and purification operations. Due to the existence of halogen atoms in the molecule, its density is higher than that of water, and it is widely used in the field of organic synthesis.
When it comes to chemical properties, it has active chemical activity because of the presence of bromine and fluorine atoms on the benzene ring. Bromine atoms can undergo nucleophilic substitution reactions, providing an opportunity for the introduction of other functional groups. The fluorine atom has high electronegativity, which causes the electron cloud density of the benzene ring to change, which affects the activity and regioselectivity of This compound is a key intermediate in the fields of medicinal chemistry and materials science, which can assist in the synthesis of a variety of high-value-added products, and has important research value and application prospects.
Technical Specifications & Labeling
For 2-bromo-1,3,4-trifluorobenzene, it is also an organic chemical. Its technical regulations and identification (commodity parameters) are necessary. To make this product, a specific method is required. The purity of the first raw material of its technical regulations, the production of 2-bromo-1,3,4-trifluorobenzene, originates from the delicate combination, and the ratio of raw materials, the temperature and pressure of the reaction are all key. When reacting, make sure that all things should be orderly and abide by their regulations.
In terms of identification, its name is established, and it should be clearly remembered. Its shape, taste, and sex are all important for identification. Such as what the color is like, what the taste is, and the sexual changes in different environments should be detailed. And its commodity parameters are related to the purity and amount of impurities, which are all accurate for judging its quality. Only by observing the rules and clear labels can we protect the good products of 2-bromo-1,3,4-trifluorobenzene.
Preparation Method
The method of preparing 2 - Bromo - 1,3,4 - Trifluorobenzene is as follows: Prepare the raw materials first, select pure fluorobenzene, and add an appropriate amount of bromine, the two are the main materials.
When making, control the temperature and pressure in the reactor. First heat up to a moderate extent, so that the fluorobenzene and bromine interact gradually, according to a certain reaction step, step by step. In the meantime, it is appropriate to use a catalyst to promote the reaction, so that the reaction speed is complete. This catalyst is selected from a special agent, which can improve the reaction efficiency.
After the reaction is completed, after separation and purification, its impurities are removed to obtain pure 2 - Bromo - 1,3,4 - Trifluorobenzene. When separating, use distillation and extraction to purify the product. When purifying, pay attention to details to ensure the quality of the product. In this way, 2 - Bromo - 1, 3, 4 - Trifluorobenzene of good quality is obtained.
Chemical Reactions & Modifications
Nowadays, there is a chemical substance, named 2 - Bromo - 1,3,4 - Trifluorobenzene. In chemical research, its reaction and modification are quite crucial.
Looking at this compound, the position of the bromine atom and the trifluorine atom affects its chemical properties. To change its properties, you can choose a suitable agent in an appropriate environment to make the reaction. If you encounter it with a nucleophilic reagent, you may be able to translocate bromine to generate a new structure.
It can also borrow the energy of light or heat to promote its intramolecular transformation and cause structural modification to obtain products with unique properties. This is useful in the synthesis of specific materials and the creation of new drugs. By observing its reaction and controlling its conditions, we can form the desired product according to our intention, which in turn adds to the progress of chemistry.
Synonyms & Product Names
Today there is a thing called 2 - Bromo - 1, 3, 4 - Trifluorobenzene. There are many names for it. Although they refer to the same name, they are used differently. This chemical thing may have different names due to different industries, regions, and uses.
In the academic world, it is often called by its scientific name to clarify its chemical composition and characteristics. It is rigorous and standardized, which is convenient for academic communication and research. However, in the community, or due to the practical needs of craftsmen, pharmacists, etc., it is given another common name. Although the scientific name is not accurate, it is easy to remember and use, and it is also convenient in practical operation.
Looking at its name, the scientific name details its molecular structure, and the identification of elements such as "bromine" and "fluorine" is clear, making it clear to scholars at a glance. And the common name may be derived from its properties and uses, such as its color, taste, and effect. These are all different names for the same thing, and each has its own use. In different contexts, it plays its unique role.
Safety & Operational Standards
2 - Bromo - 1,3,4 - Trifluorobenzene Safety and Operating Specifications
Husband 2 - Bromo - 1,3,4 - Trifluorobenzene, chemical products are also used, and those who use them should operate safely.
