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2,4-Difluorobenzene-1-Sulfonyl Chloride

2,4-Difluorobenzene-1-Sulfonyl Chloride

Hongda Chemical

Specifications

HS Code

411183

Chemical Formula C6H3ClF2O2S
Molecular Weight 226.60
Appearance Typically a solid
Physical State At Room Temperature Solid
Odor Pungent
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents
Melting Point Data varies, check literature
Boiling Point Data varies, check literature
Density Data varies, check literature
Hazard Class Corrosive, toxic
Flash Point Data varies, check literature
Cas Number Data varies, check literature

As an accredited 2,4-Difluorobenzene-1-Sulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 2,4 - difluorobenzene - 1 - sulfonyl chloride in sealed chemical - grade containers.
Storage 2,4 - difluorobenzene - 1 - sulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and moisture as it may react with water. Store it in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and contact with air. Avoid storing near reactive chemicals to prevent potential chemical reactions.
Shipping 2,4 - difluorobenzene - 1 - sulfonyl chloride is shipped in sealed, corrosion - resistant containers. It's handled with care, following strict hazardous material regulations, ensuring proper protection during transit to prevent leakage and risks.
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2,4-Difluorobenzene-1-Sulfonyl Chloride 2,4-Difluorobenzene-1-Sulfonyl Chloride
General Information
Historical Development
2,4-Difluorobenzene-1-sulfonyl chloride is also a chemical product. Its beginning was due to the study of chemistry by various sages, who wanted to obtain new quality for use in various fields. In the past, the craftsmen tried various techniques and materials, and experienced countless difficulties before they could get something. At the beginning, its preparation method was complicated and the yield was quite low, but scholars were not discouraged, and they worked hard to improve the process. After years, the preparation method became more and more refined, and the yield was also improved. In medicine, materials and other industries, it gradually shows its use. At present, 2,4-difluorobenzene-1-sulfonyl chloride has become an indispensable product. This is the result of the diligent research of scholars of all dynasties, which has led to the improvement of chemical technology and the application of it in various fields. It has a broad prospect and can be expected to bloom again in the future.
Product Overview
There is now a substance called 2,4-difluorobenzene-1-sulfonyl chloride. This is an organic compound with active properties and a wide range of uses in the field of organic synthesis.
Looking at its structure, above the benzene ring, fluorine atoms are cleverly connected to sulfonyl chloride groups. The introduction of fluorine atoms gives this substance unique physical and chemical properties. Sulfonyl chloride groups are active functional groups and can participate in many chemical reactions, such as nucleophilic substitution reactions. They can interact with nucleophilic reagents such as alcohols and amines to generate corresponding sulfonates and sulfonamides.
Preparation methods often require delicate steps and specific conditions. During the reaction process, factors such as temperature, solvent, and the proportion of reactants need to be precisely controlled to obtain this pure product. Due to its liveliness, careful storage is also required, and it should be placed in a dry and cool place to prevent deterioration. In the process of organic synthesis, 2,4-difluorobenzene-1-sulfonyl chloride is like a smart chess piece, which can build a variety of complex organic molecules and help chemical research and industrial production development.
Physical & Chemical Properties
2,4-Difluorobenzene-1-sulfonyl chloride is also an organic compound. Its physical and chemical properties are quite important to chemists. Looking at its shape, at room temperature, or a colorless to slightly yellow liquid with a pungent odor. Its boiling point and melting point are both characteristics. The boiling point is the temperature at which the liquid turns into a gas under a specific pressure, and the melting point is the boundary point at which the solid state turns into a liquid state.
In terms of its chemistry, the sulfonyl chloride group is very active and easily reacts with many reagents. In contact with water, it hydrolyzes to produce the corresponding sulfonic acid and hydrogen chloride. In the field of organic synthesis, it is often used as a sulfonylation reagent, and a sulfonyl group is introduced to change the properties of the compound. Its solubility is quite good in some organic solvents, and this property is also related to its dispersion in the reaction system and the efficiency of participating in the reaction. When chemists explore this compound, they study all kinds of properties in detail, hoping to make good use of it to promote the development of organic synthesis and open up new frontiers of chemical research.
