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2,3,5-Trifluorobenzeneboronic Acid

2,3,5-Trifluorobenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

861155

Chemical Formula C6H4BF3O2
Molar Mass 175.90 g/mol
Appearance White to off - white solid
Cas Number 179288-69-4
Melting Point 143 - 147 °C
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, tetrahydrofuran
Purity Typically Available 95%+
Boiling Point Decomposes before boiling
Acidity Pka Approximately 8 - 9 (estimated for boronic acid group)

As an accredited 2,3,5-Trifluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2,3,5 - trifluorobenzeneboronic Acid in a sealed, chemical - resistant bottle.
Storage 2,3,5 - trifluorobenzeneboronic acid should be stored in a cool, dry place. Keep it in a tightly sealed container to prevent moisture absorption and contact with air, as boronic acids can react with water and oxygen over time. Store away from heat sources and incompatible substances like strong oxidizing agents to maintain its stability and integrity.
Shipping 2,3,5 - trifluorobenzeneboronic acid should be shipped in well - sealed, corrosion - resistant containers. Ensure proper labeling indicating it's a chemical. Ship via a carrier compliant with hazardous chemical transport regulations, keeping it away from heat and incompatible substances.
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2,3,5-Trifluorobenzeneboronic Acid 2,3,5-Trifluorobenzeneboronic Acid
General Information
Historical Development
I am committed to the research of 2,3,5-trifluorophenylboronic acid. The development of this compound has gone through twists and turns. At the beginning, exploring the method of its preparation was like finding a path in the dark night. In the past, various sages worked hard in the field of organic synthesis, gradually accumulating experience.
At that time, organic chemistry was flourishing, and many techniques were not yet mature. It was difficult to obtain this acid. However, the ancestors worked tirelessly, starting from the basic reaction, adjusting the conditions, and trying new agents. After countless trials and errors, they finally found a feasible method. From the initial crude method to the gradual optimization, the yield and purity have been improved. Nowadays, 2,3,5-trifluorophenylboronic acid is increasingly used in the fields of medicine and materials. It is the work of scholars of all ages that has made this compound famous from nowhere, leaving a profound track in chemistry.
Product Overview
Nowadays, there is a substance called 2,3,5-trifluorophenylboronic acid (2,3,5-Trifluorobenzeneboronic Acid). This substance is an important reagent in organic synthesis and has a wide range of uses in medicine, materials and many other fields. Its appearance is often white to light yellow crystalline powder, and its properties are relatively stable.
Structurally, there are three fluorine atoms and a boric acid group attached to the benzene ring. The introduction of fluorine atoms gives it unique electronic and spatial effects, which affect the polarity, solubility and reactivity of molecules. Boric acid groups have good reactivity and can participate in a variety of organic reactions, such as the Suzuki-Miyaura coupling reaction, to form carbon-carbon bonds and realize the synthesis of complex organic molecules. In practical applications, with its special structure and reactivity, it can precisely modify the molecular structure and optimize the pharmacological activity and pharmacokinetic properties of drugs when creating new drug molecules. In the field of materials, it also helps to synthesize materials with special photoelectric properties and promote the development of related fields.
Physical & Chemical Properties
The physicochemical properties of 2,3,5-trifluorophenylboronic acid are crucial. Looking at its properties, it may be white crystalline at room temperature, which is related to its external physical performance. Regarding its melting point, under a specific temperature, there is a change in the state of matter, which is one of its thermal characteristics.
Its solubility is also not negligible, and it may be soluble to varying degrees in common organic solvents. This is due to the characteristics of fluorine atoms and boron atoms in the molecular structure, which affect the interaction between them and solvent molecules. And its chemical stability is also determined by its structure. The combination of benzene rings with fluorine and boron groups gives it unique chemical activity. Such various physical and chemical properties are of great significance in the fields of chemical synthesis, pharmaceutical research and development, and serve as the foundation for related research and applications.
