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2,4-Difluorobenzenesulfonyl Chloride

2,4-Difluorobenzenesulfonyl Chloride

Hongda Chemical

Specifications

HS Code

355103

Chemical Formula C6H3ClF2O2S
Molecular Weight 226.60
Appearance Typically a colorless to light - yellow liquid
Boiling Point Data may vary, but around 230 - 240°C
Solubility Soluble in common organic solvents like dichloromethane, chloroform
Purity Can be available in various purities, often 95%+ in commercial products
Odor Pungent, characteristic of sulfonyl chloride compounds
Stability Reactive, especially towards water and nucleophiles

As an accredited 2,4-Difluorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2,4 - difluorobenzenesulfonyl chloride in a tightly - sealed glass bottle.
Storage 2,4 - difluorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent contact with moisture and air, as it may react. Store it separately from incompatible substances like bases, reducing agents, and water - reactive materials to avoid dangerous reactions.
Shipping 2,4 - difluorobenzenesulfonyl chloride is a chemical that requires careful shipping. It should be packed in corrosion - resistant containers, secured to prevent leakage, and shipped in accordance with hazardous chemical transportation regulations.
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2,4-Difluorobenzenesulfonyl Chloride 2,4-Difluorobenzenesulfonyl Chloride
General Information
Historical Development
2,4-Difluorobenzenesulfonyl chloride is also an organic chemical. Its beginning originated from the research of various sages in chemistry. At the beginning, it only existed in speculation and speculation, and it was difficult to obtain it.
However, as the years went on, all chemists were determined and the research method advanced. There was a crude preparation at the beginning, although the yield was low and there were many impurities, it has become the basis for its development.
After unremitting improvement, the process has gradually become more refined, the yield has been improved, and the purity is also good. Today, 2,4-difluorobenzenesulfonyl chloride is widely used in the fields of medicine and materials, and has become an indispensable part of the chemical industry. The path of its development is like sailing against the current. If you don't advance, you will retreat. Thanks to the diligence of your predecessors, you have today's prosperity.
Product Overview
2,4 - 二氟苯磺酰氯者,乃有机合成中至关重要之试剂。其性状为无色至淡黄色液体,具强烈刺激性气味。此化合物于有机化学领域用途广泛,常作磺酰化试剂,以制备各类磺酰胺、磺酸酯等衍生物。

其制备方法多基于苯磺酰氯之氟化反应,借特定氟化试剂,在适宜反应条件下达成。于反应过程里,需留意温度、反应物比例及催化剂之使用,此皆对产物收率与纯度影响甚巨。

2,4 - 二氟苯磺酰氯在药物化学、材料科学等范畴亦具关键应用。于药物研发中,或为构建特定活性结构之关键中间体;于材料合成领域,或赋予材料独特化学与物理性能。然因其具腐蚀性与刺激性,操作时务必采取周全防护措施,确保实验人员安全与环境不受污染。
Physical & Chemical Properties
今有一物,名唤2,4 - 二氟苯磺酰氯。其性,具物理化学之特质。观其态,常温之下,或为固形,色白而质纯,状若霜雪,细腻匀整。其熔沸点,乃关键物性。熔点者,约在XX摄氏度,遇热而融,恰似春雪遇暖阳,渐化无形。沸点于XX摄氏度上下,达此高温,便如轻烟升腾,化为气态。

论其化学性,磺酰氯基团活泼非常。可与诸多试剂相化合,如醇类物质相遇,能成酯类之属,仿若一场奇妙之联姻,新生物质具别样特性。其于有机合成之域,宛如一把利刃,助力合成多样复杂之化合物,推动化学研究之进程,在科研之路,铺就砖石,意义非凡。
Technical Specifications & Labeling
2,4 - 二氟苯磺酰氯之技艺规范与标识(商品参数)
夫 2,4 - 二氟苯磺酰氯者,为化学制备所重之物料。其技艺规范,首在原料之纯。所采诸料,当合高净之准,杂质须微。于合成之程,控温、调速皆为要着。反应之温,宜稳于某域,弗使大幅起落,致反应乖张。搅拌之速,亦应适度,俾物料匀混,促反应之畅。

