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What are the chemical properties of 2-Amino-4- (Trifluoromethyl) Benzenethiol Hydrochloride?
2-Amino-4- (trifluoromethyl) phenylthiophenol hydrochloride, this is an organic compound. Its chemical properties are unique, including both amine groups, thiophenol groups and trifluoromethyl groups, which give it various characteristics.
Amine groups are basic and can react with acids to form corresponding salts. In many chemical reactions, amine groups can participate in nucleophilic substitution reactions because nitrogen atoms contain lone pair electrons, which exhibit nucleophilicity and can attack electron-deficient centers.
The activity of thiophenol groups is quite high, and the electronegativity of sulfur atoms is slightly lower than that of oxygen atoms, which makes it easier to break sulfur-hydrogen bonds, releasing hydrogen ions and showing a certain acidity. Moreover, thiophenol is easily oxidized to form disulfides. This oxidation reaction is quite important and plays a key role in the construction of intermolecular connections and some biochemical reaction mechanisms.
Trifluoromethyl is a strong electron-absorbing group with high electronegativity, which significantly affects the distribution of molecular electron clouds. Under its influence, the electron cloud density of the benzene ring decreases, which increases the difficulty of electrophilic substitution reactions on the benzene ring; however, it can increase the electron cloud density of the ortho and para-site groups relatively, which in turn affects the reaction selectivity.
In addition, the hydrochloric salt form of the compound enhances its solubility in water due to its salt formation with hydrochloric acid, which is crucial in some reactions or applications that need to be carried out in the aqueous phase.
In the field of organic synthesis, 2-amino-4- (trifluoromethyl) thiophenol hydrochloride can be used as a key intermediate for the preparation of various fluorine-containing heterocyclic compounds or molecules with special biological activities. In materials science, due to its unique chemical structure and properties, it can be used to develop new functional materials, such as optoelectronic materials.
What are the main uses of 2-Amino-4- (Trifluoromethyl) Benzenethiol Hydrochloride
2-Amino-4- (trifluoromethyl) phenylthiophenol hydrochloride, an organic compound, has important uses in many fields.
In the field of medicinal chemistry, it can be used as a key intermediate. The synthesis of many drugs often depends on compounds containing specific functional groups. The introduction of trifluoromethyl can significantly change the physical, chemical and biological activity properties of compounds. With 2-amino-4- (trifluoromethyl) phenylthiophenol hydrochloride as the starting material, through a series of organic reactions, such as substitution reactions and condensation reactions, molecular structures with specific pharmacological activities can be constructed, and then new drugs can be developed to fight various diseases.
In the field of materials science, it also shows unique value. Due to the characteristics of sulfur-containing groups and trifluoromethyl groups, it can participate in the preparation of materials with special properties. For example, in the synthesis of some photoelectric materials, the introduction of this compound may adjust the electronic transport properties and optical properties of materials. By reacting with other monomers or polymers, polymer materials with special functions can be prepared for use in organic Light Emitting Diodes (OLEDs), solar cells and other devices to improve their performance and efficiency.
In the field of organic synthesis chemistry, it is an important synthetic building block. Organic chemists can use the reactivity of amino groups and thiophenol groups to react with various electrophilic reagents and nucleophiles to construct complex organic molecular structures. By ingeniously designing the reaction route, the precise construction of the molecular skeleton and the reasonable modification of functional groups can be achieved, providing an effective way for the synthesis of organic compounds with specific structures and functions.
What is the synthesis method of 2-Amino-4- (Trifluoromethyl) Benzenethiol Hydrochloride?
To prepare 2-amino-4- (trifluoromethyl) phenylthiophenol hydrochloride, the following method can be used.
First take the aromatic hydrocarbon raw material containing the corresponding substituent, which needs to have groups that can be subsequently converted into amino groups and thiol groups. Starting with a suitable aromatic hydrocarbon, under specific reaction conditions, it undergoes a substitution reaction with a reagent containing trifluoromethyl to introduce trifluoromethyl into a specific position in the aromatic ring. This step requires the selection of an appropriate catalyst and reaction solvent to ensure a smooth reaction and high selectivity.
