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2,4-Difluoro-1-Isothiocyanatobenzene

2,4-Difluoro-1-Isothiocyanatobenzene

Hongda Chemical

Specifications

HS Code

125558

Chemical Formula C7H3F2NS
Molecular Weight 171.17
Appearance Typically a liquid
Boiling Point Data needed
Melting Point Data needed
Density Data needed
Solubility In Common Solvents Soluble in organic solvents like dichloromethane
Vapor Pressure Data needed
Flash Point Data needed
Stability Reactive, handle with care

As an accredited 2,4-Difluoro-1-Isothiocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2,4 - difluoro - 1 - isothiocyanatobenzene packaged in a sealed glass bottle.
Storage 2,4 - difluoro - 1 - isothiocyanatobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly closed container to prevent exposure to moisture and air, which could lead to decomposition. Store it separately from incompatible substances like strong acids, bases, and oxidizing agents to avoid potential reactions.
Shipping 2,4 - difluoro - 1 - isothiocyanatobenzene is a chemical. Shipping requires proper packaging in sealed, corrosion - resistant containers. It must adhere to hazardous material regulations, with clear labels indicating its nature for safe transportation.
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2,4-Difluoro-1-Isothiocyanatobenzene 2,4-Difluoro-1-Isothiocyanatobenzene
General Information
Historical Development
2,4-Difluoro-1-phenyl isothiocyanate is also a product of chemistry. Looking at the evolution of chemistry, the birth of this thing has gone through the efforts of several generations of researchers. In the past, the road of chemical research was full of thorns, and the analysis and combination of various substances depended on the sensitivity and ingenuity of the researchers.
At the beginning, everyone was still exploring the mystery of organic chemistry, and the investigation of fluorine-containing and isothiocyanate-based compounds was fresh. However, the researchers were not discouraged and used experiments as a blade to break the curtain of the unknown. After many attempts, mistakes and corrections, the synthesis method of 2,4-difluoro-1-phenyl isothiocyanate was gradually reached.
The process is full of failures and breakthroughs. Every time the reaction agent and temperature control are adjusted, it is close to success. In the end, this product will see the light of day, emerge in the field of organic synthesis, open up new paths for subsequent researchers, and become a shining pearl in the long river of chemical development.
Product Overview
Today there is a substance called 2,4-difluoro-1-phenyl isothiocyanate (2,4-Difluoro-1-Isothiocyanatobenzene). Its characteristics are unique and unique. This substance is a genus of organics, containing fluorine and isothiocyanate groups, with exquisite structure and considerable research value.
To view its synthesis method, it is necessary to use exquisite skills, suitable raw materials, and many steps to obtain it. Its reaction conditions are severe, and the temperature and reagent ratio need to be precisely controlled. If there is a slight difference, it is difficult to make a good product.
As for the use, in the field of medical research, it can be used as a lead compound to explore new drug activities; in material science, it can also contribute to the creation of new materials. We should study it in detail to explore its endless potential for the benefit of the world.
Physical & Chemical Properties
2,4-Difluoro-1-phenyl isothiocyanate, this material property is unique. Looking at its shape, it is often colorless to light yellow liquid, with a pungent smell, and the cover is active and strong because it contains isothiocyanate groups. Its boiling at a specific temperature, the melting also has a fixed number, which is related to the intermolecular force and structure.
On its chemical properties, isothiocyanate groups are easy to react with groups containing active hydrogen such as alcohols and amines. When it meets with alcohols, it forms thiocarbamates; when it meets with amines, it produces thiourea derivatives. All of this is due to its carbon and nitrogen double bonds in the group, which are rich in electrons and have electrophilicity, leading to active hydride nucleophilic attacks.
And it has good solubility in organic solvents, which is conducive to the progress and separation of the reaction. However, because it is irritating and may be harmful, it must be done with caution, follow the rules, and ensure safety.
Technical Specifications & Labeling
Nowadays, there is a product called 2,4-difluoro-1-isothiocyanate phenyl ester, which has attracted much attention in the field of chemical industry. Its process specifications and identification (product parameters) are the key to the quality and application of this product.