至于标识,当明其名“2,4 - 二氟苯磺酰氯”,并附精准之分子式、分子量。标其理化性征,诸如熔沸之点、密度几何。且警示其危害,如具腐性,触体、入目皆可致伤。又注储存之法,宜凉宜燥,避与他物杂处,防其变也。如此,方能于制备、用储之际,保其质、避其险。
Preparation Method
The method of preparing 2,4-difluorobenzenesulfonyl chloride is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials is very critical, and the main compounds and sulfonation reagents containing difluorobenzene structures, such as specific fluorobenzene and chlorosulfonic acid.
In the production process, the raw materials are first placed in a special reactor in an appropriate proportion, and stirred and mixed at a suitable temperature. In the initial reaction stage, the temperature should be controlled within a moderate range to allow the reactants to fully contact. In the reaction step, the sulfonation reaction is first initiated, which prompts the interaction of fluorobenzene and chlorosulfonic acid to form an intermediate product. This process requires precise control of the reaction time and temperature to prevent side reactions from occurring.
The catalytic mechanism is very important, and specific catalysts can be added to accelerate the reaction process and improve the purity and yield of the product. After the reaction is completed, the pure 2,4-difluorobenzenesulfonyl chloride product can be obtained after a series of separation and purification operations.
Chemical Reactions & Modifications
2,4-Difluorobenzenesulfonyl chloride, the chemical reaction and modification of this chemical substance are quite important. In the field of chemistry, it is important to explore its reaction mechanism. Looking at the reaction, we can observe the wonderful interaction of the reactants, such as meeting with various reagents, or generating substitution and addition changes.
However, the change of its properties is also the key. Hope to be able to use chemical methods to adjust its properties to suit different needs. Or change its stability, or change its activity, so that the chemical and pharmaceutical industries can develop their strengths. In order to achieve this goal, it is necessary to study its molecular structure in detail, and use chemical techniques to seek its modification. Only in this way can we obtain products with better performance and add to the progress of chemistry.
Synonyms & Product Names
Today there is a thing called 2,4-difluorobenzenesulfonyl chloride. This is a raw material for chemical industry and has a wide range of uses. It also has many synonymous names, or 2,4-difluorobenzenesulfonyl chloride, all referring to this thing.
This thing is in the industry, although the title is different, it is actually the same. Just like the ancient things, the names have different names, but their quality remains unchanged. Merchants and users all know this. Although the names are different, they are also known as the same product.
This 2,4-difluorobenzenesulfonyl chloride, with its unique properties, plays a great role in chemical synthesis and other fields, and is an indispensable thing in the industry.
Safety & Operational Standards
Specifications for the safety and operation of 2,4-difluorobenzenesulfonyl chloride
Fu 2,4-difluorobenzenesulfonyl chloride is an important substance in chemical research. It is active, and many safety and operation norms must be followed during experimental operation.
In terms of safety, this substance is corrosive to a certain extent, and it can cause injury when it touches the skin and enters the eyes. Therefore, when handling, protective equipment is indispensable. Wearing protective clothing, which is dense and corrosion-resistant, can resist its damage; wearing protective gloves, which are thick and chemical-resistant; wearing protective glasses, which are clear and have strong impact resistance, so as to protect yourself.
Furthermore, its odor is pungent and may be toxic, and it is suitable for operation in a well-ventilated place. The fume hood is the best choice. It can quickly discharge harmful gases, make the experimental environment fresh, and protect people from poisonous gases.
As for the operation specifications, when using, the utensils must be clean and dry. Dropper, pipette, etc., first rinse with reagents to remove impurities and water vapor, and then measure accurately. When pouring, the speed should be slow, and it should go down the wall of the device to prevent it from splashing.
When reacting, the control of temperature and time is crucial. According to the reaction needs, adjust the temperature with water bath, oil bath, etc., to keep the temperature constant. And be punctual, observe the reaction process, and stop at the right time according to the phenomenon.
After the experiment is completed, the disposal of residual materials and waste should also follow the norms. Do not discard them at will, when collected by classification, dispose of them according to relevant laws, so as not to pollute the environment and cause future problems.
In short, handle 2,4-difluorobenzenesulfonyl chloride, safety first, and operate in accordance with regulations, so as to ensure the smooth operation of the experiment and people's safety.
Application Area
今有一物,名曰2,4 -二氟苯磺酰氯。此化合物于诸多领域皆有妙用。于医药研制之域,可作关键中间体,助力创制新型药物,以疗愈诸般病症,提升病患康健。于材料科学之范畴,能参与特种材料合成,令材料具独特性能,如更佳之稳定性、抗腐蚀性等,应用于高新科技产品。于农药研发方面,可用于合成高效低毒农药,护佑作物生长,抵御病虫害侵袭。其用途广泛,影响深远,为诸多行业之发展添砖加瓦,实乃不可或缺之化学佳品。
Research & Development
近岁,吾于化学制品之域,专注研2,4 - 二氟苯磺酰氯。此品用途颇广,于医药、农药合成等诸多领域,皆具关键之位。

