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What are the main application fields of 3-Difluorobenzeneboronic Acid 98%?
2% 2C3-difluorophenylboronic acid (2,3-Difluorobenzeneboronic Acid), with a content of 98%, has a wide range of main application fields. In the field of medicinal chemistry, it is often a key raw material for the synthesis of new drugs. The structure of genophenylboronic acid can interact specifically with specific targets in organisms. With the introduction of difluorinated substituents, the electron cloud distribution and spatial configuration of molecules can be effectively adjusted, and the affinity between drugs and targets can be improved, thereby enhancing drug efficacy and reducing toxic and side effects. For example, when developing anti-tumor drugs, it can be used to construct pharmacopharmaceuticals with unique activities to contribute to the solution of cancer problems.
In the field of materials science, this compound also plays an important role. First, in the field of organic optoelectronic materials, it can be used as a construction unit to participate in the preparation of high-performance Light Emitting Diode (OLED) materials. Its boron atoms and fluorine atoms endow the material with unique electron transport and luminescence properties, so that the luminous efficiency of OLED devices can be improved and the service life can be extended. Second, in the preparation of functional polymer materials, it can be introduced into the main chain or side chain of the polymer through chemical reaction, giving the material special properties, such as the ability to selectively identify specific metal ions, for the detection of heavy metal ions in environmental monitoring.
In the field of organic synthesis chemistry, 2,3-difluorophenylboronic acid is an important organic boron reagent, which is widely used in various coupling reactions. Such as Suzuki-Miyaura coupling reaction, which is a classic method for constructing carbon-carbon bonds. With its halogenated aromatics or olefins under the action of suitable catalysts and bases, it can efficiently generate biphenyls or alkenylbenzene compounds with specific structures. Such products are key intermediates in the total synthesis of natural products and the creation of new materials, which greatly promote the development of organic synthesis chemistry.
3-Difluorobenzeneboronic 98% of the market price of Acid
Today, there is 2,3-difluorophenylboronic acid, with a purity of 98%. People often inquire about its market price. However, this price often changes for many reasons, and it is difficult to determine a certain number.
First, the trend of supply and demand determines its price. If at some point, the demand for 2,3-difluorophenylboronic acid in various industries increases sharply, such as pharmaceutical synthesis, material research and development, etc., and the supply is limited, its price will rise. On the contrary, if the demand is weak and the supply is abundant, the price will decline.
Second, the price of raw materials is also the key. The production of 2,3-difluorophenylboronic acid requires specific raw materials. When the price of raw materials rises, the production cost increases, and the price of the product also rises; when the price of raw materials falls, the cost decreases, and the selling price may also decrease.
Third, the manufacturing cost is related to the price. The simplicity of the production process, the amount of energy consumption, and the high and low labor costs all affect the cost. If the process is advanced, the energy consumption is low, and the labor is saved, the cost is controllable, and the price is close to the people; if the process is backward and the cost is high, the price will be high.
Fourth, the impact of market competition is considerable. If there are many manufacturers in the market, the competition is fierce, and the price may be reduced in order to compete for a share; if there are few manufacturers, the price may be high
Looking at past transactions, the price fluctuates between tens of yuan and more than 100 yuan per gram. However, this is only the past state. The current price should be checked with chemical raw material suppliers or on the chemical product trading platform to be sure.
What are the synthesis methods of 3-Difluorobenzeneboronic Acid 98%?
There are several common methods for preparing 2,3-difluorophenylboronic acid (2,3-Difluorobenzeneboronic Acid).
One is to use 2,3-difluorobromobenzene as the starting material. First, it is reacted with magnesium chips in an inert solvent such as anhydrous ether or tetrahydrofuran to form a Grignard reagent. This process requires careful operation in an anhydrous and oxygen-free environment, because the Grignard reagent is extremely active. After the Grignard reagent is generated, trimethyl borate is introduced, and then hydrolyzed to obtain 2,3-difluorophenylboronic acid. The reason for its chemical reaction is that the Grignard reagent nucleophilic substitution of trimethyl borate, and the ester group is converted into a boric acid group during hydrolysis.