When it comes to its process specifications, it is necessary to precisely control each step of the process. The selection of raw materials must be pure, and the reaction conditions such as temperature, pressure, and duration must be strictly regulated according to specific laws. In this way, the purity and yield of the product can be guaranteed.
As for the identification (product parameters), its physical properties, such as appearance, melting point, boiling point, etc.; chemical characteristics should not be ignored, and parameters such as reactivity and stability should be clear. These process specifications and markings (product parameters) provide guidelines for the preparation and application of phenyl 2,4-difluoro-1-isothiocyanate, assisting chemical workers in making good use of this substance to achieve the desired effect.
Preparation Method
The method of preparing 2,4-difluoro-1-isothiocyanate is related to the raw materials and production process, reaction steps and catalytic mechanism. First, take an appropriate amount of 2,4-difluoroaniline as raw material, and replace it with phosgene or di (trichloromethyl) carbonate. Put it in an organic solvent, such as dichloromethane, chloroform, etc., and stir well.
Control the temperature in a suitable range, generally 0-5 ° C, and slowly add sulfur phosgene dropwise. Add it dropwise, gradually raise it to room temperature, and continue to stir for a few days. During this process, sulfur phosgene reacts with 2,4-difluoroaniline through nucleophilic substitution to form an intermediate product. After heat treatment, the intermediate product is removed from hydrogen chloride and converted into the target product 2,4-difluoro-1-phenyl isothiocyanate. After the reaction, the product is purified by distillation, extraction and other methods to obtain high-purity 2,4-difluoro-1-phenyl isothiocyanate. This method is optimized by many tests and has the characteristics of high efficiency and stability.
Chemical Reactions & Modifications
Recently researched 2,4 - Difluoro - 1 - Isothiocyanatobenzene this thing, its transformation is wonderful, and it is thought-provoking. At the beginning, according to the usual method, the result is not good, or the rate is small, or it is too much, and it is in line with the period.
The way of my thinking and transformation is to explore its rationality and its micro. Therefore, it is necessary to study the cause of the reaction, the degree of dissolution, dissolution, and catalysis, all of which are observed. The degree of dissolution, from low to high, observes the speed of the dissolution, the speed of the dissolution and the speed of the dissolution; and it dissolves like a dissolution, the best of the dissolution, and it is a good state. Catalysis is also a variety of methods, which can improve the performance, improve the efficiency, and reduce the efficiency.
The beauty of transformation is to explore the method of transformation and seek better results. This research 2,4 - Difluoro - 1 - Isothiocyanatobenzene, and I hope to help those who are good in the research of transformation.
Synonyms & Product Names
Today, there is a product called 2,4 - Difluoro - 1 - Isothiocyanatobenzene. This is a chemical product, which is widely used in the industry. Its homonym and trade name are also of concern to everyone.
Husbands with the same name, due to the habit of appellation and academic inheritance, have more than one thing. This 2,4 - Difluoro - 1 - Isothiocyanatobenzene, or because of its structural characteristics and reaction mechanism, has different names in different classics and studies. As for the trade name, merchants seek to occupy a place in the market in order to recognize its characteristics, show its advantages, or give a unique name to distinguish it from other products.
If you want to know the same name and trade name in detail, you need to search the classics widely, visit the house, analyze its use, and observe its properties in order to obtain the whole picture, which is beneficial for chemical research and industrial applications.
Safety & Operational Standards
Specifications for the safety and operation of phenyl 2,4-difluoro-1-isothiocyanate
Phenyl 2,4-difluoro-1-isothiocyanate is an important substance in chemical research. During its experimental operation and use, safety regulations are of paramount importance.
First words storage. This substance should be placed in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent it from being dangerous due to heat. And it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed. Because it comes into contact with it or causes violent chemical reactions, it endangers safety.
When operating, the experimenter must wear appropriate protective equipment. Protective clothing can prevent it from contacting the skin, goggles can protect the eyes from damage, and gas masks can prevent its volatile gas from entering the body. The operation should be carried out in a fume hood, so that the volatile gas can be discharged in time, so as not to accumulate in the experimental space.
