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2,5-Difluoro-4-Nitrobenzenecarboxylic Acid

2,5-Difluoro-4-Nitrobenzenecarboxylic Acid

Hongda Chemical

    Specifications

    HS Code

    594951

    Name 2,5-Difluoro-4-Nitrobenzenecarboxylic Acid
    Molecular Formula C7H3F2NO4
    Molecular Weight 203.1 g/mol
    Appearance Solid
    Color Typically off - white to yellowish
    Melting Point Around 175 - 179 °C
    Solubility In Water Poorly soluble
    Solubility In Organic Solvents Soluble in some polar organic solvents like DMSO, DMF
    Pka Around 2 - 3 (estimated due to the acidic carboxylic acid group)
    Stability Stable under normal conditions, but may react with strong bases, strong oxidizing agents

    As an accredited 2,5-Difluoro-4-Nitrobenzenecarboxylic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 2,5 - difluoro - 4 - nitrobenzenecarboxylic acid packaged in a sealed plastic bottle.
    Storage 2,5 - difluoro - 4 - nitrobenzenecarboxylic acid should be stored in a cool, dry, and well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store it in a tightly sealed container to prevent moisture absorption and potential reactions. This helps maintain its chemical stability and reduces the risk of decomposition or hazardous interactions.
    Shipping 2,5 - difluoro - 4 - nitrobenzenecarboxylic acid is shipped in properly sealed, corrosion - resistant containers. Packaging adheres to safety regulations for chemical transport, ensuring secure transit to prevent leakage and damage.
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    2,5-Difluoro-4-Nitrobenzenecarboxylic Acid 2,5-Difluoro-4-Nitrobenzenecarboxylic Acid
    General Information
    Historical Development
    The development of 2,5-difluoro-4-nitrobenzoic acid has been gradual. In the past, various sages worked hard in the field of chemistry to explore physical properties and production methods. At first, only a few or two characteristics were known, and many of them were not caught in the preparation method.
    After several generations, scholars studied unremitting and gradually understood its synthesis path. At first, it was a simple method, but the yield was quite low and there were many impurities. After improvement and optimization steps, new reagents were used, and the yield rose and the purity was also good.
    As the years passed, its use became more and more widespread. In pharmaceutical research and development, it can be used as a key intermediate to assist in the creation of new drugs; in materials science, it also has unique contributions. Looking at its development path, it is like the stars gradually gathering, the more prosperous the light, adding many brilliant colors to the chemical forest.
    Product Overview
    2,5-Difluoro-4-nitrobenzoic acid is also an organic compound. Its shape may be in the shape of crystal powder, and its color may be white. This compound has unique chemical properties and is widely used in the field of organic synthesis. In its molecular structure, the presence of fluorine atoms and nitro groups gives it special reactivity.
    In various reactions, it can participate in the nucleophilic substitution reaction due to the activity of fluorine atoms, and is a key raw material for constructing novel organic structures. The presence of nitro groups also affects the distribution of its electron cloud, making it exhibit chemical properties that can be exploited under specific conditions. Chemists use various techniques to obtain this compound through a series of reactions with precise steps or from suitable starting materials. It plays an important role in the manufacture of fine chemicals, drug research and development, and is an important component of chemical research and industrial production.
    Physical & Chemical Properties
    2,5-Difluoro-4-nitrobenzoic acid This material has unique physical and chemical properties. Its state is often crystalline, and its color is close to white. The melting point is fixed, about a certain temperature range, which is the key to its purity. In terms of solubility, it is slightly soluble in organic solvents, such as ethanol and acetone, but insoluble in water.
    Its chemical activity is active, because it contains fluorine, nitro and carboxyl groups. Nitro has strong electron absorption, causing the electron cloud density of the benzene ring to decrease, making nucleophilic substitution prone. Carboxyl groups can form salts with bases and can also participate in esterification reactions. The introduction of fluorine atoms increases its stability and biological activity. These physical and chemical properties are of great value in fields such as organic synthesis and pharmaceutical research and development, and can be the basis for the creation of new compounds.
