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1-Nitro-4-(Trifluoromethoxy)Benzene

1-Nitro-4-(Trifluoromethoxy)Benzene

Hongda Chemical

    Specifications

    HS Code

    234782

    Chemical Formula C7H4F3NO3
    Molar Mass 193.107 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point Around 198 - 200 °C
    Density Approx. 1.48 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane
    Vapor Pressure Low at room temperature
    Flash Point Approx. 85 °C

    As an accredited 1-Nitro-4-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1 - nitro - 4 - (trifluoromethoxy)benzene in 1 - kg bottles for chemical packaging.
    Storage 1 - nitro - 4 - (trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area, away from sources of heat, sparks, and open flames as it is potentially flammable. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances to avoid dangerous reactions. Ensure proper labeling for easy identification and safety.
    Shipping 1 - nitro - 4 - (trifluoromethoxy)benzene is shipped in sealed, corrosion - resistant containers. It's transported following strict chemical regulations, ensuring proper handling to prevent spills and environmental or safety risks during transit.
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    1-Nitro-4-(Trifluoromethoxy)Benzene 1-Nitro-4-(Trifluoromethoxy)Benzene
    General Information
    Historical Development
    Taste the industry of chemical industry, with each passing day, new things emerge one after another. 1 - Nitro - 4 - (Trifluoromethoxy) Benzene, among chemical products, also has a unique history.
    In the past, the sages worked hard in the field of chemistry to explore the wonders of material changes. At first, the understanding of compounds containing fluorine and nitro groups was still shallow. However, after years of experiments, the public worked tirelessly to analyze their structures and study their properties.
    Since organic chemistry gradually emerged, the understanding of molecular structure and reaction mechanism deepened, so he focused on the synthesis of 1 - Nitro - 4 - (Trifluoromethoxy) Benzene. Beginning with a simple method, although many obstacles, he was determined.
    With the passage of time, the technology has become more and more exquisite, the synthesis method has become more and more mature, and the yield has also increased. As a result, this product has become more and more widely used in the chemical industry, or as a precursor of materials, or for special reactions. Looking at its development, it is really a wonderful page in the history of chemistry, witnessing the perseverance and wisdom of all the sages to explore.
    Product Overview
    1 - Nitro - 4 - (Trifluoromethoxy) Benzene is an important chemical substance. It may be a colorless to pale yellow liquid with specific physical and chemical properties.
    In terms of preparation, it often needs to go through a specific chemical reaction path. It needs to be synthesized effectively with suitable raw materials and strict reaction conditions, such as precise regulation of temperature, pressure and catalyst use.
    In the application field, it is very important in organic synthesis chemistry. It can be used as a key intermediate to prepare many organic compounds with special properties. For example, it can assist in the synthesis of substances with unique electronic properties or biological activities, and may have important uses in medicine, materials science and other fields.
    However, caution is also required when handling and storing it. Due to its chemical properties, specific environmental conditions may be required to ensure safety and stability and prevent potential hazards.
    Physical & Chemical Properties
    1 - Nitro - 4 - (Trifluoromethoxy) Benzene is also an organic compound. Its physical and chemical properties are related to many aspects. Looking at its physical properties, it is a colorless to pale yellow liquid at room temperature, with a special odor. Its boiling point and melting point are all characteristics. The boiling point is about a certain value, and the melting point also has a corresponding value, which is related to its phase transition.
    In terms of its chemistry, the structure of nitro and trifluoromethoxy gives it unique reactivity. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, causing its electrophilic substitution reactivity to be different from that of ordinary benzene derivatives. The existence of trifluoromethoxy also affects the molecular polarity, which is reflected in both chemical reaction and solubility. Its solubility may vary from that of common organic solvents, and under specific conditions, it can participate in a variety of organic synthesis reactions, exhibiting unique chemical behaviors.
    Technical Specifications & Labeling
    1 - Nitro - 4 - (Trifluoromethoxy) Benzene is an important chemical product. Its technical specifications and identification (product parameters) are crucial. As far as technical specifications are concerned, the chemical synthesis process needs to be precisely controlled, the raw material ratio must be accurate, and the reaction conditions such as temperature, pressure, and reaction time should be strictly regulated to ensure the purity and yield of the product. As for the identification, key product parameters such as product name, chemical formula, molecular weight, purity, and hazard warning should be clearly marked. In this way, users can accurately know the product characteristics and precautions for use, ensure the safety and effectiveness during production and application, and also facilitate the standardized circulation and quality supervision of the product in the market.
