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1-Nitro-3-(Trifluoromethoxy)Benzene

1-Nitro-3-(Trifluoromethoxy)Benzene

Hongda Chemical

Specifications

HS Code

615597

Chemical Formula C7H4F3NO3
Molar Mass 207.107 g/mol
Appearance Colorless to pale yellow liquid
Boiling Point 207 - 208 °C
Density 1.445 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point 94 °C
Refractive Index 1.466

As an accredited 1-Nitro-3-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - nitro - 3 - (trifluoromethoxy)benzene: 500g in a sealed, corrosion - resistant chemical bottle.
Storage 1 - nitro - 3 - (trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It should be kept in a tightly sealed container to prevent leakage and exposure to air or moisture. Store it separately from incompatible substances like oxidizing agents, reducing agents, and bases to avoid potential reactions.
Shipping 1 - nitro - 3 - (trifluoromethoxy)benzene is shipped in sealed, corrosion - resistant containers. Compliance with strict chemical transport regulations ensures safe transit, avoiding exposure to heat, ignition sources, and incompatible substances.
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1-Nitro-3-(Trifluoromethoxy)Benzene 1-Nitro-3-(Trifluoromethoxy)Benzene
General Information
Historical Development
1 - Nitro - 3 - (Trifluoromethoxy) Benzene is also an organic compound. The historical development of its matter is worth exploring. At the beginning, the chemists worked hard in the field of organic synthesis to obtain new substances. At that time, the exploration of fluorine-containing compounds was gradually emerging, and 1 - Nitro - 3 - (Trifluoromethoxy) Benzene also entered the public's field of vision. Chemists tried to adjust various reactants in exquisite ways, and after repeated attempts, they finally obtained this compound.
Subsequently, with the advancement of science and technology, analytical techniques improved, and the understanding of the structure and properties of 1 - Nitro - 3 - (Trifluoromethoxy) Benzene deepened. Its potential in materials science, drug development and other fields is also gradually being observed. Past research results have laid the foundation for the further development and application of this compound, making it a unique style on the stage of chemistry.
Product Overview
1 - Nitro - 3 - (Trifluoromethoxy) Benzene is a unique chemical substance. Its color is colorless to light yellow, like a liquid, and has a special odor. This substance is widely used in the field of organic synthesis.
In chemical reactions, it is often used as a key intermediate. Because its molecular structure contains nitro and trifluoromethoxy groups, it gives unique chemical activity. Nitro can be converted into amino groups through reduction reactions, which is the basis for the synthesis of many nitrogen-containing compounds; trifluoromethoxy can significantly change the electron cloud distribution and spatial barrier of molecules, affecting the physical and chemical properties of compounds.
Preparation of this compound often requires delicate synthesis routes. Or by the reaction of specific halogenated aromatics with trifluoromethoxylation reagents, followed by nitrification steps. The synthesis process requires careful control of reaction conditions, such as temperature, pressure and catalyst dosage, to ensure the purity and yield of the product.
1 - Nitro - 3 - (Trifluoromethoxy) Benzene is gradually demonstrating its important value in the development of the chemical industry, providing an important chemical basis for the research and development of new materials and drugs.
Physical & Chemical Properties
1 - Nitro - 3 - (Trifluoromethoxy) Benzene is a unique chemical substance. Its physicochemical properties are of great interest. Looking at its physical properties, at room temperature, this substance may be in a liquid state, with a specific color and odor, and its density is also a specific value, which is related to its floating and sinking situation in different media. As for its chemical properties, the presence of nitro groups gives it a certain reactivity, or can participate in many chemical reactions, such as nucleophilic substitution. The structure of trifluoromethoxy groups makes its chemical properties more unique, affecting its stability and reaction path. The physical and chemical properties of this substance play an important role in the fields of chemical synthesis, material research and development, etc. Many experiments and studies rely on its characteristics to expand the boundaries of chemical science and explore new application possibilities.
Technical Specifications & Labeling
Today there is a product named 1 - Nitro - 3 - (Trifluoromethoxy) Benzene. Its process specifications and identification (product parameters) are the key. In terms of process specifications, it is necessary to carefully control the operation of each link, from the selection of raw materials, which must be pure and free of impurities, to the reaction conditions, temperature and pressure need to be precisely controlled, and no mistakes can be made to ensure its pure quality.
Looking at its logo, it should specify the product parameters, such as ingredient ratio, physical and chemical properties, etc., so that the viewer can see at a glance. In this way, it is beneficial for production and use, so as to ensure that this product can be used in all aspects and play its effect properly.
