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2,3-Difluorobenzenesulfonyl Chloride

2,3-Difluorobenzenesulfonyl Chloride

Hongda Chemical

Specifications

HS Code

921017

Chemical Formula C6H3ClF2O2S
Molecular Weight 226.602 g/mol
Appearance Typically a colorless to light - yellow liquid
Boiling Point Approximately 243 - 245 °C
Solubility Soluble in common organic solvents like dichloromethane, chloroform
Odor Pungent, characteristic of sulfonyl chloride compounds
Reactivity Reacts with nucleophiles such as amines, alcohols to form sulfonamides and sulfonate esters respectively

As an accredited 2,3-Difluorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2,3 - difluorobenzenesulfonyl chloride packaged in a sealed glass bottle.
Storage 2,3 - difluorobenzenesulfonyl chloride should be stored in a cool, dry, and well - ventilated area. Keep it away from heat sources, flames, and incompatible substances like strong bases, oxidizing agents, and moisture. Store in a tightly - sealed container to prevent leakage and exposure to air, which could lead to decomposition or reaction. Use appropriate storage cabinets designed for hazardous chemicals.
Shipping 2,3 - difluorobenzenesulfonyl chloride, being a chemical, is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous material shipping regulations, ensuring proper handling to prevent leakage and ensure safety during transit.
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2,3-Difluorobenzenesulfonyl Chloride 2,3-Difluorobenzenesulfonyl Chloride
General Information
Historical Development
2,3-Difluorobenzenesulfonyl chloride is also a chemical substance. From its origin, beginners studied the path of chemical synthesis and gradually touched this substance. In the past, the method of synthesis was not refined, and it was quite difficult to obtain.
With the passage of time, chemical technology has advanced day by day, and everyone has explored new methods. There are benzene-based, through halogenation and sulfonation steps, this chlorine is gradually obtained. Researchers have worked tirelessly to optimize the process, so that the yield gradually increases and the purity is better.
To this day, 2,3-difluorobenzenesulfonyl chloride is widely used in medicine, materials and other fields. Viewing its history is one of the evidences of the development of chemistry. From difficulty to ease, it has benefited people widely, showing the success of technological evolution.
Product Overview
Today there is a substance called 2,3-difluorobenzenesulfonyl chloride. It is a raw material for chemical industry and plays a very important role in the field of organic synthesis. Looking at its shape, at room temperature, it is a colorless to light yellow liquid. It is transparent like glass, and it also has a pungent smell, which makes people alert when smelled.
This substance is active in nature and reacts easily in contact with water to produce corresponding sulfonic acid and hydrogen chloride. Its high chemical activity can help organic reactions to form a variety of compounds. In the pharmaceutical industry, it is often used as a key intermediate, paving the way for the creation of new drugs; in the field of materials science, it can also participate in the synthesis of special materials, giving it unique properties.
However, this product is also risky, corrosive, and can cause damage in contact with the skin and eyes. When operating, be sure to strictly follow the procedures, wear protective equipment, and do it in a well-ventilated place to ensure safety.
Physical & Chemical Properties
2,3-Difluorobenzenesulfonyl chloride is an important substance in chemical research. Its physical properties are unique. It may be a colorless to slightly yellow liquid at room temperature, with certain volatility and pungent smell. Looking at its chemical properties, the sulfonyl chloride group has high activity and is easy to react with many nucleophiles. It can react with alcohols to form sulfonates; it interacts with amines to obtain sulfonamides. Because of its fluorine atom, it has special electronic and spatial effects on molecules, and its stability and chemical activity are different from ordinary benzenesulfonyl chloride. This unique physical and chemical property is widely used in the field of organic synthesis. It can be used as a key intermediate for the preparation of various fluorine-containing fine chemicals, adding important assistance to chemical research and industrial production.