Technical Specifications & Labeling
Today there is a product called 2,4-difluorobenzene-1-sulfonyl chloride. This chemical product is related to technical specifications and identification (product parameters), and is really the key to our research.
The technical specifications are taken from the raw materials, which must be carefully screened, and the impurities need to be small. The preparation method, the temperature control is appropriate, the duration is accurate, and the reaction is complete. The steps are in sequence, and must not be disordered, so that the quality of the product can be obtained.
In terms of identification (product parameters), the appearance is clear, the color is pure and the state is stable. The number of contents must reach a high standard to prove its quality. The degree of melting and boiling is also the key. Accurate determination is to be marked in the book. Such specifications and labels can provide assurance for the use of products and ensure their correct application by all parties.
Preparation Method
To prepare 2,4-difluorobenzene-1-sulfonyl chloride, it is necessary to explain the method of preparation, which is related to the raw materials and production process, reaction steps and catalytic mechanism.
First take suitable raw materials, such as fluoroaromatic hydrocarbons and sulfonylating reagents. In the reaction kettle, control the appropriate temperature and pressure. The first step is to make the fluoroaromatic hydrocarbons and sulfonylating reagents meet, and through specific reaction steps, the two combine. This process requires a delicate catalytic mechanism, or a specific catalyst is used to promote the smooth reaction and increase its efficiency and yield.
During this period, the control of temperature and pressure is crucial, and subtle deviations can cause different reactions. After the reaction is completed, the pure product of 2,4-difluorobenzene-1-sulfonyl chloride can be obtained by separation and purification. The whole preparation method is interlocking and requires strict operation to obtain satisfactory results.
Chemical Reactions & Modifications
The product of this chemical is called 2,4-difluorobenzene-1-sulfonyl chloride. The way of its chemical application and modification is the focus of our research. The beauty of chemical application depends on the selection of agents and the appropriate temperature control, so that the yield can be increased and the purity can be improved. If you want to change its properties, or add other substances to adjust its quality, or change the order to change its properties.
If you want to make this product more stable in a certain environment, or increase its activity for a special purpose, you should study the details of the chemical application and think about the modification method. Selecting a good agent and observing the changes in time can make the product have better properties and meet all needs. This is the task of constant research, seeking between chemical application and modification, and obtaining exquisite methods to make the product better and usable by the world.
Synonyms & Product Names
Today there is a thing named 2,4-difluorobenzene-1-sulfonyl chloride. It is very important in our chemical research. The title of this thing, in addition to the correct name, also has many synonymous names.
As far as synonymous names are concerned, although they are not widely spread in the market, they are occasionally mentioned in the academic community when scholars communicate. These synonymous names vary slightly depending on the region or the focus of research.
As for the trade name, merchants give it a unique name in order to make their products unique, or combine the characteristics and uses of this thing. This trade name is well known to everyone when it is circulated and traded in the market. Although they and synonyms refer to this thing, they each have their own uses. Synonyms are convenient for academic research, and trade names are conducive to commercial promotion. The two complement each other and jointly promote the application and development of this thing in the field of chemistry.
Safety & Operational Standards
2,4-Difluorobenzene-1-sulfonyl chloride, this chemical substance is related to safety and operation standards, and we should be cautious.
Its sex tools are potentially harmful, touch the human body, or cause skin burns, eye tingling, if accidentally inhaled, it may damage the respiratory system. Therefore, when operating, protection measures are indispensable.
The operating environment should be well ventilated, so that the air flows smoothly to reduce its concentration in the air. The operator must wear protective clothing, carefully selected materials, which can effectively block this object from contacting the skin, and equipped with protective gloves, which are tough and have excellent anti-penetration performance. Eye protection should not be underestimated. Protective glasses or masks can resist this object from splashing into the eyes.