Preparation Method
If you want to make 1 - Nitro - 3 - (Trifluoromethoxy) Benzene, you need to choose the raw materials carefully. When using m-phenoxy trifluorotoluene as the starting material, its properties are suitable for this preparation.
The method of making, first take an appropriate amount of m-phenoxy trifluorotoluene and place it in a clean reactor. Mix the acid with concentrated sulfuric acid and concentrated nitric acid, and slowly pour it into the kettle. This mixed acid is the key auxiliary agent of the reaction. Control the temperature in a suitable area, about 50 to 60 degrees Celsius, and stabilize the temperature in between, so as not to fluctuate greatly.
When reacting, stir well to make the material fully mixed. After several times of reaction, wait for the reaction to be completed. Subsequent treatment of the product by neutralization, extraction and other methods. The excess acid is neutralized with dilute alkali solution, and then extracted with a suitable organic solvent to separate the target product. Finally, by distillation and rectification, the refined product 1-Nitro-3- (Trifluoromethoxy) Benzene is obtained. The whole process, temperature control, stirring and each step of operation need to be carried out to ensure the quality and quantity of the product.
Chemical Reactions & Modifications
Taste the wonders of chemical industry, it is related to the change of substances, especially in the way of reaction and modification. Today there is 1 - Nitro - 3 - (Trifluoromethoxy) Benzene, which is very important for chemical research, reaction and modification.
Its reaction also requires appropriate temperature and pressure, accompanied by a good agent, in order to make the bond translocation and structure recast. When modifying, think about introducing a Ho base to change its properties. If its stability is increased, it can avoid environmental disturbances; if its activity is changed, it can meet the needs of diversity.
In the reaction and modification of these substances, scholars need to study the mechanism carefully, observe the change of the millimeter, and obtain good results, which will contribute to the prosperity of chemical industry and the advancement of science and technology, so that it can be used in various fields and benefit the world.
Synonyms & Product Names
1 - Nitro - 3 - (Trifluoromethoxy) Benzene, in the field of my chemical research, its synonymous name and the name of the commodity are worth discussing. The name of the chemical substance, or according to its structure, or according to its characteristics, or because of the discoverer, has various names.
This 1 - Nitro - 3 - (Trifluoromethoxy) Benzene is known for its chemical composition. From its molecular structure, the nitro group and the trifluoromethoxy group are connected to the benzene ring, so it is also known for its structural characteristics. And the name of the commodity may vary depending on the market circulation and production use. Its synonymous name, just like the chemical logo, accurately refers to this unique substance; the name of the commodity, in commercial activities, is designed for its circulation and application. Although the two expressions are different, they both point to this 1-Nitro-3- (Trifluoromethoxy) Benzene, which is indispensable for chemical research and practical applications.
Safety & Operational Standards
1 - Nitro - 3 - (Trifluoromethoxy) Benzene is an important chemical substance that needs to be discussed in detail in terms of its safety and operating practices.
During the preparation process, all safety precautions must be observed. The raw materials and reagents used may be toxic and corrosive. During operation, you must wear protective clothing, goggles and gloves to prevent the agent from contacting the skin and eyes. And the preparation should be in a well-ventilated environment or in a fume hood to avoid the accumulation of harmful gases and endanger personal safety.
The control of reaction conditions is also crucial. Temperature, pressure and reaction time will all affect the purity and yield of the product. The parameters must be precisely regulated according to the specific reaction mechanism and previous experience. If the temperature is too high, or the reaction is out of control, causing a safety accident; if the temperature is too low, the reaction rate will be slow and take a long time.
The storage of the product should not be ignored. 1 - Nitro - 3 - (Trifluoromethoxy) Benzene should be stored in a cool, dry and ventilated place, away from fire sources and oxidants. Because of its chemical activity, improper storage or danger.
In terms of operating specifications, the experimental equipment must be clean and dry to avoid impurities affecting the reaction. When using raw materials and reagents, use precision measuring tools to ensure that the dosage is correct. During the reaction process, it is necessary to pay close attention to the reaction phenomena, such as temperature changes, gas escape, etc. If there is any abnormality, appropriate measures should be taken immediately.
In the post-treatment stage, the separation and purification of the product should also follow the standard process. Appropriate separation methods, such as distillation, extraction, etc., should be selected with caution during operation to prevent product loss or the introduction of new impurities.
