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2,5-Difluorobenzenesulfonyl Chloride

2,5-Difluorobenzenesulfonyl Chloride

Hongda Chemical

Specifications

HS Code

217030

Chemical Formula C6H3ClF2O2S
Molecular Weight 226.60
Appearance Typically a colorless to pale yellow liquid
Boiling Point Approximately 248 - 250 °C
Solubility Soluble in common organic solvents like dichloromethane, toluene
Reactivity Highly reactive, reacts with nucleophiles like amines, alcohols
Odor Pungent, characteristic sulfonyl chloride odor
Hazard Corrosive, causes burns to skin, eyes and respiratory tract

As an accredited 2,5-Difluorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2,5 - difluorobenzenesulfonyl chloride packaged in a sealed glass bottle.
Storage 2,5 - difluorobenzenesulfonyl chloride should be stored in a cool, dry, and well - ventilated area. Keep it away from heat sources, open flames, and moisture. Store it in a tightly sealed container to prevent leakage and exposure to air, which could lead to decomposition or reaction. It should also be separated from incompatible substances like bases, reducing agents, and water - reactive materials.
Shipping 2,5 - difluorobenzenesulfonyl chloride is a chemical that requires careful shipping. It should be packed in appropriate corrosion - resistant containers, following hazardous material regulations, and shipped under conditions to prevent exposure and ensure safe transit.
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2,5-Difluorobenzenesulfonyl Chloride 2,5-Difluorobenzenesulfonyl Chloride
General Information
Historical Development
尝闻化工之业,新品迭出,其中有物曰2,5 - 二氟苯磺酰氯。其始也,研发之士殚精竭虑,于实验室中,以诸般技法,探究其合成之途。初时,艰难重重,反应之条件、原料之配比,皆需精细权衡。

历经岁月,诸般尝试,或改进流程,或寻更佳原料。渐有所得,合成之法趋稳,产率亦渐升。此物质于医药、材料诸领域,崭露头角,用途渐广。由是观之,2,5 - 二氟苯磺酰氯之发展,乃科研者不懈钻研之成果,于化工之史,添一抹亮色。
Product Overview
2,5-Difluorobenzenesulfonyl chloride is a chemical that I have dedicated myself to studying. It is a colorless to light yellow liquid with a pungent odor and is widely used in the field of organic synthesis.
The preparation of this product requires fine operation and is often obtained by a specific reaction path. In the chemical industry, it is a key intermediate and can participate in the synthesis of many organic compounds, such as the preparation of drugs, pesticides and materials.
However, it is dangerous and needs to be guarded during operation. It is corrosive and can cause burns when exposed to the human body. Storage should also be cautious. It should be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants.
Our chemical researchers should treat this chemical with rigor, give full play to its effectiveness, and ensure the safety of experiments to promote the progress of chemical synthesis.
Physical & Chemical Properties
2,5-Difluorobenzenesulfonyl chloride has unique physical and chemical properties. Its shape is like a liquid, and its color is transparent to yellowish. Looking at its state, it is stable at room temperature, but it is prone to change when exposed to heat, open flame or strong oxidants.
Its melting and boiling point is also specific. The melting point is low, resulting in a fluid state at room temperature, which is convenient to use. The boiling point has a specific value, and it evaporates and gasifies at the corresponding temperature and pressure.
The solubility cannot be ignored. In organic solvents, it has good solubility, but in water, it has weak solubility. This property is very useful for the construction of reaction systems and product separation.
Its chemical activity is high, the sulfonyl chloride group is active, and it can react with many reagents, such as nucleophilic substitution. It is an important raw material for organic synthesis. It can produce a variety of sulfonyl compounds and is widely used in medicine, pesticides and other fields.
Technical Specifications & Labeling
2,5-Difluorobenzenesulfonyl chloride is an important chemical substance. Its process specifications and identification (product parameters) are related to many characteristics of this product.
