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2,5-Difluorobenzenethiol

2,5-Difluorobenzenethiol

Hongda Chemical

Specifications

HS Code

927943

Chemical Formula C6H4F2S
Molecular Weight 146.16
Appearance Typically a liquid
Odor Characteristic thiol - like odor
Boiling Point Data may vary, around 170 - 180 °C (approximate)
Density Data needed, but likely in the range of 1.3 - 1.5 g/cm³ (approximate)
Solubility In Water Poorly soluble in water
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, acetone
Flash Point Needs experimental determination, but likely flammable

As an accredited 2,5-Difluorobenzenethiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2,5 - difluorobenzenethiol packaged in a sealed, chemical - resistant bottle.
Storage 2,5 - difluorobenzenethiol should be stored in a cool, well - ventilated area, away from heat sources and ignition sources. It should be stored in a tightly closed container made of a material compatible with the chemical, such as glass or certain plastics. Keep it separate from oxidizing agents and strong bases to prevent reactions. Also, label the storage container clearly for easy identification and safety.
Shipping 2,5 - difluorobenzenethiol is a chemical. Shipments must follow strict hazardous material regulations. It should be properly packaged in suitable containers, labeled clearly, and transported by carriers licensed for such chemicals.
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2,5-Difluorobenzenethiol 2,5-Difluorobenzenethiol
General Information
Historical Development
2,5-Difluorothiophenol is also an organic compound. Tracing its historical development, at the beginning, chemists devoted themselves to the field of organic synthesis and expanded the category of compounds. At that time, the exploration of fluorine-containing and sulfur-containing compounds gradually flourished.
Everyone is committed to finding new synthesis methods to produce special compounds. After many trial and error, unremitting research, the method of synthesizing 2,5-difluorothiophenol was obtained. The process is difficult and requires fine control of reaction conditions, such as temperature, reagent ratio, etc.
With the passage of time, the synthesis technology has become increasingly perfect. This compound has made its mark in the fields of medicine, materials, etc., adding a touch of brilliance to the development of chemistry and laying the foundation for subsequent research, becoming an important milestone in the history of organic synthesis.
Product Overview
Description of 2,5-difluorothiophenol
Fu 2,5-difluorothiophenol is a valuable compound in the field of organic synthesis. Its characteristics are unique, it is colorless to light yellow liquid at room temperature, has a special mercaptan odor, and has certain volatility.
From the perspective of chemical structure, two fluorine atoms and a mercapto group on the benzene ring are cleverly arranged, giving it special chemical activity. This structural characteristic makes 2,5-difluorothiophenol play a key role in many chemical reactions.
In organic synthesis, it is often used as a nucleophilic reagent to participate in nucleophilic substitution reactions. It can react with halogenated hydrocarbons, acyl halides and other substrates to form new carbon-sulfur bonds, thereby synthesizing a series of sulfur-containing organic compounds. Due to the presence of fluorine atoms, the synthesized products often have good biological activity and stability, and show broad application prospects in the field of medicine and pesticide creation. For example, some drug molecules synthesized from this raw material have efficient inhibitory effects on specific disease targets.
Physical & Chemical Properties
2,5-Difluorobenzenethiol is an organic compound, and its physical and chemical properties are quite critical. Looking at its physical properties, it may be a liquid at room temperature and has a special odor. The boiling point and melting point are related to its phase change, which has a great impact on storage and application. In terms of chemical properties, it contains thiol groups and has certain reactivity. It can react with many reagents such as substitution and oxidation. Due to the fluorine atom, its chemical stability and electronic properties are unique. In the field of organic synthesis, with these physical and chemical properties, 2,5-Difluorobenzenethiol may be used as a key intermediate to participate in the construction of complex organic molecular structures and provide an important material basis for new drug research and development, material creation, etc. It is a compound of considerable research value.
Technical Specifications & Labeling
2,5-Difluorothiophenol is an important chemical product. Its technical specifications and identification (commodity parameters) are related to the quality and use of this product.
