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2,6-Difluorobenzene Boronic Acid

2,6-Difluorobenzene Boronic Acid

Hongda Chemical

Specifications

HS Code

537595

Chemical Formula C6H5BF2O2
Molecular Weight 156.91
Appearance Solid
Color White to off - white
Purity Typically high - purity in commercial products (e.g., 95%+)
Melting Point 142 - 146 °C
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Reactivity Reactive towards electrophiles, can participate in cross - coupling reactions
Odor Odorless or very faint odor
Storage Conditions Store in a cool, dry place, protected from air and moisture

As an accredited 2,6-Difluorobenzene Boronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2,6 - difluorobenzene Boronic Acid in a sealed chemical - grade plastic bottle.
Storage 2,6 - difluorobenzene Boronic Acid should be stored in a cool, dry place, away from heat and direct sunlight. Keep it in a well - sealed container to prevent moisture absorption and contact with air, which could lead to degradation. Store it separately from incompatible substances like strong oxidizing agents and bases to avoid chemical reactions.
Shipping 2,6 - difluorobenzene boronic acid should be shipped in well - sealed containers, protected from moisture and heat. Compliance with hazardous chemical shipping regulations is crucial to ensure safe transportation.
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2,6-Difluorobenzene Boronic Acid 2,6-Difluorobenzene Boronic Acid
General Information
Historical Development
2,6-Difluorophenylboronic acid is also an important agent in organic synthesis. In the past, chemists were in the field of organic synthesis, struggling to find efficient methods to produce exquisite compounds. This boric acid substance first appeared in the research and development, and many people observed its characteristics and could be used for coupling reactions, so they devoted themselves to studying.
At that time, the synthesis technique was not exquisite, and the preparation of this boric acid required many difficulties. However, after years of trial and error, they improved the process. From the simple method, gradually to the path of maturity.
Looking at its development, from the initial occasional product to stable mass production, during which countless efforts were gathered. With the advancement of chemical technology, 2,6-difluorophenylboronic acid has gradually developed its capabilities in the fields of medicine and materials, contributing to the synthesis industry, and is a bright link in the process of chemical research and development.
Product Overview
Today there is a substance called 2,6-difluorophenylboronic acid. It is an important raw material for organic synthesis and has a wide range of uses in medicine, materials and other fields. This substance is white to off-white solid and has stable properties. The preparation method often starts with fluorobenzene-containing compounds and is prepared by multi-step reaction. The reaction process requires fine control of conditions, such as temperature and reagent dosage, to obtain high-purity products. Its structure is unique, and fluorine-containing atoms give special properties and show unique activity in the reaction. Due to the strong electronegativity of fluorine atoms, it can affect the distribution of molecular electron clouds, so that the product has a unique reaction path when building complex organic structures, providing an opportunity for the synthesis of novel compounds. It is of great significance in the field of chemical research.
Physical & Chemical Properties
2,6-Difluorophenylboronic acid has specific properties. Its color is pure and clear, and it is stable at room temperature. Looking at its physical properties, the melting point can be quite computed, which is one of the important criteria when distinguishing and purifying. And its solubility varies among various solvents, or it is easily soluble in a certain agent or slightly soluble in other solutions, which is related to the affinity of its molecular structure and solvent.
In terms of its chemical properties, the activity of boron atoms is obvious. It can react with a variety of functional groups and has a wide range of uses in the field of organic synthesis. It can participate in coupling reactions and build complex molecular structures, providing opportunities for the creation of new compounds. The unique fluorine atom also affects the selectivity and rate of the reaction, making this compound shining brightly in the field of chemical research and a key material for the synthesis of delicate molecules.
Technical Specifications & Labeling
Today there is a product called 2,6-difluorophenylboronic acid. In the field of chemistry, its technical specifications and identification (product parameters) are the key.
The preparation of this 2,6-difluorophenylboronic acid requires precise methods. The selection of raw materials must be high-quality, and the reaction conditions must also be strictly set. Parameters such as temperature, pressure, and reaction time are all of the most important. If there is a slight difference, the product will be impure.
