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2,5-Difluorobenzeneboronic Acid

2,5-Difluorobenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

231037

Chemical Formula C6H5BF2O2
Molar Mass 157.91 g/mol
Appearance White to off - white solid
Melting Point 138 - 142 °C
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, THF
Pka Around 8 - 9 (approximate value for boronic acid group)
Stability Stable under normal conditions, but may react with strong oxidizing agents

As an accredited 2,5-Difluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 5 g of 2,5 - difluorobenzeneboronic Acid in a sealed, labeled chemical - grade vial.
Storage 2,5 - difluorobenzeneboronic acid should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly closed container to prevent moisture absorption, which could affect its stability. It's advisable to store it in a location separate from incompatible substances to avoid potential chemical reactions.
Shipping 2,5 - difluorobenzeneboronic acid is shipped in well - sealed containers, often in accordance with regulations for handling chemicals. Packaging ensures protection from moisture and damage during transit to maintain its quality.
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2,5-Difluorobenzeneboronic Acid 2,5-Difluorobenzeneboronic Acid
General Information
Historical Development
In the past, the development of chemical things was like the journey of the stars, shining brightly. Now, the process of 2,5-difluorophenylboronic acid is also very interesting.
At the beginning, the exploration of it was like walking on a path, and many researchers devoted themselves to it. Although the early cognition was limited, everyone was enthusiastic. As time went by, the technology gradually refined, and the analysis of its structure and characteristics became clearer. Researchers worked tirelessly and tried repeatedly in the laboratory, from the selection of raw materials to the fine-tuning of reaction conditions, all with care. Therefore, the preparation process of 2,5-difluorophenylboronic acid has been gradually improved, from prototype to maturity, just like seedlings growing into towering trees, and has a unique position in the chemical forest. Its development process is an important chapter in chemical exploration.
Product Overview
Today there is a substance called 2,5-difluorophenylboronic acid (2,5-Difluorobenzeneboronic Acid). This is a key reagent in organic synthesis and has important uses in medicine, materials and other fields. Its color is pure and good quality, and its properties are stable.
Looking at its structure, on the benzene ring, difluorine atoms are ingeniously distributed, giving unique electronic effects; boric acid groups are also active and can participate in a variety of chemical reactions. With this property, when building complex organic molecules, it can be used as a key building block to help synthesize novel drug molecules, or to prepare special functional materials. And its reaction conditions are mild and highly selective, making it a powerful tool for synthetic chemistry. Our chemical researchers often rely on this material to pioneer and innovate in order to achieve new frontiers in scientific research, hoping to contribute to the progress of many fields.
Physical & Chemical Properties
The physical and chemical properties of 2,5-difluorophenylboronic acid can be studied. Looking at its shape, at room temperature, or white to off-white powder, like frost and snow, fine and uniform. Its melting point, after fine measurement, is about a certain value range. This is the inherent characteristic of the substance, which is an important evidence when identifying and purifying.
In terms of solubility, it may have good solubility in specific organic solvents, but its solubility in water depends on the interaction between its molecular structure and water, or it is limited. Due to its chemical activity, which contains special atoms such as boron and fluorine, it can participate in many reactions in the field of organic synthesis, such as coupling reactions. It is just like a clever tool for craftsmanship, contributing to the creation of complex organic structures and achieving extraordinary results.
Technical Specifications & Labeling
Today, there is 2,5-difluorophenylboronic acid, which is very important for my chemical research. Its technical specifications and labels (commodity parameters) are related to the quality and application of a wide range of narrow.
Those who have technical specifications, from the selection of raw materials, must be pure and free of impurities in order to ensure the quality of the product. The control of the reaction requires accurate temperature, duration, and material ratio. If the reaction temperature is too high, the product will easily decompose. If it is too low, the reaction will be slow and the yield will be low. The duration is also critical. If it is insufficient, the reaction will not be completed, and if it is too long, it will consume resources. The same is true for the material ratio. Improper product purity and yield will be affected.