On technical specifications, purity is crucial, it needs to be extremely accurate, and impurities must be few to maintain its purity. Its color state is also determined, and it should be colorless to slightly yellow transparent, with no odor and variegation, which is standard. And physical and chemical constants, such as melting point, boiling point, density, etc., must be accurate and consistent with the established parameters.
As for the logo, on the packaging, it should be marked with the name "2,5-difluorothiophenol" in prominent words, with a hazard warning, such as toxic and flammable labels, to inform everyone to use it with caution. And list the product parameters in detail, such as the proportion of ingredients, the production batch, the shelf life, etc., so that the user can understand the details, use it with peace of mind, and ensure the smooth operation of the chemical industry.
Preparation Method
There is a method for preparing 2,5-difluorothiophenol, which is described in detail as follows. The raw materials are selected from fluoroaromatics and sulfur sources. Those containing fluoroaromatics need to be of good purity and few impurities to ensure a smooth reaction. The sulfur source is selected from those with suitable activity to promote efficient reaction.
The production process first puts fluoroaromatics and sulfur sources into a special reactor in precise proportions. The temperature and pressure in the kettle need to be carefully controlled to achieve the best reaction environment. The temperature is raised to a moderate extent and the constant temperature is maintained to make the two fully react. This reaction process lasts for several times, depending on the actual situation.
The first step is the mixing and blending of the two, the molecular collision, and the reaction is excited. Then the chemical bonds are broken and recombined, and the target product is gradually produced. During this period, an appropriate amount of catalyst may be added to accelerate the reaction process and optimize the reaction rate.
Refining mechanism, after the reaction is completed, the product contains impurities and needs to be finely separated. First, volatile impurities are removed by distillation; then, insoluble impurities are removed by extraction. This is repeated, and high purity 2,5-difluorothiophenol is finally obtained.
Chemical Reactions & Modifications
Recently, there are many experiences in the study of the chemical and anti-chemical modification of 2,5-difluorothiophenol. The properties of this compound are not special, and the value of its anti-chemical path is explored. In the laboratory, I used the general method to study the parts. At the beginning, according to the usual method, the anti-chemical has not been as good as the anti-chemical period, and the anti-chemical rate is low. Then think of the method, the integrity, the anti-chemical force and the amount of catalysis.








Under a certain catalytic system, the anti-chemical rate is increased to a specific level, the anti- In addition, different dissolution methods are used to investigate the reverse process, hoping to obtain a better reverse environment, so that the compound has greater efficacy and can be used in multiple domains.
Synonyms & Product Names
Today there is a thing called 2,5 - Difluorobenzenethiol. It has attracted much attention in the field of my chemical research. The alias and trade name of this substance also need to be studied in detail.
Looking at various books, looking for its same name. Or with its characteristics, another name is given, hoping to be passed on in the industry. And the determination of the trade name is related to marketing activities and must also be considered.
This 2,5 - Difluorobenzenethiol has unique chemical properties and is widely used. To clarify its alias and trade name can help the industry communicate and is beneficial to scientific research and production. We should carefully observe its nature and explore its name, so as to promote the progress of chemical research and seek the prosperity of the industry.
Safety & Operational Standards
2,5-Difluorothiophenol is an important chemical substance that is used in many fields of chemical synthesis. However, it has certain particularities, so safety and operating standards are extremely critical.
First, it is about storage. Store 2,5-difluorothiophenol in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent danger caused by excessive temperature. Because of its volatility and chemical activity, if the storage environment is improper, it is easy to leak or react with surrounding substances.
When operating, operators must strictly abide by relevant procedures. Wear appropriate protective equipment, such as protective work clothes, gloves and protective glasses. This is because 2,5-difluorothiophenol may cause irritation to the skin and eyes. If it is inadvertently touched, it may cause discomfort or even injury.