    Technical Specifications & Labeling
    The technical specification and identification of 2,5-difluoro-4-nitrobenzoic acid (product parameters)
    Fu 2,5-difluoro-4-nitrobenzoic acid is a chemical we have dedicated ourselves to researching. Its technical specifications are related to the selection of raw materials, which must be pure and free of impurities, so as to ensure high quality. The synthesis method requires precise steps, temperature control and speed regulation, all of which are fixed to make a good product.
    As for the identification (product parameters), its appearance should be a specific color and uniform particle size. The standard of purity must reach a very high level, and the impurity content is minimal. And on the packaging, clearly mark the parameters, so that the user can see at a glance, and there is no mistake. In this way, we meet our strict requirements for product technical specifications and labeling to feed users.
    Preparation Method
    The preparation method of 2,5-difluoro-4-nitrobenzoic acid is related to the raw materials and production process, reaction steps and catalytic mechanism. It is described as follows:
    First, the selection of raw materials. Select suitable starting reactants, such as specific halogenated aromatics and nitrogenation reagents, to ensure their purity and quality, so as to lay the foundation for the reaction.
    Second, the production process. The synthesis of the target product is achieved through multi-step chemical reaction. First, the halogenated aromatics are reacted with nitrogenation reagents under specific conditions, and the reaction temperature, time and material ratio are precisely controlled. This step needs to pay attention to the requirements of the reaction environment such as anhydrous and oxygen-free to prevent side reactions from breeding.
    Third, the reaction step. After the first step of the reaction, the product goes through separation, purification and other operations before being put into the subsequent reaction. Subsequent or functional group conversion steps, each step needs to be carried out according to strict operating standards to ensure the high efficiency of the reaction and the purity of the product.
    Fourth, catalytic mechanism. In the key reaction steps, a specific catalyst is added to accelerate the reaction process and improve the reaction selectivity. The amount and activity of the catalyst need to be finely regulated to ensure the optimization of the catalytic effect. In this way, high-purity 2,5-difluoro-4-nitrobenzoic acid can be prepared.
    Chemical Reactions & Modifications
    Today, there are compounds 2,5 - Difluoro - 4 - Nitrobenzenecarboxylic Acid. In chemical research, its reaction and modification are very important.
    Looking at this compound, the presence of fluorine and nitro groups gives it unique chemical properties. To explore its chemical changes, observe the performance under various reaction conditions. Or add suitable catalysts at specific temperatures and pressures to promote its reaction.
    When modifying, consider how to adjust the structure to obtain better performance. Or introduce new functional groups to change the distribution of its electron cloud, resulting in changes in both physical and chemical properties. The study of the reaction and modification of this compound is like exploring a path in the fog. Although it is full of unknowns, every step is closer to the chemical mystery, paving the way for materials science, drug research and development, and many other fields.
    Synonyms & Product Names
    2,5-Difluoro-4-nitrobenzoic acid, this substance is of great significance in the study of chemistry in China. The exploration of its heteronym and trade name is really a key corner of scientific research.
    Looking for its heteronym, due to the complicated naming rules of chemical substances, different regions, research groups or differences. Just like the chemical objects recorded in ancient books, they also have different names from time to place. 2,5-Difluoro-4-nitrobenzoic acid, or another name for its structural properties, is designed to more accurately describe its chemical nature.
    As for the trade name, merchants often give a unique name to promote and distinguish products. This compound is used in specific fields, and the trade name may highlight its advantages and uses. Such as the ancient drug dealers, in order to distinguish the drug, the name is given to the efficacy and origin. The trade name of 2,5-difluoro-4-nitrobenzoic acid is well known in the industry, which is convenient for communication and trading. Therefore, the study of aliases and trade names is indispensable for chemical research and industrial application.
    Safety & Operational Standards
    2,5-Difluoro-4-nitrobenzoic acid, this chemical substance, is related to safety and operating standards, and should be explained in detail.