    Preparation Method
    1 - Nitro - 4 - (Trifluoromethoxy) Benzene is an important organic compound. The preparation method and the selection of raw materials are crucial. Commonly used raw materials include p-chlorotrifluoromethoxy benzene and potassium nitrate.
    In the preparation process, p-chlorotrifluoromethoxy benzene is first placed in the reactor, and an appropriate amount of solvent, such as N, N - dimethylformamide, is added to promote the reaction. Then, potassium nitrate is slowly added, and the temperature is strictly controlled to maintain a specific temperature range, such as 100 - 120 ° C. In the
    reaction step, the nitrate ion undergoes a nucleophilic substitution reaction with p-chlorotrifluoromethoxylbenzene, and the chloride ion leaves to form the target product 1-Nitro-4- (Trifluoromethoxy) Benzene. During this process, the stirring rate also needs to be carefully adjusted to ensure that the reactants are fully contacted.
    After the treatment stage, the reaction is completed, the reaction solution is cooled, and the excess reactants are quenched with an appropriate amount of water. After extraction, distillation and other steps, the product is purified to obtain high-purity 1-Nitro-4- (Trifluoromethoxy) Benzene.
    Chemical Reactions & Modifications
    Taste the wonders of chemical industry, with countless changes, the chemical reaction and modification of 1 - Nitro - 4 - (Trifluoromethoxy) Benzene compound are particularly fascinating.
    In the past, the synthesis of this compound often encountered many obstacles. The reaction conditions are harsh, the yield is quite low, and there are many impurities. However, chemists are persevering and dedicated to research.
    After years of work, the reaction conditions have been improved. Adjust the temperature and pressure, and choose a delicate catalyst to make the reaction smoother. In the past, high temperature and strong pressure were required, but now mild conditions can be started. And the yield has been greatly improved, and there are few impurities.
    And its modification, chemists have come up with many ideas. Introduce different groups to change the distribution of its electron cloud, so that the compound has new characteristics. Or increase its stability, or change its solubility, and have a wider range of uses.
    The chemical road, although blocked and long, but unremitting exploration, will be able to achieve more breakthroughs in the reaction and modification of compounds such as 1 - Nitro - 4 - (Trifluoromethoxy) Benzene, which will be used by the world.
    Synonyms & Product Names
    1 - Nitro - 4 - (Trifluoromethoxy) Benzene This thing, its synonyms and trade names, are quite elegant. I tried to study it and found traces of it in the classics.
    Its synonyms, or other names, are all referring to this chemical thing. And the trade name, also with the meaning of merchants, varies from time to time and from place to place.
    This substance is widely used in the field of chemistry. However, its synonyms and trade names need to be clearly distinguished between communication and records.
    Or because of its unique nature, the name used is also different. However, they are all 1 - Nitro - 4 - (Trifluoromethoxy) Benzene. Although the names are different, they actually refer to the same thing. The beauty of chemistry can be seen here. All synonyms and trade names are for the convenience of knowing and using this thing.
    Safety & Operational Standards
    1 - Nitro - 4 - (Trifluoromethoxy) Benzene is a special chemical substance. During its preparation and application, safety and operating standards are of paramount importance.
    Preparation of this substance needs to be carried out in a well-ventilated environment. Due to its certain toxicity and irritation, operators must wear complete protective equipment, such as gas masks, protective gloves and protective clothing, to prevent contact and inhalation of harmful substances. The operating site should be equipped with complete ventilation equipment to discharge volatile gaseous substances in time to maintain fresh air.
    In terms of operation procedures, strict follow established procedures. The weighing and mixing of raw materials must be accurate, and the reaction temperature and time must be controlled to ensure a smooth reaction. For example, when adding reactants, they should be added slowly, and the reaction phenomenon should be closely observed to prevent sudden violent reactions.
    Store the substance in a cool, dry and ventilated place, away from fire sources and oxidants. Storage containers must be well sealed to prevent leakage. At the same time, clear warning signs should be posted to remind others to pay attention to safety.
    In the event of a leakage accident, immediately evacuate the surrounding personnel and start emergency treatment procedures. In the event of a small amount of leakage, it can be absorbed by inert materials such as sand and vermiculite, and properly disposed of after collection; in the case of a large amount of leakage, it is necessary to build a dike or dig a pit for containment, cover it with foam, reduce the risk of volatilization, and report it to the relevant departments in a timely manner for professional cleaning.
