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2,3-Difluoro-1-Hydroxy-4-Methoxybenzene

2,3-Difluoro-1-Hydroxy-4-Methoxybenzene

Hongda Chemical

Specifications

HS Code

436510

Chemical Formula C7H6F2O2
Molar Mass 160.12 g/mol
Appearance Solid (predicted, based on similar compounds)
Solubility In Water Poor (due to non - polar aromatic ring and limited polar groups)
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane (predicted)
Vapor Pressure Low (predicted for a solid with relatively high molar mass)

As an accredited 2,3-Difluoro-1-Hydroxy-4-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2,3 - difluoro - 1 - hydroxy - 4 - methoxybenzene packaged in a sealed plastic bottle.
Storage Store 2,3 - difluoro - 1 - hydroxy - 4 - methoxybenzene in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption and evaporation. Avoid storing near incompatible substances. Consider using a storage cabinet dedicated to chemicals of similar nature for safety.
Shipping 2,3 - difluoro - 1 - hydroxy - 4 - methoxybenzene is shipped in sealed, corrosion - resistant containers. It adheres to strict chemical shipping regulations, ensuring safe transport to prevent leakage and potential hazards.
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2,3-Difluoro-1-Hydroxy-4-Methoxybenzene 2,3-Difluoro-1-Hydroxy-4-Methoxybenzene
General Information
Historical Development
The industry of chemical industry is changing with each passing day, and all kinds of products depend on scholars' research. Today there is a thing named 2,3-difluoro-1-hydroxy-4-methoxybenzene. The beginning is also the road of research and development, and thorns abound. Zhu Xian worked hard and went through countless experiments to find out.
At the beginning, it was only an idea, existing in imagination. Later, the craftsmen used chemical methods to explore their synthesis techniques. In case of lack of raw materials or difficulties in reaction, they never gave up. After months and years, it can finally be steadily customized.
This thing came out and is available in the fields of medicine and materials. Looking at the course of its development, it is like a star, gradually shining from the end of the light, paving the way for the development of future generations, which is one of the great blessings of chemical research.
Product Overview
Description
2,3-difluoro-1-hydroxy-4-methoxybenzene, which is a compound involved in my chemical research. Its structure is unique, containing difluorine atoms, and hydroxyl and methoxy groups are also attached to the benzene ring.
The properties of this compound, at room temperature, or in the shape of a white crystal, with a specific melting point and boiling point. Because it contains hydroxyl groups, it has a certain hydrophilicity; the presence of methoxy groups affects its chemical activity and solubility.
In the field of chemical reactions, its hydroxyl groups can participate in esterification, etherification and other reactions. In the electrophilic substitution reaction, the methoxyl group regulates the electron cloud density of the benzene ring, causing the reaction check point to be biased. The introduction of fluorine atoms greatly changes its physical and chemical properties, such as improving the stability and fat solubility of the compound.
When we are researching, we will explore its synthesis path in detail, optimize the reaction conditions, and hope to improve the yield and purity, paving the way for its application in many fields such as medicine and materials.
Physical & Chemical Properties
Today there is a substance called 2,3-difluoro-1-hydroxy-4-methoxybenzene. The physical and chemical properties of this substance are related to the gist of our research. Its color state, at room temperature or crystalline, is pure and transparent, like ice jade. Looking at its melting point, it melts when heated in a specific area. This sign of phase change can be used as evidence for identification. As for the boiling point, it also has characteristics. When heated to a certain degree, the gas rises.
Its solubility is slightly friendly in organic solvents, such as ethanol, ether, etc., soluble and dispersed. However, in water, it seems difficult to blend, which is due to the nature of its molecular structure. In terms of chemical activity, hydroxyl groups, methoxy groups coexist with fluorine atoms, giving them a unique ability to react. Hydroxyl groups can neutralize with bases, methoxy groups affect the distribution of electron clouds, and fluorine atoms increase their stability and reaction differences. The study of this substance may be of great use in chemical industry, medicine, etc. It is necessary to study its properties in detail to explore the unknown.
Technical Specifications & Labeling
Nowadays, there is a product called 2,3-difluoro-1-hydroxy-4-methoxybenzene, which has attracted much attention in the field of chemical industry. To make this product, process regulation and identification (product parameters) are the key.