初涉此物,其合成之法多有繁难。原料之选、反应之条件,皆需精细考量。历经反复试炼,调整温度、压强,筛选催化剂,终得优化之法,产率与纯度皆获提升。

然研此物,安全亦为要。其具腐蚀性、刺激性,操作之时,防护务必周全。吾常思,如何于确保安全前提下,更高效制备。

展望未来,冀以此为基,拓展其应用。与诸同仁携手,深化研究,使2,4 - 二氟苯磺酰氯于更多领域发光发热,推动化学制品之研与发展,为世所用。
Toxicity Research
关于2,4 - 二氟苯磺酰氯毒性研究
夫2,4 - 二氟苯磺酰氯者,化学之物质也。于吾等化学研者而言,其毒性之究,至关重要。

观此物质,其具特殊之结构,氟与磺酰氯之基团并于苯环。氟者,活性甚强,磺酰氯亦活泼非常。此二者结合,使2,4 - 二氟苯磺酰氯之毒性或有殊性。

尝以诸般生灵验之。于小鼠者,若触此剂,皮毛或损,呼吸亦促,甚而神乱。盖因其入体后,或扰细胞之代谢,乱酶之活性。于水生生物,亦害莫大焉,可致水质变,而生物难存。

且其挥发之气,入于空气,人若吸之,伤呼吸道,致咳且喘。故研其毒性,为防其害于生灵,保环境之安,诚不可忽也。
Future Prospects
Although Chloride is not widely known at present, its future development can be looked forward to. Chemical substances can be seen in detail. This substance has a unique structure and may lead to new ways of chemical change.
In today's world, science and technology are new, and chemical research is also constantly improving. 2,4 - Difluorobenzenesulfonyl Chloride may be able to emerge in many fields such as pharmaceutical synthesis and material research and development. Its unique chemical properties, if it can be used well, can be used to make special drugs to heal diseases; or it can be synthesized into novel materials for high-tech.
Our chemical researchers, with the heart of exploration, should study unremitting. In time, 2,4 - Difluorobenzenesulfonyl Chloride will be able to bloom, for the well-being of mankind, for the advancement of science and technology, and contribute extraordinary power. Its future can be looked forward to.
Where to Buy 2,4-Difluorobenzenesulfonyl Chloride in China?
As a trusted 2,4-Difluorobenzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2,4-Difluorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2,4-difluorobenzenesulfonyl chloride?
2% 2C4-diethylaniline bisulfate, which has important uses in many fields.
In the field of chemical synthesis, it is often used as a key intermediate in organic synthesis. With its unique chemical structure, it can participate in many reactions and help build complex organic molecules. For example, in the preparation of some fine chemicals, as a starting material or a participant in a key reaction link, it promotes the formation of specific chemical bonds to achieve the synthesis of the target product. The reactions it participates in often have high selectivity and efficiency, which can effectively improve product quality and yield.
In the field of catalysis, 2% 2C4-diethylaniline bisulfate also exhibits unique properties. It can be used as a catalyst or cocatalyst for certain reactions to accelerate the reaction process by changing the activation energy of the reaction. In some chemical reactions that require harsh reaction conditions, it can achieve efficient catalysis under relatively mild conditions, thereby reducing production costs and improving production efficiency. And because of its stable structure, it can still maintain good catalytic activity and selectivity in multiple catalytic cycles.
In the field of materials science, it can be used for surface modification of materials. By chemically reacting with the surface of the material, specific functional groups are introduced to change the surface properties of the material, such as hydrophobicity, surface charge, etc. In this way, the compatibility of the material with other substances can be optimized and the application scenarios of the material can be broadened. For example, in the preparation of composites, the surface of the reinforcing phase is modified to enhance its bonding force with the matrix material, thereby improving the comprehensive properties of the composite material.
In summary, 2% 2C4-diethylaniline bisulfate plays an indispensable role in promoting the development of related industries due to its important uses in chemical synthesis, catalysis and materials science.
What are the physical properties of 2,4-difluorobenzenesulfonyl chloride?
Barium 2% 2C4 -diethylaniline sulfonate is an organic compound. Its physical properties are as follows:
This substance is mostly in the state of white crystalline powder at room temperature, and it is pure and fine in texture. Smell it, there is little special odor emitted, and it is quite odorless.
Its melting point is quite high, reaching a certain temperature square melting, this characteristic makes it stable under normal temperature environment, and it is not easy to melt and deform due to slight temperature fluctuations.
In terms of solubility, it has poor solubility in water and is difficult to effectively disperse and dissolve in water. However, some organic solvents, such as ethanol and acetone, have a certain solubility and can mix well with such organic solvents.
density is also one of its important physical properties, with a specific value, which makes it occupy a specific space and position in the system when participating in many processes or chemical reactions.
Its powdery appearance makes it fluid, and under appropriate conditions, it can be transported and mixed more smoothly, providing convenience for practical production applications.
Is the chemical properties of 2,4-difluorobenzenesulfonyl chloride stable?
Is the chemical properties of 2% 2C4-diethylaniline hydrochloride stable? This is also related to the characteristics of chemical substances.
The stability of chemical substances depends on many factors, such as molecular structure, chemical bond energy, temperature and humidity of the environment, light, pH, etc. 2% 2C4-diethylaniline hydrochloride, in its molecular structure, diethylaniline is partially combined with hydrochloric acid. In aniline compounds, nitrogen atoms have lone pairs of electrons and can combine with protons to form salts. The formation of this salt affects its stability to a certain extent.
From the molecular structure view, the substitution of diethyl group changes the density distribution of the electron cloud of the benzene ring, and the formation of hydrochloride enhances its solubility in polar solvents. However, this change in solubility may have a potential impact on its stability. In a dry environment at room temperature and pressure, in the absence of strong oxidants, reducing agents or specific catalysts, 2% 2C4-diethylaniline hydrochloride may be relatively stable.
However, in case of high temperature, the thermal motion of the molecule intensifies, the vibration of the chemical bond is enhanced, or the chemical bond is broken, triggering a decomposition reaction. And in a high humidity environment, water molecules may interact with the hydrochloride salt, affecting its structural stability. In the event of a drastic change in the acid-base environment, it acts as a hydrochloride, or reacts with an acid or base, resulting in a change in its chemical properties.
In summary, the stability of 2% 2C4-diethylaniline hydrochloride is not absolute and depends on the specific environmental conditions. Under suitable mild conditions, it can have certain stability; however, when the environmental conditions are severe, its chemical properties or changes.
What should be paid attention to when storing 2,4-difluorobenzenesulfonyl chloride?
2% 2C4-diethylaniline hydrochloride is a chemical substance. When storing it, you must pay attention to many matters.
First, you must choose a suitable place. When placed in a cool, dry and well-ventilated place. Because it is in a high temperature and humid environment, it is afraid of change. High temperature may cause it to decompose, and humid gas may make it deliquescent and damage its quality. This is just like the ancient adage: "The key to hiding things is that they are properly dry and humid, and they are moderately warm and cold."
Second, you need to avoid open flames and hot topics. This substance may be flammable, and in case of open flames or hot topics, it is easy to cause disasters, causing fire or even the danger of explosion. Therefore, in the place of storage, there must be no fire source, and it should be kept away from heat sources to prevent accidents. Gu Yun: "Prevent problems before they happen." This is the truth, and it is especially important for the storage of such chemicals.
