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2,3,4-Trifluorobenzene-1-Sulfonyl Chloride

2,3,4-Trifluorobenzene-1-Sulfonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    861489

    Chemical Formula C6H2ClF3O2S
    Molecular Weight 246.59
    Appearance Typically a colorless to pale yellow liquid
    Boiling Point Specific data may vary, but generally in a certain range relevant to its molecular structure
    Melting Point Specific value related to its crystal structure characteristics
    Density A value indicating its mass per unit volume
    Solubility Solubility in common organic solvents like dichloromethane, etc.
    Pungency Has a pungent odor
    Reactivity Reactive towards nucleophiles due to the sulfonyl chloride group
    Stability Stable under normal storage conditions but may react with certain substances

    As an accredited 2,3,4-Trifluorobenzene-1-Sulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 2,3,4 - trifluorobenzene - 1 - sulfonyl chloride packaged in a sealed glass bottle.
    Storage 2,3,4 - trifluorobenzene - 1 - sulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat and ignition sources. Keep it in a tightly sealed container to prevent moisture ingress, as it may react with water. Store it separately from incompatible substances like bases, reducing agents, and reactive metals to avoid potential hazardous reactions.
    Shipping 2,3,4 - trifluorobenzene - 1 - sulfonyl chloride is shipped in well - sealed, corrosion - resistant containers. It's transported under controlled conditions, avoiding heat and moisture, following strict chemical shipping regulations to ensure safety.
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    2,3,4-Trifluorobenzene-1-Sulfonyl Chloride 2,3,4-Trifluorobenzene-1-Sulfonyl Chloride
    General Information
    Historical Development
    In the past, in the field of organic chemistry, the search for new substances, 2,3,4-trifluorobenzene-1-sulfonyl chloride, this compound, has gradually entered the eyes of researchers. At first, it was difficult to make this compound. All kinds of attempts, or the lack of raw materials, or the steps are cumbersome, and the yield is low.
    However, scientific researchers are determined and never stop. After years of research, analyze its reaction mechanism and explore new ways. There are ways to improve, optimize the process, select suitable raw materials, and control precise conditions. Then the yield gradually increases and the quality is also excellent.
    Since then, 2,3,4-trifluorobenzene-1-sulfonyl chloride has been widely used in the chemical industry, medicine and other industries. Its historical evolution is the proof of the unremitting efforts of researchers and the development of the chemical field.
    Product Overview
    Today there is a product called "2,3,4 - Trifluorobenzene - 1 - Sulfonyl Chloride". This is a chemical product with unique characteristics. It is a white crystal, and it looks crystal clear. The properties are still stable at room temperature, but it changes when exposed to water, forming a genus of acid mist.
    This product has a wide range of uses and is a key raw material in organic synthesis. It can produce many fine chemical products, which can be used in the field of medicine to help the research of new drugs; in the field of materials, it also has its own uses to help form new materials.
    The preparation method, through a specific chemical reaction, controls the temperature, pressure and other conditions, and carefully does it to obtain this good product. However, when preparing, it should be done with caution, because it is dangerous to a certain extent, and it must be done in accordance with the standard law to ensure safety.
    Physical & Chemical Properties
    2,3,4-Trifluorobenzene-1-sulfonyl chloride is an important substance for chemical research. Its physical properties are particularly critical. Looking at its morphology, it often appears as a colorless to slightly yellow liquid at room temperature, and the texture is relatively clear. This substance is volatile to a certain extent, and its unique smell can be smelled in the air, but its taste is not very pungent.
    When it comes to chemical properties, 2,3,4-trifluorobenzene-1-sulfonyl chloride has high chemical activity. The sulfonyl chloride group is active and easily reacts with many nucleophiles. When exposed to water, it is easy to hydrolyze, generating corresponding sulfonic acid and hydrogen chloride. This reaction is violent, and the released hydrogen chloride is corrosive. It can also be substituted with alcohols, amines, etc., and is widely used in the field of organic synthesis. It can be used as a key intermediate to help build complex organic molecular structures, providing important support for chemical research and industrial production.
    Technical Specifications & Labeling
    There is a substance today, called 2,3,4-trifluorobenzene-1-sulfonyl chloride. In the process specification and identification (product parameters), it is very important.
    Its process specification requires the preparation method to be specified, from the selection of raw materials, accurate proportions, to the control of reaction conditions, such as temperature, pressure, and duration. The reaction steps are orderly and cannot be wrong in order to obtain a pure product.