In terms of process specifications, the preparation needs to follow a specific method, starting from the selection of raw materials and going through multiple careful processes to ensure accurate reaction conditions, such as temperature, pressure and time control, so that the reaction is sufficient and there are few side reactions, so as to achieve high purity products. On the
label, in addition to clearly labeling the name "2,5-difluorobenzenesulfonyl chloride", it is necessary to clarify its physical and chemical properties parameters, such as melting point, boiling point, density, purity, etc., so that users can understand its characteristics and use it safely and appropriately in various chemical fields. It has the effect of key guidelines in industrial production and scientific research experiments.
Preparation Method
The method of making 2,5-difluorobenzenesulfonyl chloride is related to the raw material and production process, reaction steps and catalytic mechanism, and is an important matter for chemical preparation.
First take an appropriate amount of 2,5-difluorobenzene as the initial raw material and mix it with chlorosulfonic acid in a specific ratio. When these two meet, in a special reactor, control the appropriate temperature, about 50 to 80 degrees Celsius, stir it to fully blend. This step is the start of the reaction and lays the foundation for subsequent changes.
The reaction gradually deepens, and the shape and color of the material in the kettle can be seen slightly changing, which is a sign of chemical changes. When the reaction reaches the expected level, the product is extracted by a delicate separation technique.
As for the catalytic mechanism, adding a few specific catalysts can promote the reaction rate and optimize the reaction path. Just like a guide, it guides the reaction to move forward smoothly, reducing energy consumption and yield, making the preparation of 2,5-difluorobenzenesulfonyl chloride more perfect and a method available for industrial production.
Chemical Reactions & Modifications
Regarding the chemical reaction and modification of 2,5-difluorobenzenesulfonyl chloride
Fu 2,5-difluorobenzenesulfonyl chloride, there is a specific one among chemical substances. Its properties in the reaction are quite worth exploring.
Looking at the reaction, it is often in an active state and phase with various substances. In case of nucleophilic reagents, sulfonyl chloride is easily replaced to form a new structure. The rules of this reaction can follow the principle of nucleophilic substitution, and different products can be obtained according to the properties and conditions of the reagents.
As for the modification, other groups can be introduced to change its chemical properties. If a fluorine-containing group is added, its lipid solubility and stability can be increased. By means of chemical methods, the distribution of electronic clouds can be adjusted, and the reaction activity can be changed. And the way of modification can also optimize its physical properties, such as the degree of melting and boiling, the solubility, etc., which is practical in chemical industry and has great significance. Exploring this change can open up new paths for chemical refinement and material innovation.
Synonyms & Product Names
2,5-Difluorobenzenesulfonyl chloride is also a raw material for chemical industry. Its synonymous name is also known. Or it is a specific variant of difluorobenzenesulfonyl chloride. In the industry, various names refer to this substance.
Guanfu This substance is widely used in the field of chemical industry. Its synonymous names vary depending on regions or industry habits. However, its essence is that 2,5-difluorobenzenesulfonyl chloride is also.
The name of its product also depends on the needs of the market and the quality of the manufacturer. Although the names are different and the quality is the same, they are all indispensable for chemical preparation, scientific research experiments and so on. Or used in organic synthesis reactions to assist in the formation of compounds; or as a raw material for fine chemicals to make special products. Therefore, 2,5-difluorobenzenesulfonyl chloride has different names, but its importance in the chemical industry cannot be underestimated.
Safety & Operational Standards
Specifications for the safety and operation of 2,5-difluorobenzenesulfonyl chloride
Fu 2,5-difluorobenzenesulfonyl chloride is an important material in chemical research. It is active. During use and operation, it is necessary to strictly observe safety and operation standards to ensure smooth experiments and personnel safety.
First words safety. This compound is corrosive and irritating to a certain extent. Therefore, when taking it, it is necessary to wear protective equipment, such as corrosion-resistant gloves, anti-goggles, and experimental clothes, to prevent it from contacting the skin and eyes and avoid burns. And the volatile gas of the thing, or harmful to breathing, when operating in a well-ventilated place, it is best to supplement it with a fume hood, so that the volatile gas can be dissipated in time, so as not to be inhaled into the body and damage health.