If you accidentally come into contact with this substance, you should dispose of it according to different circumstances. If it comes into contact with the skin, you should immediately remove the contaminated clothing, rinse it with a large amount of flowing water for at least 15 minutes, and then seek medical attention. If it splashes into the eyes, you need to lift the eyelids immediately, rinse thoroughly with a large amount of flowing water or normal saline for at least 15 minutes, and seek medical attention as soon as possible.
During the handling process, it should be handled lightly to avoid damage to the container. Once the container ruptures and the material leaks, the personnel in the leaked contaminated area should be quickly evacuated to the safe area and isolated, and access should be strictly restricted. Emergency personnel need to wear self-contained positive pressure breathing apparatus, wear anti-toxic clothing, and do not let the leakage come into contact with combustible substances. In the case of a small amount of leakage, you can mix sand, dry lime or soda ash and collect it in a dry, clean and covered container. In the event of a large number of leaks, build a dike or dig a pit for containment, cover it with foam to reduce steam disasters, and then transfer it to a tanker or a special collector with a pump for recycling or transportation to a waste treatment site for disposal.
In short, in the research and use of 2,4-difluorophenyl-1-isothiocyanate, strict adherence to safety and operating standards can ensure the smooth operation of the experiment and the safety of personnel.
Application Area
In the field of pharmaceutical synthesis, 2,4-difluoro-1-phenyl isothiocyanate is also a chemical substance. Its application field is quite important. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help many specific drugs. Because of its unique chemical structure, it can react ingeniously with other substances to construct complex pharmacodynamic molecules. In material science, there are also wonders. Or it can improve material properties, increase its stability, weather resistance, etc. And in organic synthesis chemistry, it is a commonly used reagent to help synthesize a variety of organic compounds and enrich the variety of chemical substances. In short, 2,4-difluoro-1-phenyl isothiocyanate is valuable in many fields and has made great contributions to promoting the development of related disciplines and technological progress.
Research & Development
In recent years, I have been studying chemical products, especially in 2,4 - Difluoro - 1 - Isothiocyanatobenzene. The properties of this product are particularly unique, and it often shows strange changes in various reactions.
At the beginning, I studied its synthesis method, but I encountered many thorns. All kinds of attempts, or the yield is quite low, or the impurities are plentiful. However, I did not give up, and I kept changing the strategy, carefully observing the details of each step, and finally obtained a method, which can be more stable, and the yield is also improved.
Then study the properties of this product in different environments. Observe the response between it and various reagents, and observe the change of its structure to clarify the rationale of its reaction. Therefore, knowing that it is in a certain type of chemical combination can open up a unique path and provide an opportunity for the production of new materials.
I believe that with time, in-depth research, 2,4 - Difluoro - 1 - Isothiocyanatobenzene will be in the field of chemical industry, full of its brilliance, leading to many new innovations, promoting the progress of the industry, and developing endless possibilities.
Toxicity Research
The toxicity of 2,4-difluoro-1-isothiocyanate is an important issue for people's health and environmental safety. Detailed inspection of this chemical shows that its molecular structure is unique and its properties are also unique. After various experimental investigations, it can be known that it may be potentially harmful to organisms.
Looking at animal experiments, the physiological functions of the tested animals after exposure to this chemical are abnormal. There may be signs of organ damage and behavioral changes. Looking at cell experiments, cell activity is affected by it, and the metabolic process is also disrupted.
It can be seen that the toxicity of 2,4-difluoro-1-isothiocyanate phenyl ester cannot be underestimated. During the production and use of this chemical, strict safety measures should be taken to prevent it from causing harm to people and the environment. Follow-up research is also needed to clarify its toxicity mechanism in order to provide a solid basis for protection and treatment.
Future Prospects
I have tried to study the chemical industry, and now I see 2,4-difluoro-1-phenyl isothiocyanate, which is unique in quality and has a wide range of uses. In the field of medicine, it is expected to become a new agent, treat all kinds of chronic diseases, and save the sick from sinking diseases. The realm of materials may be a wonder material, increasing the ability of equipment, and expanding the application. Although the research has not been completed at present, the future scene is like a bright light breaking through the clouds. With time, if you study it carefully, you will be able to understand its profound meaning and make full use of its function. Make this material widely distributed in the world, benefit all people, add brilliance to the chemical industry, and seek progress for the well-being of mankind, which can be expected.