Third, it should be stored in isolation from oxidants, acids, etc. Because 2% 2C4-diethylaniline hydrochloride encounters them, or has a violent chemical reaction, causing material deterioration, and even more, causing dangerous accidents. This is like water and fire are incompatible, and different types of things cannot be coexisted in the same room.
Fourth, the packaging must be intact. An intact packaging can prevent the intrusion of external factors and ensure its stable quality. If the packaging is damaged, it is easy to cause it to leak, which not only pollutes the environment, but also increases the danger. The ancients said: "If the skin does not exist, the hair will be attached." Packaging is for this substance, which is the relationship between the skin and the hair.
Fifth, the storage place should be equipped with corresponding emergency treatment equipment and suitable containment materials. Once an accident such as leakage occurs, it can be dealt with immediately to reduce its harm. This is a precautionary move, and it is also in line with the ancient people's "pre-establishment, unforeseen will be wasted". In this way, 2% 2C4-diethylaniline hydrochloride must be properly stored to ensure its safety and quality.
What are the synthesis methods of 2,4-difluorobenzenesulfonyl chloride?
The synthesis method of 2% 2C4-diethylaniline hydrochloride has various paths. The following is your detailed description.
First, 2,4-diethylaniline is used as the starting material and reacted directly with hydrochloric acid to obtain 2% 2C4-diethylaniline hydrochloride. This reaction is quite direct. In a suitable reaction vessel, 2,4-diethylaniline is slowly added to an appropriate amount of hydrochloric acid solution, stirred evenly, and the temperature and reaction time are controlled. Generally speaking, the reaction can occur at room temperature, but in order to make the reaction more complete, or it can be heated moderately, the temperature should not be too high to prevent side reactions from breeding. After the reaction is completed, a pure 2% 2C4-diethylaniline hydrochloride can be obtained through separation and purification steps, such as filtration and crystallization.
Second, 2,4-diethylaniline can be pretreated first to activate its molecular structure and enhance its reactivity. For example, it can be treated with a specific catalyst or auxiliary agent, and then reacted with hydrochloric acid. This approach can improve the reaction rate and yield. Selecting a suitable catalyst and adding it to the reaction system can change the activation energy of the reaction and make the reaction easier to proceed. However, it is necessary to pay attention to the amount and type of catalyst. Different catalysts have different effects on the reaction, and improper selection or cause the reaction to deviate from the expected path.
Third, consider the use of phase transfer catalysis. The introduction of phase transfer catalysts into the reaction system can promote the rapid transfer of reactants between different phases and accelerate the reaction process. Especially when one of the reactants is the organic phase and hydrochloric acid is the aqueous phase, the phase transfer catalyst can effectively overcome the obstacle of mass transfer between phases. Selecting suitable phase transfer catalysts, such as quaternary ammonium salts, crown ethers, etc., according to the specific conditions and requirements of the reaction, adjusting their dosage and reaction parameters can optimize the reaction effect and improve the generation efficiency of 2% 2C4-diethylaniline hydrochloride.
The above methods have their own advantages and disadvantages. In actual synthesis, many factors such as the cost of raw materials, the difficulty of controlling reaction conditions, the level of yield, and the purity of the product need to be comprehensively considered in order to choose the optimal synthesis path.