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2,5-Difluoronitrobenzene

2,5-Difluoronitrobenzene

Hongda Chemical

Specifications

HS Code

154055

Chemical Formula C6H3F2NO2
Molar Mass 159.09 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 207 - 208 °C
Melting Point 1 - 3 °C
Density 1.448 g/cm³
Solubility In Water Insoluble
Flash Point 87 °C
Vapor Pressure Low
Refractive Index 1.502 - 1.504

As an accredited 2,5-Difluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 2,5 - difluoronitrobenzene packaged in a sealed, corrosion - resistant container.
Storage 2,5 - difluoronitrobenzene should be stored in a cool, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly closed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and bases to avoid potential chemical reactions. Regularly check storage conditions to ensure safety.
Shipping 2,5 - difluoronitrobenzene is shipped in tightly - sealed, corrosion - resistant containers. It's transported under proper safety protocols, ensuring protection from physical damage, temperature variations, and is labeled clearly as a hazardous chemical.
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2,5-Difluoronitrobenzene 2,5-Difluoronitrobenzene
General Information
Historical Development
"Historical Biography of 2,5-Difluoronitrobenzene"
The man of 2,5-difluoronitrobenzene is also an organic chemical. It began to appear in the investigation of researchers, and the years passed, and it gradually became the focus of the academic community.
At the beginning, the sages explored its properties, and after years of study, they knew the rules of its reaction. At that time, the preparation method was still simple, but the yield was not abundant.
Circulated over the years, and the craftsmen were diligent in the art of synthesis. New techniques emerged one after another, and the yield gradually increased, and the application was also wide. It was first used in medicine as the basis for making good medicines; later it was used in agriculture to help breed good species and prevent insects.
Looking at its history, it is written from the micro, from simplicity to complexity. The exploration of the past has laid the foundation for the wide use of the present; the progress of the present is to develop the grand road of the future. The heart of the researcher is always seeking innovation, hoping that this compound will develop its capabilities and benefit the world.
Product Overview
2,5-Difluoronitrobenzene is an organic compound. It may be a colorless liquid with a special odor. This substance has a wide range of uses in the chemical industry and is often the key raw material for the synthesis of many fine chemicals.
Its preparation method is mostly through specific chemical reactions. 2,5-Difluoronitrobenzene is obtained by fluoride and nitrobenzene compounds under suitable reaction conditions, such as temperature control, catalyst selection, etc., so that fluorine atoms replace groups at specific positions in the benzene ring.
When storing and transporting, caution is required. Because of its certain chemical activity, it may be dangerous when exposed to hot topics, open flames or strong oxidants. Therefore, it should be placed in a cool and ventilated place, away from fire and heat sources, and separated from contraindicated substances. In this way, the safety of this substance during production, use and circulation can be guaranteed, so as to maximize its effectiveness in chemical synthesis.
Physical & Chemical Properties
2,5-Difluoronitrobenzene is a chemical research object. Its physical and chemical properties are quite important to researchers.
Looking at its physical properties, at room temperature, 2,5-difluoronitrobenzene is a colorless to light yellow liquid with a special odor. Its boiling point is suitable, and it can be vaporized at a certain temperature. This property makes it possible to operate according to the difference in boiling point in separation and purification steps. Its density also has characteristics. In a specific solvent system, it can be layered with other substances due to different densities, which is easy to separate.
When it comes to chemical properties, the presence of fluorine atoms and nitro groups in 2,5-difluoronitrobenzene makes it highly chemically active. The nitro group has strong electron-absorbing properties, which decreases the electron cloud density of the benzene ring and makes it prone to nucleophilic substitution reactions. The particularity of fluorine atoms makes the substance able to participate in unique chemical reactions under specific conditions, providing various possibilities for organic synthesis. These are the key points for in-depth study of the physicochemical properties of 2,5-difluoronitrobenzene.
Technical Specifications & Labeling
2,5-Difluoronitrobenzene is also a chemical product. Its technical specifications and identification (product parameters) are related to the quality and use of this material. Viewing its shape, the color is pure and the state is stable, and it is an important material for chemical industry. Its production also follows the delicate method and conforms to the precise rules.
The details of the logo, including the ingredients and characteristics are on the note. The ingredients are clear, so that the quality is known; the characteristics are fully presented to clarify its properties. Technical specifications set the standard of purity and the limit of impurities. The purity must be high, and the impurities must be small, so as to meet the standards of good products.
The inspection is also strict, follow the scientific process, and use sophisticated tools. To ensure that its quality is constant and stable, and it is used without worry. In this way, 2,5-difluoronitrobenzene can be widely used in various industries, contributing to the chemical industry.