#1. The method of survival
This product should be placed in a good place where it is dry, dry and well-connected. Do not approach fire or gas sources to prevent them from exploding. The container must be well sealed to avoid air and moisture contact. This product or other products have chemical reactions, and the product is easy to cause. And all the oxidizing, oil and other substances, because of their sexual activity, encounter or strong reactions.
#Second, in the operation of
operation, the operator must take appropriate precautions. If it prevents eye damage, it can protect the eyes from the liquid; gas mask, which can prevent harmful steam inhalation; corrosion-resistant gloves and work clothes, which can protect the skin from being damaged. The operation environment has the ability to apply force to drain away the steam.
Take the oil of this product, and it is appropriate to prevent it from being released. The measured utensils must be clear, dry and fine. If you accidentally wash the skin, wash it with a lot of water quickly, and wash it with soap. If it doesn't work, it will be treated immediately. If it enters the eyes, immediately wash it with physiological water or water for more than 15 minutes, and ask for help as soon as possible.
#III. If this product needs to be processed, it must not be dumped by accident. According to the relevant safety regulations, it should be handed over to the appropriate management. The packaging container should also not be used, and it should be properly handled to prevent the residue from contaminating the environment.
Therefore, those who use 2-Bromo-1,3,4-Trifluorobenzene should keep, operate, and operate in accordance with safety standards, so as to ensure personal safety, environmental safety, and make chemical research and production work.
Application Area
2 - Bromo - 1, 3, 4 - Trifluorobenzene is an important organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often used as a key intermediate to help create drugs with special pharmacological activities to deal with various diseases. In the field of materials science, it also has significant uses, and can participate in the preparation of new materials with excellent performance, such as photoelectric materials, to improve their photoelectric conversion efficiency. In the chemical industry, it is also indispensable. Through specific chemical reactions, many high value-added chemical products are derived. From this point of view, 2 - Bromo - 1, 3, 4 - Trifluorobenzene is of great value in many fields and promotes the development and progress of related industries.
Research & Development
Recently, I have been working hard on 2 - Bromo - 1, 3, 4 - Trifluorobenzene. This chemical has unique properties and exquisite structure, which has great potential in the field of organic synthesis.
I have studied its preparation method in detail and tried various paths. Either halogenation of aromatic rings, or by substitution reaction, strive to optimize the process and improve the yield. During the process, problems frequently arise, such as precise control of reaction conditions and inhibition of side reactions.
However, after repeated experiments and research, we have gradually gained something. The optimization method can improve the yield and the purity of the product. And this achievement may lay the foundation for follow-up research and is expected to expand its application in medicine, materials and other fields. In the future, we will continue to deepen our efforts to explore more possibilities, hoping to promote the research and development of this chemical and make modest contributions to academia and industry.
Toxicity Research
Today there is a product, name 2 - Bromo - 1, 3, 4 - Trifluorobenzene. We focus on toxicity studies to investigate its properties in detail. This product contains bromine and fluorine elements and has a unique structure. After many investigations, its performance in different environments was observed. In experiments, various organisms were used as samples to observe their reactions after exposure to this product.
Some organisms were affected by it and their physiological functions changed. Or slow movement, or different eating. Analysis shows that its toxicity can cause biological cell dysfunction. Although it may be available in industry, its toxicity should not be underestimated. The urgent task is to find appropriate methods to reduce its harm. Whether it is production, storage, or use, it needs to be treated with caution to prevent it from harming organisms and harming the ecology.
Future Prospects
Today, there is a product named 2 - Bromo - 1, 3, 4 - Trifluorobenzene, which is a chemical product that we have dedicated ourselves to researching. Looking at this substance, its unique characteristics and potential in many fields.
Looking to the future, this product is expected to shine in the field of materials science. With its unique chemical structure, it may help to develop new high-performance materials for aerospace applications, making aircraft lighter and stronger; it can also be used in electronic devices to improve their performance and stability.
There are also broad prospects in pharmaceutical chemistry. It may become a key intermediate to promote the synthesis of innovative drugs and contribute to human health and well-being.
Although the road ahead is long, our scientific research heart is unwavering. We firmly believe that through unremitting research, 2 - Bromo - 1, 3, 4 - Trifluorobenzene will be able to demonstrate extraordinary value in the future and bring many benefits to the world.
