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1-Nitro-2-Chloro-5-Fluorobenzene

1-Nitro-2-Chloro-5-Fluorobenzene

Hongda Chemical

Specifications

HS Code

884758

Chemical Formula C6H3ClFNO2
Molar Mass 177.545 g/mol
Appearance Solid (usually)
Physical State At Room Temperature Solid
Color May vary, often colorless to pale - colored solid
Solubility In Water Low solubility in water, likely hydrophobic
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform etc.
Odor May have a characteristic, pungent odor
Stability Stable under normal conditions but may react with strong oxidizing or reducing agents

As an accredited 1-Nitro-2-Chloro-5-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - nitro - 2 - chloro - 5 - fluorobenzene: Packed in 5 - kg drums for secure storage and transport.
Storage 1 - nitro - 2 - chloro - 5 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage. Due to its potential hazards, it should be separated from incompatible substances, and the storage area should have appropriate safety and spill - response equipment.
Shipping 1 - nitro - 2 - chloro - 5 - fluorobenzene is shipped in accordance with strict hazardous chemical regulations. It's packed in specialized containers to prevent leakage, transported by carriers licensed for such chemicals, ensuring safety during transit.
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1-Nitro-2-Chloro-5-Fluorobenzene 1-Nitro-2-Chloro-5-Fluorobenzene
General Information
Historical Development
1 - Nitro - 2 - Chloro - 5 - Fluorobenzene is also a chemical product. It originated from the research of various sages in the past. At the beginning, the academic community did not explore the benzene series containing nitrogen, chlorine and fluorine in depth. Some wise people have insight into its potential wonders and started a research journey.
The initial exploration was very difficult, and many attempts failed to achieve the goal. However, scholars are unswerving, and after repeated trials, they have improved the production method. From simple utensils to exquisite devices, from ignorance to speculation to clear mechanisms.
The years have passed, and the technology has become more and more mature. The yield of 1 - Nitro - 2 - Chloro - 5 - Fluorobenzene is gradually increasing, and the quality is better. It has emerged in the fields of medicine and materials, contributing to the advancement of science and technology. The difficulties of the past have become the foundation of today. The development of this product has also witnessed the road of chemistry, from obscure to bright, step by step.
Product Overview
1 - Nitro - 2 - Chloro - 5 - Fluorobenzene is also a chemical product. Its shape is special, its nature is special. The color may be light, and the taste is clear, so to speak. This product is synthesized by exquisite chemical technology, and the atoms are divided in a dense order to form a solid solution.
Its use is very important, and it can be an important raw material to help people find a cure for diseases. In the field of material science, it can also contribute to the special properties of materials, such as increasing their stability and resistance. However, its synthesis is not easy, and it requires fine control, harsh components, such as accuracy, strength, and caution, in order to obtain a good product. In addition, 1 - Nitro - 2 - Chloro - 5 - Fluorobenzene has its unforgettable position in the world of transformation. I will explore it in depth to make more of its capabilities.
Physical & Chemical Properties
1 - Nitro - 2 - Chloro - 5 - Fluorobenzene is an organic compound, and its physical and chemical properties are quite critical. Looking at its properties, it is mostly solid at room temperature, with a color or light yellow. Its melting point is about [X] ° C, which is determined by intermolecular forces. The boiling point is around [X] ° C, which is closely related to the molecular structure.
In terms of solubility, this substance is insoluble in water, because its molecular polarity is quite different from that of water. However, it has good solubility in organic solvents such as ethanol and ether, all because of the "similar miscibility".
Its chemical properties are active, and nitro, chlorine and fluorine atoms are all reactive. Nitro groups can be reduced, chlorine atoms and fluorine atoms can participate in the substitution reaction, and are widely used in the field of organic synthesis. It is a compound worthy of further investigation and has potential application value in many fields.
Technical Specifications & Labeling
1 - Nitro - 2 - Chloro - 5 - Fluorobenzene is an important chemical substance. Its process specifications and identification (product parameters) are crucial. In terms of process specifications, it is necessary to specify the steps of synthesis, such as the precise ratio of raw materials, and the strict control of reaction temperature and duration. The selection of raw materials must be pure and free to ensure product quality. The reaction temperature or in a specific range, the duration is also fixed, so that high-quality products can be obtained.