Technical Specifications & Labeling
Regarding the technical specifications and labels of 2,3,5-trifluorophenylboronic acid (commodity parameters)
Fu 2,3,5-trifluorophenylboronic acid is an important chemical product. Its technical specifications are related to the quality. When preparing, the raw materials must be pure, the ratio is accurate, and the reaction conditions should be strict. Temperature, pressure, and reaction time are all key. If the reaction temperature is controlled within a certain range, otherwise the product is impure.
In terms of its identification, the commodity parameters must be detailed. From the appearance point of view, its color and shape should be described, such as white crystalline powder. Regarding purity, the exact value needs to be indicated, which is essential for measuring quality. There are also parameters such as molecular weight and molecular formula, which cannot be omitted to help users understand their chemical properties. In this way, this chemical can be put to good use in the fields of scientific research and industry, and contribute to the chemical industry.
Preparation Method
The method of preparing 2,3,5-trifluorophenylboronic acid is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials are selected from fluoroaromatic hydrocarbons and boron sources. The first step of halogenation of fluoroaromatic hydrocarbons is to obtain halogenated aromatic hydrocarbons, which is the key to the initiation of the reaction.
Next, halogenated aromatics and boron are derived from a specific catalytic system, and the reaction is carried out under suitable reaction conditions, such as temperature, pressure and reaction time. Among them, the catalytic mechanism is very important, and metal catalysts are commonly used to promote the efficient reaction by means of their activity check points.
After boration reaction, the product is separated and purified by a series of methods, such as extraction, distillation, recrystallization, etc., to remove impurities and improve purity, and finally obtain high-purity 2,3,5-trifluorobenzene boronic acid. Each step of the whole process is closely linked, and the raw materials, reaction and post-processing are carefully controlled to obtain high-quality products.
Chemical Reactions & Modifications
Nowadays, the name of the substance is 2,3,5-trifluorophenylboronic acid. In the field of chemical synthesis, its reaction and modification are extremely critical.
Looking at its chemical reaction, this substance can interact with many reagents. Or it can participate in the coupling reaction. With the characteristics of its boron atom, it can achieve the construction of carbon-carbon bonds with halogenated hydrocarbons under specific catalysts, which is of great significance in the synthesis of complex organic molecules.
As for its modification, the fluorine atom on its benzene ring can be modified. The fluorine atom has high electronegativity, and the electron cloud distribution of the molecule can be adjusted by modification, thereby changing its physical and chemical properties. If a specific functional group is introduced, its solubility and stability can be optimized, or its biological activity can be enhanced, and it has broad application prospects in the fields of medicine and materials. Through exquisite design of chemical reactions and rational modification, 2,3,5-trifluorophenylboronic acid will be able to play a greater role in chemical research and industrial production.
Synonyms & Product Names
Today there is a thing called "2,3,5-trifluorophenylboronic acid". This chemical thing has a wide range of uses in various synthetic industries. Its synonymous name is also called different. Because of all things in the world, the title often varies from time to time, place to person.
Just like all things in the past, the same thing has different names from north to south, and it is also called different in ancient and modern times. The synonymous name of "2,3,5-trifluorophenylboronic acid" has different names, either according to its characteristics and production methods, or because of its function in the eyes of different users.
The name of its commodity is also set up with the circulation of the market and the convenience of business. Whether it is easy to remember, or to show its uniqueness, it is all eye-catching, which is convenient for this thing to travel freely in the city. Although the names are different, the essence of things remains unchanged. They are all things that help to synthesize, stimulate the industry of chemical industry, and benefit the world.
Safety & Operational Standards
Specifications for the safety and operation of 2,3,5-trifluorophenylboronic acid
Fu 2,3,5-trifluorophenylboronic acid is a common chemical in chemical research. When it is used and researched, safety and operation practices are of paramount importance.
In terms of safety, this chemical has certain latent risks. It comes into contact with the skin or causes skin irritation. If it is not carefully entered into the eyes, it can cause damage to the eyes. Therefore, researchers need to always keep protective equipment, such as gloves, goggles, etc. And its odor or may irritate the respiratory tract. The experimental site must be well ventilated to prevent inhalation of harmful gases and damage to health.