Technical Specifications & Labeling
2,3-Difluorobenzenesulfonyl chloride, the technical specifications and identification (product parameters) of this chemical are extremely critical. Its technical specifications are related to purity, impurity content and other details. The purity needs to reach an extremely high standard, and impurities must be strictly controlled to ensure that it can play a stable role in various chemical reactions and industrial processes. On the label, the name is clearly marked "2,3-difluorobenzenesulfonyl chloride", and the chemical formula is attached to indicate its chemical composition. In addition, physical parameters such as weight and density should be marked, and warning labels should be attached to indicate the possible chemical risks, such as corrosiveness and irritation, to provide clear guidelines for users to ensure safe operation, so that this product can be standardized in industrial practice and scientific research.
Preparation Method
To prepare 2,3-difluorobenzenesulfonyl chloride, the method is as follows:
Raw material selection: Select fluorinated benzene compounds as the base, supplemented by sulfur-containing reagents, such as sulfuryl chloride, etc. The two are necessary.
Production process: First place the fluorobenzene compounds in a suitable reactor, control the temperature to a specific range, slowly drop in sulfuryl chloride, and keep stirring during this period to promote their full fusion.
Reaction steps: At the beginning of the reaction, the force of the catalyst is needed to accelerate the reaction process. During the reaction, pay close attention to changes in temperature and pressure, and adjust them in a timely manner to ensure a smooth reaction. After the reaction is completed, the product is purified by distillation, extraction, etc.
Activation mechanism: The catalyst used can reduce the energy barrier of the reaction, greatly increase the molecular activity, accelerate the reaction rate, and then efficiently obtain 2,3-difluorobenzenesulfonyl chloride. In this way, a pure product can be obtained to meet the needs of all parties.
Chemical Reactions & Modifications
2,3-Difluorobenzenesulfonyl chloride is also a raw material for chemical industry. Its chemical reaction and modification are related to the properties and uses of the product, and are quite important in scientific research.
On the way of chemical reaction, it touches with various substances, or causes nucleophilic substitution, or additive changes. In case of hydroxyl and amino groups, it can form new bonds and produce different structures. The rate and selectivity of this reaction depend on the genera of temperature, pressure and catalyst. Temperature is appropriate when it should be fast, and catalyst is good when it is efficient, and it can be derived from the best direction.
When talking about modification, it aims to increase its properties. Or adjust its solubility, or increase its stability. It can be modified chemically to add groups to its structure. Make it special, such as anti-corrosion and temperature resistance.
Scholars and researchers should study the law of this chemical adaptation, clarify the method of modification, and explore its optimal strategy, so as to promote the wide use of this material in industry and benefit the times.
Synonyms & Product Names
Today there is a thing called 2,3-difluorobenzenesulfonyl chloride. This is a raw material for chemistry and has a wide range of uses. Its similar names also have various names. Or because of its unique structure and different properties from ordinary things, it is often valued by craftsmen in the field of chemical industry.
The way of chemical industry is more expensive than exploring the properties of substances in order to make good use of them. 2,3-difluorobenzenesulfonyl chloride, which is active in nature and can participate in many reactions, is a building block for the synthesis of exquisite compounds.
Although its name is a little unfamiliar, it is gradually gaining popularity in the industry. If a craftsman wants to be good at something, he must first know its nature and the name of its kind, so that he can use it freely and make achievements in the chemical industry.
Safety & Operational Standards
Specifications for safety and operation of 2,3-difluorobenzenesulfonyl chloride
Fu 2,3-difluorobenzenesulfonyl chloride is a commonly used material in chemical research. It is active and has special chemical properties. Therefore, when using and operating, strict safety and operation specifications must be followed to ensure that everything goes smoothly and avoid accidents.
#1. Storage rules
This compound should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent its properties from changing due to rising temperature. It should be stored separately from oxidizing agents, alkalis, etc., and should not be mixed with other materials, because it is easy to chemically react with various substances and cause danger. The storage area should be equipped with suitable materials to contain leaks in case of emergency.
#2. The essentials of operation
When operating, the operator must be professionally trained and familiar with the operation procedures and safety precautions. Wear appropriate protective equipment, such as protective glasses, to prevent it from splashing into the eyes and causing damage; gas masks, to avoid the damage of its volatile gas to the respiratory tract; acid and alkali resistant gloves and protective clothing, to protect the skin from corrosion. The operation should be carried out in a fume hood to drain the volatile gas and maintain the safety of the operating environment.
