This is an investigation into the chemical structure of 2-amino-1- (4-fluoro-3- (trifluoromethyl) phenyl) ethyl ketone 4-methylbenzene sulfonate. Its structure is described as follows:
In the main structure, there is an ethyl ketone group, and the α position of this ethyl ketone group is connected with an amino group, that is, the 2-amino-1-ethyl ketone part. The phenyl group connected to it is replaced by a fluorine atom at position 4, and the position 3 is occupied by trifluoromethyl. This main structure is complex with 4-methylbenzene sulfonate to form a salt compound. In 4-methylbenzenesulfonate, there is a methyl substitution at the 4th position of the benzene ring, and the sulfonic acid group interacts with the amino group in the main structure through ionic bonds to form a whole salt structure. The spatial arrangement and interaction of atoms and groups in this structure endow the compound with specific physical and chemical properties, and may have specific uses and reactivity in organic synthesis, medicinal chemistry and other fields.

2-Amino-1- (4-fluoro-3- (trifluoromethyl) phenyl) ethyl ketone 4-methylbenzene sulfonate has a wide range of uses. In the field of medicinal chemistry, it is often the key intermediate for the synthesis of a variety of specific drugs. The unique fluorine and trifluoromethyl in the molecular structure endow the compound with specific physical and chemical properties, such as enhanced fat solubility, making it easier for the drug to pass through the biofilm and improve bioavailability. And the presence of amino and ketone groups provides activity check points for subsequent chemical reactions. After clever derivatization, drugs with different pharmacological activities can be prepared, such as antibacterial, antiviral or anti-tumor agents.
In the field of materials science, this compound also has a place. Due to its special structure, it may be used to prepare functional materials. For example, as a raw material for the synthesis of organic semiconductor materials, with its intra-molecular electron cloud distribution characteristics, the electrical properties of the material can be adjusted. It is used in devices such as organic Light Emitting Diodes (OLEDs) or organic field effect transistors (OFETs) to improve their luminous efficiency and carrier mobility.
Furthermore, in the field of organic synthetic chemistry, it is an important building block for the construction of complex organic molecular structures. Through various organic reactions, such as nucleophilic substitution, condensation reactions, etc., it can be connected with other organic fragments to build a library of organic compounds with diverse structures, providing rich compound resources for drug research and development, material innovation, etc., and promoting the development and progress of related fields.

To prepare 2-amino-1- (4-fluoro-3- (trifluoromethyl) phenyl) ethyl ketone 4-methylbenzene sulfonate, the following ancient method can be used.
Take 4-fluoro-3- (trifluoromethyl) acetophenone first, which is the key starting material. Place it in a suitable reactor and dissolve it with an alcohol solvent such as ethanol or methanol to form a uniform liquid phase. In this solution, slowly add an ammonia source, such as ammonia water or liquid ammonia, and ammonia undergoes a nucleophilic addition reaction with the carbonyl group of 4-fluoro-3- (trifluoromethyl) acetophenone. During the reaction, the temperature should be controlled in a moderate range, generally 0-10 ° C. This low temperature can make the reaction smooth and reduce side reactions. Keep stirring, and when the reaction is complete, 2-amino-1 - (4-fluoro-3 - (trifluoromethyl) phenyl) ethyl ketone intermediates can be obtained.
Then, 4-methylbenzenesulfonic acid is prepared. Take toluene and use concentrated sulfuric acid as a sulfonating agent. The two react under heating conditions. The temperature is maintained at 100-120 ° C. The methyl ortho-position of toluene is replaced by a sulfonic acid group to form 4-methylbenzenesulfonic acid. After separation and purification, pure 4-benzenesulfonic acid is obtained.
Finally, the obtained 2-amino-1- (4-fluoro-3- (trifluoromethyl) phenyl) ethyl ketone and 4-methylbenzenesulfonic acid are put into another reactor in equal molar ratio, ethyl acetate is used as solvent, stirred and mixed. When the reaction number at room temperature, the two undergo a salt reaction to generate 2-amino-1- (4-fluoro-3- (trifluoromethyl) phenyl) ethyl ketone 4-methylbenzenesulfonate. After the reaction is completed, the pure target product can be obtained through cooling, filtration, drying and other steps.

2-Amino-1- (4-fluoro-3- (trifluoromethyl) phenyl) ethyl ketone 4-methylbenzene sulfonate, this is an organic compound. Its physical and chemical properties are quite important and are related to many fields of application.
First of all, its appearance properties are often white to off-white crystalline powder, which is easy to store and use, and is conducive to uniform dispersion in different reaction systems, which has a significant impact on the process of participating in chemical reactions.
Discussing solubility, the compound exhibits certain properties in organic solvents. In polar organic solvents, such as methanol and ethanol, it has good solubility, which makes it able to participate in the reaction smoothly in the reaction of these solvents as the medium, and achieve full contact and reaction between molecules through the action of the solvent. However, in non-polar organic solvents, the solubility is relatively poor, and this difference is due to the interaction between polar groups and non-polar groups in its molecular structure. The melting point of
is also one of the important physical properties. Its melting point is within a specific range, which can not only be used to identify the purity of the compound, but also is of great significance in the synthesis and purification process. By precisely controlling the temperature and according to the melting point characteristics, the separation and purification of the compound can be realized to ensure product quality.
In terms of chemical properties, amino groups, ketone groups and substituents on the benzene ring in the molecular structure all give them unique reactivity. Amino groups have nucleophilic properties and can participate in many nucleophilic substitution reactions, react with halogenated hydrocarbons, acid anhydrides, etc., form new chemical bonds, and expand the structural diversity of compounds. Ketone groups can undergo reduction reactions, transform into alcohols, or participate in condensation reactions to construct more complex organic structures. Fluorine atoms, trifluoromethyl groups, and methyl benzenesulfonic acid groups on the benzene ring affect the electron cloud density of the benzene ring due to their respective electronic effects, which in turn affects the overall reactivity and selectivity of the compound. These chemical properties make this compound a key intermediate in the field of organic synthesis and is widely used in medicinal chemistry, materials science and other research

Guan Jun's question is about 2-amino-1 - (4-fluoro-3 - (trifluoromethyl) phenyl) ethyl ketone 4-methylbenzene sulfonate in the market price range. However, the price of this product is difficult to determine.
Because between cities, prices often change due to many reasons. First, the price of raw materials, if the raw materials required for the production of this product are difficult to procure, the appearance of abundance is different, the cost is different, so the price of this product fluctuates. Second, the different production methods, if the method is simple, or the cost can be saved; if the delicate and complex technique is used, although the quality is high, the cost is also more, and the price is different. Third, the trend of supply and demand, if there are many people in the market, but there are few suppliers, the price will go up; if the supply exceeds the demand, the price will tend to fall. Fourth, the difference between producers, different producers, their business regulations, reputation of the tainted, also make the price difference.
Also, this product may be used in various fields, different uses have different requirements for its purity, etc., and the price is also different. And the market conditions are different in different places, east, west, north and south, the price may be different. Therefore, in order to determine its price, it is necessary to carefully investigate the market changes of chemical raw materials, consult the producers, merchants, or can know the approximate price range, but it is difficult to have a fixed number.