During use, ensure that the operating space is well ventilated. Ventilation equipment can be used to discharge volatile gases in time to prevent their accumulation in the air and reduce the risk of explosion or poisoning. And the operation process should be rigorous to avoid mixing with incompatible substances. Because 2,5-difluorothiophenol is chemically active, it can be mixed with certain substances or cause violent reactions.
Once a leak occurs, do not panic. Unrelated personnel should be evacuated quickly, and emergency treatment procedures should be started at the same time. In the event of a small leak, it can be absorbed by inert materials such as sand and vermiculite, collected in a suitable container, and properly disposed of. A large number of leaks need to be built embankments or excavated for containment, and transferred to a special collector with an explosion-proof pump for disposal.
Only by strictly following safety and operating standards can we ensure the safe use of 2,5-difluorothiophenol and give full play to its role in chemical research and production.
Application Area
2,5-Difluorothiophenol is also a chemical substance. Its application field is quite wide. In the field of pharmaceutical chemistry, it can be used as a key intermediate to help create special drugs and cure various diseases. In material science, it also has extraordinary functions, or can improve the properties of materials, making it more tough and durable, suitable for a variety of equipment and equipment. In the field of fine chemicals, it can be used to synthesize special chemicals to increase the efficiency and quality of its products. In this way, 2,5-difluorothiophenol has shown its important value in many application fields, contributing to chemical research and industrial development.
Research & Development
Modern chemistry has advanced, and various new substances have been produced one after another. 2,5 - Difluorobenzenethiol This substance is also the target of chemical research. I have been studying it for a long time, and its properties and production methods have been explored many times.
At the beginning, there were many twists and turns to explore its synthesis method. The selection of raw materials and the control of conditions all need to be carefully considered. After several adaptations, a more suitable approach can be obtained.
Its unique properties often show different properties in chemical reactions, or it can be used as a catalyst or participate in special compounds. However, its application field needs to be expanded.
The future development should focus on broadening its use and combining it with various industries. In the field of pharmaceutical research and development, it may be able to help create new agents; in the field of materials, it may be able to give birth to specific materials. I will make unremitting efforts to promote this material in the road of practicality and contribute to the development of chemistry.
Toxicity Research
Taste and smell the industry of chemical industry, the study of poisons, the most serious. Today there are things called 2,5-Difluorobenzenethiol, which are important for us to study poison.
The poison of this substance cannot be ignored. Its strong nature can be harmful if it is touched or smelled. If the skin encounters it, it may develop sores; if it inhales its qi, it may hurt the lungs. Looking at various experiments, the white rat touches this, moves slowly, and the diet is sluggish. It can be seen that its toxicity is fierce.
However, if you want to understand its toxicology, you need to investigate its chemical properties. The structure of molecules and the group of senses are all related to toxicity. And when it comes to its impact on the environment, if it is released to the outside or sewage, it will endanger life.
When we study it, it is not to harm the world, but to understand its poison and prevent it from happening, so that everyone can be spared from it, and the chemical industry can also advance safely.
Future Prospects
I try to study the technology of chemical industry, in 2,5 - Difluorobenzenethiol this thing, observe its characteristics, explore its potential. Although today is still in the stage of research, my heart looks forward to the future.
Husband 2,5 - Difluorobenzenethiol, unique structure, performance is different. Or in the field of medical creation, it can be the foundation of new drugs for treating diseases, helping doctors to eliminate diseases, saving people from diseases; It is also expected that in the process of material research and development, it will become a novel material, adding wings to industrial and technological innovation, making the utensils exquisite and durable.
Although the road ahead is long and the geometry is unknown, I firmly believe that with time, I will be able to reveal its mysteries and show its grand effect by exhausting my mind and the power of the crowd. In the future, when this thing is widely used and benefits the world, I also hope to be able to do my best in it, to achieve this grand event, and live up to my ambition to study.
Where to Buy 2,5-Difluorobenzenethiol in China?