When taking it, the action should be stable and accurate, and the utensils used must be clean and dry to prevent impurities from mixing in, affecting the quality, and avoiding adverse reactions. Weighing accurately, according to the amount required for experiment or production, more is wasteful and dangerous; less is not as expected.
When storing, choose a cool and dry place, away from heat and fire sources, because it is heated or exposed to open flames, or reacts violently. Sealed and stored to avoid contact with air and moisture, to prevent deterioration or formation of dangerous substances.
If you accidentally come into contact, you should quickly rinse the contact area with a lot of water, especially the eyes, and then seek medical treatment. In case of leakage, evacuate personnel immediately, isolate the scene, and strictly prohibit fire from entering. Emergency responders must wear professional protective equipment, use appropriate materials to absorb or contain leaks, and handle them properly. Do not dump them at will to prevent pollution to the environment.
Only by strictly observing safety and operating standards can we ensure the safety of personnel and ensure the smooth operation of experiments and production.
Application Area
2,4-Difluorobenzene-1-sulfonyl chloride is also a good product of chemistry. Its use is wide. In the production of medicine, it can be used as a key material to help form good medicines and treat various diseases. If you want to make a special antibacterial agent, this is a must, which can help the agent target accurately and effectively sterilize.
In the field of agrochemical, it can also develop its capabilities. It can be the foundation for the creation of pesticides, become an insect repellent and disease-fighting agent, protect the safety of crops, and increase the abundance of agricultural production.
And in the field of materials, it also has its function. It can be used in the production of special materials to give the material new properties, such as improving its corrosion resistance and wear resistance, making the material more suitable for special environments and expanding its use. It is 2,4-difluorobenzene-1-sulfonyl chloride, which is essential in the fields of medicine, agriculture, materials, etc., and is actually a treasure of chemical production.
Research & Development
The research and use of 2,4-difluorobenzene-1-sulfonyl chloride
The research and use of 2,4-difluorobenzene-1-sulfonyl chloride has been quite successful in the process of research and use. The method of its synthesis has been explored many times. At first, benzene was used as the base, and after halogenation and sulfonation steps, the yield was not ideal. After the easy route, the fluorobenzene was used as the starting point, and the reaction temperature, time and dosage were precisely regulated, and the yield gradually increased.
In the field of application, in the creation of medicine, it is a key intermediate. In the research and development of a new anti-cancer drug, 2,4-difluorobenzene-1-sulfonyl chloride is coupled with a specific amine compound to form a highly active anti-cancer component. In the research and development of materials, polymer materials modified with this substance have greatly increased their weathering and wear resistance.
Looking at its future, if it can optimize the synthesis process, reduce costs and improve efficiency, and expand its application in the pharmaceutical, materials and other industries, it will definitely be able to shine more brilliance, help the industry advance, and promote the development of research and application.
Toxicity Research
The chemical industry is related to people's livelihood, but the investigation of poisons in it cannot be ignored. Today, there is 2,4-difluorobenzene-1-sulfonyl chloride, which is highly toxic and needs to be investigated in detail.
Look at its chemical structure, the genus of fluorine and sulfonyl chloride, or it has special activities. In experimental studies, touching the skin may cause burning pain; it can be absorbed into the lungs, or damage the organs.
And it also has potential danger in the environment. If the soil is polluted, the vegetation may suffer from it; if the water flow is polluted, the aquarium may suffer from it.
Therefore, as a chemist, we should study its toxicity with caution, formulate preventive measures, and use this chemical substance properly to avoid the risk of its poisoning, so as to ensure the safety of people's livelihood and the environment.
Future Prospects
2,4-Difluorobenzene-1-sulfonyl chloride is a substance that I have dedicated myself to studying in the field of chemistry. Looking at the future prospects, this substance has extraordinary potential. Its unique structure, the ingenious combination of fluorine atoms and sulfonyl chloride groups, endows many specific properties.
In the field of organic synthesis, it is expected to become a key building block for the construction of novel compounds, expand the synthesis path, and open up new paths for the creation of more active drugs and materials with excellent properties. Its reactivity and selectivity are precisely regulated, and the efficient construction of complex structures may be realized.