    In terms of identification (product parameters), its physical and chemical characteristics should be indicated, such as appearance, color and taste geometry, melting point, and solubility. It is also necessary to mark the purity geometry and the number of impurities. This is the key to measuring the quality of the product. And there needs to be a safety label to warn its hazards, such as whether it is corrosive, toxic, and protective methods. In this way, a complete process specification and identification (product parameters) are of great benefit to production and use.
    Preparation Method
    The raw materials of this 2,3,4-trifluorobenzene-1-sulfonyl chloride are crucial to the production process, reaction steps and catalytic mechanism.
    The raw materials to be prepared need to be carefully selected. Starting with a suitable fluorobenzene compound, supplemented by a sulfonating reagent, the proportion and purity of the two are exquisite. If fluorobenzene needs to reach a very high purity, the activity of the sulfonating reagent should also be appropriate, otherwise the purity and yield of the product will be affected.
    In the production process, the reaction temperature, duration and stirring rate need to be precisely controlled. Before a specific temperature, slowly mix the raw materials and start stirring to make the two fully contact. The initial temperature should be low to prevent side reactions. Wait for the reaction to stabilize and then gradually heat up.
    In terms of reaction steps, the first step is the sulfonation reaction. The sulfonating reagent is cleverly combined with fluorobenzene compounds to form an intermediate product. In this step, attention should be paid to the mild reaction conditions to avoid overreaction. Then the intermediate product is modified and converted in multiple steps to obtain the final target product.
    In terms of catalytic mechanism, selecting a high-efficiency catalyst can significantly improve the reaction rate and selectivity. The catalyst can reduce the activation energy of the reaction and guide the reaction in the desired direction. However, the amount of catalyst needs to be moderate, and too much or too little is not conducive to the reaction. In this way, according to these factors, high-purity 2,3,4-trifluorobenzene-1-sulfonyl chloride can be obtained
    Chemical Reactions & Modifications
    Taste the wonders of chemical industry, related to the change of substances, the rise of new materials, all rely on the principles of chemistry. In this case, 2,3,4 - Trifluorobenzene - 1 - Sulfonyl Chloride, its chemical adaptation and modification, there is much to be investigated.
    Looking at its reaction, it often involves nucleophilic substitution and the like. The activity of halogen atoms makes sulfonyl chloride groups easy to come into contact with various nucleophilic reagents, or form sulfonate esters, or sulfonamides, which vary widely, according to different circumstances, to meet various requirements.
    As for modification, chemical modification can be used. Adjust its substituents, or change its structure to change its physicochemical properties. If it increases its stability, or strengthens its solubility, it is suitable for a wider range of domains. This is the power of chemistry. With subtle changes, the transfer of material properties is introduced, paving the way for the advancement of industry and the rise of science and technology. It is really wonderful.
    Synonyms & Product Names
    2,3,4-Trifluorobenzene-1-sulfonyl chloride, which is widely used in the field of chemical industry. Its synonymous name, or trifluorobenzene sulfonyl chloride, is also known by its structure. As for the name of the product, there are also different names in the market.
    In my research, I found that its synonymous name and trade name are different because they are called in the industry. Synonymous names are mostly based on their chemical structure and properties, and are used by people in the industry. Trade names are related to marketing activities and brand distinctions. Like chemical products, trade names also change due to different uses and audiences.
    2,3,4-trifluorobenzene-1-sulfonyl chloride, due to its special structure, can be used as a key reagent in organic synthesis and other fields, so its synonyms and trade names are carefully identified, which are of great significance in chemical research, production and trade.
    Safety & Operational Standards
    About 2,3,4-trifluorobenzene-1-sulfonyl chloride product safety and operating specifications
    2,3,4-trifluorobenzene-1-sulfonyl chloride, chemical substances are also. During its preparation, storage and use, safety and handling regulations are of paramount importance.
    When preparing, the operator must strictly follow the procedures. Wear protective gear, such as protective clothing, gloves, and eyepieces, to prevent it from touching the body and entering the eyes. When operating, it should be well ventilated to prevent its gasification and risk being invisible.
    When storing, it should be placed in a cool and dry place to avoid fire and heat sources. The receptacle must be tight to prevent it from leaking out. And it is stored separately with alkalis and alcohols to avoid reactions and cause dangerous situations.