Looking at its logo, the content of ingredients should be clear and clear, and the amount of impurities must be determined in detail. Characteristics such as appearance, color, and physical state should also be accurately described. In this way, it can be accurately applied in various application scenarios to achieve its due effect, meeting the high standards of chemical research and industrial production.
Preparation Method
The method of preparing 2,6-difluorophenylboronic acid is related to the raw materials and production process, reaction steps and catalytic mechanism. First, an appropriate amount of 2,6-difluorobromobenzene is taken as the starting material, and magnesium chips are added to it. In an anhydrous ether environment, the Grignard reaction is initiated. This step requires moderate temperature control, do not overdo it, and wait for the reaction to be sufficient to obtain 2,6-difluorophenylboronic acid intermediate.
Then, the intermediate is slowly injected into the solution of trimethyl borate, and stirred continuously to make it fully react. After the reaction is completed, hydrolysis with dilute acid precipitates 2,6-difluorophenylboronic acid crude product.
After recrystallization, a suitable solvent, such as ethanol-water mixture, is selected to purify the crude product to obtain high-purity 2,6-difluorophenylboronic acid. In the process of catalysis, an appropriate amount of transition metal catalysts, such as palladium catalysts, can be added to promote the efficient reaction and improve the yield and purity. This is a key step in the preparation of 2,6-difluorophenylboronic acid.
Chemical Reactions & Modifications
Nowadays, there are chemical substances 2,6-difluorophenylboronic acid, and I have thought a lot about its chemical reaction and modification. Looking at this substance, its structure is unique, containing fluorine atoms and boric acid groups, and its properties are different.
In chemical reactions, the electronegativity of fluorine atoms is strong, which affects the distribution of molecular electron clouds and makes the reactivity different. Such as nucleophilic substitution reactions, the electron cloud density of fluorine atoms in the ortho and para-sites decreases, and the attack check point and rate of nucleophilic reagents change.
When it comes to modification, different groups can be introduced to change their physical and chemical properties. Or enhance its solubility, which is conducive to the reaction; or adjust its acidity and alkalinity, which is applied to specific catalytic systems. This is what our generation of chemical researchers should study in depth, hoping to improve the performance of 2,6-difluorophenylboronic acid, and make achievements to expand its application in chemical, pharmaceutical and other fields.
Synonyms & Product Names
In the field of chemical industry, new products have emerged one after another. Today, there is a product called 2,6-Difluorobenzene Boronic Acid (2,6-Difluorobenzene Boronic Acid). This product is quite functional in the process of synthesis. Its alias is also well known to researchers, but its name and alias are all used to identify this unique substance.
In my research, I often encounter the situation of the same thing and the same name. Although the names of this 2,6-difluorobenzene boronic acid are different, they all refer to the same thing. Just like the ancient things, the change of title does not damage its quality. We scientific researchers need to carefully observe their characteristics and clarify that their names are different and of the same quality, so as to avoid the risk of misuse during the experiment, so as to achieve the purpose of research and help the progress of the chemical industry.
Safety & Operational Standards
Specifications for the safety and operation of 2,6-difluorophenylboronic acid
F 2,6-difluorophenylboronic acid is a common compound in chemical research. During its experimental operation and research process, safety and standardized operation are of paramount importance, which is related to the safety of researchers and endangers the success or failure of the experiment.
#1. Storage requirements
This compound should be placed in a cool, dry and well-ventilated place. Avoid direct sunlight to prevent decomposition or deterioration caused by light. Storage containers must be tightly sealed to prevent contact with air and moisture. Cover them from contact with water or moisture, for fear of chemical reactions, affecting quality, or even dangerous.
#2. Rules of Operation
When operating, the researcher should wear suitable laboratory clothes, protective gloves and goggles. This is to prevent the compound from contacting the skin and eyes, causing burns or other injuries. It is best to operate in a fume hood, which can drain the volatile gaseous substances in time to prevent them from accumulating in the experimental environment and harming the human body.