As for the identification (product parameters), its physical properties such as color, odor, melting point, boiling point, etc. should be clearly marked. Purity is a key parameter, which needs to reach a very high standard, and the impurity content must be extremely low. In addition, the packaging specifications also need to be clear to facilitate storage and transportation. This is the main point of 1 - Nitro - 2 - Chloro - 5 - Fluorobenzene's process specifications and identification (product parameters), which are related to product quality and application.
Preparation Method
The method of making 1 - Nitro - 2 - Chloro - 5 - Fluorobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. First take an appropriate amount of 2 - Chloro - 5 - Fluorotoluene as the starting material and place it in a clean reactor. Mix concentrated sulfuric acid and concentrated nitric acid in an appropriate ratio and slowly drop it into the kettle. This is the nitrification reaction step. Control the temperature in a suitable range, about 50 to 60 degrees Celsius, to prevent side reactions.
After the reaction is completed, the product is poured into ice water, extracted and separated to obtain a crude product. Then purified by distillation and recrystallization to obtain pure 1 - Nitro - 2 - Chloro - 5 - Fluorobenzene. This process requires precise control of the reaction conditions of each step, and the catalyst used can improve the reaction rate and yield. For example, specific metal salt catalysts, with their activity checking points, promote the reaction to proceed efficiently, and the product can be stably prepared according to this process.
Chemical Reactions & Modifications
1 - Nitro - 2 - Chloro - 5 - Fluorobenzene is an important compound. In chemical research, its chemical reaction and modification have attracted much attention.
In the past, the reaction of this compound was mostly limited by traditional methods, and the effect was not satisfactory. Today, many chemists are working hard to find better reaction conditions and modification strategies.
After repeated experiments and research, it was found that moderate changes in reaction temperature and catalyst type could significantly increase the reaction rate of 1 - Nitro - 2 - Chloro - 5 - Fluorobenzene, and the purity of the product was also improved.
As for modification, the attempt to introduce specific functional groups has given this compound new physical and chemical properties, which may have extraordinary application potential in the fields of materials science. In this way, the continuous exploration of its chemical reactions and modifications will surely inject new vitality into the development of the chemical field.
Synonyms & Product Names
1 - Nitro - 2 - Chloro - 5 - Fluorobenzene This compound, its synonyms and trade names, are quite worth exploring. In my opinion, in the field of chemical industry, this compound may have many other names. Due to industry habits, regional differences, and even different research directions, various names have been derived.
Or named after its chemical properties are similar, such as common names related to compounds containing similar nitro groups, chloro groups, and fluoro groups. Or trade names are obtained according to its preparation process and use. However, it basically refers to this 1 - Nitro - 2 - Chloro - 5 - Fluorobenzene. This compound has its unique efficacy and status in the fields of organic synthesis, and its diverse synonyms and trade names also reflect the rich and complex ecology of the chemical industry.
Safety & Operational Standards
1 - Nitro - 2 - Chloro - 5 - Fluorobenzene is a chemical substance. It is crucial to its safety and operating standards. It needs to be discussed in detail.
Where this substance is involved, safety is the first priority. Its nature may be dangerous, and safety regulations must be followed when handling it. In the place, ventilation must be good to dissipate harmful gases that may escape, so as to avoid their accumulation and harm to people. The operator is in front of suitable protective equipment, such as gas masks, which can filter harmful gases; the gloves are chemically resistant to protect the skin of the hands; wear protective clothing to fully protect the body.
When operating, strictly follow the norms. When taking this product, the measurement must be accurate, and there should be no difference of millimeters. When stirring, the rate is moderate to make the reaction uniform. During the heating process, the temperature should be controlled stably. According to the needs of the reaction, do not let the temperature exceed the limit and cause accidental changes. After the reaction, dispose of the product and waste, and also follow the regulations. Do not dump it at will to prevent pollution of the environment.
Store this product, also pay attention to it. When placed in a cool, dry and ventilated place, avoid fire and heat sources. Store it separately from other things to prevent interaction and risk. The logo is clear, indicating its name, nature and hazards, so that those who see it can be alerted.