In terms of identification (commodity parameters), the purity should be detailed, which is the key to measuring quality. The content geometry and impurity geometry should be clearly marked. The appearance characteristics should not be ignored, and the color and state can provide the user with the basis for the initial judgment of quality. The packaging specifications should also be clear to facilitate access and storage. In this way, the quality of 2,5-difluorophenylboronic acid can be guaranteed and it is suitable for use.
Preparation Method
There are currently methods for preparing 2,5-difluorophenylboronic acid, which are described in detail below.
For raw materials, take the halogenated difluorobenzene and borate esters as the basis. The preparation process involves first making the halogenated difluorobenzene and magnesium chips in anhydrous ether, controlling the temperature moderately, triggering a Grignard reaction and forming a Grignard reagent. This is the key preliminary. It is necessary to keep the environment anhydrous and anoxic to prevent the Grignard reagent from deactivating.
Next, the Grignard reagent is slowly injected into the borate ester solution, stirring continuously, and the temperature is controlled steadily, so that the two can fully react. This step of the reaction is related to the purity of the product, and stirring and temperature control are all
After the reaction is completed, the borate ester is hydrolyzed with dilute acid to convert the borate ester into boric acid. After purification by extraction, distillation, recrystallization, etc., impurities are removed to obtain pure 2,5-difluorophenylboronic acid. The transformation mechanism is based on the activity of halides, the nucleophilicity of Grignard reagents and the reaction law of borate esters, which are interlocked to obtain the best product.
Chemical Reactions & Modifications
Today there is a chemical substance called 2,5 - Difluorobenzeneboronic Acid. The investigation of its chemical reaction and modification is the focus of our chemists. This compound exhibits unique properties in various reactions. To make its performance better, the reaction mechanism needs to be studied in detail.
Past research has yielded some results. However, to achieve perfection, we still need to improve. There is room for improvement in reaction conditions, such as temperature, pressure, and catalyst selection. Changing the conditions of chemical reactions is expected to improve the purity and yield of the product.
We should study it diligently in the spirit of ancient scholarship, gain insight into the mystery of its chemical reaction, and seek good strategies for its modification, so that this compound can be used in more fields and benefit the world.
Synonyms & Product Names
Today there is a thing called 2,5-difluorophenylboronic acid (2,5-Difluorobenzeneboronic Acid). This thing has a wide range of uses in the field of chemistry. Its nicknames and trade names are also important in the academic community.
covers chemical substances, and the names vary widely, either according to their structure, or according to their characteristics, or according to their origin and use. 2,5-difluorophenylboronic acid also has many synonymous names and commodity names. Although these names are different, they actually refer to the same thing.
We are chemical researchers. When exploring this thing, we need to carefully investigate its synonymous names and trade names. In this way, we can accurately grasp its relevant information in various literatures and studies without confusion. It also helps the academic community to communicate, so that everyone can understand what has been said, and jointly promote the progress of chemical research.
Safety & Operational Standards
Specifications for the safety and operation of difluorophenylboronic acid
For difluorophenylboronic acid, difluorophenylboronic acid is also commonly used in chemical research. In the process of its research and preparation, safety and operation standards are of paramount importance.
The first word is safe. This substance has certain chemical activity and comes into contact with other substances or reacts. Therefore, it is necessary to choose a cool, dry and well-ventilated place to avoid direct sunlight and high temperature. When taking it, protective equipment, such as gloves and goggles, must be worn to prevent it from touching the skin, entering the eyes, and causing damage.
Times and operating specifications. At the beginning of the experiment, read the relevant information carefully to clarify its properties and reaction characteristics. In the setting of the reaction device, when it is strict and fit, the components are firmly connected to prevent leakage of liquid and air. During the reaction, closely observe the temperature, pressure and other conditions, and control them according to the set procedure. If there is any abnormality, take measures quickly to ensure the safety of the experiment.
And when dealing with waste, also follow the specifications. Do not discard it at will. When it is collected by classification, dispose of it according to the specified method to avoid polluting the environment.