    When using, it should not be ignored. Operate in the fume hood to reduce the harm of air. Take an appropriate amount and do not let it leak. If there is contact or entry, flush with water quickly and seek medical attention.
    2,3,4-trifluorobenzene-1-sulfonyl chloride Although it has its function in chemical research, it must be safe and well-regulated. Operators must be careful to ensure their own safety and research.
    Application Area
    2,3,4-Trifluorobenzene-1-sulfonyl chloride is very useful in various application fields. In the field of Guanfu medicinal chemistry, it can be a precursor for the synthesis of drugs with specific curative effects. With its fluorine-containing and sulfonyl chloride group characteristics, it can introduce active structures into drug molecules, improve the lipophilicity and metabolic stability of drugs, and help to precisely target and bind biological targets, so that the efficacy of the prepared drugs is better.
    In the field of materials science, it also has its own uses. It can participate in the synthesis of polymer materials with its chemical activity, giving materials excellent properties such as chemical resistance and wear resistance. The materials modified by it can play a key role in high-end industries, electronic devices and other fields, and achieve extraordinary results.
    is that 2,3,4-trifluorobenzene-1-sulfonyl chloride is of great value in the application fields of medicine and materials. To be explored in depth by researchers, to make the best of their talents and develop their great use.
    Research & Development
    In recent years, I have made great efforts in the research of 2,3,4 - Trifluorobenzene - 1 - Sulfonyl Chloride. At the beginning, there were many obstacles in the preparation method. The raw materials are rare, and the reaction conditions are harsh, often resulting in low yield.
    However, I did not dare to slack off, and I searched the classics and visited various houses. After months of research, the process was improved, and the new catalyst was used to control the precise temperature, so that the reaction was smooth. The yield gradually increased, and the quality was also excellent.
    Looking at its application, it can be used in the synthesis of medicine to make special drugs to treat intractable diseases; in the field of materials, it can make strange materials with special properties. This is a clear effect of scientific research progress.
    Although we have made progress today, there is still a long way to go. I should continue to study, seek better methods, and expand wider applications, hoping to add luster to the academic and industrial circles and promote their vigorous development.
    Toxicity Research
    The toxicity of 2,3,4 - Trifluorobenzene - 1 - Sulfonyl Chloride was studied today. This compound has a unique appearance. In the experimental investigation, white mice and other subjects were used to observe their reactions. After administration of this substance, the white mice seemed to be uneasy at first, a little bit, or now sluggish.
    After in-depth analysis, it was found that if this substance is not carefully entered into the body, it can be caused by contact with the mouth, nose or skin. Its poison can disrupt the metabolism of the body and disturb the ability of the organs. Light or feel unwell, dizziness, and severe may endanger life.
    We need to be careful. When handling this object, we must abide by strict regulations and prepare protective equipment to prevent the risk of poisoning. This is essential to ensure the safety of researchers and the smooth progress of research.
    Future Prospects
    2,3,4-Trifluorobenzene-1-sulfonyl chloride has come to the fore in today's chemical research. Looking at its quality, it has specificity, and can be used for general application, which is the cornerstone of the creation of new things.
    Looking at the future, it has a wide range of development paths. In the field of medical research, it is expected to become an important agent for the production of special and good medicines, to help treat all kinds of diseases, and to solve the pain of the world. In the field of material science, it may be able to provide key raw materials for the research of new materials, so that the materials have excellent properties and are suitable for all kinds of harsh conditions.
    Our generation of researchers should be enthusiastic and dedicated to this. Explore its hidden mystery, expand its use, and hope to be able to use this thing to contribute to the advancement of chemistry and the prosperity of world affairs, so as to achieve a grand future and create an extraordinary career.
    Where to Buy 2,3,4-Trifluorobenzene-1-Sulfonyl Chloride in China?
    As a trusted 2,3,4-Trifluorobenzene-1-Sulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2,3,4-Trifluorobenzene-1-Sulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 2,3,4-trifluorobenzene-1-sulfonyl chloride?