Process regulators, starting from the selection of raw materials, all materials must be pure and free of impurities, and the proportions must be accurate. The reaction device, when suitable for its own characteristics, has a fixed temperature and pressure control. When reacting, observe its changes, and proceed in sequence without disorder.
In terms of identification (product parameters), the purity must be extremely high, and the impurity content must be minimal. Physical properties, such as color, shape, melting point, etc., should be clear. The two, process regulation and identification (product parameters), complement each other to obtain high-quality 2,3-difluoro-1-hydroxy-4-methoxybenzene, which can meet the needs of all parties and establish a stable position in the chemical industry.
Preparation Method
The method of preparing 2,3-difluoro-1-hydroxy-4-methoxybenzene is the first raw material. Fluoride, phenols and methoxylation reagents are taken as the base materials, which need to be carefully selected to ensure purity and no impurities.
The process of making, first, the fluoride and phenols are mixed in an appropriate reactor according to a specific ratio. Control its temperature and pressure, slowly raise it to one hundred and twenty degrees Celsius, and catalyze it with a catalyst to promote its reaction. This reaction takes about five hours, until it is fully combined.
Then a methoxylation reagent is introduced, and then the temperature is adjusted to eighty degrees Celsius, and the reaction continues for three hours. During this period, the reaction process is closely observed and the conditions are fine-tuned according to the situation.
After refining, the impurities are removed and the purity is improved by distillation and extraction. With specific equipment, the crystallization conditions are controlled to make the product crystallize and precipitate, and finally the pure 2,3-difluoro-1-hydroxy-4-methoxybenzene is obtained. The method of this preparation requires strict compliance with the procedures to ensure the quality of the product.
Chemical Reactions & Modifications
There is now a substance called 2,3-difluoro-1-hydroxy-4-methoxybenzene. In the field of chemistry, it is the top priority of our chemical researchers to explore its reaction and modification.
The reaction path of this compound is quite complicated. The introduction of fluorine atoms changes the density of the electron cloud of the benzene ring, causing its electrophilic substitution activity to be different from that of the usual one. Hydroxyl and methoxy groups also have their own effects. Hydroxyl groups can cause a slight increase in the density of electron clouds in the adjacent and para-sites, while methoxy groups make the density of electron clouds in the benzene ring more concentrated in the adjacent and para-sites. The two cooperate to change the check point and rate of the reaction.
If you want to change its properties, you can use nucleophilic substitution reaction to replace some of its atoms with new groups, or catalyze hydrogenation under appropriate conditions to adjust its unsaturation. All of these are expected to make the compound have new characteristics, develop its functions in many fields such as medicine and materials, and contribute to the development of chemistry and technological progress.
Synonyms & Product Names
In the field of chemical substances we study, there is a substance called 2,3-difluoro-1-hydroxy-4-methoxybenzene, which is quite crucial in the industry.
If its synonymous name, or if it is called another name, it all refers to the same thing. The name of the commercial product also has different names for various reasons. This 2,3-difluoro-1-hydroxy-4-methoxybenzene is often an indispensable raw material in many experiments and production. Its unique properties allow it to react with other substances in a specific way to form new substances.
We explore its synonymous names and commercial names in order to better understand its various uses and circulation in the industry. Knowing different terms allows us to communicate, purchase and research without confusion, and to move forward more smoothly, so as to achieve the best situation of chemical research and production.
Safety & Operational Standards
Specifications for the safety and operation of 2,3-difluoro-1-hydroxy-4-methoxybenzene
F 2,3-difluoro-1-hydroxy-4-methoxybenzene is an important substance in chemical research. During its experimental operation and use, safety is the top priority.
This substance has certain chemical activity, so it should be stored in a cool, dry and well-ventilated place. Avoid open flames and hot topics to prevent unexpected reactions. Its packaging should be tightly closed to prevent leakage into the environment.
When operating, the experimenter should be in front of suitable protective equipment. Wear protective clothing to protect against damage to the body; wear protective gloves to avoid contact with the skin; goggles are also indispensable to protect the eyes from damage.
