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What are the main uses of 2-Amino-5-Bromo Trifluoromethoxy Benzene?
2-Amino-5-bromotrifluoromethoxybenzene is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
It plays a pivotal role in medicinal chemistry. Using this as a starting material, through a series of delicate chemical reactions, it can construct many biologically active molecular structures, paving the way for the development of new drugs. For example, it can be linked to other compounds containing active groups through specific reactions to create drug molecules with affinity and inhibitory activity to specific disease targets, assisting the development of anti-disease drugs.
In the field of materials science, it also shows unique uses. With its special chemical structure, it can participate in the preparation of functional materials with specific properties. For example, in the preparation of optoelectronic materials, it can be introduced as a structural unit, endowing the material with unique electron transport and optical properties, and contributing to the development of new optoelectronic materials.
In addition, in the field of pesticide chemistry, 2-amino-5-bromotrifluoromethoxylbenzene can also play a role. After reasonable chemical modification and transformation, pesticide ingredients with efficient pest control effects can be prepared, providing an effective means for agricultural pest control. In short, due to its structural characteristics, it is an important basic substance in organic synthesis in many fields, promoting research and development in various fields.
What are the synthesis methods of 2-Amino-5-Bromo Trifluoromethoxy Benzene
The synthesis method of 2-amino-5-bromotrifluoromethoxylbenzene is quite complicated and diverse. Common ones can be obtained from the starting material through multiple steps.
First, start with a benzene ring compound containing a specific substituent. Before the appropriate conditions, the benzene ring is brominated. This bromination process requires careful selection of brominating reagents, such as bromine, N-bromosuccinimide (NBS), etc. If bromine is used, it is often necessary to use a suitable catalyst, such as iron powder or iron tribromide, to precisely replace the bromine atom in a specific position of the benzene ring to achieve the target bromine substitution product.
Next, the trifluoromethoxy group is introduced. This step can be achieved by nucleophilic substitution reaction. Select a suitable trifluoromethoxylation reagent, such as potassium trifluoromethoxy, etc., and react under a specific solvent system and temperature conditions. The solvent may be a polar aprotic solvent, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), etc., in order to create an environment conducive to the reaction, so that the trifluoromethoxy group can be successfully integrated into the benzene ring.
In addition, the introduction of amino groups is also the key. Or by the method of nitro reduction. First nitrate the benzene ring and introduce nitro groups. Mixed acid (a mixture of nitric acid and sulfuric acid) is commonly used in nitrification reactions. According to the characteristics of the reaction substrate, the ratio of mixed acid and the reaction temperature are precisely adjusted to introduce nitro groups into the appropriate position. Then, the resulting nitro compound is reduced with a suitable reducing agent, such as hydrogen-palladium-carbon catalytic reduction system, or iron powder-hydrochloric acid system, etc., to obtain an amino group, and finally 2-amino-5-bromotrifluoromethoxylbenzene.
Or there may be other synthesis paths, but the reaction route needs to be carefully designed according to the availability of raw materials, the ease of control of reaction conditions, and the cost. Efficient synthesis of this compound can be achieved.
What are the physical properties of 2-Amino-5-Bromo Trifluoromethoxy Benzene?
2-Amino-5-bromotrifluoromethoxy benzene, this physical property belongs to the category of organic compounds. Looking at its chemical structure, bromine atoms, trifluoromethoxy groups and amino groups live in specific positions and interact, resulting in unique physical properties.
First of all, under normal temperature and pressure, it often takes the shape of white to pale yellow crystalline powder, with fine texture. This color state is derived from the distribution of electron clouds and energy level transitions within the molecule. Light interacts with it, and light of a specific frequency is absorbed or reflected, resulting in this color.
As for the melting point, it has been experimentally measured to be about [X] ° C. The value of the melting point is closely related to the intermolecular forces. There are van der Waals forces, hydrogen bonds and other forces between molecules. In this compound, the amino group can participate in the formation of hydrogen bonds, which enhances the intermolecular forces, and requires a higher temperature to overcome them, thus presenting a specific melting point.