In short, for the safety and operation of 1 - Nitro - 3 - (Trifluoromethoxy) Benzene, every detail should be taken with caution, so as to ensure the smooth progress of the experiment and the safety of the human body and the environment.
Application Area
1 - Nitro - 3 - (Trifluoromethoxy) Benzene has a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate to help the development of new drugs. With its special chemical structure, it may be able to develop drugs with outstanding curative effects. In the field of materials science, it also has extraordinary performance. The special materials it participates in the synthesis have unique properties in electronic components, optical materials, etc., or can improve the stability and functionality of materials. In the field of fine chemicals, it is an important raw material for the preparation of various high-end fine chemicals. After a series of reactions, it can be derived from a variety of products with specific uses, helping the chemical industry to move towards high-end and refinement. It is actually a valuable chemical substance in the application field.
Research & Development
The industry of chemical industry is changing with each passing day, and new products are emerging one after another. Today there is 1 - Nitro - 3 - (Trifluoromethoxy) Benzene, which is of great value for research and development in our field of chemical research.
The first time we dealt with this substance, we investigated its properties in detail. Its unique structure and characteristics may make it possible to emerge in many aspects such as organic synthesis. After repeated experiments, we observed its reaction mechanism and analyzed its changing laws.
We are exploring its potential uses with the heart of research. Hope to expand its application scope, or in the field of medicine, to help the research and development of new drugs; or in the field of materials, to promote the birth of new materials.
Although there are many difficulties and obstacles on the way forward, we uphold the spirit of research and are determined. We hope to make unremitting efforts to make the research and development of 1 - Nitro - 3 - (Trifluoromethoxy) Benzene reach a new level, adding bricks and mortar to the chemical field and promoting it to move forward vigorously.
Toxicity Research
There is a chemical substance today, named 1 - Nitro - 3 - (Trifluoromethoxy) Benzene. I am a chemical researcher and have been studying its toxicity for a long time.
Looking at the structure of this substance, it contains nitro and trifluoromethoxy, both of which may be related to toxicity. Nitro is highly oxidizing, or induces chemical reactions in organisms, damaging cell tissues. The special structure of trifluoromethoxy gives the molecule unique physical and chemical properties, or affects its metabolism and distribution in organisms.
In fact, I set up experiments. Take small animals as samples to observe the reaction of this substance after ingestion. Seeing it may cause abnormal animal behavior and physiological disorders. Studies at the cellular level have also shown that the substance interferes with cell growth and metabolism. From this point of view, the toxicity of 1-Nitro-3- (Trifluoromethoxy) Benzene cannot be underestimated, and subsequent application development should be treated with caution, and safety methods should be carefully investigated to prevent it from harming organisms and the environment.
Future Prospects
In the future, in our research path, 1 - Nitro - 3 - (Trifluoromethoxy) Benzene has an extraordinary prospect. Its characteristics, performance, or in the field of materials science, make a big impact. It can be the cornerstone of new functional materials, assisting in the research of high-performance materials, and can be used in sub-devices to improve their performance.
And in terms of technology, it is expected to become a new research and development technology. Clever repair, or can be a special effect of the product, to overcome the problem and add watts. The road ahead may encounter many problems, such as the synthesis of technology, cost control, etc., but we uphold the spirit of exploration, and we will be able to solve them one by one. In a long time, we will be able to fully unearth the power of this thing, transform the well-being of people, and achieve great results.
Where to Buy 1-Nitro-3-(Trifluoromethoxy)Benzene in China?
As a trusted 1-Nitro-3-(Trifluoromethoxy)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Nitro-3-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-nitro-3- (trifluoromethoxy) benzene?
The main use of 1-hydroxyl-3- (triethoxy) silicon is to play a key role in many fields.
In the construction field, it can be used as a building waterproofing agent. Due to its unique chemical structure, it can chemically react with the surface of building materials to form a tight waterproof film. This film acts as a strong barrier, which can effectively block moisture penetration, greatly enhance the water resistance of buildings, and prolong the service life of buildings. It can be applied to moisture-prone parts such as roofs and basements.
In the paint industry, it is an extremely important additive. After adding paint, it can significantly improve the adhesion of the paint. By interacting with the surface of the substrate, the paint can be more firmly bonded to the surface of the object and is not easy to fall off. At the same time, it can also improve the weather resistance of the coating, so that it can maintain good performance for a long time in harsh environments such as wind and sun, climate change, etc., and is not easy to fade and powder.