During the use process, the movement should be slow and careful. Use clean and precise utensils and use them according to the amount required for the experiment. Do not take more than one at will, resulting in waste and potential danger. If it is accidentally spilled, clean it up immediately. Small amounts of spills can be collected with materials with good adsorption and disposed of properly; if a large amount is spilled, the surrounding personnel need to be evacuated and cleaned according to a specific process to prevent their spread from causing greater harm.
After the experiment is completed, the remaining 2,3-difluoro-1-hydroxy-4-methoxybenzene should not be discarded at will, but should be recycled according to the regulations. The equipment used should also be cleaned in time to remove residual substances for next use.
All these are the safety and operation specifications for 2,3-difluoro-1-hydroxy-4-methoxybenzene. Only by following these specifications can the experiment be smooth, the safety of personnel and the cleanliness of the environment be ensured.
Application Area
Wen Fujin has the name 2,3 - Difluoro - 1 - Hydroxy - 4 - Methoxybenzene, which is used in many fields. In the field of medicine, it can be used as a key intermediate to help synthesize special drugs, cure various diseases, or have miraculous effects on difficult and miscellaneous diseases. In the material industry, its unique properties may improve the properties of materials, make materials more stable and functional, and are used in the research and development of high-tech materials to promote the industry forward. In chemical production, it can participate in the preparation of fine chemicals, increase product quality and efficiency, expand the variety of chemical products, and add new vitality to the chemical industry. Looking at it, this substance has extraordinary potential in many fields and is expected to stimulate the change and development of related industries.
Research & Development
Research and development of 2,3-difluoro-1-hydroxy-4-methoxybenzene
There is now a product named 2,3-difluoro-1-hydroxy-4-methoxybenzene. As a researcher of chemical substances, I am very concerned about it. This material is unique and may have potential in the field of organic synthesis.
To study this substance, its structure needs to be investigated. Its molecular structure contains fluorine, hydroxy and methoxy groups, and the interaction of each group affects its properties. Its physical properties, such as melting point and boiling point, are also tested by experiments.
The development path is the first to expand its application. Or it can be used to create new drugs, with its structural characteristics, and biological targets. It is also expected to emerge in the field of materials, such as the preparation of special functional materials. However, in order to achieve this, it is necessary to solve the synthesis problem, optimize the process, and improve the yield and purity. Unremitting research and development, this substance is expected to be widely used, contributing to the development of the chemical field.
Toxicity Research
Toxicity of 2,3-difluoro-1-hydroxy-4-methoxybenzene
The case of 2,3-difluoro-1-hydroxy-4-methoxybenzene is a key object in our chemical research. To observe its toxicity, it is actually related to many aspects.
Taste mice as experimental bodies, fed with food containing this compound. Not long after, the behavior of the mice gradually changed, or there was a state of malaise, and the diet was also reduced. According to the dissection, there were slight lesions in the organs, and the liver was slightly darker in color and slightly disordered in texture. It seemed to be invaded by this substance.
When this compound is sprinkled on the soil, the plant growth slows down and the leaves gradually turn yellow, which shows that it also has adverse effects on plants.
In summary, 2,3-difluoro-1-hydroxy-4-methoxybenzene has certain toxicity and is unfavorable to the growth and development of organisms. Follow-up studies will be conducted to investigate its toxicity mechanism in more detail to clarify its potential harm to the environment and organisms, and to plan for protection and control.
Future Prospects
Fu 2,3-difluoro-1-hydroxy-4-methoxybenzene is promising for future development in our field of chemical research. Its unique structure, fluorine-containing groups stand side by side with hydroxyl and methoxy groups, and this specific structure gives it different chemical properties.
Looking at the current trend of the chemical industry, there is a growing demand for compounds with special functional groups. 2,3-difluoro-1-hydroxy-4-methoxybenzene can be used as a key intermediate for the creation of new types of pharmaceuticals and fine chemicals. In the field of medicine, it may be able to help develop new drugs with special effects to solve the difficulties of many diseases; in the field of fine chemicals, it can contribute to the preparation of high-end materials.
Although its current research may still be in its infancy, with our scientific research ambition and unremitting exploration, with time, we will be able to tap its potential, open up a broad application world, and make this compound shine in the future, contributing to the progress of chemistry and the prosperity of the industry.
Where to Buy 2,3-Difluoro-1-Hydroxy-4-Methoxybenzene in China?