Second discussion on the rules of operation. When weighing, it is advisable to use precise instruments and move gently to prevent it from spilling. If there is any inadvertent spilling, clean it up in an appropriate manner as soon as possible. If covered with inert materials, collect it carefully and dispose of it properly according to regulations. During the reaction operation, it is necessary to precisely control the temperature and time, and observe the process of the reaction in detail. Because of its high reactivity, a little carelessness may cause the reaction to go out of control. And the post-reaction treatment also needs to be cautious. The steps of product separation and purification are carried out according to the established laws and cannot be changed without authorization.
Furthermore, storage is also critical. 2,5-difluorobenzenesulfonyl chloride should be placed in a cool, dry and ventilated place, away from fires and heat sources, to prevent it from deteriorating or causing danger due to environmental factors. And it should be placed separately from reactive substances to avoid accidental reactions.
In short, in the research and use of 2,5-difluorobenzenesulfonyl chloride, safety and operating standards must not be ignored. Only by adhering to this rule can we move forward steadily on the road of chemical research, avoid all kinds of risks, and achieve the expected goal.
Application Area
2,5-Difluorobenzenesulfonyl chloride has various uses in today's chemical research and application. In the field of pharmaceutical creation, this compound can be used as a key intermediate. With its unique chemical properties, it can cleverly react with various reagents to form molecules with specific pharmacological activities, paving the way for the development of new pharmaceuticals.
In the field of materials science, it can also be used. It can participate in the process of surface modification of materials, and through chemical reactions, give materials special properties, such as enhancing their corrosion resistance and improving their hydrophobicity.
In the field of fine chemicals, 2,5-difluorobenzenesulfonyl chloride can be used to prepare special dyes, fragrances and other fine chemicals. By precisely manipulating the reaction conditions, products with unique properties and quality can be obtained to meet the diverse needs of different industries for fine chemicals.
Research & Development
Today, there is a chemical substance called "2,5 - Difluorobenzenesulfonyl Chloride", and we have made progress in our research. This substance has unique properties and has great potential in the field of organic synthesis.
At the beginning, I carefully observed its structure and found that its bonding is exquisite and the atomic arrangement is orderly. After repeated experiments, its physicochemical properties were measured, and its degree of melting and dissolution was known.
Then explore its reaction path, try to combine it with a variety of reagents, and observe its changes. Under specific conditions, we have obtained novel products with unique structures or different functions.
We will continue to study and optimize the synthesis method, hoping to improve its yield and reduce its cost. With time, it will be able to expand its use in the fields of medicine and materials, and shine brightly for the well-being of the world, so as to promote the progress of chemistry and the prosperity of science and technology.
Toxicity Research
The chemical industry is related to people's livelihood, but the study of poisons must not be careless. Today there is a substance named "2,5 - Difluorobenzenesulfonyl Chloride", and the study of its toxicity is particularly important.
This substance is highly corrosive and touches the skin, like a fire burning the body, causing the skin and flesh to fester and suffer unbearably. If it enters the eyes, it will damage the vision, and even blind. And its breath is pungent, inhaled into the lungs, hurts the respiratory tract, causes coughing and asthma, and for a long time, lung diseases will be entangled.
We should strictly abide by the procedures and prepare protective equipment. The conclusion obtained must be made public in order to alert the public, make known its harm, avoid its risks, protect the well-being of the people, and protect the tranquility of the environment.
Future Prospects
Today there is a thing called 2,5-difluorobenzenesulfonyl chloride. Looking at this chemical thing, its future development is quite impressive. This material is unique, and it may emerge in various fields of chemical industry.
Over time, with the advancement of scientific research, it may be possible to find a good path in the preparation of new materials. With its characteristics, it may be possible to improve the properties of materials, making them strong, wear-resistant and have special functions. In the development of medicine, it may also make extraordinary achievements, helping to create new and good medicines and solve the pain of everyone.
Although there may be thorns in the road ahead, we chemical researchers should be enthusiastic and unremitting exploration. It is hoped that with wisdom and sweat, it will expand the boundaries of its application, develop its grand future, add luster to the world, and create the well-being of everyone.
Where to Buy 2,5-Difluorobenzenesulfonyl Chloride in China?