Second, 2,3-difluoroaniline is used as the starting material. First, it is reacted with sodium nitrite under acidic conditions to make a diazonium salt. Then, the diazonium salt is reacted with boron-containing reagents such as sodium borohydride to prepare the target product. In this method, the diazotization reaction needs to strictly control the temperature and reaction conditions to prevent the decomposition of diazonium salts.
In addition, 2,3-difluorobenzene is used as the raw material. Halogen atoms, such as bromine atoms, are first introduced through a halogenation reaction to generate 2,3-difluorobrobenzene. The subsequent steps are similar to the method using 2,3-difluorobrobenzene as the starting material, that is, the Grignard reagent is first prepared, and then reacted with trimethyl borate and hydrolyzed.
Each of these methods has its own advantages and disadvantages. The method of starting with 2,3-difluorobromobenzene is relatively easy to obtain, but the preparation conditions of Grignard reagent are harsh. The method of starting with 2,3-difluoroaniline has more complicated diazotization reaction steps. In actual synthesis, the appropriate synthesis path should be carefully selected according to the availability of raw materials, cost and requirements for product purity.
3-Difluorobenzeneboronic Acid 98% Quality Standard
2% 2C3 - difluorophenylboronic acid (2% 2C3 - Difluorobenzeneboronic Acid) 98% Quality Standard is related to the criterion for the determination of the quality of this chemical. The appearance of this product is often white to off-white crystalline powder, which is a visual and observable characterization. Its purity is crucial, and the purity of 98% indicates that the impurity content needs to be strictly controlled at a very low level to meet its quality requirements. Impurities or chemical reaction deviation affect the performance of the product. The melting point range is also an important indicator, and a specific melting point range can verify the stability of its material structure and purity. The moisture content is also critical. Excessive moisture or side reactions such as hydrolysis interfere with its chemical activity, so it should be maintained within an appropriate range. In addition, the content of heavy metals should also be strictly limited, because it may have potential adverse effects on subsequent reactions and applications. In short, these many Quality Standards are to ensure that 2% 2C3-difluorophenylboronic acid 98% can play a stable and reliable role in various chemical synthesis, pharmaceutical research and development and other applications.
What are the storage conditions for 3-Difluorobenzeneboronic Acid 98%?
2% 2C3-difluorophenylboronic acid 98% (i.e. 2,3-Difluorobenzeneboronic Acid 98%) is a reagent commonly used in organic synthesis. Its storage conditions are quite important, which is related to its quality and utility.
This reagent should be stored in a cool, dry and well-ventilated place. Because of the cool environment, it can slow down the rate of chemical reactions that may occur, and avoid decomposition or deterioration due to excessive temperature. Dry place, it can prevent it from contacting with water vapor. Boric acids are easy to interact with water, and after absorbing water, they may change their chemical properties, which in turn affects their performance in synthetic reactions. Good ventilation is also indispensable, which can disperse harmful gases that may be generated by trace volatilization of the reagent in time, and preserve the safety of the storage environment.
Furthermore, it should be placed in a sealed container. Sealing can effectively isolate the air and prevent the reaction of gases such as oxygen and carbon dioxide with it. Oxygen may cause oxidation, and carbon dioxide may also chemically change with some components in the reagent, impairing its purity and activity.
When storing, it is also necessary to keep away from fire sources, heat sources and strong oxidants. 2,3-Difluorophenylboronic acid In case of open flame, hot topic or contact with strong oxidants, or there is a risk of combustion or explosion, endangering storage safety and personal safety.
After use, it is necessary to seal the container as it was in time to prevent it from being exposed to air for a long time, in order to maintain its high purity and stable chemical properties, and achieve the desired reaction effect in subsequent use.
