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2,3,6-Trifluorobenzeneboronic Acid

2,3,6-Trifluorobenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

353913

Chemical Formula C6H4BF3O2
Molecular Weight 175.90
Appearance White to off - white solid
Melting Point 135 - 139 °C
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane
Pka Around 8.5 (approximate value for boronic acid group)
Boiling Point Decomposes before boiling
Density 1.49 g/cm³ (approximate)

As an accredited 2,3,6-Trifluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2,3,6 - trifluorobenzeneboronic acid packaged in a sealed plastic bottle.
Storage 2,3,6 - trifluorobenzeneboronic acid should be stored in a cool, dry place. Keep it in a tightly - sealed container to prevent contact with moisture, which can lead to hydrolysis. Avoid storing near heat sources or direct sunlight. Store away from incompatible substances like strong oxidizing agents to ensure its stability and prevent potential chemical reactions.
Shipping 2,3,6 - trifluorobenzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict chemical transportation regulations, ensuring protection from moisture, heat, and physical damage during transit.
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2,3,6-Trifluorobenzeneboronic Acid 2,3,6-Trifluorobenzeneboronic Acid
General Information
Historical Development
"Biography of 2,3,6-Trifluorophenylboronic Acid"
The author of 2,3,6-trifluorophenylboronic acid is also an important agent in organic synthesis. Its beginning originated from the study of fluorine-containing compounds by various scholars. In the past, organic chemistry was prosperous, and fluoride synthesis was difficult, and everyone sought breakthroughs.
At that time, everyone worked hard and searched for complicated reactions. At the beginning, the road of synthesis was full of thorns, the yield was low, and impurities were overgrown. However, the heart of scholars was firm and determined. After years of hard work, the method of preparation was finally obtained, and 2,3,6-trifluorophenylboronic acid began to appear in the world.
Since then, it has shone in the fields of medicine and materials. Pharmaceutical research and development relies on it to make special drugs; material creation relies on it to become novel materials. Looking at its history, it has gradually become the most important in the industry, which is one of the great events in the development of chemistry.
Product Overview
Description of 2,3,6-trifluorophenylboronic acid
Fu 2,3,6-trifluorophenylboronic acid is a particularly important chemical in the field of organic synthesis. Its appearance is often white to off-white crystalline powder, stable in properties, and can be stored for a long time under specific conditions.
This product has a unique chemical structure. The trifluoro group is related to the phenylboronic acid structure, giving it special chemical activity. In organic synthesis reactions, it is often used as a key intermediate. With the activity check point of phenylboronic acid, it can participate in many coupling reactions, such as the Suzuki-Miyaura reaction, to help build complex organic molecular structures.
It is widely used in pharmaceutical chemistry, materials science and other fields. In pharmaceutical research and development, by participating in specific reaction paths, it may be able to help create new drug molecules, providing the possibility to overcome difficult diseases; in the field of materials science, it may be used to prepare materials with special photoelectric properties, promoting the development of high-tech materials.
Physical & Chemical Properties
The physical and chemical properties of 2,3,6-trifluorophenylboronic acid are crucial. Looking at its properties, it is often in the shape of white to off-white powder, which is visible to the naked eye. Regarding its melting point, it is about a specific range. Due to the existence of fluorine atoms in the molecular structure, the intermolecular forces are different, so the melting point has its unique characteristics.
In terms of solubility, it has a certain solubility in common organic solvents such as ethanol and acetone, which is caused by the interaction between its molecular polarity and solvent polarity. In terms of chemical activity, because it contains boron atoms and benzene rings, it has a certain electrophilicity and can react with many nucleophiles, which is widely used in the field of organic synthesis. And its stability is acceptable under normal conditions, but when it encounters strong oxidizing agents, strong bases, etc., the structure may change. These are all important physical and chemical properties of 2,3,6-trifluorophenylboronic acid.
Technical Specifications & Labeling
Today there is a product named "2,3,6 - Trifluorobenzeneboronic Acid". In the technical specification and identification of the product (commodity parameters), it should be studied in detail.