When weighing 2,6-difluorophenylboronic acid, the action should be precise and gentle, and use clean and dry utensils. If it is accidentally spilled, it should be cleaned immediately to prevent pollution of the environment and affect the follow-up experiment.
#3. Emergency measures
If the skin is accidentally exposed to this compound, rinse it with plenty of water immediately, and then seek medical treatment. If it gets into the eye, it should not be delayed. Immediately rinse with flowing water for a few minutes to make sure that the foreign body is completely removed, and then seek medical assistance quickly.
During the experiment, if there is a leak, cut off the fire source first to prevent fire. In the case of a small amount of leakage, it can be collected in a suitable container with clean appliances; if there is a large amount of leakage, it is necessary to evacuate personnel, set up a warning area, and professionals use suitable materials to absorb and remove it.
In short, in the research and operation of 2,6-difluorophenylboronic acid, strict adherence to safety and operating standards can ensure the smooth operation of the experiment and the safety of personnel.
Application Area
2,6-Difluorophenylboronic acid, this substance has a wide range of uses. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help form special drugs and cure various diseases. In the field of material science, it can contribute to the construction of new materials, endow materials with unique properties, and is suitable for optoelectronics and other fields. In the field of organic synthesis, it is often used as a coupling reaction reagent. With its activity, it cleverly builds complex organic structures. Therefore, 2,6-difluorophenylboronic acid plays a pivotal role in many application fields. It is an indispensable substance for chemical research, injecting vitality into the development of various fields, and promoting scientific and technological progress and innovation.
Research & Development
In recent years, I have been in the field of chemical industry, focusing on the research of 2,6 - Difluorobenzene Boronic Acid products. This material is very different, and it has great functions in the process of organic synthesis.
At the beginning, I studied its preparation method, tried all kinds of things, but encountered many thorns. The choice of raw materials, the degree of mixing, and the reaction environment all need to be carefully considered. After many tests, a method can be obtained, which can be more stable. Although the yield is not perfect, it already has a usable basis.
Then, explore the path of its application. In the field of drug synthesis, try to combine with other substances to form a special agent. Also in the place of material preparation, observe its properties, and hope to add new materials. Although progress is not achieved overnight, every small achievement adds to the heart of striving forward.
I believe that with time and in-depth research, this product will shine brightly in the process of research and development, adding brilliance to the chemical industry.
Toxicity Research
The industry of chemical industry is related to people's livelihood, but the study of poisons in it should not be careless. Today there is 2,6 - Difluorobenzene Boronic Acid, and our generation should investigate its toxicity in detail.
Examine this compound in detail, its molecular structure is unique, or it contains toxic groups. In order to understand its harm, take all kinds of living beings as tests and observe their reactions. Apply it to rats and observe changes in their diet, movement, and spirit. And use cells as research to explore its fundamental impact on life.
After many experiments, we have first obtained clues. It may disturb the metabolism of cells, disrupt their order, and damage the health of living beings. Although the results are not complete, the toxicity has already appeared. Our generation of chemical researchers should have a heart of reverence, explore its nature, avoid harm for the world, and protect the chemical industry, which is beneficial but harmless, and continues endlessly.
Future Prospects
I have tasted and researched 2,6 - Difluorobenzene Boronic Acid, and I know that it has infinite potential in the field of chemical industry. Although it is not widely used today, its characteristics, good reactivity and excellent selectivity can be used in many organic synthesis processes, and it is a key agent.
My heart looks forward to the future. This product may be created in medicine, assisting in the research of special effects, and treating the world's diseases. In the research and development of materials, creating novel materials should meet diverse needs. Although there may be thorns in the road ahead, science and technology are advancing day by day and exploring endlessly. With time, it will surely be able to shine brightly, contribute to the well-being of mankind, and develop unprecedented grand plans. It will become an extraordinary career and live up to the hope of my generation's research.
