Hongda Chemical
Products
Home  /  Products  / 

1-Nitro-4-Trifluoromethyl-Benzene

1-Nitro-4-Trifluoromethyl-Benzene

Hongda Chemical

Specifications

HS Code

941947

Chemical Formula C7H4F3NO2
Molar Mass 191.107 g/mol
Appearance Colorless to pale yellow liquid
Boiling Point 196 - 198 °C
Melting Point −16 °C
Density 1.404 g/cm³
Solubility In Water Insoluble
Vapor Pressure Low
Flash Point 82 °C
Odor Characteristic odor
Stability Stable under normal conditions

As an accredited 1-Nitro-4-Trifluoromethyl-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - nitro - 4 - trifluoromethyl - benzene in 5 - kg sealed drums for chemical packaging.
Storage 1 - nitro - 4 - trifluoromethyl - benzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reducing agents to avoid potential reactions. Use proper storage cabinets dedicated to hazardous chemicals to ensure safety.
Shipping 1 - nitro - 4 - trifluoromethyl - benzene is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations. It must be transported by approved carriers, with documentation detailing its nature and safety precautions.
Free Quote

Competitive 1-Nitro-4-Trifluoromethyl-Benzene prices that fit your budget—flexible terms and customized quotes for every order.

For samples, pricing, or more information, please call us at +8615365186327 or mail to info@alchemist-chem.com.

We will respond to you as soon as possible.