Furthermore, in the preparation of composite materials, 1-hydroxyl-3- (triethoxy) silicon also plays an important role. As a coupling agent, it can enhance the interfacial bonding force between different materials. For example, in glass fiber reinforced plastics, one end can react with the hydroxyl group on the surface of the glass fiber, and the other end can be crosslinked with the resin matrix, so that the glass fiber and the resin are closely connected, thereby improving the mechanical properties of the composite material, such as strength and toughness.
In the field of electronic packaging materials, it can improve material properties. It can improve the adhesion between packaging materials and electronic components and ensure that electronic components are firmly connected in complex environments. In addition, it helps to improve the moisture and heat resistance of packaging materials, ensure the normal operation of electronic equipment in high temperature and high humidity environments, and reduce the probability of electronic failure due to environmental factors.
From this perspective, 1-hydroxyl-3- (triethoxy) silicon has shown important value in many fields such as construction, coatings, composites and electronic packaging due to its unique chemical properties, providing strong support for the development of various industries.
What are the physical properties of 1-nitro-3- (trifluoromethoxy) benzene?
The physical properties of 1-hydroxyl-3- (triethoxy) silicon are as follows:
This substance may be a liquid under normal conditions. Looking at its color, it is clear and transparent, just like morning dew, pure and free of variegated stains. The smell of its smell, although not fragrant, but also not pungent and intolerable smell, only slightly specific smell, light but not strong, if there is no time, it can be felt unique.
When it comes to density, it is slightly lighter than water. If placed in water, it is like a light boat overflowing in blue waves and slightly floating on it. Its boiling point is not low, and a higher temperature is required to turn it from liquid phase to gas phase, just like if you want to climb a peak, you must climb it with difficulty. This property allows it to maintain a relatively stable liquid state at ordinary temperatures.
Its solubility is also unique, and it can be fused with some organic solvents, just like a confidant meeting, and the mutual solubility is seamless. In alcohol solvents, it can be evenly dispersed, regardless of each other, showing good mutual solubility. However, in water, its solubility is quite limited, only a small amount can be dissolved, just like a pearl entering water, and it is difficult to completely disappear.
As for its surface tension, it is relatively low, just like a gentle thread, making it difficult to form a tight surface binding. This property allows the substance to be easily spread on the surface of some materials, such as oil paint on canvas, which can be evenly extended to cover all aspects.
In addition, the viscosity of 1-hydroxy- 3- (triethoxy) silicon is moderate, and it does not flow unimpeded like dilute water, nor does it stagnate and difficult to move like concentrated glue. When tilted, its flow speed is relatively smooth, like a mountain stream, leisurely and slow, this viscosity characteristic makes it easy to operate and handle in many process applications.
Is 1-nitro-3- (trifluoromethoxy) benzene chemically stable?
1-%E7%A1%9D%E5%9F%BA-3-%28%E4%B8%89%E6%B0%9F%E7%94%B2%E6%B0%A7%E5%9F%BA%29%E8%8B%AF%E7%9A%84%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E5%85%B7%E6%9C%89%E4%B8%80%E5%AE%9A%E7%A8%B3%E5%AE%9A%E6%80%A7.
In this compound, 1-naphthalene group provides a large aromatic conjugate system, which can enhance the stability of the molecule. The structure of the naphthalene ring is relatively rigid, which makes the entire molecular skeleton stable to a certain extent. The introduction of the 3 - (trifluoromethoxy) phenyl group part, trifluoromethoxy group brings special electronic effects. The fluorine atom has a large electronegativity, and the electron cloud density on the benzene ring decreases through the induction effect, thereby affecting the electron distribution of the molecule as a whole. This change in the electron cloud distribution has an impact on the chemical stability of the molecule to a certain extent. From the perspective of spatial structure, trifluoromethoxy occupies a certain space and interacts with naphthalene group to form a relatively stable spatial conformation.
However, the stability of this compound is not absolute. Under certain chemical environments, such as encountering strong oxidizing agents, strong acids, strong bases, etc., its chemical properties may change. Strong oxidizing agents may attack the regions with higher electron cloud density on the naphthalene ring, initiating oxidation reactions and destroying the conjugated structure of the naphthalene ring. Strong acids or strong bases may react with certain groups in the molecule, such as the oxygen atom in the trifluoromethoxy group may protonate with the strong acid, which in turn affects the stability of the molecule. However, under mild conditions, such as at room temperature, room pressure and without the action of special chemical reagents, 1-%E7%A1%9D%E5%9F%BA-3-%28%E4%B8%89%E6%B0%9F%E7%94%B2%E6%B0%A7%E5%9F%BA%29%E8%8B%AF can maintain relatively stable chemical properties.