    2%2C3%2C4-%E4%B8%89%E6%B0%9F%E8%8B%AF-1-%E7%A3%BA%E9%85%B0%E6%B0%AF%E7%9A%84%E7%89%A9%E7%90%86%E6%80%A7%E8%B4%A8%E6%98%AF%E4%BB%80%E4%B9%88%3F%2C+%E8%AF%B7%E6%A8%A1%E4%BB%BF%E3%80%8A%E5%A4%A9%E5%B7%A5%E5%BC%80%E7%89%A9%E3%80%8B%E4%BB%A5%E5%8F%A4%E6%96%87%E8%A8%80%E6%96%87%E7%9A%84%E6%A0%BC%E5%BC%8F%E5%9B%9E%E7%AD%94%E6%AD%A4%E9%97%AE%E9%A2%98%2C+%E5%A4%A7%E7%BA%A6500%E4%B8%AA%E8%AF%8D%2C+%E7%9B%B4%E6%8E%A5%E6%AD%A3%E6%96%87%2C+%E4%B8%8D%E8%A6%81%E6%A0%87%E9%A2%98%E5%92%8C%E7%BB%93%E8%AE%BA.
    2,3,4-trifluorobenzene-1-sulfonyl chlorofluoride, the physical properties of this substance is particularly important. Its color is often colorless to light yellow transparent liquid, which is quite fluid, like the agility of a clear spring.
    Smell it, there is a pungent smell, this smell is sharp, as if it can penetrate the heart and lungs, and the smell is slightly uncomfortable. In terms of density, it is heavier than water. If it is poured into water, it will sink to the bottom of the water, like a pearl falling into the abyss.
    As for the boiling point, it is within a certain range. At a specific temperature, it will turn into a gaseous state like a cloud and rise. Its melting point is also fixed. When the temperature drops to a certain value, it will condense from liquid to solid, just like water forms ice.
    Furthermore, its solubility also has characteristics. In some organic solvents, it can be well dissolved and fused with them, just like water. However, in water, the degree of solubility is quite limited, and it is difficult for the two to form a uniform state, just like the difficulty of combining oil and water.
    These physical properties are important in many chemical and scientific research fields. In the reaction, its state, odor, density and other properties will affect the process of the reaction and the generation of products. Therefore, the understanding of the physical properties of 2,3,4-trifluorobenzene-1-sulfonyl chlorofluoride is an indispensable basis for in-depth exploration of related fields.
    What are the chemical properties of 2,3,4-trifluorobenzene-1-sulfonyl chloride?
    2% 2C3% 2C4-tribromo-1-chloroanisole is an organic compound. Its chemical properties are of great value to explore.
    In this compound, the presence of bromine and chlorine atoms endows it with unique reactivity. Bromine and chlorine are both halogen elements and have strong electronegativity. Therefore, 2% 2C3% 2C4-tribromo-1-chloroanisole can exhibit special performance in nucleophilic substitution reactions.
    When the nucleophilic reagent wants to attack this molecule, the location of the bromine and chlorine atoms will affect the difficulty and path of the reaction. Generally speaking, halogen atoms can be replaced by nucleophilic reagents as leaving groups. However, due to the slight difference in atomic radius and electronegativity between bromine and chlorine, the departure ability is also different. In general, iodine has the strongest departure ability, followed by bromine and chlorine. In 2% 2C3% 2C4-tribromo-1-chloroanisole, bromine atoms are relatively easier to leave, resulting in nucleophilic substitution reactions that are more likely to occur at the carbon atoms connected to bromine atoms.
    In addition, the phenyl ring structure of this compound also affects its chemical properties. The benzene ring has a conjugated system, the electron cloud distribution is relatively uniform, and the properties are relatively stable. However, the substitution of halogen atoms will change the electron cloud density of the benzene ring. The halogen atom is an electron-absorbing group, which will reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction on the
    And because it contains methoxy group, methoxy group is the power supply group, which can increase the density of electron clouds in the adjacent and para-position of the phenyl ring. Therefore, in some reactions, electrophilic reagents may prefer to attack the adjacent and para-position of the methoxy group.
    In short, the chemical properties of 2% 2C3% 2C4-tribromo-1-chloroanisole are determined by the interaction of its halogen atom with the phenyl ring and methoxy group. It may have specific applications and reactions in organic synthesis and other fields.
    What are the main uses of 2,3,4-trifluorobenzene-1-sulfonyl chloride?
    2% 2C3% 2C4-trifluorobenzene-1-sulfonyl chloride is a crucial reagent in the field of organic synthesis, and has a wide range of uses in medicinal chemistry, materials science, and many other aspects.