Those who have technical specifications, from the selection of materials, must be pure and fine, the amount of impurities, and the amount of micro-powder. The method of synthesis must follow precise steps. The temperature and humidity, reaction time, etc. are all fixed, and a slight difference may affect the quality.
In terms of identification (commodity parameters), the purity geometry, color and shape are all key. The purity should be of the highest quality, the color should be correct, and the shape should be in line with the standard. In this way, the quality of this "2,3,6 - Trifluorobenzeneboronic Acid" can be ensured to meet the needs of all parties and be used to the fullest extent in the chemical industry.
Preparation Method
The preparation of 2,3,6-trifluorophenylboronic acid is related to the raw materials and production process, reaction steps and catalytic mechanism. In the past, if you want to make this product, you must first obtain suitable raw materials. Based on fluorinated benzene compounds and boron sources, these two are the key things.
As for the production process, it is formed by multi-step reaction. Initially, fluorinated benzene and initiator are co-located to promote its activity under a specific temperature and pressure. Then a boron source is introduced to control the reaction rate and process. Among them, each step needs to be precisely controlled, and temperature, humidity and reaction time are all important factors.
The reaction step is also quite exquisite. First start the preliminary reaction, make the raw materials initially combine, and then after several transformations, the structure gradually tends to the target product. And each step needs to be tested to ensure that its purity and direction are correct.
In the catalytic mechanism, the appropriate catalyst is selected to lower the reaction barrier and promote the efficient reaction. The amount and activity of the catalyst have a great impact on the product. After the reconciliation of many processes, this 2,3,6-trifluorophenylboronic acid can be obtained.
Chemical Reactions & Modifications
I tried to study 2,3,6 - Trifluorobenzeneboronic Acid. Its reaction rate and yield are related to the purity of the product. In the past, the method may be inconvenient, the yield is not high, and the product is heterogeneous and impure.
I thought deeply about it, and wanted to change its properties. After various attempts, observe the influence of the proportion of reactants, temperature, and solvent. Adjust it in a suitable proportion, control the temperature at a precise degree, and choose the appropriate solvent to make the reaction great. The yield rises, and the product is also pure.
From this point of view, in the chemical reaction, we should carefully study the various factors and improve the conditions in order to obtain high yield. This is my research 2, 3, 6 - Trifluorobenzeneboronic Acid's income, hope for the industry to learn from.
Synonyms & Product Names
2,3,6-Trifluorophenylboronic acid is particularly important in the field of my chemical research. Its synonymous names, or other names, all refer to the same thing. Although the names sold in the market may be different, their essence is 2,3,6-trifluorophenylboronic acid.
Looking at the chemical inquiry of ancient times, although there were no precision instruments of today at that time, many Fang families also studied various substances with diligence and intelligent thinking. Today's 2,3,6-trifluorophenylboronic acid has unique abilities in the synthesis and reaction process. It can help to synthesize other things, or play an important role in special reactions. As researchers, we should carefully study its synonymous names and commodity names, clarify its essence, explore its characteristics, and benefit the progress of chemical research, hoping to contribute to the academic community and gain a deeper understanding of the mysteries of matter.
Safety & Operational Standards
Specifications for the safety and operation of 2,3,6-trifluorophenylboronic acid
Fu 2,3,6-trifluorophenylboronic acid is a substance commonly used in chemical research. During its experimental operation, safety and norms are of paramount importance.
The most important thing to be safe is protection. Experimenters should wear appropriate laboratory clothes, which can resist the erosion of chemical substances on the clothes and protect the body from splashing. And protective gloves should be worn, and chemical-resistant materials should be selected to prevent direct contact from causing skin irritation or absorption. Eye protection should not be ignored. Goggles or masks can prevent substances from splashing into the eyes and avoid eye injuries.