    The preparation of this substance must be in a well-ventilated environment. Workers must wear protective gear, such as gas masks, protective gloves and goggles, to prevent damage to the body, eyes and breathing.
    Its nature may be irritating. If it touches the skin, rinse it with plenty of water as soon as possible. If the situation is serious, seek medical attention. When entering the eyes, rinse it with water for a long time and seek medical attention. Inhalation accidentally, leave the scene quickly, and go to a place with fresh air. If you feel unwell, call for medical assistance urgently.
    When operating, avoid it being close to the kindling and heat source to prevent accidents. Its storage should be in a cool, dry and ventilated place, and it should be stored separately from oxidants, reducing agents and other foreign substances to avoid reaction.
    When weighing, use a precise device, and the action should be slow to prevent it from raising dust. When mixing, stir gently and mix slowly, and observe the reaction situation.
    The disposal of waste must comply with environmental protection regulations. Do not dispose of it at will, when collected and disposed of according to regulations, so as not to pollute the environment.
    In short, when handling 2,5-difluoro-4-nitrobenzoic acid, safety is always the priority, and the rules of operation are strictly followed to ensure that everything goes smoothly and people are safe.
    Application Area
    2,5-Difluoro-4-nitrobenzoic acid is useful in many fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help synthesize specific drugs and cure various diseases. For example, for some inflammatory diseases, the drugs it participates in the synthesis can precisely act on the focus and relieve discomfort. In the field of materials science, it is also indispensable. Special materials made from this raw material have unique physical and chemical properties and can be used in high-end electronic equipment to improve their performance. Furthermore, in the fine chemical industry, it can give products different characteristics, such as enhancing the color fastness of dyes and optimizing the volatile energy of fragrances. Therefore, 2,5-difluoro-4-nitrobenzoic acid is a crucial presence in the fields of medicine, materials, and chemical industry, promoting the continuous development of various industries.
    Research & Development
    In recent years, I have dedicated myself to the research of 2,5-difluoro-4-nitrobenzoic acid. This compound has unique characteristics and has great potential in many fields. I deeply feel that its research and development are of great significance.
    At the beginning, its structure was analyzed, its physicochemical properties were explored, and its essence was clarified. I tried various synthesis methods to seek an efficient and pure way. The process was difficult and I encountered repeated setbacks, but I did not dare to slack off.
    After repeated experiments, a method was obtained to optimize the synthesis. The purity of the product was improved, and the yield was also increased. On this basis, explore the possibility of its application in medicine, materials and other fields.
    Looking at the present, although some achievements have been made, the road ahead is still long. In the future, I should continue to study and tap its potential, hoping that this compound can shine in various fields, contribute to the development of scientific research, and hope to benefit the world.
    Toxicity Research
    Toxicity study of 2,5-difluoro-4-nitrobenzoic acid
    Fu 2,5-difluoro-4-nitrobenzoic acid is a chemical research substance. Now its toxicity is investigated in detail.
    The toxicity of this substance is related to the safety of life. After various experiments, it can be known that it has an impact on microbial insects and plants. Tested by insects, at low concentrations, it may cause their movement to be sluggish and growth to be blocked; at high concentrations, it can kill. In plants, it can disrupt their physiological order and hinder their growth and germination.
    The reason for its toxicity is due to the fluorine and nitro groups in the structure. Fluoride, the activity is quite strong; nitro also has special properties, the two are synergistic, easy to interact with the molecules in the biological body, and disrupt its biochemical path.
    Although the general outline of its toxicity is now clear, it still needs to be deeply explored to fully understand it, so that when using this substance, it can avoid harm and profit, and protect the environment and the safety of life.
    Future Prospects
    Fu 2,5-difluoro-4-nitrobenzoic acid is promising for future expansion in our field of chemical research. Its unique structure, fluorine and nitro groups, endow many special properties.
    In organic synthesis, it may be a key building block, and with its activity check point, a variety of novel compounds can be constructed. And the introduction of fluorine atoms can change the physical and chemical properties of molecules. In the process of drug development, it may become a potential lead compound, and it is expected to produce better drugs with less side effects.