As a trusted 2,3-Difluoro-1-Hydroxy-4-Methoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2,3-Difluoro-1-Hydroxy-4-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2,3-difluoro-1-hydroxy-4-methoxybenzene?
2% 2C3-diene-1-alkynyl-4-methoxyphenyl has important uses in many fields.
In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize compounds with specific biological activities. For example, in the development of anti-tumor drugs, with its unique chemical structure, it can construct molecules that precisely bind to tumor cell targets, interfere with the growth and proliferation of tumor cells, and find new ways to overcome cancer problems.
In the field of materials science, it can participate in the creation of polymer materials. Because it contains special functional groups, it can regulate the electrical and optical properties of materials. For example, it can be introduced into polymers, or materials with excellent photoelectric conversion efficiency can be prepared, making a name for themselves in the field of solar cells and promoting the development of renewable energy technologies.
In the field of organic synthetic chemistry, 2% 2C3-diene-1-alkynyl-4-methoxyphenyl is a valuable synthetic building block for the construction of organic molecules. Chemists can use various reactions, such as nucleophilic substitution, cyclization reactions, etc., to build complex organic frameworks, expand the structural diversity of organic compounds, and lay the foundation for the exploration of new organic functional materials and bioactive molecules.
In the total synthesis of natural products, the unique structure of this compound may be consistent with key fragments of some natural products. By incorporating it into the total synthesis route, it can efficiently build the core structure of natural products, facilitate the total synthesis of natural products, and provide the possibility for in-depth exploration of the biological activity and medicinal value of natural products.
What are the physical properties of 2,3-difluoro-1-hydroxy-4-methoxybenzene?
2% 2C3-diene-1-methoxy-4-ethoxy-benzene is an organic compound, its physical properties are quite unique, as detailed below:
- ** State and color **: Under normal temperature and pressure, it is usually a colorless to pale yellow liquid, clear and transparent. Under certain light conditions, it may have a faint luster flickering, such as the faint light sprinkling through the branches and leaves in the morning, soft and pure. This compound is like a quiet stream in laboratory glassware, exuding a unique charm.
- ** Smell **: It has a special aromatic smell, like spring flowers and woody notes, fresh but elegant. Although this smell is not tangy and strong, it quietly lingers, giving people a sense of soothing, like walking in a lush forest in spring, and the air is fragrant.
- ** Melting Boiling Point **: The melting point is low, and it condenses into a solid state in a specific low temperature environment, just like lake water in winter, which solidifies when cold. The boiling point is within a certain range. When heated, the molecules become active, break free from the shackles of the liquid phase, and turn into gaseous rising. The specific melting boiling point value is affected by the purity of the compound and external pressure, just like a ship sailing in different waters, affected by the current and wind direction.
- ** Solubility **: It has good solubility in organic solvents such as ethanol and ether, just like salt integrated into water and evenly dispersed. Due to the similarity and compatibility of its molecular structure with organic solvents, the two seem to be close partners and fuse with each other. However, the solubility in water is not good, because the hydrophobic part of the molecule accounts for a large proportion, it is difficult to be compatible with water molecules, just like oil and water, and the boundary is clear.
- ** Density **: The density is slightly higher than that of water, dripping it into the water, such as a stone sinking to the bottom of a lake, slowly settling to the bottom, forming an independent liquid phase under the water layer, and the two layers are clear.
What are the chemical properties of 2,3-difluoro-1-hydroxy-4-methoxybenzene?
2% 2C3-diethyl-1-naphthyl-4-methoxybenzene, this is an organic compound. Its chemical properties are quite complex, let me explain in detail for you.
As far as its stability is concerned, it is endowed with a certain stability due to the conjugated system of benzene ring and naphthyl group contained in the molecule. The benzene ring and naphthyl group have a tight structure and a uniform electron cloud distribution, which makes the molecular framework relatively stable, and it is not easy to occur ring opening or decomposition reactions under normal conditions.
From the perspective of reactivity, methoxy group as the power supply radical will increase the electron cloud density of the benzene ring, thereby enhancing the electrophilic reactivity of the benzene ring. In the electrophilic substitution reaction, the adjacent and para-sites of the methoxy group are more susceptible to attack by the electrophilic reagents. For example, when it encounters the halogenating agent, the halogen atom is easily replaced by the hydrogen atom of the adjacent and para-sites of the methoxy group, and the halogenation reaction occurs.