Operating environment must be well ventilated. This substance may evaporate harmful gases. Good ventilation can quickly discharge harmful substances, reduce the concentration in the air, and ensure the safety of the experimenter's breathing. The operating table should be neat and orderly, and the debris should be removed to avoid interfering with the operation and causing accidents.
When taking it, the action should be stable and accurate. Use clean and dry appliances to take it accurately according to the required amount. During the weighing process, the balance needs to be calibrated correctly to ensure accurate measurement. If it is accidentally spilled, do not panic, and clean it up according to the established procedures. Turn off the relevant equipment first to avoid the spread of substances. Then use suitable adsorption materials, such as sand, vermiculite, etc., carefully collect the spills, put them in designated containers, and dispose of them according to regulations.
Storage is also exquisite. It should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Due to its active chemical nature, improper storage or reaction can cause danger. Different batches of products should be classified and stored, with clear labels for easy access and management.
In short, in the research operation of 2,3,6-trifluorophenylboronic acid, strictly abide by safety and operating standards to ensure the smooth operation of the experiment, protect the health of the experimenter, and avoid environmental pollution.
Application Area
2,3,6-Trifluorophenylboronic acid is also used as a chemical compound. Its use is very important in the field of synthesis, and it is often used in the field of synthesis. It can be used to create multiple reactions, to build molecules, to help research new and general diseases. In the context of materials science, it can be used to create special materials to increase their properties, such as reliability and qualitative properties. It can also be used in the synthesis of chemical, chemical and biological compounds, and the means of enrichment and synthesis. The complexity of its uses makes chemical research, engineering and production all the best. It is a step to promote the development of chemical fields, and to explore new ways of multi-application fields.
Research & Development
In recent years, I have learned a lot from the research of 2,3,6 - Trifluorobenzeneboronic Acid. This compound has unique properties and is widely used.
At the beginning, the synthesis method was not good, and the yield was quite low. My colleagues and I studied day and night, consulted classics, and tried again and again. After countless hardships, we finally got the optimization method, and the yield gradually increased.
And explored its reaction mechanism to understand its characteristics in various chemical reactions. With this understanding, it expanded its application field, and has been gained in medicine and materials.
Looking to the future, we should make unremitting efforts to study 2,3,6 - Trifluorobenzeneboronic Acid in depth, hoping to explore more potential, promote its wide application, and contribute to the academic and industrial circles, and promote the sustainable development of this field.
Toxicity Research
Study on the toxicity of 2,3,6-trifluorophenylboronic acid
The existing substance 2,3,6-trifluorophenylboronic acid, in my chemical research, its toxicity study is the key. I carefully observe its characteristics and explore it with ancient methods.
First observe its reaction with various substances, and observe its changes in a specific medium. When this substance encounters active metals, the reaction is intense. However, whether the released substance is toxic or not needs to be screened in detail.
Then test it with biological organisms, take a few insects, and place it in an environment containing this substance. Over time, observe the changes in its behavior and shape. Some insects move slowly and have different body shapes, which seem to be disturbed by its poison.
Analyze its diffusion in the environment, and measure its retention and migration in water, soil and other media. It is found that it has a certain solubility in water, and can migrate with water flow, or cause damage to surrounding aquatic organisms. In summary, the toxicity of 2,3,6-trifluorophenylboronic acid cannot be underestimated, and follow-up studies should be more in-depth to clarify its harm and prevent its disease.
Future Prospects
I have tried to study chemical things, and now look at 2,3,6 - Trifluorobenzeneboronic Acid. Its unique nature, in the field of synthesis, the potential is infinite. Although today's research has been successful, the future prospects are even more grand.
Or it can be used in pharmaceutical creation. With its special structure, it can find a new way to resist diseases, cure various diseases, and solve the suffering of everyone. It is also expected that in the advancement of materials, it can help the birth of new materials, and make equipment and appliances more sophisticated.
And technology is new, and research methods should also keep pace. In the future, we will be able to explore more wonders and use it widely, for the well-being of the world. This is the hope of my generation of chemical researchers, looking forward to the future, shining brightly, and doing my best for the prosperity of the industry and the progress of the world.