    In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of various fluorinated drugs. Due to the unique electronic properties and physiological activities of fluorine atoms, fluorinated drugs often have higher bioavailability, metabolic stability, and affinity with targets. With 2% 2C3% 2C4-trifluorobenzene-1-sulfonyl chloride, fluorosulfonyl groups can be introduced into the molecular structure of drugs, thereby modifying the physicochemical properties and biological activities of drugs. For example, when synthesizing some antibacterial and anti-tumor drugs, the groups introduced by the reagent can optimize the interaction between the drug and specific biological targets and improve the efficacy of the drug.
    In the field of materials science, it can participate in the synthesis of functional polymer materials. For example, the preparation of fluoropolymers, such polymers often exhibit excellent chemical resistance, low surface energy and excellent thermal stability due to the presence of fluorine atoms. The sulfonyl chloride group provided by 2% 2C3% 2C4-trifluorobenzene-1-sulfonyl chloride can react with other monomers to create polymer materials with unique properties, which are very useful in coatings, plastics and other fields. For example, the obtained fluoropolymer coating has good anti-fouling and wear resistance, and is suitable for protective coatings of high-end equipment.
    In addition, in other aspects of organic synthetic chemistry, 2% 2C3% 2C4-trifluorobenzene-1-sulfonyl chloride is also often used to construct fluoroaryl sulfonamide compounds, etc., providing an effective way for the diversified modification of organic molecular structures, helping chemists to create more organic compounds with novel structures and unique properties.
    What is the synthesis method of 2,3,4-trifluorobenzene-1-sulfonyl chloride?
    To prepare 2,3,4-triene heptyl-1-aldehyde, the following ancient method can be used.
    First take an appropriate carbon chain substrate, which needs to have a modifiable check point to gradually introduce the required double bonds and aldehyde functional groups. The reaction of allyl halide with suitable organometallic reagents, such as Grignard reagent or organolithium reagent, can build a preliminary carbon skeleton. In this reaction, the halogen atom of the allyl halide is active. When encountering the organometallic reagent, the halogen atom leaves, and the metal atom combines with it to form a new carbon-carbon bond. This is the basic step for building a carbon chain.
    Then, through a selective oxidation reaction, the functional group at a specific position is converted into an aldehyde group. A mild oxidizing agent, such as manganese dioxide or PCC (chlorochromate pyridinium salt), can be selected to oxidize the alcohol hydroxyl group to an aldehyde group under suitable solvent and reaction conditions, and it is necessary to ensure that the double bond is not affected. During the reaction, the choice of solvent is crucial, and aprotic solvents such as dichloromethane are often preferred because they can dissolve substrates and oxidants without interfering with the reaction process.
    Furthermore, when a double bond is introduced, the elimination reaction can be used. Select an appropriate halogenated hydrocarbon derivative, and the elimination reaction occurs under the action of a base to form a double bond. The strength and dosage of the base need to be precisely controlled. Too strong a base may lead to overreaction, affecting the position and configuration of the double bond. Commonly used bases such as potassium carbonate, potassium tert-butanol, etc., are selected according to the characteristics of the substrate. The reaction temperature also needs to be regulated. Different combinations of bases and substrates have different suitable temperatures. Generally, the best reaction temperature is found between room temperature and heating reflux.
    In the preparation process, each step of the reaction needs to be separated and purified to remove impurities and obtain a pure product. Distillation, column chromatography and other means can be used to effectively separate the products according to the physical and chemical properties of the products and impurities to ensure the purity of the products in each step, so as to facilitate the next reaction and finally obtain 2,3,4-triene heptyl-1-aldehyde.
    What are the precautions for storing and transporting 2,3,4-trifluorobenzene-1-sulfonyl chloride?
    2% 2C3% 2C4-tribromobenzene-1-sulfonic acid is a chemical substance, and it is necessary to pay attention to all kinds of things when it is stored.
    First of all, it should be placed in a dry place. This is because the substance is easily affected by moisture. If it is exposed to moisture or causes it to become deliquescent, it will affect its chemical properties. Second, it should be stored in a safe place to avoid high-temperature open fires. Because of its sensitivity to temperature, high temperature environment or chemical reactions, it is even more likely to burn or explode. Third, it needs to be stored separately with oxidation, acid and other substances. Due to its chemical activity, this substance is easy to react and endanger safety.
    For the second time, it is necessary to use suitable packaging materials to prevent the package from breaking due to collision, shock, etc. during the transportation, and the leakage of items. It is also necessary to ensure the safety of all phases, such as fire equipment, so as to avoid accidents that may occur., familiar with the dangerous characteristics of