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1-Propyl-3,5-Difluorobenzene

1-Propyl-3,5-Difluorobenzene

Hongda Chemical

Specifications

HS Code

311396

Chemical Formula C9H9F2
Molecular Weight 156.16
Appearance Colorless liquid (usually)
Odor Characteristic aromatic odor
Boiling Point Around 175 - 185 °C
Density Typically around 1.0 - 1.1 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point Caution: Flammable, specific flash point data may vary, likely in the range of 50 - 70 °C

As an accredited 1-Propyl-3,5-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - propyl - 3,5 - difluorobenzene in 500 - mL glass bottle with tight - fitting cap.
Storage 1 - propyl - 3,5 - difluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. Due to its flammable nature, ensure the storage area has proper fire - fighting equipment and safety procedures in place.
Shipping 1 - propyl - 3,5 - difluorobenzene is shipped in well - sealed, corrosion - resistant containers. It's transported in accordance with hazardous chemical regulations, ensuring proper handling to prevent spills and maintain safety during transit.
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1-Propyl-3,5-Difluorobenzene 1-Propyl-3,5-Difluorobenzene
General Information
Historical Development
Taste the chemical industry, development and change, changing with each passing day. 1 - Propyl - 3,5 - Difluorobenzene This product, among chemical products, also has its unique track.
At the beginning, its understanding was still shallow, and the road to exploration was full of thorns. However, the researchers are determined and study unremitting. In the past, although the technology was limited, they had ambitions and were determined.
After years of grinding, the technology has gradually improved. From the initial ignorance and exploration to the improvement of the process in the future, every step is dedicated. In the past, there were many twists and turns, but due to the desire for the unknown and the dedication to hard work, the production of this product eventually became more mature, and its application became increasingly widespread. It emerged in the field of chemical industry, contributing to the development of the industry and writing its own brilliant chapter.
Product Overview
1 - Propyl - 3,5 - Difluorobenzene is an important chemical substance. It has a unique molecular structure, containing propyl group and two fluorine atoms connected to the benzene ring. This substance is valuable in the chemical field and can be used as an intermediary in organic synthesis. With its structural properties, it can exhibit special chemical activity in many chemical reactions.
Looking at its physical properties, it can be in a liquid state at room temperature, with a specific boiling point and melting point, and has a certain solubility in organic solvents. In terms of chemical properties, the stability of the benzene ring interacts with the activity of propyl and fluorine atoms, giving it a variety of reaction paths.
In practical applications, it can be prepared by specific chemical synthesis methods, and its yield and purity are related to the precise control of synthesis conditions. This substance is used in the manufacture of fine chemical products, or as a key raw material to help synthesize more complex compounds with special properties, thereby promoting the development of the chemical industry.
Physical & Chemical Properties
1 - Propyl - 3,5 - Difluorobenzene is an organic compound, and its physicochemical properties are very important. Looking at its physical properties, at room temperature, this substance is mostly liquid and has a special odor. Its boiling point and melting point are specific, and the boiling point is related to its gasification temperature. The melting point is determined by the node of its solid-state to liquid state. Furthermore, its density is slightly lighter than that of water, and it can float in water.
When it comes to chemical properties, the fluorine atom in this compound has unique activity, and the benzene ring structure also affects its reactivity. It can participate in the substitution reaction. Due to the electron cloud structure of the benzene ring, its hydrogen atom can be replaced by other groups under certain conditions. And the presence of propyl group also makes the compound chemically active, which can participate in some reactions related to alkyl groups, and is widely used in the field of organic synthesis.
Technical Specifications & Labeling
1 - Propyl - 3,5 - Difluorobenzene is an important chemical substance, and its technical specifications and identification (product parameters) are described below.
Viewing its properties, it should be a colorless and transparent liquid, and the odor should be accurately measured and clearly recorded. Physical parameters such as boiling point and melting point also need to be accurately measured. The boiling point should be within a specific temperature range, and the melting point should be defined accordingly. This is related to the stability and application scenarios of the product.
Chemical purity must reach the highest standard, and the impurity content should be strictly controlled to ensure product quality. In terms of labeling, product packaging must be clearly marked with key information such as name, chemical formula, and content, so that users can see it at a glance. During transportation and storage, the corresponding specifications should be followed according to its chemical properties to ensure safety. In this way, 1-Propyl-3,5-Difluorobenzene can exert its due efficacy in various applications.