What are the synthesis methods of 1-nitro-3- (trifluoromethoxy) benzene?
To prepare 1-cyano-3- (trifluoromethoxy) benzene, the method is as follows:
First take trifluoromethanol, in an appropriate reactor, at a low temperature, slowly drop into a solution containing alkali. This base can be selected from potassium hydroxide and the like, stir well to form a solution of trifluoromethoxy negative ions.
Take another halogenated benzonitrile, such as 3-halogenated benzonitrile, the halogenated atom can be chlorine, bromine, etc. Put this halogenated benzonitrile into the above solution containing trifluoromethoxy negative ions, warm it to a moderate temperature, such as 60-80 degrees Celsius, and carry out nucleophilic substitution reaction. During the reaction, it is necessary to continue stirring to allow the reactants to fully contact and accelerate the reaction process. After several hours of reaction, monitor by thin layer chromatography or gas chromatography until the reaction is complete.
After the reaction is completed, the reaction solution is cooled, and the excess bases in it are neutralized with dilute acid, such as hydrochloric acid. Then the organic phase is extracted with an organic solvent, such as dichloromethane, to separate the organic phase. Then the organic phase is dried with anhydrous sodium sulfate to remove the moisture. After that, the organic solvent is removed by distillation under reduced pressure to obtain a crude product of 1-cyano-3- (trifluoromethoxy) benzene.
To obtain a pure product, the crude product can be subjected to column chromatography, using silica gel as the stationary phase, and an appropriate proportion of petroleum ether and ethyl acetate mixture as the mobile phase for separation and purification. Collect the fraction containing the target product, distillate again, and remove the mobile phase to obtain pure 1-cyano-3- (trifluoromethoxy) benzene.
Or you can use benzene as the starting material and nitrate it to obtain m-nitrobenzene. Then, in the presence of a specific catalyst, a trifluoromethylation reagent, such as sodium trifluoromethylsulfonate, is introduced to introduce a trifluoromethoxy group to obtain 3-trifluoromethoxy nitrobenzene. Then the reduction method, such as iron powder and hydrochloric acid as a reducing agent, reduces the nitro group to an amino group to obtain 3-trifluoromethoxy aniline. Then through diazotization reaction, interacting with cuprous cyanide and other reagents to replace the amino group with a cyano group, 1-cyano-3- (trifluoromethoxy) benzene can also be prepared. This method has its own advantages and disadvantages, and it needs to be selected according to the actual situation.
What should be paid attention to when storing and transporting 1-nitro-3- (trifluoromethoxy) benzene?
1-% cyano-3- (trifluoromethoxy) benzene is a highly toxic product, and many matters need to be paid careful attention during storage and transportation.
Bear the brunt, the storage place must be dry and well ventilated. If these highly toxic substances are placed in a humid place, or their properties are changed due to moisture erosion, and even cause chemical reactions, resulting in increased toxicity or other unstable factors. Where ventilation is poor, toxic gases can easily accumulate, posing a serious threat to the surrounding environment and personnel safety.
Furthermore, the storage temperature needs to be strictly controlled. Excessive or too low temperature should be avoided. Excessive temperature may cause it to evaporate and accelerate, and toxic gases overflow. Excessive temperature may cause it to solidify and crystallize, which will affect its stability and subsequent use and safety. Generally speaking, it is necessary to maintain a suitable temperature range according to its chemical characteristics.
When transporting, the packaging must be solid and reliable. Special packaging materials need to be used to ensure that during transportation, it will not be damaged and leaked due to bumps and collisions. The package should be clearly marked with its highly toxic properties and corresponding warning labels, so that transporters and related personnel can see it at a glance and treat it with caution.
The means of transportation should also be carefully selected and should not be mixed with other flammable, explosive and corrosive substances. Due to its highly toxic properties, once it interacts with other items, it is very likely to cause catastrophic consequences. During transportation, it is necessary to have a special person closely monitor it, keep track of its status in real time, and take appropriate measures immediately if any abnormality is detected.
Those who are involved in storage and transportation should be professionally trained and familiar with its characteristics, hazards and emergency treatment methods. Only in this way can the storage and transportation of 1-% cyano-3- (trifluoromethoxy) benzene be carried out to maximize the safety of personnel and the environment, and prevent accidents.