In short, in the research and operation of difluorophenylboronic acid, safety is always the priority, and the operation norms can be followed to ensure the smooth operation of the experiment and protect the safety of the person and the environment.
Application Area
Nowadays, there is a thing called 2,5-difluorophenylboronic acid, which is used in various fields. In the process of medical development, this compound is often a key material. Due to its unique structure, it can interact with many biomolecules to help synthesize specific drugs, or it can cure difficult diseases, bringing good news to the sick.
In the field of materials science, 2,5-difluorophenylboronic acid is also indispensable. Using it as a raw material, materials with specific properties can be made. For example, those with excellent photoelectric properties can be used in new display technologies to make the picture clearer and more gorgeous; or materials with good stability can be used in high-end electronic devices to ensure long-term stable operation.
In the field of organic synthesis, it is an important reagent. It can participate in a variety of reactions, help build complex organic molecular structures, expand the boundaries of organic synthesis, and contribute to the development of organic chemistry, enabling many novel synthetic pathways to be realized.
Research & Development
In recent years, I have been in the field of chemistry, focusing on the research of 2,5-difluorophenylboronic acid. This product has extraordinary uses in organic synthesis and can add subtle effects to various reactions.
At the beginning, I explored the preparation method of it, and it was tried many times before it was stable. The ratio of raw materials and reaction conditions were carefully considered to ensure that the yield and purity were high.
Then, observe its performance in different reaction systems. Coupling with halogenated aromatics, the bonding is precise, and the product structure is clear, paving the way for the creation of novel compounds.
Looking to the future, we hope to use this as a basis to expand its application. In drug research and development, it may help the advent of new drugs; in material science, it may endow materials with unique properties. I would like to dedicate my efforts to promoting the continuous evolution of this product and contributing to the progress of chemistry.
Toxicity Research
Nowadays, there is a substance called 2,5-difluorophenylboronic acid, which has attracted much attention in chemical research. We focus on toxicity studies to investigate the characteristics of this substance in detail.
After many investigations, we have observed its molecular structure, the basis of this difluoride, or specific changes in organisms. Apply experimental methods to various types of test organisms. Observe its physiological characteristics, observe its behavior differences, and test its biochemical changes in vivo.
However, the study of toxicity cannot be done overnight. Many factors, such as the amount of dose, the duration of exposure, and the variety of test organisms, all affect the results. Although it has been obtained, it is still necessary to cultivate the whole leopard carefully, collect data, and accumulate experimental tests in order to obtain the judgment of its precise toxicity for future use and ensure safety.
Future Prospects
Today there is a product called 2,5-difluorophenylboronic acid. This is a good product of chemistry and has a wide range of uses. Although it is still in the research realm, the future prospects are limitless.
Let me look at this product, its structure is unique and its properties are also unique. In the field of organic synthesis, it can be used as a key reagent to help the reaction proceed smoothly and obtain exquisite products.
With time, if the research is advanced and the technology is mature, it may emerge in the field of medicine. It can be used to create new drugs with special effects, cure various diseases, and solve the suffering of patients. Or in the field of material science, show your skills and give birth to novel materials to meet the needs of technological development.
Our chemical researchers should study diligently, explore its potential, and look to the future to make this 2,5-difluorophenylboronic acid shine and add well-being to the world. This is our vision for the future.
Where to Buy 2,5-Difluorobenzeneboronic Acid in China?
As a trusted 2,5-Difluorobenzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2,5-Difluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2,5-difluorophenylboronic acid?
2% 2C5-diethoxybenzoic acid, although this substance is not detailed in "Tiangong Kaiwu", it is widely used based on ancient and modern chemical applications.
First, in the field of pharmaceutical preparation, this acid can be used as a key synthetic raw material. Genetic benzoic acids have many antibacterial and anti-inflammatory effects. 2% 2C5-diethoxybenzoic acid can be converted into pharmaceutical ingredients that inhibit bacteria through specific chemical reactions, or as an important intermediate for anti-inflammatory drugs, helping to relieve the inflammatory response of the human body.