As a trusted 2,5-Difluorobenzenethiol manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2,5-Difluorobenzenethiol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2,5-difluorothiophenol?
2% 2C5-diethylbenzamide, its main uses have many aspects. In the field of medicine, it is often used as a central nervous system stimulant. It can stimulate the nervous system, improve mental state and alertness, and has a certain improvement effect on some symptoms caused by the decline or inhibition of nervous system function, such as drowsiness, mental malaise, etc. For example, in some specific medical scenarios, it is used to wake up patients in pre-coma or slightly disturbed consciousness and help them recover.
In the industrial field, it can be used as an important intermediate in organic synthesis. With its unique chemical structure, it can participate in the synthesis of many complex organic compounds. For example, when synthesizing some polymer materials with special properties, 2% 2C5-diethylbenzamide can be used as a key starting material or reaction aid to construct polymer polymers with specific properties and structures through specific chemical reaction paths. These polymers play an important role in the production of industrial products such as plastics and rubber.
In scientific research, it is an important experimental reagent. Researchers use it to conduct various chemical experiments and pharmacological studies to explore new chemical reaction mechanisms, drug targets, etc. For example, in cell biology experiments, to study its impact on cell physiological functions and metabolic processes, so as to provide theoretical basis and experimental basis for the development of new drugs or therapeutic methods.
What are the physical properties of 2,5-difluorothiophenol?
The physical properties of 2% potassium 2C5-diethylbenzoate are as follows:
This substance is mostly in the shape of a white crystalline powder under normal conditions, and the texture is fine and uniform. When it is smelled, the smell is light, almost no obvious special smell, and it rarely causes a strong sense of smell.
When it comes to solubility, its solubility in water is limited, and it can only be slightly soluble. When placed in organic solvents such as ethanol and ether, it exhibits good solubility and can be evenly dispersed quickly to form a uniform solution system.
As for the melting point, it is about a specific temperature range. This temperature is the critical value for its conversion from solid to liquid. Accurate determination is of great significance for its identification and purity determination. In general, its melting point is relatively stable, and its repeatability is quite high under standard experimental conditions.
Its density is also an inherent physical property, and it has a unique value compared with other common compounds. This density property plays an indispensable role in practical application scenarios such as material separation and mixing, and can help determine its distribution in mixtures and the choice of separation methods.
In addition, its particle size distribution also affects many properties and applications. Small particle size can increase its specific surface area, thereby improving its reactivity or dissolution rate with other substances; while larger particle size may affect its dispersion and fluidity in some cases. Overall, the physical properties of 2% 2C5-diethylbenzoate potassium are of great significance in the research and application of chemical industry, medicine and many other fields.
Is the chemical properties of 2,5-difluorothiophenol stable?
The chemical properties of 2% 2C5-diethylbenzenesulfonic anhydride are quite stable under normal conditions. This is due to the characteristics of its molecular structure. In the molecular structure of the substance, the benzene ring provides a stable support for the overall structure with the stability of its conjugate system. Although the sulfonic anhydride group has a certain activity, the presence of diethyl groups shields it in space, thereby reducing the influence of external factors on its activity check point.
And diethyl groups, as electron-supplying groups, can increase the electron cloud density of the benzene ring through electronic effects, strengthen the electron interaction within the molecule, and further improve the stability of the molecule. In the general environment, 2% 2C5-diethylbenzenesulfonic anhydride rarely reacts spontaneously without specific initiation conditions, such as high temperature, strong oxidants, and strong bases.
However, when exposed to high temperature, the internal energy of the molecule increases, the vibration of each atom intensifies, or the sulfonic anhydride bond breaks, resulting in decomposition reactions. Strong oxidants may launch oxidative attacks on its phenyl ring or sulfonic anhydride group, changing its chemical structure. Strong bases can also react with sulfonic anhydride groups, causing chemical changes such as hydrolysis. However, without such extreme or specific conditions, the chemical properties of 2% 2C5-diethylbenzenesulfonic anhydride can be said to be stable, and its inherent chemical form and properties can be maintained for a certain period of time.