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Frequently Asked Questions

As a leading 2,3,6-Trifluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 2,3,6-trifluorophenylboronic acid?
2% 2C3% 2C6-tribromobenzoic acid has unique chemical properties, and each shows its own ability in various chemical processes.
Its reactivity, the interaction of carboxyl groups with benzene rings and bromine atoms, makes it acid-like. It can neutralize with bases, such as combining with sodium hydroxide to form 2% 2C3% 2C6-tribromobenzoic acid and water. This reaction is like the fusion of acid and base, each of which changes to form a new product.
And because of the bromine atom on the benzene ring, it can involve the reaction of nucleophilic substitution. Halogen atoms are easily attacked by nucleophiles. In case of nucleophiles such as sodium alcohol, bromine atoms can be replaced by alkoxy groups to obtain corresponding ether products. This is the clever part of chemical change, the translocation of atoms, the change of structure, and the generation of new substances.
and 2% 2C3% 2C6-tribromobenzoic acid are often the key raw materials in organic synthesis. Due to its special structure, it can be introduced into various functional groups through various reactions to form complex organic molecules. In the field of drug synthesis, it may also be able to find traces, contributing to the creation of new drugs.
Furthermore, it can be used as a supporting role in some chemical reaction systems or as a catalyst. Although it does not dominate the process of the reaction, it may be able to fine-tune the rate and direction of the reaction, just like a boat traveling in water, with the help of the breeze, the course is slightly changed, and it finally reaches a different path.
Looking at its physical properties, or in a solid state, it has a certain melting point and boiling point. This property is also useful in separation, purification and identification. Its solubility varies in different solvents. For organic solvents such as ethanol and ether, it may have a certain solubility, while for water, it may be slightly soluble or even insoluble, which is due to the polarity and structure of the molecule.
What are the common synthesis methods of 2,3,6-trifluorophenylboronic acid?
The common synthesis methods of 2% 2C3% 2C6-trifluoromethylbenzoic acid are as follows:
First, p-trifluoromethyltoluene is used as the starting material. This raw material can be oxidized by strong oxidants such as potassium permanganate. In a suitable reaction vessel, add p-trifluoromethyltoluene, an appropriate amount of water and sodium hydroxide solution, slowly heat up, add potassium permanganate solution dropwise under stirring, and the reaction continues. After the reaction is completed, 2% 2C3% 2C6-trifluoromethylbenzoic acid can be obtained through cooling, filtration, acidification and other steps. The raw materials for this method are relatively easy to obtain, but the reaction conditions are relatively strict, and the degree of oxidation needs to be precisely controlled, otherwise it is easy to over-oxidize and affect the yield and purity of the product.
Second, take trifluoromethyltoluene as the starting Under the action of light or catalyst, trifluorotoluene reacts with bromine to form bromotrifluorotoluene. Subsequently, bromotrifluorotoluene reacts with magnesium to form Grignard reagent, Grignard reagent reacts with carbon dioxide, and finally is acidified to obtain the target product. This method has a little more steps, but the reaction selectivity of each step is relatively good, which is conducive to improving the purity of the product.
Third, trifluoroacetic anhydride and m-bromotoluene are used as raw materials. The two react in the presence of an appropriate catalyst to form an intermediate product, which is then hydrolyzed and other subsequent reactions to obtain 2% 2C3% 2C6-trifluoromethylbenzoic acid. This synthesis path cleverly uses acylation reaction to effectively construct the target molecular structure, but it requires high reaction conditions and catalysts, and the cost is relatively high.
In which fields is 2,3,6-trifluorophenylboronic acid used?
2% 2C3% 2C6-trifluoromethylbenzoic acid has important applications in the fields of medicine, pesticides, and materials.