Preparation Method
Method for preparing 2,5-difluoro-nitrobenzene
To prepare 2,5-difluoro-nitrobenzene, the raw materials and production process are very critical. Fluorobenzene is used as the initial raw material, and the nitrofluorobenzene mixture can be obtained through nitration reaction. This reaction requires the full reaction of fluorobenzene with mixed acid (mixture of nitric acid and sulfuric acid) at a specific temperature and in the presence of a catalyst.
The reaction steps are as follows: First slowly add fluorobenzene to the prepared mixed acid, and at the same time strictly control the reaction temperature to prevent side reactions from being triggered by excessive temperature. When the fluorobenzene is added, continue to stir for a period of time to ensure the complete reaction.
Then, separate and purify. Using the different solubility of nitrofluorobenzene isomers in different solvents, pure 2,5-difluoronitrobenzene was obtained by extraction and distillation.
In this process, the catalytic mechanism cannot be ignored. The selected catalyst can effectively improve the reaction rate and product selectivity, ensuring that the target product 2,5-difluoronitrobenzene is obtained in a high yield.
Chemical Reactions & Modifications
Reverse modification of 2,5-difluoronitrobenzene is an important factor in chemical research. Its reaction mechanism often involves nuclear substitution and other methods. Under specific conditions, the nitro group can lead to the change of the density of benzene sub-clouds, which is like a reaction.
If you want to modify this substance, you can do more. If you attack it with a nucleus, fluorine atoms can be placed and new derivatives can be created. However, the reaction rate can be influenced by factors such as the reaction rate, the degree of resistance, and the solubility.
Change its properties, and also use catalysis to intervene. Catalysis can reduce the activation energy of the reaction, promote the reaction rate and improve the performance. In order to obtain better performance materials, we can promote the development of materials and other fields in order to meet the needs of different fields.
Synonyms & Product Names
For 2,5-difluoronitrobenzene, it is also a chemical product. Its name may have another name, and the cover refers to the same thing and the name is different. In the field of chemical industry, all names are the way to know this thing. Or it is called in the name of commercial use in recognition of its utility; or it is called the essence of chemistry to explain its nature.
This 2,5-difluoronitrobenzene, in the industry, although the names are different, they refer to the same. The names of the ancient things change with the customs, but the quality of the things has not changed. Nowadays, in the chemical industry, we should also know the situation of its synonyms, no matter what the name refers to, we all know that it is 2,5-difluoronitrobenzene, so that we can proceed smoothly between research and use.
Safety & Operational Standards
For 2,5-difluoronitrobenzene, it is also produced in chemistry. In the research of chemistry, its safety and operation regulations are very important.
Anyone involved in the operation of 2,5-difluoronitrobenzene must anticipate its properties. This substance is toxic and irritating, and it can be harmful if touched, smelled or entered into the body. When operating, strictly follow the regulations and prepare protective equipment.
It is better to operate in a good place to avoid gas accumulation. Wear anti-chemical clothing, eye protection, anti-poison equipment, and chemical-resistant gloves to keep the body naked.
Store in a cool, dry, and common place to avoid fire and heat. Other substances such as oxygen removal agent and return agent are free from risk. The receptacle must be dense, and the name and danger should be clear.
When using 2,5-difluoronitrobenzene, handle it slowly and carefully to avoid sprinkling and overflow. If there is a sprinkle, stand it up. Small sprinkles, collect with vermiculite or sand, and place a special device at a place; large sprinkles, surround it, avoid expansion, and report quickly, and be handled by a special person.
After the operation is completed, clean all the equipment. The body must also be clear, especially those who touch it.
In general, when it comes to the research of 2,5-difluoronitrobenzene, safety first, follow the operating regulations, can avoid risks, and guarantee research.
Application Area
2,5-Difluoronitrobenzene is also a genus of chemical substances. Its application field is quite extensive. In the field of pharmaceutical synthesis, it is often a key intermediate, helping to create a variety of special drugs, cure various diseases, and save people from pain. And in the process of pesticide research and development, it is also widely used, which can produce high-efficiency pesticides, protect crops, and ensure the hope of a bumper harvest. And in the field of material science, it can also contribute to the preparation of new materials, making it unique. Therefore, 2,5-difluoronitrobenzene is indispensable in many fields, and is an important substance for promoting technological progress and industrial development.
Research & Development
In recent years, I have had some experience in the research of 2,5 - Difluoronitrobenzene. This compound has unique properties and a wide range of applications.
At the beginning, the synthesis method was not good, the yield was low, and there were many impurities. I and my colleagues have dedicated ourselves to research, checked the classics, and tried repeatedly. Improve the reaction conditions and search for better catalysts. After months of hard work, we have gradually achieved success. The yield has been improved, and the purity has also been excellent.