Where to Buy 2-Bromo-1,3,4-Trifluorobenzene in China?
As a trusted 2-Bromo-1,3,4-Trifluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Bromo-1,3,4-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-Bromo-1,3,4-Trifluorobenzene?
2-Bromo-1,3,4-trifluorobenzene is also an organic compound. It has a wide range of uses and plays an important role in the field of organic synthesis.
Bearing the brunt, it is the key raw material for the preparation of special functional materials. In the manufacture of electronic materials, through delicate chemical reactions, 2-bromo-1,3,4-trifluorobenzene can be converted into substances with special electrical properties, which can help the miniaturization and efficiency of electronic devices. For example, the manufacture of new organic semiconductor materials, the uniqueness of their molecular structure gives the material excellent carrier transport performance, which can be used in organic Light Emitting Diode (OLED), organic field effect transistor (OFET) and other devices to improve the efficiency of display and information processing.
Furthermore, in the field of medicinal chemistry, it is also an indispensable synthetic building block. Medicinal chemists can cleverly use the properties of halogen-containing atoms to construct complex drug molecular skeletons through halogenation reactions, nucleophilic substitution reactions and many other steps. For example, in the synthesis of some compounds with specific biological activities, 2-bromo-1,3,4-trifluorobenzene can introduce fluorine-containing groups. The special electronic effects and biological activities of fluorine atoms can enhance the binding force between drugs and targets, improve the efficacy and selectivity of drugs, and provide an important foundation for the development of new drugs.
In addition, in the field of pesticide chemistry, it can also be used. Through reasonable chemical modification, high-efficiency, low-toxicity and environmentally friendly pesticides can be prepared. The introduction of fluorine atoms can change the physical and chemical properties of pesticide molecules, such as fat solubility, stability, etc., making it easier to penetrate the surface of pests, enhance the poisoning effect on pests, and reduce the negative impact on the environment, which is in line with the current needs of green agriculture.
In summary, 2-bromo-1,3,4-trifluorobenzene has shown great application potential in many fields such as materials, medicine, pesticides, etc., promoting technological innovation and development in various fields.
What are the physical properties of 2-Bromo-1,3,4-Trifluorobenzene?
2-Bromo-1,3,4-trifluorobenzene is also an organic compound. It has unique physical properties and is widely used in various fields of chemical industry.
Looking at its properties, under normal temperature and pressure, 2-bromo-1,3,4-trifluorobenzene is mostly colorless to light yellow transparent liquid. Smell it, there is often a special smell emitted. Although this smell is not pungent and intolerable, it is also distinct and recognizable, which is one of its characteristics.
When it comes to boiling point, it is about 147-149 ° C. This boiling point value makes it change from liquid state to gaseous state under specific temperature conditions. This property is of great significance in chemical operations such as distillation and separation. Its melting point is about -44 ° C, indicating that at lower temperatures, the substance will solidify from liquid to solid.
The density of 2-bromo-1,3,4-trifluorobenzene is about 1.81g/cm ³, which is heavier than water, so if mixed with water, it will sink to the bottom. Its solubility is also a key property. It is slightly soluble in water, but it can be well miscible with many organic solvents, such as ethanol, ether, acetone, etc. This solubility property provides convenience for its use as a solvent or reactant in organic synthesis reactions.
Furthermore, the vapor pressure of 2-bromo-1,3,4-trifluorobenzene also has a certain value at a specific temperature, which is related to its existence and behavior in the gas phase. And because its molecular structure contains halogen atoms, it has certain chemical activity and shows unique reactivity in various chemical reactions.
From the above, the physical properties of 2-bromo-1,3,4-trifluorobenzene, such as properties, melting point, density, solubility, etc., are the basis for its application in chemical production, organic synthesis and other fields, and have far-reaching impact on the development of related industries.
Is 2-Bromo-1,3,4-Trifluorobenzene chemically stable?
The chemical properties of 2-bromo-1,3,4-trifluorobenzene are still stable. In this compound, the bromine atom is connected to the trifluorobenzene ring. The fluorine atom has strong electronegativity, and above the benzene ring, it will affect the distribution of electron clouds.
Because of the strong electronegativity of the fluorine atom, the electron cloud density of the benzene ring can be reduced, and the electrophilic substitution activity of the benzene ring can be reduced. Its electron-absorbing effect is transmitted to the entire benzene ring system through induction and conjugation.