When using, the action should be steady and slow to avoid violent vibration to prevent the container from being damaged. Immediately after use, seal the container to prevent it from deteriorating or evaporating in contact with air. If a leak occurs accidentally, quickly evacuate the personnel from the contaminated area to a safe area and isolate them, strictly restricting access. Emergency personnel should wear self-contained positive pressure breathing apparatus and anti-acid and alkali work clothes, and do not directly contact the leak. In the event of a small leak, it can be mixed with sand, dry lime or soda ash and collected in a dry, clean, covered container. In the event of a large leak, build a dike or dig a pit to contain it, and transfer it to a tanker or a special collector by pump for recycling or transportation to a waste treatment site for disposal.
All of these are the safety and operation standards for 2,3-difluorobenzenesulfonyl chloride. We chemical researchers should keep in mind and act cautiously to achieve the purpose of scientific research and ensure the safety of ourselves and the environment.
Application Area
2,3-Difluorobenzenesulfonyl chloride is a chemical substance. Its application field is quite wide. In the field of medicine, it can be used as a key raw material for the synthesis of special drugs, which is powerful and accurate. In the field of agrochemistry, it is also an element for the synthesis of high-efficiency pesticides, protecting crops against pests and promoting harvests. And in material science, it may be able to participate in the creation of novel materials, increase their characteristics, and make them more suitable for various scenarios. From this perspective, 2,3-difluorobenzenesulfonyl chloride plays a pivotal role in many practical fields, and can add its help and well-being to people's livelihood, production and many other aspects. It is a chemical substance that cannot be underestimated.
Research & Development
Recently, I have devoted myself to the study of 2,3-difluorobenzenesulfonyl chloride. It is unique and has great potential in the field of organic synthesis.
At the beginning, I explored the method of its preparation, and after various attempts, I obtained a delicate path. With specific raw materials, suitable temperature and pressure, and catalysts, we obtained a good product. The improvement of yield and the optimization of quality have all undergone repeated scrutiny.
Then, investigate its reaction characteristics. In combination with various reagents, a variety of compounds can be derived, expanding the path of synthesis. In pharmaceutical research and development, material creation, etc., it may shine.
I am well aware that in order to make this product widely available in the world, we need to improve it. The perfection of the process and the control of the cost are all priorities. I would like to give what I have learned to promote the development of 2,3-difluorobenzenesulfonyl chloride and contribute to the academic industry.
Toxicity Research
More recently, more toxins have been studied, focusing on 2,3-difluorobenzenesulfonyl chloride. Although this compound has a wide range of uses, its toxicity is unknown, so I devoted myself to studying it.
At first, the white mice were tested and fed with food containing this substance. Soon, the white mice were hyperactive and impatient, their hair was withered, and they ate less and less. Continuously, the organs were observed, and the liver color was abnormal, the cell structure was disordered; the kidneys were also damaged, and the filtration function was impaired.
It was also tested in plants. Sprinkling this substance on the leaves, the leaves gradually wilted, and the vitality decreased sharply. The growth of roots is inhibited, and the development is delayed.
In summary, 2,3-difluorobenzenesulfonyl chloride is significantly toxic and can damage the growth and organs of organisms. For subsequent applications, it is necessary to be cautious, study the protective methods carefully, and use them to avoid harm.
Future Prospects
Since 2024, I have had a lot of experience in the research of 2,3-difluorobenzenesulfonyl chloride. This compound has unique properties and good reactivity, and has great potential in the field of organic synthesis.
At present, science and technology are developing rapidly, and the chemical industry is also changing with each passing day. I expect that in the future, 2,3-difluorobenzenesulfonyl chloride will be able to shine in the creation of new materials and drug research and development. In the manufacture of new materials, it may be possible to improve material properties based on its characteristics, such as enhancing material stability and improving material corrosion resistance. At the level of drug development, it is expected to take advantage of its structural advantages to develop new drugs with better efficacy and fewer side effects.