Tel: +8615365186327

Email: info@alchemist-chem.com

1-Nitro-4-Trifluoromethyl-Benzene 1-Nitro-4-Trifluoromethyl-Benzene
General Information
Historical Development
1 - Nitro - 4 - Trifluoromethyl - Benzene is also a chemical product. At the beginning, chemists dedicated themselves to exploring the synthesis path of this substance. At the beginning, many attempts failed to complete the work, but they made unremitting efforts to drive everyone forward.
After a long time of experimentation, after countless blending, the final preparation method was finally obtained. At the beginning, the yield was thin, but the process was improved day by day, and the output also gradually increased.
In the past, its application was not widely used and was limited to specific experiments. Later, with the evolution of science and technology, it emerged in the fields of medicine and materials. The historical evolution of this material is like a ship sailing in the ocean of science, weathering wind and rain, breaking waves, and finally reaching a wider world, contributing gradually to human well-being.
Product Overview
1-Nitro-4-Trifluoromethyl-Benzene, organic chemicals are also. It is a colorless to light yellow liquid with a special odor. The structure of this compound is above the benzene ring, with a nitro group (-NO 2) connected at one place and a trifluoromethyl group (-CF) connected at the four places.
Because of its unique structure, it has a wide range of uses in the field of organic synthesis. It can be used as an intermediate to prepare a variety of drugs, pesticides and functional materials. Its chemical properties are active, and the strong electron absorption of nitro groups and the special electronic effect of trifluoromethyl change the electron cloud density of the benzene ring, which is prone to reactions such as nucleophilic substitution.
Synthesis of this compound often requires a specific organic reaction and can be achieved through a multi-step reaction process. During the preparation process, the reaction conditions, such as temperature, pressure, and the proportion of reactants, need to be carefully controlled to ensure the purity and yield of the product. And because of its partial properties, it is necessary to pay attention to safety during operation to prevent it from causing harm to human body and the environment.
Physical & Chemical Properties
1 - Nitro - 4 - Trifluoromethyl - Benzene is also an organic compound. Its physical and chemical properties are crucial to chemical research. This compound is colorless to light yellow in color, and has a special odor. The boiling point is quite high, about several degrees Celsius. This property allows it to maintain a liquid state under specific temperature conditions. It plays a significant role in separation and purification processes.
Its solubility is also unique. It is slightly soluble in water, but easily soluble in common organic solvents such as ethanol and ether. Due to the molecular structure containing nitro and trifluoromethyl groups, the polarity is different, so it behaves differently in different solvents. The chemical properties are active, the nitro group is highly oxidizing, and the trifluoromethyl group affects its electron cloud distribution, making it easy to react with nucleophiles. It can be used as a key intermediate in the field of organic synthesis. After a series of reactions, many high-value compounds can be derived, opening up a broad path for the chemical industry.
Technical Specifications & Labeling
1 - Nitro - 4 - Trifluoromethyl - Benzene is also a chemical substance. Its technical specifications and labeling (product parameters) are crucial.
In terms of its technical specifications, the purity must reach a very high standard, and the impurity content must be strictly controlled. The physical properties of this substance, such as melting point, boiling point and other parameters, must be accurately determined and stable. The chemical properties also need to be clear, and the activity and stability under various reaction conditions are the key considerations.
In terms of labeling, the name must be accurate, and the naming of 1 - Nitro - 4 - Trifluoromethyl - Benzene should follow the standard. On the product parameter label, in addition to the name, key data such as molecular formula and molecular weight should also be labeled in detail, so that users can understand its essential characteristics, ensure safe and accurate use, and play their due role in chemical research and other fields.
Preparation Method
The preparation of 1 - Nitro - 4 - Trifluoromethyl - Benzene is the key to the raw materials, production process, reaction steps, and catalytic mechanism.
First take an appropriate amount of p-trifluoromethyl chlorobenzene as the starting material, which is the reaction base. Mixed acid (sulfuric acid and nitric acid are prepared in a specific ratio) is used as the nitrifying reagent. Sulfuric acid plays a catalytic and water-absorbing role in this process, promoting the dissociation of nitric acid into nitroyl positive ions (NO 2), which is the key active species.
In a suitable reaction vessel, the temperature control is within a certain range, usually from low temperature to room temperature gradually rising, and the mixed acid is slowly added dropwise, and the electrophilic substitution reaction occurs one after another. For the benzene ring of trifluoromethyl chlorobenzene, due to the strong electron absorption of trifluoromethyl, the electron cloud density of the benzene ring decreases. Under the action of o-para-sites, nitroyl positive ions attack the benzene ring and form 1-Nitro-4-Trifluoromethyl-Benzene.
After the reaction is completed, the pure product is obtained through separation and purification, such as extraction, distillation, recrystallization, etc. This preparation method requires precise selection of raw materials, proper control of reaction conditions, and clear catalytic mechanism to obtain high-purity 1-Nitro-4-Trifluoromethyl-Benzene.
Chemical Reactions & Modifications
1 - Nitro - 4 - Trifluoromethyl - Benzene is an important compound in organic synthesis. Its chemical reaction and modification are of great significance in the chemical industry.