When handling, handle it with care. Do not damage the container or cause material leakage. In case of leakage, take emergency measures as soon as possible. Evacuate the crowd, ban fire and electricity, and prevent the risk of explosion. Dispose of leaks, according to their characteristics, or adsorption, or neutralization, to ensure the safety of the environment.
In short, the safety and operation specifications of 1 - Nitro - 2 - Chloro - 5 - Fluorobenzene must be strictly observed to ensure the safety of personnel and the environment, so that the relevant operations are smooth and risk-free.
Application Area
1 - Nitro - 2 - Chloro - 5 - Fluorobenzene is a unique chemical substance. Its application field is quite wide. In the field of medicinal chemistry, it is often used as a key intermediate to help synthesize specific drugs to cure various diseases. In the field of materials science, it also has important functions and can participate in the preparation of materials with special properties, such as substances with high stability and unique optical properties. In pesticide chemistry, this compound can be used as a basic raw material to create efficient and low-toxicity pesticides to protect crop growth and resist the attack of pests and diseases. All these highlight the key value of 1 - Nitro - 2 - Chloro - 5 - Fluorobenzene in different application fields, which is of great significance to promote the development of related industries.
Research & Development
In recent years, Yu devoted himself to the research of 1-Nitro-2-Chloro-5-Fluorobenzene. This compound has special properties and is quite useful in various fields. At first, analyze its structure, clarify the arrangement of atoms, probe the characteristics of bonds, and understand the rationale, so that follow-up research can be feasible.
Study its synthesis method and try various paths. After many attempts, I chose a certain method, but although the product was obtained, the yield was not perfect. Then I thought about improved strategies, adjusted the temperature and pressure of the reaction, and easy to use the agent, and finally the yield gradually increased and the purity was also standard.
The application of this product is also studied. In the field of medicine, it is expected to be the raw material for new pharmaceuticals and assist in the research of special drugs; in the field of materials, it may be involved in the creation of new materials, which are specific.
I will continue to research this compound, hope to expand its use, promote its progress, and take more steps in the way of research and development, so as to promote its wide use in the world and benefit all parties.
Toxicity Research
The properties of taste and smell are related to use and people. Today there is 1 - Nitro - 2 - Chloro - 5 - Fluorobenzene, which is quite remarkable in the field of chemistry. The study of its toxicity is crucial.
This substance belongs to the genus halogenated nitrobenzene. Halogen and nitro, or cause it to be toxic. Nitro easily reacts with biomolecules, disturbing their order; halogen atoms, or increase their fat solubility, easily enter the body of organisms.
From an experimental point of view, if applied to animals, or see physiological changes. If it affects its metabolism, cause damage to the organs. At the cell level, or the stability of the broken cell membrane, the function of the cell is disrupted.
However, the study of toxicity is not achieved overnight. When the differences in dosage, duration and route are carefully observed, and the mechanism of its toxicity is explored, accurate cognition can be obtained, and the right path can be guided for protection and application, ensuring people's safety and protecting the environment.
Future Prospects
Wuguanfu 1 - Nitro - 2 - Chloro - 5 - Fluorobenzene is a promising product in the future. It has endless potential in various fields of chemical industry. Or it can be used to create new drugs to help the world's diseases. With its characteristics, it can accurately treat drugs and double the curative effect.
It is also expected to help the research and development of new materials, so that materials have specific properties, which will shine in the fields of aerospace and electronics. When the technology is refined, the preparation method is better, and the cost is gradually reduced, it will be widely used in the world.
Our generation should study it diligently, explore its endless mysteries, and hope to use it as a foundation to open a new chapter in the future and create a brilliant career, so that this material will benefit all generations, live up to our scientific research expectations, and pave the way for future generations.
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Frequently Asked Questions

As a leading 1-Nitro-2-Chloro-5-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Nitro-2-Chloro-5-Fluorobenzene?
1-Nitro-2-chloro-5-fluorobenzene is also an organic compound. It has a wide range of uses and has important applications in various fields of chemical industry.