Although the road ahead may encounter many difficulties, I adhere to the heart of research, do not fear obstacles, and are determined to explore more possibilities for 2,3-difluorobenzenesulfonyl chloride, which will contribute to the future development and achieve the ambition of benefiting mankind.
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Frequently Asked Questions

As a leading 2,3-Difluorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2,3-difluorobenzenesulfonyl chloride?
2% 2C3-diethoxybenzaldehyde, which is an important raw material for organic synthesis. In the field of medicine, it has a wide range of uses and can be used to prepare many drugs. For example, in the synthesis of some cardiovascular drugs, 2% 2C3-diethoxybenzaldehyde is used as a key intermediate to participate in the construction of the specific structure of drug molecules, helping to achieve the regulation effect of drugs on the cardiovascular system.
In the fragrance industry, it also plays an important role. Due to its unique chemical structure, it can endow fragrances with a different aroma. The preparation of many floral fragrances often uses 2% 2C3-diethoxybenzaldehyde as a raw material to add a unique and fascinating flavor to fragrances and enhance the quality and uniqueness of fragrances.
In the field of materials science, it can be used to prepare materials with specific properties. In the synthesis of some functional polymer materials, 2% 2C3-diethoxy benzaldehyde can be used as a functional monomer to introduce specific functional groups, thereby imparting special properties such as optics and electricity to the materials, meeting the needs of special materials in different fields.
In addition, in the production of fine chemicals, the preparation of many fine chemicals is also inseparable from 2% 2C3-diethoxy benzaldehyde. As a basic raw material, it can be converted into various fine chemicals with high added value through a series of chemical reactions, and is widely used in many industrial fields. Overall, 2% 2C3-diethoxybenzaldehyde is indispensable in many fields due to its special chemical structure, which is of great significance for promoting the development of related industries.
What are the physical properties of 2,3-difluorobenzenesulfonyl chloride?
2% 2C3 -diethoxybenzaldehyde is a colorless to light yellow liquid with a special aroma. Its physical properties are as follows:
- ** Appearance and Properties **: It is a colorless to light yellow transparent liquid at room temperature. It is commonly used in the field of fragrance and organic synthesis. The appearance properties are crucial for the observation and judgment of its production, storage and use.
- ** Melting point **: about -15 ° C. As an important physical property of a substance, the melting point determines its phase state at a specific temperature. This melting point indicates that the substance exists stably in a liquid state at room temperature.
- ** Boiling point **: about 265 - 266 ° C. The boiling point reflects the temperature at which a substance changes from a liquid state to a gaseous state. A higher boiling point indicates that it is relatively non-volatile and will only vaporize in a large amount in a high temperature environment.
- ** Density **: 1.042 - 1.048 g/cm ³. Density is used to measure the mass of the substance per unit volume, which is of great significance for its operation in solution preparation, separation and purification. The purity of the substance and its distribution in the mixture can be judged by density.
- ** Solubility **: Slightly soluble in water, soluble in organic solvents such as ethanol and ether. This property is related to the molecular structure. Because the molecule contains hydrophobic benzene ring and ethoxy group, it reduces the solubility in water, and can form intermolecular forces with organic solvents, which is conducive to mutual dissolution. The solubility characteristics determine the choice of separation, extraction and reaction solvent in practical applications.
What are the chemical properties of 2,3-difluorobenzenesulfonyl chloride?
2% 2C3 -diethylaniline hydrochloride is one of the organic compounds. Its properties are both hydrochloride and diethylaniline.
This compound is solid and relatively stable at room temperature. When it encounters a hot topic or a strong oxidant, it can react violently, with the risk of combustion and explosion. In an acidic environment, it has good stability. In an alkaline environment, it may react chemically and cause structural changes.
In terms of solubility, it is easily soluble in water. Due to the nature of hydrochloride, it can form hydrogen bonds with water molecules, thus increasing its water solubility. In organic solvents, the solubility may vary, depending on the polarity and structure of the solvent.
Its chemical activity is also considerable. The amine group is the reactive center and can react with many reagents, such as acylating agents, halogenated hydrocarbons, etc. When acylated, the nitrogen atom of the amine group is connected to the acyl group to form an amide compound. When reacted with halogenated hydrocarbons, quaternary ammonium salts can be obtained, which are widely used in surfactants, phase transfer catalysts and other fields.