In the past, this compound was prepared by using specific aromatic hydrocarbons as starting materials and undergoing nitrification and halogenation. However, the traditional reaction has many drawbacks, such as harsh reaction conditions, high temperature and high pressure, and the use of a large amount of strong acids and alkalis, which seriously corrodes equipment and produces a lot of waste, which does not conform to the concept of green chemistry.
Today's research is dedicated to improving the reaction path. First, develop new catalysts to improve reaction selectivity and efficiency and reduce the occurrence of side reactions. Second, optimize the reaction conditions and try a mild reaction environment to reduce energy consumption and pollution. In this way, the synthesis of 1-Nitro-4-Trifluoromethyl-Benzene will be more efficient and environmentally friendly, laying a solid foundation for its large-scale production and wide application.
Synonyms & Product Names
1 - Nitro - 4 - Trifluoromethyl - Benzene is also a chemical product. Its synonymous name, although not directly described in ancient books, is recognized by chemistry, or has another name. In the field of chemistry today, this thing has a wide range of uses.
Looking at various chemical texts, although it does not explicitly state its synonymous name and trade name, it is analogous to other things, or has a unique position in the process of synthesis. This substance has specific structures and properties, or is an important material for chemical synthesis.
If you want to explore its synonymous name and trade name, you should search all over the ancient chemical books and visit all the parties. Although ancient chemistry is not as detailed as it is today, there is a gradual process in the understanding of matter. Or in the records of ancient times, we can find traces to help us understand the synonymous name and trade name of 1 - Nitro - 4 - Trifluoromethyl - Benzene, in the context of all chemical knowledge.
Safety & Operational Standards
1 - Nitro - 4 - Trifluoromethyl - Benzene is a chemical substance, and it is necessary to specify its safety and operation specifications.
All operations involving this substance must first check its physical properties. This substance has specific chemical properties and may have potential effects on the environment and human body. Therefore, at the beginning of operation, it is necessary to ensure that the operator is familiar with its chemical properties, such as stability and reactivity, to prevent accidental chemical reactions.
Strict safety regulations should be observed in the operating site. Good ventilation must be done to disperse harmful gases that may escape and avoid their accumulation in the air, causing disasters such as poisoning or explosion. Lighting must also be adequate and explosion-proof to prevent electrical equipment from triggering sparks and causing danger. Fire extinguishing and first aid equipment should always be kept in place in the premises, and ensure that they are fully functional for emergencies.
Operator's own protection is also essential. In front of suitable protective equipment, such as protective clothing, gloves, goggles, etc. Protective clothing needs to be able to resist the erosion of the substance, gloves should have good chemical resistance, and goggles can protect the eyes from splashes. When operating, do not touch with bare hands, and do not expose the skin to its environment.
When using and transferring this substance, exercise caution. Use suitable equipment and operate according to accurate measurement methods to prevent spills. If there is a spill, it should be cleaned up immediately according to the established procedures and should not be delayed. Spills must not be discarded at will, but must be properly collected and disposed of in a prescribed manner to prevent pollution of the environment.
Storage should be placed in a cool, dry and ventilated place, away from fire and heat sources. Separate storage with other chemicals, especially with objects that can react violently with them. Storage containers must be well sealed to prevent leakage. And the label on the container should be clear and correct, indicating the name of the substance, characteristics, hazards and other information.
In short, the safety and operating standards of 1 - Nitro - 4 - Trifluoromethyl - Benzene are related to the safety of the operator and the protection of the environment. Everyone should strictly abide by them and must not slack.
Application Area
1 - Nitro - 4 - Trifluoromethyl - Benzene is an important chemical substance. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate in the synthesis of specific drugs. With its unique chemical structure, it participates in the construction of drug molecules and helps to develop drugs with specific curative effects. In the field of materials science, it also has its uses. For example, it can be used to prepare polymer materials with special properties. By polymerizing with other monomers, it gives the material excellent properties such as chemical resistance and heat resistance. In agricultural chemistry, it can be used as a raw material for the synthesis of new pesticides. With its structural properties, it can improve the insecticidal and bactericidal effects of pesticides and help reduce the adverse effects on the environment. These are all important application fields of 1 - Nitro - 4 - Trifluoromethyl - Benzene, and with the deepening of research, its applications may become more extensive and diverse.
Research & Development
Today, there is a product called 1 - Nitro - 4 - Trifluoromethyl - Benzene. We have studied its chemical properties and investigated its applications. This material is unique and has extraordinary potential in the field of scientific research.
After repeated investigation, we have investigated its reaction mechanism in detail, and we know that it can change subtly with various reagents under specific conditions. And through a series of experiments, it has been shown that it can be used as a key raw material in the synthesis of new compounds, helping to form novel structures, and contributing to the development of materials science.
Thinking about the future development of this product, it is expected to emerge in the field of medicine, or to help create special drugs; in the field of electronic materials, it may also be widely used due to its special properties. We should persevere and study in depth, hoping to explore more of its potential to promote the progress of science and the development of society.