In terms of solubility, it shows good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide. Due to the principle of "similar miscibility", the intermolecular forces between the organic solvent molecules and the compound are suitable and can be interspersed and mixed with each other. In water, the solubility is poor. Because water is a strong polar solvent, it has a large polar difference and weak interaction with the compound molecules.
Volatility is relatively low. The molecular mass is large and the intermolecular force is strong. It requires high energy for the molecule to escape from the liquid phase and enter the gas phase. Therefore, the volatility is not high, and it exists more stably in the solid or liquid state at room temperature.
The density is about [X] g/cm ³, which depends on the molecular mass and the way of molecular accumulation. The molecular mass is determined. When the molecular mass is determined, in the solid or liquid state, the degree of molecular accumulation determines the density.
The physical properties of 2-amino-5-bromotrifluoromethoxylbenzene are determined by their unique chemical structure. They have specific applications and significance in the fields of organic synthesis, drug development, etc. Due to these properties.
What is the market price of 2-Amino-5-Bromo Trifluoromethoxy Benzene?
I don't have the exact market price of 2-amino-5-bromotrifluoromethoxylbenzene. However, if you want to check its price, you can explore it from several ends.
First, the trading platform for chemical raw materials is an important place. In today's world, many chemical products are sold on online platforms, and such platforms gather suppliers, and the prices are also listed. You can go to the well-known domestic chemical trading network, such as Mobell, to search for this product in detail with keywords, or you can get quotations from different manufacturers, and you can also observe the ups and downs of its price and the price differences under different batches.
Second, communicate directly with suppliers. In the chemical industry, manufacturers and distributors have first-hand price information. You can use industry exhibitions and B2B platforms to find suppliers of this product, and inquire by email, phone, etc. When inquiring, it is advisable to specify the required quantity, purity requirements, delivery place, etc., because all factors can change the price.
Furthermore, industry information and reports are also valuable sources. Professional media and consulting organizations in the chemical industry often publish industry reports, which may involve the price trend of specific products, market supply and demand analysis. Such as ICIS, ICIS and other institutions, their reports are based on extensive market surveys and data collection, which can help us know the macro trend and future trend of this product price.
In addition, market supply and demand, raw material costs, policies and regulations, and international situations can all influence the price of 2-amino-5-bromotrifluoromethoxybenzene. If the market demand for this product is strong, and the supply is tight, the price may rise; the price of raw materials fluctuates, which will also cause changes in production costs, which will affect the selling price. Changes in policies and regulations on environmental protection and production qualifications can also indirectly affect the price. If the international situation is turbulent, trade policies, exchange rate fluctuations, etc., may cause changes in the price of this product. Therefore, when looking at its market price, we should comprehensively consider all factors.
What are the precautions for storing and transporting 2-Amino-5-Bromo Trifluoromethoxy Benzene?
2-Amino-5-bromotrifluoromethoxylbenzene is an organic compound. When storing and transporting, there are many key things to pay attention to.
One is related to storage. This compound should be stored in a cool, dry and well-ventilated place. Because it is sensitive to heat, high temperature can easily cause it to deteriorate or cause chemical reactions, so it should be kept away from heat sources and open flames. At the same time, air and moisture may also affect it, and it needs to be sealed to prevent contact with oxygen, moisture and other substances in the air. For example, it can be placed in a sealed glass or plastic bottle, tightly sealed to avoid external factors. In addition, it should be stored separately from oxidizing agents, acids, alkalis and other chemicals to prevent uncontrollable chemical reactions and endanger safety.
Second, for transportation. The transportation process must ensure that the packaging is complete and well sealed to prevent leakage. Because of its certain toxicity and irritation, once leaked, it will not only cause pollution to the environment, but also may endanger the health of transporters. Transportation vehicles need to be equipped with corresponding emergency treatment equipment and protective equipment. If leakage unfortunately occurs, it can be properly handled in time. When transporting, follow relevant transportation regulations and standards, choose appropriate transportation methods and routes, avoid densely populated areas and environmentally sensitive areas, and minimize latent risks. In conclusion, whether it is storage or transportation of 2-amino-5-bromotrifluoromethoxylbenzene, it must be treated strictly to ensure the safety of personnel and the environment.