As a trusted 2,5-Difluorobenzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2,5-Difluorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2,5-difluorobenzenesulfonyl chloride?
2% 2C5 -diethylbenzaldehyde oxime ether is mainly used in many fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate to participate in the preparation of drugs with specific curative effects. With its unique chemical structure, it can react with other compounds to build complex and biologically active molecular structures, helping to develop new drugs and providing possibilities for the treatment of various diseases.
In the field of materials science, it can be used to synthesize polymer materials with special properties. By polymerizing with specific monomers, materials are endowed with unique properties such as excellent stability and optical properties, and are widely used in optical materials, high-performance plastics and other fields to promote the development and innovation of materials science.
In the research and development of pesticides, 2% 2C5-diethylbenzaldehyde oxime ether plays an important role. It can be used as an active ingredient or intermediate to develop high-efficiency, low-toxicity and environmentally friendly pesticide products, which helps to improve the pest control effect of crops, ensure the smooth progress of agricultural production, and ensure the yield and quality of agricultural products.
In organic synthetic chemistry, it is an extremely important synthetic building block. Chemists can use various organic reactions to construct rich and diverse organic compounds according to their structural characteristics, expanding new directions and paths for the research of organic synthetic chemistry, and helping to explore more novel chemical substances and reaction mechanisms.
In summary, 2% 2C5-diethylbenzaldehyde oxime ether has important uses that cannot be ignored in many fields such as medicine, materials, pesticides and organic synthesis, and is of great significance to promoting the progress and development of related fields.
What are the physical properties of 2,5-difluorobenzenesulfonyl chloride?
2% 2C5 -diethylbenzaldehyde oxime ether is an organic compound with unique physical properties. Its properties are usually white to light yellow crystalline powder, which is quite stable at room temperature and pressure.
Looking at its melting point, it is about a specific range. This property is of great significance for the identification and purification of this substance. Due to different purity and crystal form, the melting point may be slightly different, so the precise determination of the melting point can determine its purity.
In terms of solubility, it shows good solubility in organic solvents such as ethanol, acetone, and dichloromethane, but has little solubility in water. This property needs to be taken into account when extracting, separating and selecting the reaction solvent. Proper selection of solvent can improve the reaction efficiency and product purity.
Furthermore, its boiling point also has a corresponding value. Under specific pressure conditions, the compound will change from liquid to gaseous when it reaches the boiling point. Boiling point information is indispensable for operations such as distillation separation and concentration.
In addition, the density of 2% 2C5 -diethylbenzaldehyde oxime ether is also a specific value. In chemical production and experimental operations, the density data is of great significance for material measurement, equipment design, and is related to the reaction process and product quality.
In practical applications, these physical properties are interrelated and affected. For example, using its solubility difference, separation is achieved by extraction operation; according to the characteristics of melting point and boiling point, purification is achieved by recrystallization, distillation and other means. A comprehensive understanding of the physical properties of 2% 2C5-diethylbenzaldehyde oxime ether is of great significance for its application in organic synthesis, drug research and development, materials science and other fields, which can help optimize experimental programs, improve product quality, and promote the development of related fields.
Is the chemical properties of 2,5-difluorobenzenesulfonyl chloride stable?
2% 2C5-diethylbenzaldehyde oxime ether is an organic compound. Its chemical properties are stable under specific conditions, but it also has specific reactivity.
This compound contains a benzene ring structure. The benzene ring has a certain stability due to the conjugation system and can participate in electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. Under appropriate conditions, the hydrogen atom on the benzene ring can be replaced by other groups.
2% 2C5-diethylbenzaldehyde oxime ether has unique chemical properties. In the oxime ether bond, nitrogen and oxygen atoms have solitary pairs of electrons, which can participate in coordination or chemical reactions. It can form complexes with metal ions and may have applications in catalysis and materials science.
Furthermore, the substituent (diethyl) of the compound affects its electron cloud distribution and spatial structure. Ethyl is the power supply group, which can increase the electron cloud density of the benzene ring, affecting the activity and selectivity of electrophilic substitution reaction. Spatially, the presence of diethyl changes the molecular shape and steric resistance effect, which has an effect on the reaction process and product configuration.