Although the bromine atom is also an electron-absorbing group, its electron-giving conjugation effect can also be exhibited in some reactions. Overall, 2-bromo-1,3,4-trifluorobenzene can maintain relatively stable under normal conditions.
However, in the presence of strong nucleophiles, bromine atoms may be replaced by nucleophiles. For example, in the presence of appropriate bases and nucleophiles, nucleophiles can attack carbon atoms connected to bromine, undergo nucleophilic substitution reactions, and bromine atoms leave to form new compounds.
In the case of strong oxidants, although the benzene ring is relatively stable, the substituents may be oxidized. However, under normal circumstances, without special conditions, the chemical properties of 2-bromo-1,3,4-trifluorobenzene are stable, and its structure and properties can be maintained under normal storage and operation conditions.
What are the synthesis methods of 2-Bromo-1,3,4-Trifluorobenzene?
The synthesis of 2-bromo-1,3,4-trifluorobenzene is an important topic in the field of organic synthesis. One of the common synthesis paths is to use trifluorobenzene as the starting material. First, the trifluorobenzene is brominated with an appropriate brominating agent, such as bromine (Br ²), and catalyzed by a catalyst such as iron powder (Fe) or iron tribromide (FeBr ²). This reaction condition needs to be carefully regulated, and the temperature should be controlled in a moderate range to prevent the formation of polybrominated by-products. Usually, under low temperature conditions, the reaction selectivity is more inclined to the bromination of the target site, and 2-bromo-1,3,4-trifluorobenzene can be obtained.
In addition, it can start from halogenated aromatics containing fluorine. Achieved by suitable metal-catalyzed cross-coupling reaction. For example, fluorinated halogenated aromatics are catalyzed with brominating reagents in palladium (Pd) catalysts such as tetra (triphenylphosphine) palladium (Pd (PPh)), in the presence of a suitable solvent, such as N, N-dimethylformamide (DMF). The base can be selected from potassium carbonate (K 2O CO), etc. This reaction condition is mild and has good compatibility with functional groups, which can effectively synthesize the target product.
Another method is to use fluorine-containing phenolic compounds as starting materials. The phenolic hydroxyl group is first converted into a group that is easy to leave, such as sulfonate group. Then, under the condition of nucleophilic substitution reaction, it is reacted with brominating reagents and converted into 2-bromo-1,3,4-trifluorobenzene through appropriate steps. This path requires multiple steps of reaction, each step of which needs to be precisely controlled to ensure high yield and purity. Each synthetic method has its own advantages and disadvantages, and the actual application needs to be based on specific needs, raw material availability and cost factors.
What to pay attention to when storing and transporting 2-Bromo-1,3,4-Trifluorobenzene
2-Bromo-1,3,4-trifluorobenzene is an organic compound. When storing and transporting, many points must be paid attention to.
When storing, the first choice of environment. It should be placed in a cool and ventilated place, because the compound is prone to chemical changes due to heat, or even cause dangerous reactions. If the temperature is too high, it may increase its volatilization, which will not only consume materials, but also volatile gases or pose safety hazards.
Furthermore, ensure that the storage area is dry. Moisture may react with 2-bromo-1,3,4-trifluorobenzene, affecting its purity and quality. Humid environment or cause reactions such as hydrolysis to occur, changing the molecular structure and making the product ineffective.
At the same time, keep away from fire and heat sources, because it is flammable, in case of open flames, hot topics or cause combustion and explosion, threatening the safety of personnel and facilities.
Storage containers are also crucial, and well-sealed containers should be selected to prevent leakage. Metal or special plastic containers can be selected to ensure that the material does not chemically react with the compound and maintain its stability.
When transporting, the packaging must be sturdy. According to relevant regulations, suitable packaging materials and methods should be used to prevent leakage due to collision and vibration caused by package damage during transportation.
Transportation vehicles must meet safety standards and be equipped with corresponding fire equipment and leakage emergency treatment equipment. Once a leak occurs, it can be responded to in time to reduce the hazard.
And transportation personnel should be professionally trained to be familiar with the properties, hazards and emergency treatment methods of 2-bromo-1,3,4-trifluorobenzene. The transportation process is strictly operated to ensure transportation safety.