Where to Buy 2,6-Difluorobenzene Boronic Acid in China?
As a trusted 2,6-Difluorobenzene Boronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2,6-Difluorobenzene Boronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main application fields of 2,6-difluorophenylboronic acid
2% 2C6-diethylnaphthalenesulfonic acid is useful in various fields. Its primary application lies in the preparation of dyes. Using it as raw material, dyes with bright color and good fastness can be prepared. In the textile printing and dyeing industry, dyes can give fabrics brilliant color and last for a long time without fading.
It also plays an important role in the manufacture of surfactants. The surfactant derived from it can significantly reduce the surface tension of liquids, making liquids easier to spread and penetrate. It is widely used in detergents, emulsifiers and other fields to help achieve decontamination and dispersion.
Furthermore, it is also indispensable in the field of pharmaceutical synthesis. It is often a key intermediate for the synthesis of specific drugs. With its unique chemical structure, pharmaceutical ingredients with specific pharmacological activities can be obtained through a series of reactions, providing an important cornerstone for pharmaceutical research and development.
Complex in some organic synthesis reactions, acting as an excellent catalyst. It can effectively promote the progress of the reaction, improve the reaction rate and yield, optimize the synthesis process, and play an important catalytic role in the preparation of fine chemical products, making production more efficient and economical.
In summary, 2% 2C6-diethylnaphthalenesulfonic acid has shown important application value in many fields such as dyes, surfactants, pharmaceutical synthesis and organic synthesis catalysis. It is a widely used and key chemical substance in the chemical industry.
What are the synthesis methods of 2,6-difluorophenylboronic acid?
There are several methods for the synthesis of 2% 2C6-diethylnaphthoquinone acid. One method can start with naphthalene. First, the naphthalene and acetic anhydride are used in an appropriate catalyst, such as anhydrous aluminum chloride. Naphthalene has the structure of an aromatic ring, and acetic anhydride carries an acetyl group. When encountering this catalyst, the electrophilic substitution reaction can be initiated. The hydrogen on the naphthalene ring selects the activity check point and is replaced by an acetyl group, which forms the genus of acetyl naphthalene.
Then, the resulting acetyl naphthalene is oxidized. With a suitable oxidizing agent, such as chromic acid or its salts, under suitable solvent and reaction conditions, the acetyl side chain can be oxidized. In a severe oxidation atmosphere, the carbon-hydrogen bond of the side chain is gradually broken, and the carboxyl group is finally obtained. If the conditions are carefully controlled, the acetyl group at a specific position can be oxidized to a carboxyl group, and the basic structure of the carboxyl group in the target 2% 2C6-diethylnaphthoquinone acid can be obtained.
There are other methods, or start from naphthalene derivatives with specific substituents. If there are naphthalene compounds with appropriate ethyl substitutions, they can be synthesized by a series of reactions such as specific oxidation and carboxylation. This process requires fine regulation of reaction conditions, such as temperature, polarity of solvent, and ratio of reactants, all of which are related to the direction of the reaction and the purity of the product.
Another way, or the use of coupling reaction strategies. If there is a halide containing naphthyl group, and a nucleophilic reagent containing carboxyl group and ethyl group, under the catalysis of suitable metal catalysts, such as palladium-based catalysts, the molecular structure of 2% 2C6-diethylnaphthoquinone acid is gradually established through coupling steps. However, such methods require quite high reaction conditions. The choice and dosage of catalysts, the purity of the reaction system, etc. are all key elements, and caution is required to make the synthesis smooth and obtain high-purity products.
What are the physical and chemical properties of 2,6-difluorophenylboronic acid?
2% 2C6-diethylnaphthoquinone acid has specific properties and is related to both ends of chemical properties.