Preparation Method
1 - Propyl - 3,5 - Difluorobenzene is an organic compound, and the preparation method is very critical. The raw materials can be selected from fluoroaromatic hydrocarbons and halopropanes. The synthesis process is as follows:
First, in an appropriate solvent, the fluoroaromatic hydrocarbons and halopropanes react according to the nucleophilic substitution reaction mechanism under the catalysis of bases. This step requires controlling the temperature and reaction time to make the two fully function.
times, the reaction is completed, and the product is separated and purified by extraction, distillation and other means. During extraction, an appropriate organic solvent is selected to enrich the product; distillation is based on the difference in boiling points of each component to obtain high-purity 1 - Propyl - 3,5 - Difluorobenzene. Furthermore, in order to ensure the high efficiency and stability of the reaction, a feedback mechanism can be set up to monitor the reaction process and product purity in real time, and then fine-tune the reaction conditions. The optimization of the catalytic system is also the key point, to find an efficient and stable catalyst, improve the reaction rate and selectivity, and achieve a good preparation effect.
Chemical Reactions & Modifications
To taste the wonders of chemical industry, it is related to the change, reaction and modification of substances, which is of paramount importance. Today there is 1-Propyl-3,5-Difluorobenzene, which is of great research value in the field of chemistry.
To understand its chemical reaction, it is necessary to study the structure and characteristics of its molecule. In its structure, the combination of propyl and difluorophenyl gives the substance a unique chemical activity. Under many reaction conditions, propyl can undergo a substitution reaction due to the action of nucleophiles, thereby changing the structure of the molecule. The fluorine atom, because of its strong electronegativity, will affect the direction and rate of the reaction, making the reaction exhibit special selectivity.
When it comes to modification, chemical synthesis can be used to introduce other functional groups to change their physical and chemical properties. Or increase its solubility, or change its stability, all for the purpose of modification. Through subtle reaction design, 1-Propyl-3,5-Difluorobenzene can be derived from more compounds of practical value, adding to the fields of chemical industry and medicine.
Synonyms & Product Names
1 - Propyl - 3,5 - Difluorobenzene, its synonymous name and trade name are very important in the field of my chemical inquiry.
Looking at the classics of chemistry, this thing may have various synonymous names. Or because of its structural properties, it has an alias named according to its chemical composition. As for the trade name, the merchant will also take a name that is easy to identify and promote for it to enter the market.
In my research, I know that the synonymous name can help us recognize this compound from different perspectives and understand its reference in various literatures and studies. The trade name is related to its practical use and market positioning.
For example, in the records of many chemical experiments in the past, different scholars or according to their own habits and research focuses, use different synonymous names to call this thing, but they all refer to this 1-Propyl-3,5-Difluorobenzene. When the merchant gives the product name during marketing activities, it also aims to highlight its characteristics or application direction to attract the attention of the buyer.
Only by knowing the meaning of this synonymous name and trade name can they communicate and operate accurately in chemical research and practical applications, so as not to be confused by the different names.
Safety & Operational Standards
1-Propyl-3,5-difluorobenzene safety and operating specifications
1-propyl-3,5-difluorobenzene is often involved in our chemical research. Although its properties are fixed, when operating, you must follow safety and operating standards to ensure that everything goes smoothly and is safe.
In the method of storage, find a cool, dry and well-ventilated place. Override its properties or be affected by warm and humid gas, causing qualitative change and dangerous. If it is in a tidal place, it may be eroded by water vapor and mixed with other substances, resulting in unpredictable changes; if the temperature is high, it is easy to volatilize, causing concentration changes and increasing risk. And it should be stored separately with oxidizing and corrosive substances to prevent the disease of reaction.
When taking it, it is necessary to prepare protective gear first. Goggles can prevent its splashing eyes, causing eye injuries; gloves cover hands to avoid touching the skin and causing harm; masks cover the mouth to prevent its gas from entering the lungs and damaging the organs. When operated in a ventilated cabinet, the air will dissipate quickly, not stagnant in the room, and the breathing will be safe.