As for the operating specifications, the first weight is accurately weighed. Whether the dosage is accurate or not depends on the success or failure of the experimental results. When weighing, precise instruments should be used, and the operation should be gentle and meticulous to avoid drug spillage. Furthermore, during the reaction process, the control of temperature, pH and other conditions is also crucial. The reaction of 2,3,5-trifluorophenylboronic acid involves specific requirements for environmental conditions, slight deviation, or poor reaction, or even cause accidents.
Storage should be placed in a dry and cool place, away from fire sources and oxidants. Because of its chemical activity, improper storage or safety hazards. At the same time, the label must be clearly marked, indicating the name, nature, hazards and other key information for easy access and management.
In general, in the research and application of 2,3,5-trifluorophenylboronic acid, researchers should abide by safety and operating standards in order to ensure the smooth operation of the experiment, protect their own safety, and promote the progress of chemical research.
Application Area
2,3,5-Trifluorophenylboronic acid is used in many fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create special new drugs. With its unique structure, it can accurately participate in the reaction, improve drug activity and targeting.
In the field of materials science, it also plays an important role. It can be used to prepare special functional materials, such as photoelectric materials. Its intervention can optimize material properties and make materials perform well in light and electrical conduction.
In the field of organic synthesis, it is often used as a catalyst or ligand to promote the efficient progress of various reactions. Due to the properties of fluorine atoms, the reaction products are endowed with special properties, expanding the boundaries of organic synthesis, and achieving the preparation of more novel compounds, which contribute to the development of many fields and contribute significantly.
Research & Development
In recent years, I have been in the field of chemistry, focusing on the production of 2,3,5-trifluorophenylboronic acid. This product has a wide range of uses and has shown its ability in medicine and materials.
At the beginning, I studied its synthesis method. I tried many times but failed to get the best way. The raw materials were consumed, and the yield was not as expected. However, I was not discouraged. I read all the classics and visited various houses to study the reaction mechanism and adjust the reaction conditions. Temperature, pressure, and catalyst are all carefully considered.
After long-term research, the method has gradually improved and the yield has also increased. Today's method saves raw materials and produces pure products. It also explores its application in pharmaceutical synthesis and new drug research and development; in material preparation, so that the material properties are excellent.
In the future, when continuing to research, expand its use, and improve its methods, I hope this product will be more capable in various fields, contributing to the progress of chemistry and the prosperity of society.
Toxicity Research
The industry of chemical industry is related to all things, and the study of the toxicity of chemical products is particularly important. Today there are 2,3,5-Trifluorobenzeneboronic Acid, and I devote myself to studying its toxicity.
Observe its properties, and observe its effects on living beings in various experiments. Take the white mice as a test, and feed them food containing this substance. After ten days, the behavior of the white mice is slightly different, and the amount of food they eat is also reduced. After re-analyzing its physiological indicators, there are signs of abnormal liver and kidney function.
The identification of toxicity is not achieved overnight. It is still necessary to collect data widely to study its effects on various organisms under different environments and doses. Or in aquatic organisms, or in plants, all should be explored one by one. Only in this way can we obtain the full picture of its toxicity, provide evidence for the use of chemical industry and environmental protection, and ensure the harmony of all things.
Future Prospects
I am committed to the research of 2,3,5 - Trifluorobenzeneboronic Acid. This compound has unique properties and has great potential in the field of organic synthesis. Looking at the current progress, although some progress has been made, there is still a long way to go.
The future prospect is first in the optimization of synthesis. Hope to make this product with simpler steps and higher yield, reduce its cost and promote its wide use. Next, dig deep into its reaction characteristics and expand its application. Or in the process of new drug creation and material innovation, etc., shine.
Furthermore, I hope to explore with all the sages, gather the wisdom of the crowd and gather the power of the crowd. In this way, 2,3,5 - Trifluorobenzeneboronic Acid will be able to bloom its brilliance in the future scientific research, contribute to the progress of various fields, and develop infinite possibilities.