Bearing the brunt, it is a key intermediate in pharmaceutical synthesis. In the creation of Gai Pharmaceutical, various organic compounds are often relied on as starting materials, and complex drug molecular structures are constructed through many chemical reaction steps. 1-Nitro-2-chloro-5-fluorobenzene can introduce specific functional groups due to its unique chemical structure, laying the foundation for the synthesis of drugs with specific pharmacological activities. For example, it can be converted into heterocyclic compounds containing nitrogen, chlorine, fluorine and other elements through a series of reactions. Such compounds may show affinity and activity to biological targets related to specific diseases, such as tumors and inflammation, and are expected to be developed into new therapeutic drugs.
Furthermore, it also plays an important role in the field of pesticides. The development of pesticides today pursues high efficiency, low toxicity and environmental friendliness. 1-nitro-2-chloro-5-fluorobenzene can be used as a raw material for the synthesis of new pesticides. The introduction of fluorine atoms can often significantly improve the biological activity and stability of compounds. Pesticides synthesized on this basis may have stronger contact-killing, stomach-poisoning or internal absorption effects on pests, and due to the unique structure, they may be able to avoid the resistance problem of some traditional pesticides, providing a better choice for crop pest control.
In addition, it also has potential uses in the field of materials science. With the advancement of science and technology, the demand for special functional materials is increasing. This compound may participate in the synthesis of materials with specific photoelectric properties. For example, in the preparation of organic photoelectric materials, the nitro, chlorine, and fluorine atoms in its structure may adjust the electron cloud distribution of the material, thereby affecting the conductivity and fluorescence properties of the material, providing the possibility for the development of new display materials, optoelectronic devices, etc.
In summary, 1-nitro-2-chloro-5-fluorobenzene has important uses in many fields such as medicine, pesticides, and materials science, and is an indispensable organic compound in the chemical industry.
What are the physical properties of 1-Nitro-2-Chloro-5-Fluorobenzene?
1-Nitro-2-chloro-5-fluorobenzene is one of the organic compounds. Its physical properties are quite important, let me tell you in detail.
First of all, its appearance, under room temperature and pressure, this substance is often a light yellow to yellow liquid, and its color is bright and characteristic. Although its smell is not exhaustive, it must be in a specific environment, or it can emit a unique smell. However, the exact description of this smell needs more detailed experimental investigation.
As for the melting point and boiling point, these two are important physical parameters of the substance. Although the exact value is not available, it can be inferred that the melting point is within a certain range, because the melting point of similar compounds is more regular. The boiling point should also be the same, inferred according to its molecular structure and chemical properties, or within a certain range, but it needs to be determined accurately by experiments.
Density is also one of its key physical properties. Although the measured value is not available, its molecular composition and the properties of similar compounds can be regarded as a reference for preliminary research.
In terms of solubility, this substance may have a certain solubility in organic solvents. Because of the nitro group, chlorine atom and fluorine atom in the molecule, its solubility is affected. For example, common organic solvents, such as ethanol and ether, may interact with them to some extent, causing them to partially dissolve. However, the specific degree of dissolution needs to be accurately determined through experiments to clarify their dissolution characteristics in different solvents.
1-nitro-2-chloro-5-fluorobenzene Although some of the physical properties are not yet known, according to chemical principles and the characteristics of similar compounds, many reasonable speculations can be made to provide direction for subsequent in-depth research, and accurate data need to be determined by rigorous experimental investigation.
What are the chemical properties of 1-Nitro-2-Chloro-5-Fluorobenzene?
1-Nitro-2-chloro-5-fluorobenzene is one of the organic compounds. Its chemical properties are unique and valuable to explore.
The substitution reaction is first discussed. Because there are nitro groups, chlorine atoms and fluorine atoms on the benzene ring, these substituents have a great impact on the electron cloud density distribution of the benzene ring. Nitro is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring, making it difficult for the electrophilic substitution reaction to occur, and the reaction check point is mostly in the meso position. In case of electrophilic reagents, the reagents mostly attack the meso-position of the benzene ring, and although chlorine and fluorine are ortho-para-position groups, their localization effect changes due to the influence of nitro groups.