In materials science, or due to the characteristics of fluorine, improve the stability, corrosion resistance and electrical properties of materials. Such as the preparation of high-performance electronic materials and functional coatings to meet the demanding needs of future technologies.
I am convinced that with time, through unremitting exploration and research, 2,4-difluorobenzene-1-sulfonyl chloride will be able to shine in many fields, contribute to human progress, and open up a new future.
Where to Buy 2,4-Difluorobenzene-1-Sulfonyl Chloride in China?
As a trusted 2,4-Difluorobenzene-1-Sulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2,4-Difluorobenzene-1-Sulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2,4-difluorobenzene-1-sulfonyl chloride?
2% 2C4-diethyl-1-naphthalaldehyde has a wide range of main uses. In the field of organic synthesis, this is a key intermediate. It can be converted into many organic compounds with special structures and properties through specific chemical reactions, such as some biologically active drug molecules or material monomers with excellent properties.
In the field of drug development, it can act as a starting material to synthesize new therapeutic drugs through a series of delicate chemical modifications and reaction steps. For example, in the development of anti-tumor drugs, compounds with high selective inhibitory effect on tumor cells can be designed after appropriate derivatization.
In the field of materials science, it can be used to prepare organic optoelectronic materials with unique functions. Due to the special structure of naphthalene ring and aldehyde group, through rational molecular design and synthesis, materials with excellent photoelectric properties can be obtained, such as organic Light Emitting Diode (OLED) materials, which have broad prospects in the field of display technology and can help to achieve higher resolution and brighter color display effects.
In the fragrance industry, 2% 2C4-diethyl-1-naphthalaldehyde can impart a unique aroma to fragrances due to its unique chemical structure, providing the possibility for the formulation of new and unique fragrances. It can be used in perfumes, air fresheners and other products to meet people's diverse needs for aroma.
What are the physical properties of 2,4-difluorobenzene-1-sulfonyl chloride?
The physical properties of 2% 2C4-diethyl-1-nitrobenzene are as follows:
This substance is a liquid at room temperature, and it is colorless to light yellow in appearance, with a slight odor. Its density is higher than that of water. If it is mixed with water, it will sink underwater. The boiling point is about 270 ° C. At this temperature, the liquid will turn into a gaseous state and rise. The melting point is about -20 ° C. The temperature drops below this point, that is, it changes from a liquid state to a solid state.
2% 2C4-diethyl-1-nitrobenzene is insoluble in water, but it can be well miscible with many organic solvents such as ethanol, ethyl ether, and benzene. Due to the principle of "similarity and miscibility", its molecular structure is compatible with organic solvents, so it can blend with each other.
Its volatility is low, and under normal temperature and pressure, the rate of molecular escape into the air is slow. However, although the volatility is low, it cannot be ignored. Because of its certain toxicity, if exposed to the environment containing this substance for a long time, it may be harmful to human health.
In addition, the refractive index of 2% 2C4-diethyl-1-nitrobenzene also has a specific value. When light passes through this substance, its propagation direction and speed will change accordingly according to its refractive index. This property is often one of the important basis for identifying and analyzing this substance.
Is the chemical properties of 2,4-difluorobenzene-1-sulfonyl chloride stable?
2% 2C4-diethyl-1-nitrobenzene is an organic compound. The stability of its chemical properties is related to many factors, let me explain in detail.
Structurally, the benzene ring has a conjugated system, which endows the compound with certain stability. The delocalization of the π electron cloud of the benzene ring reduces the energy of the system and stabilizes the structure. However, the ethyl and nitro groups of its side chain also affect the stability.
Ethyl is the power supply group, which can provide electrons to the benzene ring through induction and superconjugation effects, enhancing the electron cloud density of the benzene ring. Although this effect makes the benzene ring more prone to electrophilic substitution, it stabilizes the benzene ring structure to a certain extent.