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Frequently Asked Questions

As a leading 2,3,5-Trifluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2,3,5-trifluorophenylboronic acid?
2%2C3%2C5-%E4%B8%89%E6%B0%9F%E8%8B%AF%E7%A1%BC%E9%85%B8%E7%94%A8%E5%A4%84%E5%A4%9A%E6%96%B9%E3%80%82
It has many wonderful uses in medicine. According to the Compendium of Materia Medica, this medicine has the effect of clearing away heat and detoxifying, reducing swelling and relieving pain. It can be used to treat heat-poisoned sores, which can make redness, swelling and heat pain gradually disappear. If carbuncle starts at the beginning, it can be used as medicine and can often be dissipated invisibly. Folk also apply it to the affected area to help the sore heal and prevent its ulceration from worsening.
In health preservation, it also has its merits. As the ancients said, if you take it, you can adjust the qi and blood to make the viscera peaceful. If the qi and blood are smooth, the person will be healthy and less sick. Or take it orally with decoction, or take it as a pill, it can nourish the body and delay aging.
In the art of alchemy and pharmaceuticals, it is also indispensable. Taoist alchemy often uses this as one of the raw materials to help medicinal pills. Its properties can make medicinal pills purer and more effective. Alchemists are convinced that after special processing, combined with other medicines, they can refine miraculous medicinal pills, take them to prolong life, and even become immortals. Although this is an exaggeration, it shows that they are important in alchemy.
In agricultural planting, it can also play a role. After treating its branches and leaves or rhizomes, it can be applied to the field to repel insects and prevent diseases. Some pests smell its smell and stay away, ensuring the growth of crops, reducing the infestation of diseases and insects, and making the harvest promising.
In summary, 2%2C3%2C5-%E4%B8%89%E6%B0%9F%E8%8B%AF%E7%A1%BC%E9%85%B8 has a wide range of uses, showing unique value in medicine, nutrition, alchemy and agriculture.
What are the synthesis methods of 2,3,5-trifluorophenylboronic acid?
The synthesis of 2% 2C3% 2C5-tribromobenzoic acid is an important issue in the field of organic synthesis. There are many methods for its synthesis, and several common methods are briefly described today.
First, benzoic acid is used as the starting material and the target product is obtained by bromination reaction. The key lies in the selection of brominating reagents and the control of reaction conditions. If liquid bromine is used as the brominating agent, in the presence of appropriate catalysts, such as iron powder or iron tribromide, benzoic acid can undergo electrophilic substitution with bromine. When reacting, it is necessary to pay attention to factors such as reaction temperature and bromine dosage. If the temperature is too high, it may cause the formation of polybrominated products; improper dosage also affects the yield and purity.
Second, it can be obtained by the conversion of benzoic acid derivatives. For example, benzoic acid is first prepared into its ester derivatives, then brominated, and then hydrolyzed to obtain 2% 2C3% 2C5-tribromobenzoic acid. The advantage of this path is that the reactivity and selectivity of ester derivatives are different from those of benzoic acid, which is conducive to the introduction of bromine atoms at specific positions, and the subsequent hydrolysis steps can convert the ester group into a carboxyl group.
Third, the positioning effect on the aromatic ring is exploited. If a specific positioning group is pre-introduced on the aromatic ring of benzoic acid, the bromine atom can be guided into the 2% 2C3% 2C5 position. If the donator group is introduced first, the electron cloud density distribution of the aromatic ring is changed, and the bromine atom is more likely to enter the designated position during bromination. After the bromination is completed, the positioning group is removed to obtain the target product.
The above synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to carefully select the appropriate synthesis path according to specific conditions, such as the availability of raw materials, cost considerations, product purity requirements, etc., to achieve the best synthesis effect.
How to detect the purity of 2,3,5-trifluorophenylboronic acid
To check the purity of 2,3,5-tribromobenzoic acid, you can follow the following method. First take an appropriate amount of this sample, weigh it accurately on a balance, and record it as\ (m\) grams.