Second, in the field of materials science, it also has considerable use. In the synthesis of polymer materials, it can be used as a functional monomer to participate in polymerization reactions. By polymerizing with other monomers, polymer materials are endowed with specific properties, such as improving the solubility and thermal stability of materials, or even endowing them with unique optical or electrical properties, thus expanding the application of materials in different fields, such as electronic devices, optical instruments, etc.
Third, it is also indispensable in the production of fine chemical products. In the manufacturing process of fine chemicals such as fragrances and dyes, 2% 2C5-diethoxybenzoic acid can be used as a starting material or intermediate. Due to its unique molecular structure, after chemical modification, it can generate fragrance components with special flavors, adding a different fragrance to the fragrance industry; it can also provide a basis for the synthesis of dyes with specific colors and properties, meeting the needs of diverse dyes in textile, printing and dyeing industries. From this perspective, although 2% 2C5-diethoxybenzoic acid is not mentioned in Tiangong Kaiwu, it has shown important application value in many fields such as medicine, materials, and fine chemicals, promoting the development and progress of various industries.
What are the synthesis methods of 2,5-difluorophenylboronic acid?
There are various ways to synthesize 2% 2C5-diethylbenzoic acid, and each has its own reasons. The following is detailed by Jun Chen.
First, benzoic acid is used as the starting material, and halogenation can be used to introduce halogen atoms to specific positions in the benzene ring, such as the 2-position or the 5-position. Then an alkylation reaction is used to connect the halogen atom to the ethyl group. The key to this is the precise control of the halogenation reaction, so that the halogen atom is exactly in the desired position, and the alkylation step also needs to grasp the reaction conditions to prevent side reactions from occurring. For example, when halogenation, select the appropriate halogenating agent, temperature, catalyst, etc., so that the reaction can proceed as expected; when alkylation, select the appropriate alkylating reagent, base and solvent to improve the yield.
Second, using benzene as the initial raw material, first through Friedel-Crafts alkylation reaction, the ethyl-based benzene ring is introduced to generate ethylbenzene. Then, the ethylbenzene is acylated, an acyl group is introduced at a specific position in the benzene ring, and then the acyl group is reduced to an alkyl group, and the final product is 2% 2C5-diethylbenzoic acid. This path requires attention to the regioselectivity of the Friedel-Crafts reaction, so that ethyl and acyl groups enter the benzene ring according to the plan, and the reduction step also needs to be carefully operated to ensure that the reaction is smooth and the product is pure.
Third, m-diethylbenzene is used as the raw material, and the methyl group on the benzene ring is oxidized to the carboxyl group by oxidation reaction. The choice of conditions for the oxidation reaction is extremely important, such as choosing an appropriate oxidizing agent, such as potassium permanganate, potassium dichromate, etc., to control its concentration, reaction temperature and time, in order to effectively obtain 2% 2C5-diethylbenzoic acid and avoid the disturbance of side reactions such as excessive oxidation.
The synthesis of 2% 2C5-diethylbenzoic acid has its own refinement and difficulty. It is necessary to choose the most suitable method according to the actual situation, such as the availability of raw materials, cost considerations, equipment conditions, etc., in order to achieve the purpose of high-efficiency and high-purity synthesis.
What are the physical and chemical properties of 2,5-difluorophenylboronic acid?
2% 2C5-diethylbenzofuran-6-carboxylic acid is a kind of organic compound. Its physical and chemical properties are unique and worth studying.
In terms of its physical properties, under normal temperature and pressure, it is mostly solid, and the appearance may be white to light yellow crystalline powder. This is due to the intermolecular force and orderly arrangement. The melting point is related to the difficulty of the molecule breaking free from the lattice. After experimental determination, the melting point is in a specific range, and the specific value varies slightly due to differences in measurement conditions. It has different solubility in common organic solvents, and has a certain solubility in polar organic solvents such as ethanol and acetone. Due to the principle of similar miscibility, the molecular polarity interacts with the solvent to cause it to partially dissolve; while in non-polar solvents such as n-hexane, the solubility is poor, which is due to the mismatch of molecular polarity.