    In the field of material science, it may be able to participate in the creation of special materials. Due to the existence of nitro groups, materials can be endowed with specific electrical and optical properties. We are convinced that with time, through in-depth investigation and unremitting research, 2,5-difluoro-4-nitrobenzoic acid will bloom and make outstanding contributions to future technological progress and life improvement, leading us to a new realm.
    Where to Buy 2,5-Difluoro-4-Nitrobenzenecarboxylic Acid in China?
    As a trusted 2,5-Difluoro-4-Nitrobenzenecarboxylic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2,5-Difluoro-4-Nitrobenzenecarboxylic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2,5-difluoro-4-nitrobenzoic acid?
    2% 2C5-diene-4-carbonylbenzoic acid, which has many applications in the field of medicinal chemistry. It can be used as a key intermediate for the synthesis of many biologically active compounds.
    In the journey of drug development, novel drug molecules with specific pharmacological activities can be created by structural modification and derivatization of 2% 2C5-diene-4-carbonylbenzoic acid. For example, it can be interconnected with other compounds containing active groups through chemical reactions to construct more complex and diverse drug precursors, thus laying the foundation for the search for innovative drugs with high efficiency and low toxicity.
    In the field of organic synthesis, it is often used as a core building block. Due to its special molecular structure, it has multiple reactive check points and can participate in various classical organic reactions, such as esterification and amidation reactions. Through these reactions, it can be ingeniously integrated into the larger organic molecular structure, contributing to the synthesis of organic materials with special functions and structures.
    In addition, in the field of materials science, after appropriate chemical modification, 2% 2C5-diene-4-carbonylbenzoic acid may endow materials with certain unique properties, such as improving the solubility, thermal stability and optical properties of materials, thereby expanding the application range of materials. Overall, 2% 2C5-diene-4-carbonylbenzoic acid has shown significant application value in many scientific fields due to its unique structure and chemical properties.
    What are the physical properties of 2,5-difluoro-4-nitrobenzoic acid?
    2% 2C5-diethyl-4-chlorophenylacetic acid, this material has unique properties. At room temperature, it is often in a crystalline state, with a white color, as pure as frost and snow, and a regular crystal shape, which seems to be carefully carved.
    Regarding its melting point, the melting point is quite fixed, and it is in a certain temperature range. It seems to adhere to its own principles and is not easily shaken by the outside world. When heated to the melting point, it gradually melts from a solid state to a liquid state, just like ice and snow melting and turning into a flexible fluid. The boiling point is also fixed. At this temperature, it will boil and vaporize, showing the wonderful change of matter from liquid phase to gas phase. In terms of solubility, in common organic solvents, such as ethanol, ether, etc., it is quite soluble, just like a fish entering water, and the two blend seamlessly. However, in water, the solubility is very small, just like oil and water, which is difficult to blend. This property is related to the ratio of hydrophilic and hydrophobic groups in the molecular structure.
    In terms of density, it is heavier than water. If it is placed in water, it will slowly sink, like a heavy object entering the water, and fall steadily. Its smell is unique, although not rich and pungent, it has its own unique smell, like a secret logo, showing its unique identity.
    Stability is also worth mentioning. Under normal environmental conditions, it is quite stable and can maintain its own chemical structure and properties for a long time. However, when exposed to extreme conditions such as specific chemical reagents, high temperature, and strong light, the molecular structure may change, triggering a chemical reaction, just like a calm lake throwing boulders into it, breaking the original tranquility.
    What are the synthesis methods of 2,5-difluoro-4-nitrobenzoic acid?
    To prepare 2,5-diene-4-carbonylphenylacetic acid, there are three methods.
    One is the halogenated aromatic hydrocarbon coupling method. First, the halogenated benzaldehyde is taken, and it is coupled with the alkenyl halide under the catalysis of palladium to form the alkenyl benzaldehyde. Then react with the cyanide reagent to obtain the cyanyl derivative. After hydrolysis, 2,5-diene-4-carbonylphenylacetic acid is obtained. This way, the palladium catalyst is expensive, but the reaction selectivity is quite good, and the yield is also considerable.