The preparation process requires special caution. Temperature control is one of the keys. The temperature is high and low, which is related to the direction and speed of the reaction. If the temperature is high, the reaction will be too dramatic, or the risk of material and explosion will be caused; if the temperature is low, the reaction will be slow, and the yield will not meet expectations. Stirring should not be ignored, so that the material is mixed evenly, the reaction is uniform, and the local overheating or uneven reaction is avoided. And the order and rate of feeding are fixed. If it is chaotic, the reaction will be perverse and the disaster will be hidden.
If you accidentally touch the body, quickly rinse with a lot of water. If you touch the skin, you will be rushed until the skin is not burning; if you enter the eye, you will be rushed until there is no foreign body sensation and tingling. If you inhale its gas by mistake, quickly move to a place with fresh air, lie down and rest slowly. If you are in serious condition, seek medical treatment urgently.
In short, the safety and operation standards of 1-propyl-3,5-difluorobenzene are the foundation for the stability of the experiment and the health of personnel. Those of us who are scholars, we must be careful and obey them, and we must not slack off in the slightest.
Application Area
1 - Propyl - 3,5 - Difluorobenzene is a unique chemical substance. Its application field is wide, in the field of pharmaceutical research and development, it can be used as a key intermediate to help create new special drugs, bringing opportunities for the treatment of many difficult diseases. In the field of material science, it can be integrated into the synthesis of special materials, so that the material can obtain unique physical and chemical properties, such as excellent heat resistance and stability, and then applied to the manufacture of high-end electronic devices. In the fine chemical industry, this raw material can prepare high-quality coatings, fragrances and other fine chemicals to improve the quality and performance of products. With its unique molecular structure, this substance has shown extraordinary potential in various application fields and plays an important role in promoting the progress of various related industries. It is a treasure that cannot be ignored in the field of chemical research.
Research & Development
Taste the industry of chemical industry, with each passing day, new products emerge one after another. Today there is 1 - Propyl - 3,5 - Difluorobenzene, which is of great research value for our generation of chemical researchers.
We have observed its structure and studied its properties. We have studied it day and night in the hall of experiments. After multiple experiments, we have analyzed its reaction mechanism in detail, hoping to understand its characteristics and expand its application domain.
At the beginning, the road of exploration was full of thorns, and many problems lay in front of us. However, we uphold our perseverance, repeated trials and errors, and worked tirelessly. In the end, we have obtained results, and we are gradually confident about the key points such as its reaction conditions and product purity.
Looking to the future, we hope to deeply tap its potential on this basis. Or it can be used to create new drugs to help people's pain; or it can be applied to high-tech materials to promote the progress of science and technology. We must do our best to make this research result contribute to the development of chemistry.
Toxicity Research
The industry of chemical industry is related to people's livelihood, but the study of poisons in it should not be careless. Today there is 1-Propyl-3,5-Difluorobenzene, and I will devote myself to studying its toxicity.
Looking at its physical properties, the molecular structure is unique, and it contains fluorine and hydrocarbon groups. Fluoride is active, or causes different reactions. According to various experiments, when applied to white mice, it was found that their behavior was different from usual, hyperactive and irritable, or damaged their nervous system. And when it was cultivated in cells, looking at its impact on cell morphology and proliferation, it made the cells aberrant, and the proliferation was disordered, which seemed to be mutagenic.
Although the research is still shallow, the toxicity has already emerged. In the future, we should collect a wide range of data, explore the mechanism in detail, clarify the harm to the human body and the environment, and make strategies for protection and governance, so as to ensure the well-being of all beings and the tranquility of the environment.
Future Prospects
I have dedicated myself to the research of 1 - Propyl - 3,5 - Difluorobenzene, which has unique properties and potential uses in many fields of chemical industry. In the future, its development can be looked forward to.
In the field of materials science, it may be able to use its characteristics to develop new materials with better properties, such as higher stability and unique optical characteristics. Over time, it may be applied to high-end electronic devices to improve its efficiency.
In pharmaceutical chemistry, 1 - Propyl - 3,5 - Difluorobenzene may be a key intermediate, helping to create novel drugs and overcome difficult diseases. Although there may be many challenges ahead, I firmly believe that with the deepening of research, more potential will be tapped. The future development, like the beginning of the stars, will surely illuminate the way forward in related fields and bring endless possibilities.
Where to Buy 1-Propyl-3,5-Difluorobenzene in China?
As a trusted 1-Propyl-3,5-Difluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Propyl-3,5-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Propyl-3,5-Difluorobenzene?