As for chemical properties, its molecular structure contains carboxyl groups and is acidic. It can neutralize with bases to generate corresponding carboxylates and water. This reaction is a process of acid-base proton transfer, showing its acidic characteristics. At the same time, benzofuran rings endow it with certain aromatic properties. Under specific conditions, electrophilic substitution reactions such as halogenation and nitrification can occur. Due to the uneven distribution of electron cloud density in the ring system, specific locations are vulnerable to attack by electrophilic reagents, thus realizing structural modification and derivatization, providing rich possibilities for organic synthesis. And under acid catalysis, it can undergo esterification reaction with alcohols to generate ester compounds with different functional groups, expanding its application in organic synthesis and materials science.
In short, the study of the physicochemical properties of 2% 2C5-diethylbenzofuran-6-carboxylic acid lays the foundation for its application in chemical industry, medicine, materials and other fields.
What are the precautions for storing and transporting 2,5-difluorophenylboronic acid?
2% 2C5-diethyladipic acid. When storing and transporting this product, it is necessary to pay attention to many key matters.
First storage environment. It is advisable to find a cool, dry and well-ventilated storage place. Because 2% 2C5-diethyladipic acid is afraid of heat and moisture. If it is placed in a high temperature and humid place, it may cause its properties to change and affect quality. If it is heated, it may increase its chemical activity, or cause adverse reactions such as decomposition; if it is damp, it may cause it to dissolve, agglomerate, or even mildew. And the storage place should be kept away from fire and heat sources to prevent open flames to prevent fire, because it may be flammable.
Second, the package is sealed. It needs to be packed in a well-sealed package to prevent contact with the air. It may react with oxygen, water vapor and other components in the air, causing deterioration. And the packaging material should also be carefully selected, and it should be able to withstand the chemical attack of 2% 2C5-diethyladipic acid and not react with it to ensure the integrity and sealing of the package.
As for the transportation, it should not be ignored. The transportation vehicle must be clean, dry, and free of other residual chemicals to prevent cross-contamination. And the temperature should be strictly controlled during transportation to avoid large temperature fluctuations. The driving should also be smooth, to avoid bumps and vibrations, to prevent the package from being damaged, resulting in the leakage of 2% 2C5-diethyladipic acid. In the unfortunate event of a leak, it should be dealt with immediately according to the established emergency response procedures to prevent harm to the environment and personal safety. Transportation personnel also need professional training to be familiar with the characteristics and emergency treatment methods of 2% 2C5-diethyladipic acid to ensure the safety of the transportation process.
What is the approximate market price of 2,5-difluorophenylboronic acid?
The price of 2% 2C5-diethoxybenzoic acid in the market is generally difficult to determine. The price often varies due to various reasons, such as the source of the material, the coarseness of the process, the supply and demand of the market, and the different strategies of merchants.
If the source of the material is discussed, the abundance of the raw material is directly related to its price. If the raw material is abundant, the production is easy and the price is flat; if the raw material is thin, the production is difficult and the price is often high.
The coarseness of the process is also the main reason. The method of refining can make the product excellent, but the cost may increase, and the price will also follow. If the simplicity of the process is low, the quality may not be as good, and the price will also be different.
The supply and demand of the city, especially its price. If the demand is strong and the supply is small, the price will be raised; if the supply exceeds the demand, the price will be depressed.
And the merchants have their own strategies, either to make profits for the market competition, or to hold the price for the protection of profit, all of which cause the price to fluctuate.
In today's market, the price of this product is in the range of hundreds to thousands of yuan per kilogram. However, this is only an approximate number. The actual price must be subject to the current market conditions and the details of the transactions involved. To know the exact price, you should consult the market, trade merchants or relevant companies of chemical materials.