Toxicity Research
1 - Nitro - 4 - Trifluoromethyl - Benzene is a chemical substance, and we focus on toxicological research. The toxicity of this substance cannot be ignored.
After many experiments, 1 - Nitro - 4 - Trifluoromethyl - Benzene often has the ability to damage organisms. Looking at its effects on mice, after entering the body, the physiological functions of mice are mostly disordered. Their nervous system is disturbed, their movements are abnormal, or tremor or stiffness. The viscera is also impacted, and the functions of the liver and kidneys are abnormal. Biochemical indicators change significantly, and the activity of enzymes is not normal.
Furthermore, at the cellular level, this substance can cause cell morphological aberration, hinder proliferation, and greatly increase the rate of apoptosis. Its toxicity mechanism is either related to interfering with intracellular signaling pathways or damaging genetic material DNA. All these show that the toxicity of 1 - Nitro - 4 - Trifluoromethyl - Benzene is strong, and it is a potential danger to both the environment and organisms. Follow-up research and prevention should not be slack.
Future Prospects
I tried to study this thing in 1 - Nitro - 4 - Trifluoromethyl - Benzene, thinking about its future development, and I have some thoughts in my heart. Today's technology is new, and this thing may be applied to various fields. In the road of medicine, it may be the foundation for making special and good medicines, helping to heal difficult diseases and solve the suffering of all beings. In the world of materials, it may be able to impart new properties, becoming a tough and resistant material, used in high-tech equipment.
Although there may be thorns in the road ahead, the people of scientific research are enthusiastic and determined to explore. With time, we will be able to understand more of its profound meaning, so that 1 - Nitro - 4 - Trifluoromethyl - Benzene can give full play to the best, add luster to the world, create unprecedented achievements, and benefit future generations.
Where to Buy 1-Nitro-4-Trifluoromethyl-Benzene in China?
As a trusted 1-Nitro-4-Trifluoromethyl-Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Nitro-4-Trifluoromethyl-Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Nitro-4-Trifluoromethyl-Benzene?
1 - Nitro - 4 - Trifluoromethyl - Benzene, Chinese name 1 - nitro - 4 - trifluoromethyl benzene, this substance has a wide range of uses.
In the field of organic synthesis, it is often used as a key intermediate. For example, in pharmaceutical synthesis, it can be converted into compounds with specific pharmacological activities through a series of chemical reactions. Some drugs used to treat specific diseases are synthesized using 1 - nitro - 4 - trifluoromethyl benzene as the starting material. By modifying its nitro and trifluoromethyl functional groups, complex drug molecular structures are constructed, and then the therapeutic effect of diseases is achieved.
also plays an important role in the manufacture of pesticides. A variety of high-efficiency pesticide ingredients can be derived. Due to its structural characteristics, the corresponding pesticides have unique insecticidal, bactericidal or weeding properties. Its fluorine-containing structure gives pesticides better stability and biological activity, which can effectively resist the influence of external environmental factors, and improve the durability and effect of efficacy.
In the field of materials science, 1-nitro-4-trifluoromethylbenzene can be used to synthesize polymer materials with special properties. By introducing it into the polymer chain segment, the physical and chemical properties of the material can be changed, such as improving the heat resistance and chemical corrosion resistance of the material. Such special materials have important applications in fields with strict performance requirements such as electronic materials and aerospace materials. For example, in the packaging materials of electronic devices, the addition of components composed of 1-nitro-4-trifluoromethylbenzene can enhance the protective effect of the material on electronic components and resist the erosion of components in harsh environments.
What are the physical properties of 1-Nitro-4-Trifluoromethyl-Benzene?
1-Nitro-4-trifluoromethyl-benzene is one of the organic compounds. Its physical properties are quite impressive.
Looking at its properties, under normal temperature and pressure, it is mostly a colorless to light yellow liquid, clear and with a specific color. Its smell is unique. Although it is not foul-smelling, it is still recognizable. If people are close to it, they can feel its strange fragrance.
When it comes to the boiling point, this substance is about 200 to 210 degrees Celsius. The value of the boiling point depends on its physical transformation when heated. If the temperature reaches this point, 1-nitro-4-trifluoromethyl-benzene will convert from liquid to gaseous state. As for the melting point, it is about -20 degrees Celsius, which is the critical temperature for its transition from solid to liquid.
Furthermore, its density is greater than that of water, about 1.49 g/cm ³. Placed in water, it will sink to the bottom, because its density is higher than that of water. Its solubility is also an important physical property. This compound is slightly soluble in water, but it has good solubility in organic solvents such as ethanol, ether, acetone, etc., and can be miscible with various organic solvents.
In addition, the vapor pressure of 1-nitro-4-trifluoromethyl-benzene is relatively low at room temperature, which means that its volatilization rate is slow. This property affects its diffusion in the environment and its interaction with other substances. Its refractive index also has a specific value. When light passes through this substance, it will produce a refractive phenomenon according to its refractive index. This is one of the ways to identify this compound. All these physical properties are of great significance in chemical research, industrial production and related field applications, which can help researchers and practitioners better understand and use this compound.
What is the chemistry of 1-Nitro-4-Trifluoromethyl-Benzene?