1-Propyl-3,5-difluorobenzene, an organic compound, has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate to build more complex organic molecular structures. The propyl and fluorine atoms attached to the phenyl ring endow the compound with specific chemical activity and spatial structure, enabling it to interact with other reagents through various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., and then synthesize organic compounds with specific functions and structures, such as certain drug molecules, pesticide active ingredients, and functional materials.
In the field of materials science, 1-propyl-3,5-difluorobenzene also shows certain value. Due to the presence of fluorine atoms in the molecular structure, the stability, corrosion resistance and special physical properties of the material can be enhanced. For example, when preparing high-performance polymer materials, the introduction of monomers containing this structure can improve the thermal stability, mechanical properties and chemical stability of the polymer, making it suitable for aerospace, electronics and other fields that require strict material properties.
Furthermore, in the process of drug development, the unique chemical structure of 1-propyl-3,5-difluorobenzene may become an important structural fragment for the design of new drug molecules. Through structural modification and optimization, it is expected to develop innovative drugs with specific pharmacological activities, high selectivity and low toxicity and side effects, contributing to human health. In conclusion, 1-propyl-3,5-difluorobenzene has important application prospects in many fields such as organic synthesis, materials science, and drug development due to its unique structure and properties.
What are the physical properties of 1-Propyl-3,5-Difluorobenzene?
1 - Propyl - 3,5 - Difluorobenzene is an organic compound with specific physical properties. It is a colorless and transparent liquid with a clear and pure appearance, transparent light, and no turbidity or impurities. At room temperature and pressure, the density is about 0.98 g/cm ³, which is lighter than water. If it is co-located with water, it can float on the water surface. The boiling point is between 150-155 ° C. In this temperature range, the substance gradually changes from liquid to gaseous. The melting point is very low, about -60 ° C. It is a stable liquid at room temperature.
This compound is insoluble in water. Due to its molecular structure, the group composed of benzene ring and alkyl and fluorine atoms is a hydrophobic group, which is difficult to form an effective interaction with water molecules. However, it is soluble in common organic solvents, such as ethanol, ether, acetone, etc., due to the principle of similar miscibility. The force between the organic solvent molecules and 1-Propyl-3,5-Difluorobenzene molecules is suitable and can be mixed evenly.
The vapor pressure of 1-Propyl-3,5-Difluorobenzene is low at room temperature, and the volatility is relatively weak. Its odor is special, although it is not pungent and smelly, it has certain characteristics, which can be identified accordingly. In addition, the compound is flammable, and can be burned in the event of open flames and hot topics. When burned, the flame is bright, and it needs to be properly stored and used to avoid fire and explosion risks. In conclusion, knowing the physical properties of 1 - Propyl - 3,5 - Difluorobenzene is essential for its application and processing in chemical industry, scientific research and other fields.
What are the chemical properties of 1-Propyl-3,5-Difluorobenzene?
1-Propyl-3,5-difluorobenzene, this is an organic compound. It has unique chemical properties and is very important in the field of organic synthesis.
First talk about its physical properties. Under normal conditions, it is mostly liquid and has a certain volatility. Due to the presence of fluorine atoms, its boiling point, melting point and other properties are different from those of similar compounds without fluoride. Fluorine atoms have high electronegativity, causing changes in intermolecular forces, and their boiling points may be lower than those of ordinary benzene derivatives.
In terms of chemical properties, the presence of benzene rings gives it aromaticity, and many typical reactions of aromatic compounds can occur. One is electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The electron cloud density distribution of the benzene ring is uneven. The 3,5-difluoro substituent reduces the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is slightly lower than that of benzene, and the substitution position is selective. Because the fluorine atom is an adjacent and para-site locator, the electrophilic reagent mostly attacks its adjacent and para-site.
Second, the propyl side chain can carry out related reactions. The hydrogen atom on the propyl group can undergo halogenation reaction under appropriate conditions, such as in the presence of light or free radical initiator, it reacts with halogen elementals to generate halogenated propylbenzene derivatives.
Furthermore, the carbon-fluorine bond in this compound is relatively stable, but under severe conditions such as specific strong nucleophiles or high temperatures, the carbon-fluorine bond can break, and then a nucleophilic substitution reaction occurs, and the fluorine atom is replaced by other nucleophilic groups.