    Only in this way can the research and production of 1-Nitro-4- (Trifluoromethoxy) Benzene be effectively carried out under the premise of ensuring the safety of personnel and the environment.
    Application Area
    1 - Nitro - 4 - (Trifluoromethoxy) Benzene is a wonder of chemistry. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create special drugs, cure various diseases, and save people from pain. In the field of material science, it can participate in the preparation of high-performance materials, so that the materials have unique physical and chemical properties, such as excellent stability and weather resistance, to meet many special needs. In the field of pesticide research and development, it also has its application, or can help to become efficient and low-toxic pesticides, protect crops, and ensure the hope of a bumper harvest. With its unique chemical structure, it blooms brilliantly in various application fields, contributing to the well-being of mankind and the progress of science and technology.
    Research & Development
    Today there is a thing called 1 - Nitro - 4 - (Trifluoromethoxy) Benzene. We study it as a service, hoping to make progress.
    Study the properties of this thing, observe its shape and quality, and study its law of reaction. In the experimental room, apply various methods to observe its changing state. Or it is turned by heat, or it is transformed by an agent, all of which are recorded in detail.
    Also think about the use of this thing, consider its possibility in work, medicine, and various professions. Hope to develop its strengths and use it for the world.
    The process of research, although it is difficult, we will never stop. It is hoped that with the work of the times, it will clarify its principles, promote its development, and make it useful to the world, contributing to the cause of research and progress.
    Toxicity Research
    1 - Nitro - 4 - (Trifluoromethoxy) Benzene is also a chemical substance. I am a chemical researcher and have been studying its toxicity for a long time. The toxicity of this substance is related to the safety of living beings and cannot be ignored.
    Taste the classics, there is no detailed record of its toxicity, so I led a team to strictly seek it with scientific methods. After repeated experiments, the effect of it on various organisms was observed. In mouse experiments, if you touch it or eat it, you can see that its behavior is abnormal and its physiological functions are also disordered.
    It is also observed that it spreads in the environment, and it also harms the surrounding vegetation. Or cause yellow leaves to wither and lose vitality. From this perspective, 1 - Nitro - 4 - (Trifluoromethoxy) Benzene is toxic to a certain extent. When it is produced and used, it is necessary to strictly follow the procedures to prevent its leakage and ensure the safety of all living beings and the environment.
    Future Prospects
    I tried to study 1 - Nitro - 4 - (Trifluoromethoxy) Benzene, thinking about its future prospects, and looking forward to it. Today's technology is new, and this compound may have extraordinary development in various fields.
    Looking at the present, in materials science, it may help to develop new materials with strange properties, increase the stability and functionality of materials, and open up new paths for construction, electronics and other industries. In medicinal chemistry, it is also expected to become a key intermediate. Through exquisite synthesis paths, new drugs with better curative effects and fewer side effects can be prepared, and patients' pain can be relieved.
    With the rise of the concept of green chemistry, the development of an efficient and environmentally friendly method for synthesizing 1 - Nitro - 4 - (Trifluoromethoxy) Benzene is an important task in the future. This will not only reduce production costs, but also protect the beauty of the environment. I am convinced that in time, 1 - Nitro - 4 - (Trifluoromethoxy) Benzene will shine brightly, making immeasurable benefits for human well-being and creating a new prosperous world.
    Where to Buy 1-Nitro-4-(Trifluoromethoxy)Benzene in China?
    As a trusted 1-Nitro-4-(Trifluoromethoxy)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Nitro-4-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1-nitro-4- (trifluoromethoxy) benzene?
    1-Cyano-4- (trifluoromethoxy) benzene is a crucial chemical raw material in the field of organic synthesis. It has a wide range of uses and plays a key role in many aspects such as medicine, pesticides, and materials.
    In the field of medicine, this compound exhibits excellent biological activity and is often used to create new drugs. Due to its unique chemical structure, it can be precisely combined with specific targets in organisms to exert therapeutic effects. For example, in the development of anti-cancer drugs, 1-cyano-4- (trifluoromethoxy) benzene is a key intermediate. After a series of chemical reactions, it can construct drug molecules with high anti-cancer activity, providing strong support for overcoming cancer problems.
    In the field of pesticides, this compound can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. With its special chemical properties, pesticides can give pesticides good insecticidal and bactericidal properties, and have little impact on the environment, which is in line with the current green agricultural development needs. After clever design and synthesis, the resulting pesticides can effectively resist various crop diseases and pests, ensure the thriving growth of crops, and improve grain yield and quality.