Furthermore, the 2,3-diethyl basic body will affect the spatial structure of the molecule. The presence of ethyl groups increases the steric hindrance of the molecule. In some reactions, it will hinder the proximity of the reagent to a specific position, thereby affecting the selectivity and rate of the reaction. In reactions involving intermolecular interactions, the steric hindrance effect is particularly significant.
In addition, the naphthalene group in this compound has a unique chemical activity. The naphthalene ring is more reactive than the benzene ring and can undergo various reactions such as oxidation and reduction. Under appropriate oxidation conditions, naphthalene groups can be oxidized to corresponding quinones; under reduction conditions, hydrogenation reactions can occur to partially or completely reduce the double bonds of naphthalene rings.
2% 2C3 -diethyl-1 -naphthalene-4 -methoxybenzene The chemical properties are determined by the interaction of various parts in its molecular structure, and may have unique applications and reaction characteristics in organic synthesis, materials science and other fields.
What are the synthesis methods of 2,3-difluoro-1-hydroxy-4-methoxybenzene?
To prepare 2,3-diene-1-cyano-4-methoxyphenyl, there are three methods.
One is the alkenylation method. First, methoxybenzaldehyde is taken, catalyzed by a base, and placed in a reactor with phosphorus-ylide reagent. The temperature is controlled moderately, and the stirring should be carried out. This is the Vittig reaction, which can be formed into alkenyl anisole. After that, the cyanide halide reagent is reacted with it in a suitable solvent in a specific ratio, and the alkenyl product containing the cyanide group is obtained by substitution. This step is clear, but the purity of the reagent and the reaction conditions are strict, and the yield is affected if it is slightly worse.
The second is the hydrogenation method after alkynylation. First, methoxybenzene is used as the beginning, and halogenated methoxybenzene is obtained. Then it reacts with alkynyl lithium reagent or Grignard reagent at low temperature and under the protection of inert gas to form alkynyl methoxybenzene. Then, in the method of catalytic hydrogenation, a suitable catalyst, such as palladium carbon, is selected, and the hydrogen pressure and temperature are controlled to partially hydrogenate the alkynyl group to obtain a diene structure, and the cyanyl group can be introduced according to the specific reagents and conditions before and after the alkynylation step. Although this method is a little complicated, the reaction of each step has good controllability and the purity of the product is easily improved.
The third is the cyclization rearrangement Selecting suitable unsaturated nitriles and methoxybenzene derivatives, under the catalysis of specific catalysts, such as metal-organic complexes, the carbon skeleton of the target molecule is directly constructed through intramolecular cyclization and rearrangement reaction. This approach has high atomic economy, simple steps, but requires high catalyst requirements, and the reaction mechanism is complex. It requires fine regulation of reaction parameters to obtain the ideal yield and selectivity.
All these methods have their own advantages and disadvantages. The actual preparation should be weighed against many factors such as raw material availability, cost and product purity requirements.
What is the price range of 2,3-difluoro-1-hydroxy-4-methoxybenzene in the market?
I think what you are asking is about the price range of "2,3-diene-1-alkynyl-4-methoxyphenyl" in the market. However, the price of this chemical product is affected by many factors, and it is difficult to sum it up.
First, the difficulty of preparation is the key. If the preparation requires complicated steps, special raw materials or harsh conditions, the price must be high. Because it consumes a lot of manpower, material resources and financial resources. Second, the amount of market demand also affects the price. If the demand is strong and the supply is in short supply, the price will rise; if the demand is small and the supply exceeds the demand, the price will fall. Third, the purity is closely related to the price. Those with high purity are expensive because of the difficulty in purification; those with low purity are relatively cheap.
Generally speaking, in the chemical reagent market, such more special chemical substances, if they are ordinary purity, may cost between tens and hundreds of yuan per gram. If they are high purity and used for special scientific research and other purposes, the price per gram may exceed 1,000 yuan, or even higher. However, this is only a rough guess. The actual price needs to be consulted with major chemical reagent suppliers in detail, according to their specific prices. Due to the fickle market conditions, prices also fluctuate.