Under normal storage and use conditions, 2% 2C5-diethylbenzaldehyde oxime ether can be relatively stable without the influence of improper external factors (high temperature, strong acid-base, strong oxidizing agent or reducing agent, etc.). However, in a specific reaction system, it will undergo corresponding chemical changes with the reagents in contact according to the reaction conditions, showing various chemical activities. Overall, its stability and reactivity coexist, determined by the environment and conditions.
What is the preparation method of 2,5-difluorobenzenesulfonyl chloride?
2% 2C5-diethylbenzene blue dye. To make it, the method is as follows:
First take an appropriate amount of ethylbenzene and place it in a clean reactor. For ethylbenzene, one of aromatics, it is the base material for the reaction. The kettle has good airtightness and temperature control devices to ensure the stability of the reaction environment.
Times, add a specific catalyst. This catalyst needs to have high activity and selectivity, which can promote the substitution reaction of ethylbenzene at a specific position to obtain 2% 2C5-diethylbenzene. When the amount of catalyst is precisely controlled, the reaction will be too fast and impurities will be easily generated; at least the reaction will be slow and take too long.
Then, heat up to a suitable reaction temperature. This temperature depends on the characteristics of the reaction and the activity of the catalyst. Generally speaking, the reaction rate and product selectivity are good within a certain temperature range. During the reaction, it is necessary to continuously stir to make the reactants fully contact with the catalyst, so that the reaction can proceed uniformly.
After the reaction is completed, the product is derived from the reactor. At this time, the product may contain unreacted ethylbenzene, catalyst and other impurities, so it needs to be separated and purified. First, by distillation, using the difference in the boiling point of each component, 2% 2C5-diethylbenzene crude product is separated. Then further purification by extraction, crystallization and other means can obtain pure 2% 2C5-diethylbenzene.
To make it blue, another color developing agent needs to be prepared. According to the principle of dye chemistry, select the suitable chromogenic agent and mix it with 2% 2C5-diethylbenzene in a certain proportion. The mixing process also requires temperature control and stirring to make the two fully react and combine, and then obtain 2% 2C5-diethylbenzene blue dye. The whole preparation process requires strict operation and precise control of the amount to obtain high-quality dyes.
What are the precautions for storing and transporting 2,5-difluorobenzenesulfonyl chloride?
2% 2C5-diethylbenzaldehyde oxime ether, when storing and transporting, all kinds of precautions are quite important.
When storing, the first location should be selected. It is advisable to choose a cool, dry and well-ventilated place to avoid direct sunlight, because light may cause the properties of this thing to mutate, which will damage its quality. The warehouse temperature also needs to be controlled, and it should not be too high. If it is too high, it will increase the risk of volatilization or reaction. And it must be kept away from fire, heat sources, and the risk of fireworks. It must be prevented. A little carelessness will cause disaster.
Furthermore, this substance should be stored separately from oxidizing agents, acids, alkalis, etc. Because of its active chemical properties, it can be co-stored with various chemicals, or react violently, causing explosions, leaks and other dangerous situations. Storage containers should also be carefully selected, and corrosion-resistant and well-sealed materials must be used to prevent leakage. Regularly check the container for damage or leakage. If so, dispose of it quickly.
As for transportation, the transportation vehicle must have corresponding qualifications. Drivers and escorts should be familiar with the characteristics of this substance and emergency response methods. During transportation, vehicles should be stable to avoid bumps and sudden brakes to prevent leakage caused by damage to the container. Summer transportation, especially to prevent high temperature, feasible shading and cooling measures. If you pass through a densely populated place, it is advisable to travel quickly and avoid staying for a long time.
When loading and unloading, the operator should use protective equipment, such as gas masks, protective gloves, etc., to avoid contact with the skin and respiratory tract. The operation should be gentle to avoid damage to the container caused by brutal loading and unloading. In case of leakage, quickly launch emergency plans, evacuate the crowd, seal the scene, and professionals properly dispose of it according to the characteristics of the object. In this way, 2% 2C5-diethylbenzaldehyde oxime ether can be stored and transported safely.