    The second is the hydroxyaldehyde condensation-oxidation method. Starting with acetophenone derivative and alkenyl aldehyde, under alkali catalysis, hydroxyaldehyde condensation is carried out to form α, β-unsaturated carbonyl compounds. Then oxidize with suitable oxidants, such as potassium permanganate, etc., to obtain the target product. The raw materials of this method are easy to obtain, but the reaction steps are slightly complicated, and the oxidation process requires precise temperature control and reaction conditions to prevent excessive oxidation.
    The third is the rearrangement-addition method. With a specific rearrangement substrate, the intermediate product is obtained by rearrangement reaction. After addition with nucleophiles, and then appropriate treatment, 2,5-diene-4-carbonyl phenylacetic acid can be obtained. The reaction conditions are mild, but the preparation of the rearrangement substrate is difficult and requires fine synthesis.
    Each method has its advantages and disadvantages. When selecting the method, it is necessary to comprehensively consider the availability of raw materials, cost, yield and purity requirements to achieve the optimal synthesis effect.
    What are the precautions for storing and transporting 2,5-difluoro-4-nitrobenzoic acid?
    2% 2C5-diethyl-4-chlorophenylbutyric acid, this is a very important chemical substance. During storage and transportation, many key matters need to be paid special attention.
    First, when storing, be sure to choose a cool, dry and well-ventilated place. Due to its nature, it may be affected by temperature and humidity. If placed in a high temperature and humid place, it may deteriorate. For example, in summer heat, if the storage environment is poor, the substance may undergo chemical reactions and lose its original characteristics.
    Second, it should be stored separately from oxidants, acids, bases, etc. This is because the substance is chemically active, and contact with the above substances can easily cause violent reactions, or there is a risk of combustion or explosion. If a strong oxidizer meets the substance, it is very likely to trigger an uncontrollable chemical reaction.
    Third, when transporting, the packaging must be tight and stable. It is necessary to ensure that the packaging will not be damaged due to bumps and collisions during transportation, resulting in material leakage. For example, long-distance land transportation, the road conditions are complicated. If the packaging is not strong, material leakage will not only pollute the environment, but also may endanger the safety of transporters and surrounding people.
    Fourth, the transportation vehicle must be equipped with corresponding fire protection and emergency treatment equipment. In the event of an accident during transportation, such as leakage, emergency treatment can be carried out in time to reduce the harm. Assuming a leak occurs during transportation, if there is no emergency equipment, the leaked material may spread wantonly, causing greater harm.
    In conclusion, whether it is storing or transporting 2% 2C5-diethyl-4-chlorophenylbutyric acid, relevant norms and standards must be strictly followed to ensure the safety of personnel and the environment.
    What is the market price range for 2,5-difluoro-4-nitrobenzoic acid?
    For 2% 2C5-diethyl-4-chlorophenylacetic acid, the price range of the market cannot be determined. The price of this medicine often changes for various reasons.
    The price may vary depending on the producer. Generally, the price of the medicine prepared by the high-quality manufacturer may be slightly higher; and the price of others may be slightly lower.
    The amount is also related to the price. If the purchase quantity is large, the price may be reduced due to the benefit of discount; if the purchase quantity is small, the price may be as usual.
    The supply and demand of the city is the main reason for the price. If there are many people seeking, but few suppliers, the price will rise; if the supply exceeds the demand, the price will fall.
    In addition, the regulation of the government and the adjustment of taxes can make the price change. The incentive of the government, the reduction of taxes, the reduction of the fees of the producers, the price may be lower; on the contrary, the increase of the government and the increase of taxes, the fee rises and the price rises.
    Although it is difficult to determine the price range, according to the normal conditions of the city, the price fluctuates between tens of yuan and hundreds of yuan. If the buyer wants to know the exact price, he should carefully observe the market conditions and compare the prices of the various houses.