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What are the main uses of 1-Propyl-3,5-Difluorobenzene?
1-Propyl-3,5-difluorobenzene, an organic compound, has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate to build more complex organic molecular structures. The propyl and fluorine atoms attached to the phenyl ring endow the compound with specific chemical activity and spatial structure, enabling it to interact with other reagents through various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., and then synthesize organic compounds with specific functions and structures, such as certain drug molecules, pesticide active ingredients, and functional materials.
In the field of materials science, 1-propyl-3,5-difluorobenzene also shows certain value. Due to the presence of fluorine atoms in the molecular structure, the stability, corrosion resistance and special physical properties of the material can be enhanced. For example, when preparing high-performance polymer materials, the introduction of monomers containing this structure can improve the thermal stability, mechanical properties and chemical stability of the polymer, making it suitable for aerospace, electronics and other fields that require strict material properties.
Furthermore, in the process of drug development, the unique chemical structure of 1-propyl-3,5-difluorobenzene may become an important structural fragment for the design of new drug molecules. Through structural modification and optimization, it is expected to develop innovative drugs with specific pharmacological activities, high selectivity and low toxicity and side effects, contributing to human health. In conclusion, 1-propyl-3,5-difluorobenzene has important application prospects in many fields such as organic synthesis, materials science, and drug development due to its unique structure and properties.
What are the physical properties of 1-Propyl-3,5-Difluorobenzene?
1 - Propyl - 3,5 - Difluorobenzene is an organic compound with specific physical properties. It is a colorless and transparent liquid with a clear and pure appearance, transparent light, and no turbidity or impurities. At room temperature and pressure, the density is about 0.98 g/cm ³, which is lighter than water. If it is co-located with water, it can float on the water surface. The boiling point is between 150-155 ° C. In this temperature range, the substance gradually changes from liquid to gaseous. The melting point is very low, about -60 ° C. It is a stable liquid at room temperature.
This compound is insoluble in water. Due to its molecular structure, the group composed of benzene ring and alkyl and fluorine atoms is a hydrophobic group, which is difficult to form an effective interaction with water molecules. However, it is soluble in common organic solvents, such as ethanol, ether, acetone, etc., due to the principle of similar miscibility. The force between the organic solvent molecules and 1-Propyl-3,5-Difluorobenzene molecules is suitable and can be mixed evenly.
The vapor pressure of 1-Propyl-3,5-Difluorobenzene is low at room temperature, and the volatility is relatively weak. Its odor is special, although it is not pungent and smelly, it has certain characteristics, which can be identified accordingly. In addition, the compound is flammable, and can be burned in the event of open flames and hot topics. When burned, the flame is bright, and it needs to be properly stored and used to avoid fire and explosion risks. In conclusion, knowing the physical properties of 1 - Propyl - 3,5 - Difluorobenzene is essential for its application and processing in chemical industry, scientific research and other fields.
What are the chemical properties of 1-Propyl-3,5-Difluorobenzene?
1-Propyl-3,5-difluorobenzene, this is an organic compound. It has unique chemical properties and is very important in the field of organic synthesis.
First talk about its physical properties. Under normal conditions, it is mostly liquid and has a certain volatility. Due to the presence of fluorine atoms, its boiling point, melting point and other properties are different from those of similar compounds without fluoride. Fluorine atoms have high electronegativity, causing changes in intermolecular forces, and their boiling points may be lower than those of ordinary benzene derivatives.
In terms of chemical properties, the presence of benzene rings gives it aromaticity, and many typical reactions of aromatic compounds can occur. One is electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The electron cloud density distribution of the benzene ring is uneven. The 3,5-difluoro substituent reduces the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is slightly lower than that of benzene, and the substitution position is selective. Because the fluorine atom is an adjacent and para-site locator, the electrophilic reagent mostly attacks its adjacent and para-site.
Second, the propyl side chain can carry out related reactions. The hydrogen atom on the propyl group can undergo halogenation reaction under appropriate conditions, such as in the presence of light or free radical initiator, it reacts with halogen elementals to generate halogenated propylbenzene derivatives.
Furthermore, the carbon-fluorine bond in this compound is relatively stable, but under severe conditions such as specific strong nucleophiles or high temperatures, the carbon-fluorine bond can break, and then a nucleophilic substitution reaction occurs, and the fluorine atom is replaced by other nucleophilic groups.