Then, the obtained aromatic hydrocarbon derivative containing trifluoromethyl is nitrified and nitro is introduced into the aromatic ring. This process requires strict conditions such as reaction temperature, concentration ratio of nitric acid and sulfuric acid, etc., because it is necessary to control the introduction position of nitro groups to make them in a suitable relative position to trifluoromethyl groups.
The obtained nitro compound is suitable for reducing agents, such as hydrogen under the action of metal catalysts (such as palladium carbon), or chemical reducing agents such as ferrous salts, the nitro group is reduced to an amino group to obtain an aromatic compound containing amino groups and trifluoromethyl groups.
Finally, for the step of introducing a sulfhydryl group on the aromatic ring, the aromatic compound can be reacted with a halogenating reagent first, a halogen atom is introduced at a specific position in the aromatic ring, and then reacted with a sulfhydrate-containing reagent such as sodium hydride to introduce The final product is reacted with hydrogen chloride gas or hydrochloric acid to form the corresponding hydrochloride, that is, 2-amino-4- (trifluoromethyl) phenylthiophenol hydrochloride. During the whole process, the separation and purification of each step of the reaction are also critical. According to the nature difference between the product and the impurity, extraction, distillation, recrystallization and other methods are selected to obtain high-purity target products.
2-Amino-4- (Trifluoromethyl) Benzenethiol Hydrochloride in Storage and Transportation
2-Amino-4- (trifluoromethyl) phenylthiophenol hydrochloride is a chemical substance, and many matters must be paid attention to during storage and transportation.
Store first. This substance should be stored in a cool and dry place. Because it is quite sensitive to heat, if it is in a high temperature environment, it may cause changes in properties, or even deterioration and failure. And it should be placed in a well-ventilated place to prevent the accumulation of harmful gases. In addition, it must be stored separately from oxidants, acids and other substances. The cover is dangerous because of its active chemical properties, it encounters with oxidants, or causes violent reactions; it may also react chemically with acids, which may damage its quality. The storage container must be tightly sealed to prevent contact with the air due to moisture, oxygen, etc. in the air or its interaction.
As for transportation, it should not be neglected. Before transportation, make sure that the packaging is intact. Packaging materials must have good protective properties, which can resist vibration, collision and friction, so as to avoid material leakage caused by damage to the container. During transportation, the temperature should be strictly controlled to avoid heat. At the same time, the transportation vehicle should also be well ventilated. And should not be mixed with contraband items, so as to avoid accidental contact and disaster on the way. Escort personnel must be familiar with the characteristics of the substance and emergency treatment methods. In case of emergencies, they can respond properly in time to ensure the safety of transportation.
What is the market price range for 2-Amino-4- (Trifluoromethyl) Benzenethiol Hydrochloride?
2-Amino-4- (trifluoromethyl) phenylthiophenol hydrochloride, the price of this product in the market, it is difficult to determine the exact number. The price often varies due to many reasons, such as the amount of production, the quality of the advantages and disadvantages, the demand for the boom and bust, the time is different, and even the price of the business is different.
Looking at the market conditions, if its quality is high and the supply and demand are stable, the price per gram may be around tens of gold to hundreds of gold. However, if the raw materials are scarce, the production is suddenly reduced, and there are many seekers, the price will rise, or up to hundreds of gold per gram. On the contrary, if the production is abundant and the demand is small, the price may fall below tens of gold per gram.
The price varies depending on the purity and packaging sold in the market. For high purity, the price is always higher than that of ordinary ones; for large packages, the average price per gram or slightly lower than that of small packages.
Therefore, if you want to know the exact price, you must carefully check the current price in the market and consult many merchants to get a near-real price. And this price is constantly changing, and it cannot be held for a long time. It must be subject to real-time market conditions.