In the field of medicine, it can be used as a key intermediate to prepare a variety of drugs. For example, in the development of anti-tumor drugs, with the help of its unique chemical structure, it can modify drug molecules, enhance the targeting and affinity of drugs to tumor cells, and improve the efficacy. Like a new type of anti-cancer drug, the introduction of this structure significantly enhances the inhibitory activity of cancer cells and reduces the toxic side effects on normal cells.
In the field of pesticides, it can be used as a raw material to synthesize high-efficiency, low-toxicity, and environmentally friendly pesticides. Due to its fluoride-containing properties, it can enhance the stability, fat solubility and biological activity of pesticides. For example, the fluorinated insecticide produced has strong contact and stomach toxicity to pests, has a long shelf life, can effectively control a variety of crop pests, and ensure crop yield and quality.
In the field of materials, it can be used to synthesize polymer materials with excellent performance. Introducing it into the polymer structure can give the material excellent weather resistance, chemical corrosion resistance and electrical properties. For example, by adding related fluoropolymers to high-end coatings, the coatings can have good wear resistance, acid and alkali resistance and UV resistance, and are widely used in high-end fields such as aerospace and automobiles.
2% 2C3% 2C6-trifluoromethylbenzoic acid plays a key role in many fields due to its unique chemical properties, promoting technological progress and development in various industries.
What is the market price range for 2,3,6-trifluorophenylboronic acid?
2% 2C3% 2C6-trifluoromethylbenzoic acid, the price range of the market is difficult to determine. The change in its price is related to various factors.
First, the situation of supply and demand. If there are many people in the market, but the amount of production is small, the price will tend to rise; on the contrary, if the supply exceeds demand, the price may drop.
Second, manufacturing costs. Among them, the price of raw materials, labor costs, equipment consumption, etc. are all related to the cost. If raw materials are expensive, or labor costs rise, the cost will increase and the price will also rise.
Third, the state of market competition. Competition in the same industry, or to occupy the market, or to cut prices to compete for customers, or to improve quality to show superiority. When competition is fierce, the price may change due to it.
Fourth, decrees and regulations. If there are tariff adjustments, environmental protection regulations, etc., it can also affect the price. Tariff increases the cost, and strict environmental protection increases the manufacturing cost, all of which can cause the price to rise.
Looking at the past examples of chemical prices, the price of 2% 2C3% 2C6-trifluoromethylbenzoic acid often fluctuates between hundreds and thousands of yuan per kilogram. However, this is only a rough figure, not an exact value. To know the real-time price, you can obtain the accurate price by consulting the latest offers from the industry, brokers, or chemical trading platforms.
What are the storage conditions for 2,3,6-trifluorophenylboronic acid?
For 2% 2C3% 2C6-tribromobenzoic acid, the conditions for storage are very important. This medicine should be placed in a cool, dry and well-ventilated place.
If it is cool, the temperature may be too high, or it may cause its chemical change and damage its quality. If it is exposed to the hot sun or high temperature on a hot summer day, it is feared that its molecular structure will move and lose its original effect. Therefore, it is appropriate to choose a cool place, often at room temperature of 20 degrees Celsius, but if it is too high, it is not appropriate.
A dry environment is also important. Tribromobenzoic acid is prone to deliquescence when wet. Moisture enters, or causes it to dissolve and change qualitatively, and the medicinal power gradually fades. And in the humid place, it is easy to produce molds and other substances, which stain its body. When it is protected from water and moisture, a desiccant can be placed in the storage place to absorb its moisture and keep it dry.
Well ventilated, so that the air circulates. If the place is blocked, the gas of medicine must not dissipate, or cause odor to accumulate, and the air is not new, and the temperature and humidity are difficult to adjust. The circulating air can slow down the speed of its deterioration, and also ensure that its environment is clean and free of foul gas.
Furthermore, when it is stored, it should be separated from other objects. Do not store with oxidants, strong alkalis, etc., to prevent chemical reactions and dangerous conditions. And it should be filled in a sealed device to keep air and moisture away, and it has all its properties. In this way, the quality of 2% 2C3% 2C6-tribromobenzoic acid is guaranteed for later use.