First talk about its chemical properties. This substance contains functional groups such as carboxyl groups and quinone groups. Carboxyl groups are acidic and can neutralize with bases to produce corresponding salts and water. In case of sodium hydroxide, the two combine to form salts and water, which is a common case of acid-base neutralization. Quinone groups have redox properties. In appropriate circumstances, they can obtain electrons and be reduced, and they can also lose electrons and be oxidized. When oxidized, other substances can be oxidized, and they themselves become valent due to the gain of electrons. This redox property is a key position in many chemical reactions.
Describe its physical properties again. 2% 2C6-diethylnaphthoquinone acid is mostly in solid form at room temperature, with a specific color or a unique color. Its melting point and boiling point are fixed. The melting point is the critical temperature at which a substance changes from solid to liquid state, and the boiling point is the critical temperature at which it changes from liquid to gaseous state. And its solubility is also an important physical property. In organic solvents, it may have good solubility. In water, the degree of solubility may vary, due to the interaction between molecular structure and solvent molecules. Its density is related to the mass per unit volume and is also one of the factors that characterize its physical properties.
In short, 2% 2C6-diethylnaphthoquinone acid has such chemical and physical properties due to its unique molecular structure. It has potential uses in various fields such as chemical engineering and medicine. It needs to be further explored by scholars to understand its mysteries and effects.
What are the precautions for storing and transporting 2,6-difluorophenylboronic acid?
2% 2C6-diethylnaphthalenesulfonic acid, when storing and transporting, pay attention to many matters.
First storage environment. This substance should be placed in a cool, dry and well-ventilated place. If it is exposed to high temperature or humidity, it may cause its properties to mutate, or even induce chemical reactions. For example, high temperature can easily cause its volatilization to accelerate, while moisture may cause it to absorb moisture and agglomerate, which will damage its quality. And it needs to be stored separately with oxidants, alkalis and other substances to prevent interaction and lead to danger.
When transporting, the packaging must be tight. Choose suitable packaging materials, which are strong and can prevent leakage. If the packaging is not good and there is a slight bump and vibration during transportation, it may cause the material to leak, which not only pollutes the environment, but also increases the safety hazard. At the same time, the transportation vehicle should also ensure that it is clean, dry, and free of other residues that may react with it.
Furthermore, the person handling this substance should have professional training and be familiar with its characteristics and emergency disposal methods. Transportation and storage sites should be equipped with complete fire and leakage emergency treatment equipment. In the event of a leak, it can be dealt with quickly to reduce damage hazards.
In terms of identification, storage containers and transportation tools should be clearly marked with their names, characteristics, danger warnings and other information. Make contacts clear at a glance, operate with caution, and avoid accidental contact with danger due to ignorance. Therefore, it is necessary to ensure the safety of 2% 2C6-diethylnaphthalenesulfonic acid during storage and transportation.
What is the market price trend of 2,6-difluorophenylboronic acid?
Today, there is 2,6-diethylnaphthalenesulfonic acid, and its market price trend is quite popular. Looking at the market, in the past few years, the price of this sulfonic acid fluctuated, just like the waves on the river surface, from time to time.
At the beginning, due to abundant raw materials, stable supply, and no surge in demand, its price was still stable and hovered within a reasonable range. Then, things were fickle, and the origin of raw materials changed occasionally, causing the supply of raw materials to tighten and the cost to rise sharply. Just like a boat going against the current, difficult and abnormal, the price of this sulfonic acid also rose, and the increase was considerable.
Not long after, the market merchants saw this and adjusted their strategies one after another, or increased production, or looked for new sources. Over time, the supply gradually returns to normal, and although the demand has increased, it has not reached the expected high. Like water overflowing when it is full, the sign of oversupply gradually appears, and the price then falls.
Recently, due to industry innovation, new processes and substitutes have occasionally come out, which has had a significant impact on the market. However, this sulfonic acid still has a place due to its own characteristics. Although its price has dropped slightly, it has not fallen sharply. The future price trend is still unknown. Or due to new changes in raw materials and sudden changes in demand, there will be waves again; or with market adjustment, it will gradually stabilize. It is necessary to observe the changes in the industry before we can see what it is.