The hydroly Chlorine atoms can be hydrolyzed under suitable conditions. When heated with a strong alkali such as sodium hydroxide aqueous solution, chlorine atoms can be replaced by hydroxyl groups to obtain corresponding phenolic compounds. In this process, the control of reaction conditions is crucial. Temperature and alkali concentration both affect the reaction rate and yield.
and reduction reaction. Nitro groups can be reduced. In reduction systems such as iron and hydrochloric acid, nitro groups can be gradually reduced to amino groups to obtain amino-containing compounds. This reaction can be used to synthesize nitrogen-containing organic intermediates and is widely used in the field of organic synthesis. The chemical properties of 1-nitro-2-chloro-5-fluorobenzene are rich and diverse, and it has great potential in the field of organic synthesis. Through the regulation of different reaction conditions, a variety of organic compounds with specific functions can be prepared.
What are 1-Nitro-2-Chloro-5-Fluorobenzene synthesis methods?
The synthesis methods of 1-nitro-2-chloro-5-fluorobenzene have many different paths. First, it can be started from suitable aromatic compounds. If fluorobenzene is used as a raw material, the nitro group is introduced into the benzene ring through a nitration reaction. This step requires careful preparation of reaction conditions, such as reaction temperature, the proportion of nitrifying reagents used, etc. The commonly used nitrifying reagent is a mixed acid of concentrated nitric acid and concentrated sulfuric acid. The temperature is controlled in a moderate range, so that the nitro group can be selectively introduced into the specific position of fluorobenzene to obtain fluorobenzene derivatives containing nitro groups.
Thereafter, the obtained product is chlorinated. Select suitable chlorination reagents, such as chlorine gas, thionyl chloride, etc. If chlorine is used, a catalyst is often required to help, such as ferric trichloride. This chlorination step also requires precise control of the conditions to ensure that the chlorine atoms are just in the target position, and finally 1-nitro-2-chloro-5-fluorobenzene is obtained.
Another path can be started from chlorobenzene. First nitrate chlorobenzene, introduce nitro groups, and then carry out fluorination reaction. Fluorination reaction or use a specific fluorination reagent, such as potassium fluoride, under suitable solvent system and reaction conditions, so that fluorine atoms replace hydrogen atoms at specific positions on the benzene ring, through a series of reactions to obtain the target product.
Or start with nitrobenzene and proceed with chlorination and fluorination in sequence. Choosing the appropriate chlorination agent during chlorination and adjusting the conditions according to the reaction characteristics during fluorination are all feasible ways to synthesize this compound. Each method has its own advantages and disadvantages, and the appropriate synthesis strategy needs to be carefully selected according to the actual demand, availability of raw materials, cost considerations and other factors.
What are the precautions in storage and transportation of 1-Nitro-2-Chloro-5-Fluorobenzene?
1-Nitro-2-chloro-5-fluorobenzene is an organic compound. When storing and transporting, many matters need to be paid attention to.
First, storage, because of its certain chemical activity and potential danger, should be placed in a cool, dry and well-ventilated place. If the storage environment temperature is too high, it is easy to cause its chemical properties to change or cause chemical reactions, so it is necessary to avoid direct sunlight and heat sources. Furthermore, this compound should be stored separately from oxidants, reducing agents, acids, bases and other substances. Due to the characteristics of its chemical structure, contact with the above substances, or react violently, endangering safety. And the storage area must be clearly marked, indicating the name of the compound, danger and other information, so that personnel can identify and prevent it. At the same time, the storage container should be checked regularly to see if there is any leakage. If the container is damaged and leaks, 1-nitro-2-chloro-5-fluorobenzene will evaporate or come into contact with air, moisture, etc., or cause more serious consequences.
As for transportation, transportation vehicles must meet relevant safety standards and have necessary protective and emergency equipment. During the loading process, ensure that the packaging is in good condition to prevent collision and friction from causing damage to the packaging. During transportation, drivers should drive carefully to avoid sudden braking, sharp turns and other operations to prevent the goods from shaking and colliding. In addition, the transport unit should formulate a sound emergency plan, clarify the response measures for possible leaks, fires and other accidents, and the transport personnel need to undergo professional training, familiar with the danger of the compound and emergency treatment methods. In this way, the safety of 1-nitro-2-chloro-5-fluorobenzene during storage and transportation can be ensured.