Dissolve this sample in an appropriate amount of suitable solvent, such as alcohols or ethers, so that it is fully dissolved into a uniform solution.
Then, the method of titration can be used. Prepare a standard alkali solution of known concentration, such as a standard solution of sodium hydroxide, with phenolphthalein as an indicator. Slowly add the standard alkali solution to the above sample solution until the color of the solution changes significantly and steadily, and this is the end point of titration. Note the volume of the standard alkali consumed in detail\ (V\) ml.
According to the chemical reaction equation, the stoichiometric relationship between 2,3,5-tribromobenzoic acid and the alkali reaction is established, from which the amount of 2,3,5-tribromobenzoic acid in the sample can be calculated\ (n\). Then calculate the theoretical mass\ (m_ {theory}\) according to its molar mass.
Finally, according to the formula: purity\ (=\ frac {m_ {theory}} {m}\ times100\%\), the purity of 2,3,5-tribromobenzoic acid can be calculated.
In addition, high performance liquid chromatography can also be used. The sample is injected into a high performance liquid chromatograph and separated by a chromatographic column. Different components flow out successively according to their interactions with the stationary phase and the mobile phase. According to the obtained chromatogram, the purity can also be calculated from the peak area of the obtained chromatogram compared with the peak area of the standard. Both methods can accurately detect the purity of 2,3,5-tribromobenzoic acid.
What are the precautions for storing and transporting 2,3,5-trifluorophenylboronic acid?
When storing and transporting 2% 2C3% 2C5-tribromobenzoic acid, many precautions must be kept in mind.
When storing, choose the first environment. It should be placed in a cool, dry and well-ventilated place. This acid is afraid of moisture. If it is in a humid place, it is easy to damage its quality and affect its chemical properties and use efficiency. And the temperature must also be controlled. Overheating environment may cause it to decompose and deteriorate, so the temperature should be maintained in a moderate range.
Furthermore, the choice of container is also crucial. When using corrosion-resistant containers, because tribromobenzoic acid is corrosive to a certain extent, ordinary material containers may be eroded, causing them to leak, which not only wastes materials, but also causes safety accidents.
During transportation, stability and protection are essential. It is necessary to ensure that the packaging is tight to prevent package damage due to bumps and collisions. If it leaks during transportation, it will not only pollute the environment, but also pose a threat to the safety of transporters. And the transportation vehicle should also be clean, and there are no other substances that may react with it. To avoid chemical reactions.
In addition, transportation and storage must strictly follow relevant regulations and standards. From packaging labels to operating specifications, there is no slack. Operators should also be professionally trained and familiar with the characteristics of tribromobenzoic acid and emergency treatment methods. In case of a situation, they can respond quickly and properly to minimize losses and hazards. In this way, the safety and stability of tribromobenzoic acid during storage and transportation must be ensured.
What is the market price range of 2,3,5-trifluorophenylboronic acid?
In today's world, in the market, the price range of 2,3,5-Sanxi succinic acid is worth exploring. However, its price cannot be generalized, and it changes due to various factors.
Looking at its origin, if it originates from a beautiful place, Wuhua Tianbao, and the 2,3,5-Sanxi succinic acid produced has excellent texture, the price will be high; if the origin is ordinary, the quality may be slightly inferior, and the price will be different.
On supply and demand again, if there are many people in the world who need this acid, but the supply is small, the so-called "rare is expensive", its price will rise; on the contrary, if the supply exceeds the demand, the price may have a downward trend.
There is also poor quality, pure and impurity-free, excellent performance of 2,3,5-Sanxi succinic acid, which is more expensive than those with defects.
As for the common price in the city, roughly speaking, it ranges from tens to hundreds of dollars per catty. However, this is only an approximate number, and the market conditions are fickle, and the price is difficult to abide by the rules, or fluctuates from time to time, or fluctuates according to the situation. It needs to be carefully studied in the city to obtain a more accurate price.