    In the field of materials, 1-cyano-4- (trifluoromethoxy) benzene can be used to prepare high-performance functional materials. Introducing it into the structure of polymer materials can significantly improve the thermal stability, chemical stability and mechanical properties of materials. For example, in electronic materials, polymers synthesized from this raw material can be used to manufacture high-performance circuit boards, display screens and other electronic components to improve the performance and reliability of electronic devices.
    1-Cyano-4 - (trifluoromethoxy) benzene is indispensable in many fields such as medicine, pesticides, and materials due to its unique chemical structure and excellent properties, and plays an important role in promoting the development of related industries.
    What are the physical properties of 1-nitro-4- (trifluoromethoxy) benzene?
    1-Cyano-4- (trifluoromethoxy) benzene, this is an organic compound. Its physical properties are quite characteristic, let me tell you in detail.
    This compound is mostly solid at room temperature, and its melting point and boiling point are very important in chemical practice and theoretical research. The melting point is the temperature at which a substance changes from a solid state to a liquid state. After experimental investigation, it is known that the melting point of 1-cyano-4- (trifluoromethoxy) benzene is in a specific range. This property makes the substance stable at the corresponding temperature environment, providing an important basis for related process operations.
    The boiling point is the temperature at which the substance changes from a liquid state to a gas state. Its boiling point reflects the difficulty of gasification of the compound when heated. The boiling point of 1-cyano-4 - (trifluoromethoxy) benzene determines its operating conditions in chemical processes such as distillation and separation, and is of great significance for purification and refining processes.
    Looking at its solubility, this compound exhibits different solubility characteristics in specific organic solvents. In some polar organic solvents, it has a certain solubility, but in non-polar solvents, the solubility is different. This property can help chemists skillfully design processes in the extraction and separation process of organic synthesis to achieve efficient separation and purification of target products.
    In addition, the density of 1-cyano-4- (trifluoromethoxy) benzene is also an important physical parameter. Density characterizes the mass of the substance per unit volume, which is an indispensable data for material balance and reaction system design. Accurately grasping its density is helpful for accurately formulating the proportion of the reaction material and ensuring the smooth progress of the reaction.
    Furthermore, the appearance of the compound is often white or off-white crystalline powder. This appearance feature can be used for intuitive judgment when preliminary identification and quality control.
    In summary, the melting point, boiling point, solubility, density and appearance of 1-cyano-4- (trifluoromethoxy) benzene are of great significance in many fields of organic synthesis and chemical production, providing key reference for relevant practitioners to promote process optimization, Product Research & Development and other work.
    Is 1-nitro-4- (trifluoromethoxy) benzene chemically stable?
    The stability of the chemical properties of 1-% heptyl-4- (trifluoromethoxy) benzene is related to many aspects. The stability of this substance has different characterizations in different situations.
    Looking at its molecular structure, heptyl is a long-chain alkyl group, which has a certain steric hindrance effect. The existence of this alkyl group can affect the interaction between molecules to a certain extent and contribute to its stability. The steric hindrance of long-chain alkyl groups may prevent other molecules from approaching the active check point of the benzene ring, making it difficult for the reaction to occur, thereby improving the overall stability.
    Furthermore, the 4- (trifluoromethoxy) part, the trifluoromethoxy group has a strong electronegative fluorine atom. The electronegativity of fluorine atoms is very high, which can affect the electron cloud density distribution of the benzene ring through induction effects. In this way, the electron cloud of the benzene ring may be more concentrated in a specific area, making the benzene ring structure more stable. At the same time, the bond formed by the fluorine atom and the surrounding atoms has a higher bond energy. To break this bond and initiate a reaction requires a higher energy. This also contributes to the stability of the compound.
    However, the stability is not absolute. Under special reaction conditions, such as high temperature, strong acid-base or the presence of specific catalysts, the stability of 1-% heptyl-4- (trifluoromethoxy) benzene may be challenged. High temperature can endow molecules with higher energy, intensify molecular motion, and enhance the vibration of chemical bonds, thereby increasing the possibility of reactions. Strong acid-base environments may react with some groups in the molecule, breaking the original electron cloud balance and chemical bond stability.
    Overall, 1-% heptyl-4- (trifluoromethoxy) benzene has certain chemical stability under conventional conditions due to the resistance effect of alkyl groups in the molecular structure and the electronic effect and high bond energy characteristics of trifluoromethoxy groups. However, under extreme conditions, its stability may change, depending on the specific reaction situation.