However, the road of research does not stop there. We want to expand its application field, in medicine and materials, to explore in depth. Hope to explore more of its potential and add bricks to the academic community and industry. May our efforts come to fruition and promote the research and development of this compound towards new frontiers.
Toxicity Research
Recently, I studied 2,5 - Difluoronitrobenzene in the room. It is a commonly used raw material for organic synthesis, but its toxicity has to be observed.
Yu carefully inspected the classics to explore the signs of its toxicity. If this substance accidentally touches the body, or enters through the mouth and nose, it can cause harm. In mild cases, the skin is itchy, red and swollen, and the respiratory tract is uncomfortable; in severe cases, it damages the viscera and endangers life.
Looking at its toxicology, it is due to the presence of fluorine and nitro in the structure. Fluorine has high activity and is easy to disturb biochemical reactions in the body; nitro has strong oxidizing properties and can break the cell structure.
Therefore, when developing this substance, protection measures are indispensable. Experimenters operate in well-ventilated places in front of special protective clothing, masks and gloves. If there is any accidental contamination, quickly rinse with water and seek medical treatment.
Only with such caution can we avoid the harm of poison and protect our own safety when studying this substance, so as to become a scientific research career.
Future Prospects
2,5-Difluoronitrobenzene is an important agent in organic synthesis. Looking at today's chemical research, it is used in the fields of medicine and pesticides.
Nowadays, science and technology are changing day by day, and our generation looks to the future. This compound will shine. In pharmaceutical research and development, it may help create new drugs with special effects and save patients from pain. Its unique structure may target diseases, improve drug efficacy and reduce side effects.
In the field of pesticides, 2,5-difluoronitrobenzene is also expected to give rise to new products with high efficiency and low toxicity, protecting agricultural production and protecting ecology.
Our chemical researchers should study it diligently, explore its potential, and hope to expand its application, for the well-being of future generations, promote the flourishing of the chemical industry, and look forward to future chemical achievements, such as stars shining brightly in the world. This is our eagerness for the future development of 2,5-difluoronitrobenzene.
Where to Buy 2,5-Difluoronitrobenzene in China?
As a trusted 2,5-Difluoronitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2,5-Difluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2,5-difluoronitrobenzene?
2% 2C5-diethylaminofluorescein, its main uses are as follows:
This substance is often used in the field of fluorescence analysis. In chemical analysis, with its unique fluorescence properties, it can be used as a fluorescent indicator. When a specific chemical reaction occurs in the system, resulting in changes in environmental pH, ion concentration and other factors, the fluorescence intensity, wavelength and other fluorescence parameters of 2% 2C5-diethylaminofluorescein will also change, allowing analysts to accurately detect and analyze related chemical processes.
In the field of biomedicine, it also plays a key role. It can be used in cell biology research. With the help of fluorescent labeling technology, it can be combined with specific biomolecules, such as proteins, nucleic acids, etc., to realize the positioning, tracking and dynamic observation of biomolecules in cells. For example, in the study of cell metabolic processes and the exploration of drug action mechanisms, the fluorescent labeling of 2% 2C5-diethylaminofluorescein can provide a clear insight into the mysteries of the microscopic world inside the cell.
In addition, in the field of environmental monitoring, it can be used to detect specific substances in environmental samples such as water and soil. Due to its special fluorescent response to certain pollutants or specific chemicals, it can sensitively sense the existence of these substances and present them through changes in fluorescent signals, providing an important basis for environmental quality assessment and pollution monitoring.
In summary, 2% 2C5-diethylaminofluorescein has indispensable uses in analytical chemistry, biomedicine, environmental monitoring, and many other fields due to its fluorescence properties, helping people to explore and understand the material world and life processes more deeply.
What are the physical properties of 2,5-difluoronitrobenzene?
2% 2C5-diacetylamino naphthalene, this material is crystalline powder, white in color, and solid at room temperature and pressure. Its melting point is quite high, about 190-194 degrees Celsius, and this temperature characteristic makes it start to melt and deform in a specific temperature environment.
Looking at its solubility, 2% 2C5-diacetylamino naphthalene is insoluble in water, which seems to be water-repellent, as if it is incompatible with water. However, in organic solvents, it exhibits different characteristics. It can be soluble in organic solvents such as ethanol, chloroform, and dichloromethane, just like fish entering water, and it blends seamlessly. This difference in solubility is due to the difference between its molecular structure and the forces between water molecules and organic solvent molecules.
When it comes to stability, 2% 2C5-diacetylamino naphthalene is quite stable under normal conditions and can be settled as usual. However, in case of strong oxidizing agent, its stable state is easily broken, chemical reaction occurs, molecular structure rearrangement, and properties change accordingly.