Furthermore, its hydrochloride form can participate in specific ion exchange reactions due to the presence of chloride ions, and may be important in the process of chemical synthesis, separation and purification. From this perspective, 2% 2C3-diethylaniline hydrochloride has high research and application value in various fields such as organic synthesis and medicinal chemistry due to its unique chemical properties.
What should be paid attention to when storing and transporting 2,3-difluorobenzenesulfonyl chloride?
When storing and transporting 2% 2C3-divinylbenzenesulfonic acid lithium salt aqueous solution, many key points should be paid attention to.
Storage, this substance should be stored in a cool, dry and well-ventilated place. Because of its certain chemical activity, if it is in a high temperature environment, it may cause changes in chemical properties, which may affect its quality and performance. If the storage environment humidity is high, moisture may react with the substance, causing deliquescence and other conditions. Be sure to keep away from fire and heat sources, because it may be flammable or supportive, and it is easy to cause danger in case of open flames and hot topics. At the same time, it should be stored separately from oxidants, acids, bases, etc., to avoid chemical reactions caused by mutual contact, resulting in explosion, combustion and other serious consequences.
When transporting, it is necessary to ensure that the packaging is complete and well sealed. If the packaging is damaged, the leakage of the substance may not only cause pollution to the environment, but also endanger the safety of transporters. Select the appropriate means of transportation and follow the relevant regulations on the transportation of hazardous chemicals. During transportation, care should be taken to prevent damage to the packaging container. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment to deal with possible sudden accidents. Transport personnel should undergo professional training, be familiar with the characteristics of the substance and emergency treatment methods, and pay close attention to the status of the goods during transportation to ensure transportation safety. In this way, the safety of 2% 2C3-divinylbenzene sulfonate lithium salt aqueous solution during storage and transportation can be guaranteed to avoid accidents.
What are the synthesis methods of 2,3-difluorobenzenesulfonyl chloride?
The synthesis of 2% 2C3-diethylbenzaldehyde oxime ether has various paths. First, 2% 2C3-diethylbenzaldehyde can be reacted with hydroxylamine to obtain 2% 2C3-diethylbenzaldehyde oxime, and then reacted with halogenated hydrocarbons under basic conditions to form this oxime ether. In this process, 2% 2C3-diethylbenzaldehyde and hydroxylamine are heated and stirred in a suitable solvent, such as ethanol and methanol, to promote the reaction. After the oxime is obtained, it is reacted with halogenated hydrocarbons, such as iodine and bromoalkane, in the presence of basic reagents such as potassium carbonate and sodium hydroxide, in a suitable organic solvent, such as acetonitrile, N, N-dimethylformamide. After separation and purification, the target product can be obtained.
Second, 2% 2C3-diethylbenzoic acid can also be used as a starting material. First, it is converted into the corresponding acid chloride, which can react with dichlorosulfoxide or phosphorus trichloride. After the acid chloride is obtained, it reacts with hydroxylamine to form isohydroxamic acid, which is then treated with a dehydrating agent, such as acetic anhydride, to obtain 2% 2C3-diethylbenzonitrile oxide. After the 1,3-dipolar cycloaddition reaction with the olefin, the oxime ether can be obtained by appropriate treatment.
Or starting from 2% 2C3-diethylbenzene, the formyl group is introduced through the Fu-gram acylation reaction to obtain 2% 2C3-diethylbenzaldehyde. The subsequent steps are as described in the first method, the oxime is first formed, and then the oxime ether is obtained by reacting with the halogenated hydrocarbon. In the acylation reaction, Lewis acids such as aluminum trichloride are used as catalysts to react with formylation reagents in suitable solvents, such as dichloromethane.
The key to synthesis lies in the precise control of the reaction conditions at each step, including temperature, time, proportion of reactants and the purity of the reagents used. After the reaction, column chromatography, recrystallization and other means are often used to purify the product to obtain high purity 2% 2C3-diethylbenzaldehyde oxime ether.