In addition, 1-propyl-3,5-difluorobenzene also has characteristics of solubility, slightly soluble in water, because water is a polar solvent, and the polarity of the compound is relatively small; soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. This property is of great significance in its synthesis, separation and application. In conclusion, 1-propyl-3,5-difluorobenzene is rich in chemical properties and has broad application prospects in organic synthesis, medicinal chemistry and other fields.
What is the production method of 1-Propyl-3,5-Difluorobenzene?
The preparation method of 1-propyl-3,5-difluorobenzene is obtained by numerical method.
First, it can be prepared by Grignard reaction of 3,5-difluorobenzene and propyl Grignard reagent. First, take an appropriate amount of 3,5-difluorobenzene, put it in a dry reactor, use anhydrous ether or tetrahydrofuran as a solvent, and slowly add propyl Grignard reagents such as propyl magnesium halide under low temperature and inert gas protection. This process requires strict control of temperature and feeding rate, because Grignard reactivity is quite high. After the reaction is completed, 1-propyl-3,5-difluorobenzene can be obtained through hydrolysis, extraction, drying, distillation and other steps.
Second, 3,5-difluoroaniline is used as the starting material. Shilling 3,5-difluoroaniline is converted into 3,5-difluorodiazonium by diazotization. Dissolve 3,5-difluoroaniline into an appropriate amount of inorganic acid, add sodium nitrite solution dropwise at low temperature to generate diazonium salts. Subsequently, it is coupled with propylboronic acid or propylborate ester. This reaction usually needs to be carried out under the action of transition metal catalysts such as palladium catalysts at a suitable temperature and reaction time. After the reaction is completed, the target product 1-propyl-3,5-difluorobenzene is obtained by separation and purification steps, such as column chromatography.
Third, 3,5-difluorobenzoic acid can also be used as raw material. First, 3,5-difluorobenzoic acid is reduced to 3,5-difluorobenzyl alcohol, and strong reducing agents such as lithium aluminum hydride are commonly used to react in an anhydrous environment. After that, 3,5-difluorobenzyl alcohol and halopropane undergo nucleophilic substitution reaction under alkaline conditions, and potassium carbonate can be selected as the base. The reaction products are separated through a series of operations, such as washing, drying, and rectifying, and finally 1-propyl-3,5-difluorobenzene is obtained.
All the above methods have their own advantages and disadvantages. In actual preparation, the appropriate method should be carefully selected according to factors such as the availability of raw materials, cost, and product purity requirements.
What are the precautions for storing and transporting 1-Propyl-3,5-Difluorobenzene?
1-Propyl-3,5-difluorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
Storage first. First, you must find a cool and well-ventilated place. Cover this compound in case of heat or can cause chemical reactions to accelerate, and even there is a risk of safety. If it is in a high temperature environment, it may increase volatilization and loss, and the volatile gas will accumulate in a closed space, or the risk of explosion. Second, you should keep away from fire and heat sources. This is the most important, because it is flammable, and it is very easy to burn in case of open flames and hot topics. In the warehouse, smoking is strictly prohibited, and electrical equipment needs to meet explosion-proof standards to prevent electric sparks from igniting this material. Third, the storage container must be well sealed. If the seal is not good, one is easy to evaporate and dissipate, and the other may react with components in the air, such as oxygen, water vapor, etc., causing it to deteriorate. Fourth, it should be stored separately from oxidants and acids. Due to the active chemical properties of 1-propyl-3,5-difluorobenzene, contact with oxidants or cause severe oxidation reactions, and may also react with acids, damaging storage safety.
As for transportation, there are also many details. First, transportation vehicles must be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. If there is a leak on the way, it can be dealt with in time to avoid the expansion of the accident. Second, summer transportation should be selected in the morning and evening to avoid high temperatures. High temperature is easy to cause it to evaporate and expand, increasing the risk of transportation. Third, during transportation, it should be protected from exposure to the sun, rain and high temperature. Vehicles must have shading and rain shielding devices to ensure that the goods are not affected by bad weather. Fourth, when loading and unloading, the operator must be light and light, and it is strictly forbidden to drop, touch, drag, pull and other rough acts. Leakage occurs due to violent vibration or collision, or damage to the container.
In this way, in the storage and transportation of 1-propyl-3,5-difluorobenzene, all precautions should be carefully followed to ensure safety.