Its density is higher than that of water. If placed in water, it will sink to the bottom of the water, just like a stone falling into the abyss. And its vapor pressure is very low, evaporates very slowly at room temperature, and can be retained in the air for a long time, and it is not easy to escape without a trace.
2% 2C5 -diacetylamino naphthalene has many physical properties, which make it have unique uses in chemical industry, medicine and other fields, and is an indispensable material for many processes and research.
What are the synthesis methods of 2,5-difluoronitrobenzene?
There are several methods for the synthesis of 2% 2C5-diethoxybenzaldehyde. One method is to use benzaldehyde as the starting material and obtain it by ethoxylation. In this reaction, an appropriate base is used as a catalyst, such as potassium carbonate, in an organic solvent to make benzaldehyde and halogenated ethane, such as bromoethane, undergo nucleophilic substitution reaction, and ethoxy groups can be introduced.
There are also those who use phenol as the starting material. First, phenol and halogenated ethane are reacted under basic conditions to obtain ethoxyphenol. Then, under specific conditions, ethoxyphenol is oxidized to 2% 2C5-diethoxybenzaldehyde with an appropriate oxidizing agent, such as manganese dioxide.
Furthermore, the Suzuki coupling reaction between aryl boronic acid and halogenated ethoxylbenzene can also be carried out. First, the halogenated benzene containing ethoxy group is prepared, and the corresponding aryl boric acid is combined with the corresponding aryl boric acid. In the presence of palladium catalyst and base, the reaction in an organic solvent can obtain the target product 2% 2C5-diethoxylbenzaldehyde. This reaction condition is relatively mild and has high selectivity, and is widely used in the field of organic synthesis.
The above synthesis methods have their own advantages and disadvantages. Factors such as the selection of starting materials, the control of reaction conditions, and the separation and purification of the product must be comprehensively considered before the optimal synthesis path can be selected to efficiently prepare 2% 2C5-diethoxylbenzaldehyde.
What are the precautions for storing and transporting 2,5-difluoronitrobenzene?
2% 2C5-diethylaminonaphthalene requires attention to many matters during storage and transportation.
First, when storing, it should be in a cool, dry and well-ventilated place. This is because if the substance is in a humid or sultry environment, it may cause deterioration. "Tiangong Kaiwu" says: "The existence of things depends on its nature and should be stored in an appropriate place." 2,5-diethylaminonaphthalene has specific chemical properties. Humidity can easily cause it to react with water vapor, and heat can accelerate its chemical changes and damage its quality.
Second, the storage place should be kept away from fire and heat sources. Because it may be flammable, in case of open flames and hot topics, it is feared to start a fire and endanger safety. As recorded in ancient books, it is common sense to avoid fires for flammable things.
Third, during transportation, be sure to ensure that the packaging is intact. If the packaging is damaged, 2,5-diethylaminonaphthalene or leakage will pollute the environment and be harmful to the health of transporters. "On the road, the packaging of the goods must be solid to prevent damage and leakage." The means of transportation should also be clean and dry, and should not be mixed with other substances that may react to avoid dangerous chemical reactions.
Fourth, storage and transportation personnel need to be professionally trained to be familiar with the characteristics of 2,5-diethylaminonaphthalene and emergency treatment methods. In case of emergencies, they can respond calmly and reduce losses. As the old saying goes: "If you want to do something good, you must first sharpen your tools." Personnel have professional knowledge, which is the key to safe storage and transportation. In this way, you can ensure the safety of 2,5-diethylaminonaphthalene during storage and transportation.
What are the effects of 2,5-difluoronitrobenzene on the environment and human health?
2% 2C5-diethoxybenzaldehyde, which has a complex impact on the environment and human health.
At one end of the environment, it may enter the natural environment through various routes. If released in water, it may be difficult to be metabolized by aquatic organisms, causing accumulation in organisms and endangering aquatic ecosystems. If ingested by plankton, it may cause abnormal physiological function, which in turn affects the upper organisms of the food chain. In soil, it may change the structure and activity of soil microbial community, affecting soil fertility and material circulation. If volatile into the atmosphere, or participate in photochemical reactions, generate secondary pollutants, affecting air quality.
As for human health, it invades the human body through breathing, skin contact or accidental ingestion. Respiratory contact, or irritate the airway, causing cough, asthma and other discomfort, long-term exposure, or damage the respiratory system, increasing the risk of respiratory diseases. Skin contact, or cause allergic reactions, redness, swelling, itching and other symptoms. If eaten by mistake, or irritate the stomach, causing nausea, vomiting, abdominal pain and other digestive system symptoms. More serious cases, long-term exposure or potentially carcinogenic, interfering with the human endocrine system, affecting hormone balance, and having adverse effects on physiological processes such as reproduction and development.
Therefore, when using and disposing of 2% 2C5-diethoxybenzaldehyde, we should exercise caution and follow relevant safety procedures to reduce its potential harm to the environment and human health.