What are the synthesis methods of 2,5-difluorothiophenol?
The synthesis method of 2% 2C5-diethylbenzoic anhydride has various ways, which are described as follows:
First, benzoic acid and acetic anhydride are used as raw materials, supplemented by an appropriate amount of catalyst, and they are co-heated at a suitable temperature. This reaction requires fine regulation of the temperature and the ratio of raw materials. If the temperature is too low, the reaction will be slow; if the temperature is too high, it will be prone to side reactions. Mix benzoic acid and acetic anhydride in a certain molar ratio, such as 1:1.2, put it into a reactor, add a catalyst such as concentrated sulfuric acid, heat it to 120-150 ° C, and continue to stir. During the reaction, closely monitor the reaction progress, and determine the reaction endpoint by means of thin layer chromatography (TLC When the reaction is completed, the reaction liquid is cooled, and the impurities are removed by washing with water, alkali washing, drying and other steps, and then distilled to collect the specific boiling point fraction to obtain 2% 2C5-diethylbenzoic anhydride.
Second, prepared by reacting 2% 2C5-diethylbenzoic acid with acetyl chloride. Place 2% 2C5-diethylbenzoic acid in the reaction vessel, add an appropriate amount of organic solvent, such as dichloromethane, and stir to dissolve. Subsequently, slowly add acetyl chloride dropwise, and at the same time add an acid binding agent, such as triethylamine, to neutralize the hydrogen chloride generated by the reaction. The reaction is carried out at a low temperature, such as 0-5 ° C, to prevent side reactions from occurring. After the dropwise addition is completed, heat up to room temperature and continue the reaction for a period of time. At the end of the reaction, the crude product is obtained by separation, washing, concentration, etc., and then purified by recrystallization to obtain pure 2% 2C5-diethylbenzoic anhydride.
Third, the method of reacting acid chloride with carboxylate can be used. First, 2% 2C5-diethylbenzoic acid is made into a corresponding carboxylate, such as sodium salt, and reacts with 2% 2C5-diethylbenzoyl chloride in an organic solvent. Choose a suitable solvent, such as N, N-dimethylformamide (DMF), heat it to a suitable temperature, usually 80-100 ° C, and react for several hours. After the reaction is completed, it is cooled, filtered, and the filtrate is distilled under reduced pressure to remove solvents and impurities to obtain the target product 2% 2C5-diethylbenzoic anhydride.
These three synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to carefully choose according to factors such as raw material availability, cost, and product purity requirements to achieve the best synthesis effect.
What are the precautions for storing and transporting 2,5-difluorothiophenol?
For 2% 2C5-diethylbenzoic anhydride, various precautions are very important during storage and transportation.
Its nature is flammable, and it is very easy to burn in case of open flames and hot topics. Therefore, when storing, it should be placed in a cool and ventilated warehouse, away from fire and heat sources, and the storage temperature should not exceed 30 ° C. It should be stored separately from oxidants, acids, and alkalis, and mixed storage should not be avoided. In the warehouse, suitable materials should be prepared to contain leaks.
During transportation, make sure that the container does not leak, collapse, fall, or damage. When transporting, keep away from fire and heat sources to prevent direct sunlight. Transport vehicles should be equipped with the appropriate variety and quantity of fire equipment and leakage emergency treatment equipment. It is best to transport in the morning and evening in summer to avoid high temperatures. When transporting by road, follow the specified route and do not stop in residential areas and densely populated areas. When transporting by rail, do not slip away.
When handling, it should be lightly loaded and unloaded to prevent damage to packaging and containers. And when the operator is working, when wearing a self-priming filter gas mask (half mask), wearing chemical safety glasses, wearing anti-poison penetration work clothes, wearing rubber oil-resistant gloves to protect their own safety.
All of these are to ensure the safety of 2% 2C5 -diethylbenzoic anhydride during storage and transportation, and should not be slack.