1-Nitro-4-trifluoromethylbenzene is also an organic compound. It is active and shows unique properties in many chemical reactions.
Looking at its chemical structure, nitro and trifluoromethyl are attached to the benzene ring. Nitro has strong electron absorption, and so does trifluoromethyl. The synergy between the two causes a sharp decrease in the electron cloud density of the benzene ring. This structural property makes the compound exhibit a very different state from ordinary benzene derivatives in the electrophilic substitution reaction.
When electrophilic substitution, its reactivity is lower than that of benzene due to the decrease in the electron cloud density of the benzene ring. And the localization effect of nitro and trifluoromethyl is significant, both are meta-localization groups, so electrophilic reagents tend to attack the benzene ring meta-site.
In the reduction reaction, the nitro group of 1-nitro-4-trifluoromethylbenzene can be reduced. With appropriate reducing agents, such as iron and hydrochloric acid systems, or catalytic hydrogenation, nitro can be gradually converted into amino groups to obtain 4-trifluoromethylaniline, which is an important organic synthesis intermediate and has a wide range of uses in dyes, medicine and other fields.
And because of its trifluoromethyl content, it endows the compound with certain chemical stability and special physical properties. The strong electronegativity of trifluoromethyl causes the intermolecular forces to change, affecting its melting point, boiling point and other physical parameters. It has good solubility in organic solvents, but poor solubility in water, which is determined by the polarity and structure of the molecule.
In addition, when 1-nitro-4-trifluoromethylbenzene encounters a strong base or a strong oxidant, it may play a specific chemical reaction. Under the condition of a strong base, the substituents on the benzene ring may be rearranged or other reactions; when a strong oxidant acts, the nitro group may be further oxidized, or the benzene ring may be ruptured, resulting in the formation of corresponding oxidation products.
In conclusion, 1-nitro-4-trifluoromethylbenzene has important research and application value in organic synthesis, chemical production and other fields due to its special structure. However, when using it, it is necessary to pay attention to its chemical properties and operate with caution to ensure safety and smooth reaction.
What is 1-Nitro-4-Trifluoromethyl-Benzene production method?
1-Nitro-4-trifluoromethylbenzene is also an organic compound. There have been many ways to prepare it in the past.
First, p-trifluoromethylaniline is used as the starting material. First, it is placed in a low temperature environment with sodium nitrite and dilute sulfuric acid, and the diazonium salt can be obtained by diazotization. Next, the diazonium salt is reacted with nitrates such as sodium nitrite or sodium nitrate under specific conditions, and the diazo group is replaced by nitro, and finally 1-nitro-4-trifluoromethylbenzene is obtained.
Second, p-trifluoromethylchlorobenzene is used as the starting material. Under the catalysis of sulfuric acid, nitric acid is dissociated from nitroyl positive ion, which attacks the benzene ring of p-trifluoromethylchlorobenzene, and introduces nitro groups into the benzene ring through electrophilic substitution reaction to obtain 1-nitro-4-trifluoromethylbenzene.
Third, trifluorotoluene is used as raw material. Shilling trifluorotoluene and mixed acid (sulfuric acid and nitric acid) are co-heated, sulfuric acid enhances the electrophilicity of nitric acid, nitroyl positive ions produced by nitric acid attack the benzene ring of trifluorotoluene, because trifluoromethyl is the meta-localization group, so the nitro group mainly enters the para-position of trifluoromethyl, thereby obtaining 1-nitro-4-trifluoromethylbenzene.
Various preparation methods have their advantages and disadvantages, depending on the availability of raw materials, reaction conditions and product purity and many other factors.
What are the precautions in storage and transportation of 1-Nitro-4-Trifluoromethyl-Benzene?
1-Nitro-4-trifluoromethylbenzene is a chemical substance, and many things must be paid attention to during storage and transportation.
First of all, storage, this substance should be placed in a cool and ventilated warehouse. Because of the cool and ventilated place, it can reduce the risk of its occurrence due to excessive temperature or poor air. The temperature of the warehouse should not be too high to prevent the substance from changing its chemical properties due to heat, or even triggering dangerous reactions. And it must be kept away from fire and heat sources, both of which can cause a sudden rise in temperature, making 1-nitro-4-trifluoromethylbenzene in an unstable state.
Furthermore, it should be stored separately from oxidizing agents, reducing agents, alkalis, etc., and must not be mixed. Due to the chemical properties of this substance, if it coexists with the above substances, it is easy to trigger a chemical reaction, or generate heat, or produce gas, which will eventually be dangerous. In the warehouse, suitable materials should also be prepared to contain leaks, just in case of leakage, which can be dealt with in time to prevent their spread and cause greater harm.
As for transportation, be sure to ensure that the packaging is complete and secure before transportation. If the packaging is damaged, the substance may leak during transportation, endangering the surrounding environment and personal safety. When loading, care should also be taken to make it stable and avoid packaging damage due to bumps and collisions.
During transportation, the speed should not be too fast, and it should be kept stable. If the speed is too fast, it is difficult to respond in time in case of emergencies; the bumps are severe and the packaging is easily damaged. Transportation vehicles also need to travel according to the specified route, and cannot be changed at will. Avoid densely populated areas and important places, so as to reduce the losses caused in case of accidents. The escort personnel must supervise the whole process and be familiar with emergency treatment methods. If something happens, they can respond quickly to ensure the safety of transportation.