    What are the synthesis methods of 1-nitro-4- (trifluoromethoxy) benzene?
    To make 1-cyano-4- (trifluoromethoxy) benzene, you can follow the following ancient method.
    First, start with 4-chlorobenzonitrile, and place it in a kettle with sodium trifluoromethyl oxide, and control it at an appropriate temperature between one hundred and twenty to one hundred and forty degrees to cause a nucleophilic substitution reaction. The two interact in the kettle, and the chlorine atom is replaced by trifluoromethoxy, so 1-cyano-4- (trifluoromethoxy) benzene is obtained. However, in this process, the preparation of sodium trifluoromethyl oxide needs to be cautious, because its activity is quite high and it is easily decomposed in contact with water. First, silver trifluoromethanesulfonate and sodium methoxide are prepared in an anhydrous environment, and the equipment used needs to be dried to prevent hydrolysis and affect the yield of the product.
    Second, p-fluorobenzonitrile is used as the base to make it meet with the trifluoromethoxylation reagent. Potassium trifluoromethoxy can be selected as the reagent, and it can be used in aprotic solvents, such as N, N-dimethylformamide, heated to ninety to one hundred and ten degrees. The reaction of fluorine atoms and trifluoromethoxy groups is exchanged to obtain 1-cyano-4- (trifluoromethoxy) benzene. The choice of this solvent is quite critical. Non-protic solvents can increase the solubility and activity of potassium trifluoromethoxy, and promote the progress of the reaction. During the reaction, pay attention to the control of temperature. If it is too high, side reactions will occur, and if it is too low, the reaction will be slow and the yield will not be good.
    Third, start with 4-hydroxybenzonitrile. Let it meet with trifluoromethylation reagents, such as trifluoromethylsulfonic anhydride, and in an alkaline environment, such as potassium carbonate, the hydroxyl group is replaced by trifluoromethoxy to obtain 1-cyano-4 - (trifluoromethoxy) benzene. Among them, the degree of alkalinity needs to be appropriate, and too much or too little alkali is unfavorable to the reaction. The amount of potassium carbonate should be calculated accurately according to the amount of 4-hydroxybenzonitrile to achieve the best reaction effect. And after the reaction is completed, the purification of the product should also be fine. The method of column chromatography can be used to select an appropriate eluent to purify the product from the reaction system.
    What should be paid attention to when storing and transporting 1-nitro-4- (trifluoromethoxy) benzene?
    For 1-% heptyl-4- (triethoxysilyl) benzene, many key matters must be paid attention to during storage and transportation.
    The first thing to pay attention to is the ambient temperature. This compound is quite sensitive to temperature, and high temperature can easily cause its chemical properties to change, or even cause adverse reactions such as decomposition. Therefore, it is best to store it in a cool place, and the general temperature should be maintained at 5 to 25 degrees Celsius. If the transportation process passes through high temperature areas, it is necessary to take effective cooling measures, such as the use of refrigeration equipment or thermal insulation materials, to prevent excessive temperature from damaging its quality.
    Second, the control of humidity cannot be ignored. Because it contains siloxy groups, it is easy to hydrolyze in contact with water, which in turn affects its performance. The storage environment should be kept dry, and the relative humidity should be controlled below 40%. When transporting, the packaging must have good moisture resistance. Sealed plastic bags, aluminum foil bags, etc. can be selected, and a desiccant should be placed in the packaging to absorb water vapor that may invade.
    Furthermore, attention should be paid to the integrity of the packaging. This compound is corrosive and irritating to a certain extent. If the packaging is damaged, it may not only leak and pollute the environment, but also pose a threat to personnel safety. Before storage and transportation, the packaging should be carefully checked for cracks, damage, etc., to ensure that the packaging is firmly sealed. At the same time, the packaging material should be able to withstand the chemical action of the compound and not react with it.
    In addition, keep away from fire sources, heat sources and strong oxidants during storage and transportation. This compound is flammable, and in case of open flames, hot topics or contact with strong oxidizing agents, there is a risk of combustion and explosion. Storage places and transportation vehicles should be equipped with corresponding fire protection equipment, and fireworks are strictly prohibited.
    Finally, marking and identification are essential. Information such as the name, properties, hazard characteristics and emergency treatment methods of the compound should be clearly marked on the outside of storage containers and transportation vehicles, so that personnel can identify and respond to possible emergencies.