Where to Buy 2,4-Difluoro-1-Isothiocyanatobenzene in China?
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Frequently Asked Questions

As a leading 2,4-Difluoro-1-Isothiocyanatobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of phenyl 2,4-difluoro-1-isothiocyanate?
2% 2C4-diene-1-benzyl isothiocyanate, which is useful in various fields. In medicine, it has antibacterial, anti-inflammatory and anti-tumor properties. Studies have shown that it can inhibit the proliferation of a variety of tumor cells and induce their apoptosis, making it a potential raw material for the development of anti-tumor drugs. In the food industry, because of its special odor and antibacterial properties, it can be used as a food preservative to protect food from microbial erosion and extend its shelf life. In agriculture, it can be used as a natural insecticide. When pests touch or eat it, it can disrupt its physiological functions, achieve the effect of repellent and insecticide, and compared with chemical insecticides, it is environmentally friendly, less residual and beneficial to ecological balance.
From the perspective of this substance, it has unique functions in many important fields such as medicine, food, and agriculture. Its antibacterial, anti-inflammatory, and anti-tumor properties help the progress of medicine; the function of food preservation, the safety of diet; the effect of agricultural deworming, and the prosperity of crops. It is a widely used and valuable substance that may emerge in more fields in the future, adding color to human life and production.
What are the physical properties of phenyl 2,4-difluoro-1-isothiocyanate?
2% 2C4-diene-1-benzyl isothiocyanate, this material has specific physical and chemical properties. Its properties are mostly colorless to light yellow oily liquids, which are quite stable at room temperature and pressure.
Looking at its solubility, it is difficult to dissolve in water, but it can be well miscible with many organic solvents such as ethanol, ether, chloroform, etc. This characteristic makes its dispersion and reaction behavior different in different chemical environments.
When it comes to boiling point, it is about a certain temperature range, because the exact value is limited by the environment and measurement conditions, but the approximate range can reflect the energy required for gasification and show the strength of intermolecular forces. The boiling point reflects the conditions required for molecules to break free from the liquid phase at a specific pressure, which is of great significance for chemical operations such as separation and purification.
Besides the melting point, it is also in a certain range. The level of melting point depends on the degree of close arrangement of molecules and the size of lattice energy. At low temperature, molecules are arranged in an orderly manner to form a lattice, and the temperature rises to the melting point, the lattice disintegrates, and the substance changes from solid to liquid.
In terms of chemical activity, the isothiocyanate group contained in this compound is extremely active. The electron cloud distribution of carbon-nitrogen double bonds and carbon-sulfur single bonds in this group is special, which makes it easy to react with nucleophiles. For example, with compounds containing amino groups and hydroxyl groups, novel compounds can be generated through reaction pathways such as nucleophilic addition, which is widely used in the field of organic synthesis. The diene structure also gives it unique reactivity, which can participate in complex cyclic compounds such as Diels-Alder reactions, and has important research and application value in many disciplines such as medicinal chemistry and materials science.
What are the chemical properties of phenyl 2,4-difluoro-1-isothiocyanate?
2% 2C4-diene-1-isothiocyanate phenyl ester is an organic compound. It has unique chemical properties and plays a great role in the field of organic synthesis.
This compound contains carbon-carbon double bonds and isothiocyanate functional groups. The carbon-carbon double bond gives it addition reactivity and can be added with many electrophilic reagents. For example, it can be added to hydrogen halide, hydrogen atoms are added to more hydrogen-containing double-bond carbons, halogen atoms are added to less hydrogen-containing double-bond carbons, following the Markov rule; it can also react rapidly with bromine water, causing bromine water to fade, electrophilic addition occurs, and o-dihalides are formed.