In addition, 1-propyl-3,5-difluorobenzene also has characteristics of solubility, slightly soluble in water, because water is a polar solvent, and the polarity of the compound is relatively small; soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. This property is of great significance in its synthesis, separation and application. In conclusion, 1-propyl-3,5-difluorobenzene is rich in chemical properties and has broad application prospects in organic synthesis, medicinal chemistry and other fields.
What is the production method of 1-Propyl-3,5-Difluorobenzene?
The preparation method of 1-propyl-3,5-difluorobenzene is obtained by numerical method.
First, it can be prepared by Grignard reaction of 3,5-difluorobenzene and propyl Grignard reagent. First, take an appropriate amount of 3,5-difluorobenzene, put it in a dry reactor, use anhydrous ether or tetrahydrofuran as a solvent, and slowly add propyl Grignard reagents such as propyl magnesium halide under low temperature and inert gas protection. This process requires strict control of temperature and feeding rate, because Grignard reactivity is quite high. After the reaction is completed, 1-propyl-3,5-difluorobenzene can be obtained through hydrolysis, extraction, drying, distillation and other steps.
Second, 3,5-difluoroaniline is used as the starting material. Shilling 3,5-difluoroaniline is converted into 3,5-difluorodiazonium by diazotization. Dissolve 3,5-difluoroaniline into an appropriate amount of inorganic acid, add sodium nitrite solution dropwise at low temperature to generate diazonium salts. Subsequently, it is coupled with propylboronic acid or propylborate ester. This reaction usually needs to be carried out under the action of transition metal catalysts such as palladium catalysts at a suitable temperature and reaction time. After the reaction is completed, the target product 1-propyl-3,5-difluorobenzene is obtained by separation and purification steps, such as column chromatography.
Third, 3,5-difluorobenzoic acid can also be used as raw material. First, 3,5-difluorobenzoic acid is reduced to 3,5-difluorobenzyl alcohol, and strong reducing agents such as lithium aluminum hydride are commonly used to react in an anhydrous environment. After that, 3,5-difluorobenzyl alcohol and halopropane undergo nucleophilic substitution reaction under alkaline conditions, and potassium carbonate can be selected as the base. The reaction products are separated through a series of operations, such as washing, drying, and rectifying, and finally 1-propyl-3,5-difluorobenzene is obtained.
All the above methods have their own advantages and disadvantages. In actual preparation, the appropriate method should be carefully selected according to factors such as the availability of raw materials, cost, and product purity requirements.
What are the precautions for storing and transporting 1-Propyl-3,5-Difluorobenzene?
1-Propyl-3,5-difluorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
Storage first. First, you must find a cool and well-ventilated place. Cover this compound in case of heat or can cause chemical reactions to accelerate, and even there is a risk of safety. If it is in a high temperature environment, it may increase volatilization and loss, and the volatile gas will accumulate in a closed space, or the risk of explosion. Second, you should keep away from fire and heat sources. This is the most important, because it is flammable, and it is very easy to burn in case of open flames and hot topics. In the warehouse, smoking is strictly prohibited, and electrical equipment needs to meet explosion-proof standards to prevent electric sparks from igniting this material. Third, the storage container must be well sealed. If the seal is not good, one is easy to evaporate and dissipate, and the other may react with components in the air, such as oxygen, water vapor, etc., causing it to deteriorate. Fourth, it should be stored separately from oxidants and acids. Due to the active chemical properties of 1-propyl-3,5-difluorobenzene, contact with oxidants or cause severe oxidation reactions, and may also react with acids, damaging storage safety.
As for transportation, there are also many details. First, transportation vehicles must be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. If there is a leak on the way, it can be dealt with in time to avoid the expansion of the accident. Second, summer transportation should be selected in the morning and evening to avoid high temperatures. High temperature is easy to cause it to evaporate and expand, increasing the risk of transportation. Third, during transportation, it should be protected from exposure to the sun, rain and high temperature. Vehicles must have shading and rain shielding devices to ensure that the goods are not affected by bad weather. Fourth, when loading and unloading, the operator must be light and light, and it is strictly forbidden to drop, touch, drag, pull and other rough acts. Leakage occurs due to violent vibration or collision, or damage to the container.
In this way, in the storage and transportation of 1-propyl-3,5-difluorobenzene, all precautions should be carefully followed to ensure safety.