Nitro is a strong electron-absorbing group. Through induction and conjugation effects, it absorbs electrons from the benzene ring, resulting in a decrease in the electron cloud density of the benzene ring. This effect reduces the electrophilic substitution activity of the benzene ring, but enhances the stability of the benzene ring to oxidants and other reagents. Due to the fact that oxidants attack electron-rich systems more often, the electron cloud density of the benzene ring decreases, making it difficult to be oxidized.
However, the presence of nitro groups makes this compound potentially reactive. Nitro groups can undergo reduction reactions and be converted into other functional groups such as amino groups. And under specific conditions, such as high temperature, light or the presence of catalysts, 2% 2C4-diethyl-1-nitrobenzene may decompose and rearrange, and the stability will be reduced.
In summary, 2% 2C4-diethyl-1-nitrobenzene is usually stable, but under certain conditions, its chemical properties may change and various chemical reactions occur.
What are the synthesis methods of 2,4-difluorobenzene-1-sulfonyl chloride?
To prepare 2,4-diethyl-1-nitrobenzene, the method is as follows:
First take an appropriate amount of benzene, place it in a reactor, use aluminum trichloride as a catalyst, and introduce ethylation reagents, such as chloroethane. This reaction requires moderate temperature control, about a certain temperature range, so that benzene and chloroethane undergo Fu-gram alkylation reaction. After this step, ethylbenzene can be obtained.
Then, the ethylbenzene is treated again, and under suitable reaction conditions, such as under the action of a mixed acid composed of concentrated sulfuric acid and concentrated nitric acid, a nitrification reaction occurs. The mixing ratio of acid needs to be precisely prepared, and the temperature needs to be strictly controlled in order to selectively introduce nitro to the appropriate position to obtain 2-ethyl-1-nitrobenzene. After
, repeat the operation of the first step, and introduce ethyl into 2-ethyl-1-nitrobenzene again with aluminum trichloride catalysis. This process still needs to pay attention to the reaction temperature and reagent dosage conditions, so that the ethyl group can be successfully connected, and the final product is 2,4-diethyl-1-nitrobenzene.
During the reaction process, the products of each step need to be carefully separated and purified. Such as distillation, extraction, recrystallization and other means to remove impurities to obtain pure target products. Each step of the reaction requires rigorous operation, paying attention to factors such as temperature, pressure, and reagent ratio, in order to effectively improve the yield and purity of the product.
What should be paid attention to when storing and transporting 2,4-difluorobenzene-1-sulfonyl chloride?
When storing and transporting 2% 2C4-diethyl-1-nitronaphthalene, the following matters should be paid attention to:
First, the storage place must be kept cool, dry and well ventilated. This is because the substance is heated or wet, which is very likely to cause danger. If it is in a high temperature environment, its chemical properties may become more active, increasing the risk of reaction; while a humid environment may cause it to react with moisture, which in turn affects the quality and even produces harmful by-products.
Second, the storage container must be properly selected. It is advisable to use a metal or plastic container with good sealing performance, which can effectively avoid its volatilization and leakage. Metal containers are sturdy and durable, and can withstand a certain pressure; plastic containers have good corrosion resistance. However, no matter what kind of container is used, it is necessary to ensure that the material does not chemically react with 2% 2C4-diethyl-1-nitronaphthalene.
Third, during transportation, protective measures should be taken. It should be firmly placed to prevent damage to the container due to bumps and collisions. Vehicles need to have corresponding fire and explosion-proof devices, because the substance has certain flammability and explosive properties. At the same time, transport personnel must be familiar with relevant safety knowledge and emergency treatment methods, in case of leakage and other situations, and can respond quickly and properly.
Fourth, it should be strictly stored and transported separately from oxidants, acids and other substances. 2% 2C4-diethyl-1-nitronaphthalene is in contact with these substances, which is prone to violent chemical reactions, resulting in serious consequences such as fire and explosion.
Fifth, storage and transportation sites should be equipped with complete fire protection facilities and leakage emergency treatment equipment. Such as fire extinguishers, fire sand, adsorption materials, etc., so that in the event of an emergency, rescue and treatment can be carried out in time to minimize harm.