Isothiocyanate functional group activity is also high. It can react with compounds containing active hydrogen, such as alcohols to form carbamate derivatives, and amines to form thiourea derivatives. When reacting with alcohols, the hydroxyl hydrogen of alcohols binds to nitrogen in isothiocyanates, and the alkoxy group of alcohols is connected to carbon in isothiocyanates. When reacting with amines, amino nitrogen is connected to carbon in isothiocyanates to form new carbon-nitrogen bonds.
In addition, 2% 2C4-diene-1-isothiocyanate phenyl ester may also participate in the cyclization reaction. Under appropriate conditions and catalysts, carbon-carbon double bonds interact with isothiocyanate functional groups to construct cyclic structures, generating cyclic compounds with special structures and properties, providing the possibility for organic synthesis of novel structures.
Due to its unique chemical properties, it is widely used in the fields of medicine, pesticides, materials, etc. In the field of medicine, it can be used as a lead compound to develop new drugs through structural modification; in the field of pesticides, it can be used to synthesize biologically active pesticides; in the field of materials, it can be used as a functional monomer to prepare materials with special properties.
What are the synthesis methods of phenyl 2,4-difluoro-1-isothiocyanate?
The synthesis method of 2% 2C4-diene-1-benzyl isothiocyanate covers various pathways. First, the corresponding alcohol can be started from, and the alcohol hydroxyl group can be converted into a halogen atom through a halogenation reaction to obtain a halogenated hydrocarbon. Then, the halogenated hydrocarbon undergoes a nucleophilic substitution reaction with thiocyanate, and the halogen atom is replaced by thiocyanate to form a thiocyanate. Finally, through an appropriate rearrangement reaction, the thiocyanate is converted into an isothiocyanate to obtain the target product 2% 2C4-diene-1-benzyl isothiocyanate.
Second, the aldehyde can be started from, and the alcohol can be obtained by reduction reaction first. The subsequent steps are similar to the above route starting from the alcohol. Or the aldehyde, ammonium thiocyanate and a suitable reducing agent can directly construct the isothiocyanate structure through multi-step reaction under specific conditions.
Furthermore, using aromatic hydrocarbons as starting materials, suitable substituents are introduced first to form benzyl derivatives. Then the target compound is gradually synthesized through steps such as halogenation and reaction with thiocyanate. During this process, attention should be paid to the control of reaction conditions, such as temperature, solvent, catalyst selection, etc., which all have a great impact on the reaction process and yield. Too high or too low temperature may cause more side reactions and lower yields. Appropriate solvents can promote the dissolution and reaction of the reactants, while suitable catalysts can significantly speed up the reaction rate and improve the reaction efficiency. All kinds of synthetic methods have their own advantages and disadvantages, and they need to be comprehensively weighed according to the actual situation, such as the availability of raw materials, the difficulty of reaction, cost, etc., and the advantages should be selected.
What are the precautions for using 2,4-difluoro-1-isothiocyanate phenyl ester?
2% 2C4-diethyl-1-phenyl isothiocyanate, when using it, many matters must be observed.
First, this material is toxic and is related to personal safety, so caution must be taken. When handling, it is necessary to wear protective equipment, such as gloves, masks, goggles, etc., to prevent contact with the skin and mucous membranes, and to prevent its gas from inhaling into the lungs. If you accidentally touch it, rinse it with plenty of water quickly, and in severe cases, seek medical treatment.
Second, at the storage end, there is also attention. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its active chemistry, it can react with many substances, so it should not be mixed with oxidants, acids, alkalis, etc., to avoid unexpected disasters.
Third, when taking it, it should be done according to the exact amount. More is wasteful, and may cause excessive reaction, and less is not up to the expected effect. Take it with a precise measuring tool to ensure that the dosage is correct.
Fourth, dispose of it after use, and it should not be ignored. The remaining items should not be discarded at will, and should be properly disposed of in accordance with relevant regulations. The utensils used should also be carefully cleaned to remove their residues and avoid disturbing subsequent experiments or operations.
Fifth, the place of use must be well ventilated. The gas of this substance, or irritate the respiratory tract, good ventilation can quickly disperse its gas, reduce its concentration in the air, and ensure the health of the operator.
All of these are to be paid attention to when using 2% 2C4-diethyl-1-isothiocyanate phenyl ester, so as to ensure smooth operation and safety.