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What are the main uses of 1- (methylthio) -4- (trifluoromethyl) benzene?
1- (methylsilyl) -4- (trifluoromethyl) benzene, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
Looking at the process of organic synthesis, many complex and delicate organic compounds are constructed from 1- (methylsilyl) -4- (trifluoromethyl) benzene. Due to their unique molecular structures, methylsilyl and trifluoromethyl give them special chemical activity and steric resistance. With this property, chemists can skillfully use various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., to modify and expand their molecular structures, thereby deriving many organic compounds with unique properties and functions.
In the field of materials science, it also has extraordinary performance. After appropriate chemical transformation and modification, it can be introduced into the structure of polymer materials. The strong electronegativity of trifluoromethyl can significantly improve the chemical resistance, thermal stability and surface properties of materials. The existence of methyl silicon groups may improve the flexibility and processing properties of materials. In this way, high-performance materials suitable for aerospace, electronic devices, automobile manufacturing and many other high-end fields can be prepared.
In the field of medicinal chemistry, 1- (methylsilyl) -4- (trifluoromethyl) benzene also plays an important role. Due to its special structure, it can be used as a pharmacophore or auxiliary structure to introduce drug molecules. Trifluoromethyl can enhance the lipid solubility of drug molecules, promote their transmembrane transportation, and improve bioavailability; methyl silyl may have a positive impact on the metabolic stability and targeting of drug molecules, helping to develop more efficient and safe new drugs.
What are the physical properties of 1- (methylthio) -4- (trifluoromethyl) benzene?
1 - (methylphenyl) -4 - (trifluoromethyl) benzene, this is an organic compound. Its physical properties are as follows:
Looking at its appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid, with clear quality and good fluidity, like a clear spring in the mountains.
Smelling its smell often exudes a specific aromatic smell. Although the smell is not rich and strong, it is unique. It is like a strange fragrance hidden in the flowers, which inadvertently burrows into people's olfactory perception.
In terms of its melting point, it is between -20 ° C and -10 ° C. In this low temperature environment, the compound gradually solidifies from liquid to solid, like a smart dancer standing still under the command of low temperature into a beautiful picture.
And the boiling point is roughly in the range of 200 ° C to 220 ° C. When the temperature rises to this range, the compound will sharply transform from liquid to gaseous, turning into a curling and rising invisible state, dissipating into the air like a cloud.
As for the density, it is about 1.2 - 1.3g/cm ³, which is slightly higher than that of common water. If it is placed in the same container as water, it will sink to the bottom like a stable stone.
In terms of solubility, this compound is difficult to dissolve in water, but it can show good miscibility with many organic solvents, such as ethanol, ether, dichloromethane, etc. This is like people with different personalities. Although it is difficult to coexist harmoniously with water, they can closely blend with these organic solvents at the molecular level to form a uniform and stable mixed system.
Is 1- (methylthio) -4- (trifluoromethyl) benzene chemically stable?
The chemical properties of 1 - (methylsilyl) -4 - (trifluoromethyl) benzene are relatively stable. In this compound, the methylsilyl group is connected to the trifluoromethyl group through the benzene ring. In the methylsilyl group, the silicon atom has an empty d-orbit and can accept electron pairs. However, after it is connected to the benzene ring, the electron cloud distribution changes under the influence of the benzene ring conjugation system, which stabilizes the group to a certain extent. Trifluoromethyl has strong electron absorption, which reduces the electron cloud density of the benzene ring, especially in the ortho and para-position.
On the whole, the strong electron-absorbing effect of 1- (methylsilyl) -4- (trifluoromethyl) benzene trifluoromethyl decreases the electron cloud density on the benzene ring, and the electrophilic substitution reaction activity decreases. If there is an attack of electrophilic reagents, it is more inclined to meta-substitution, because the density of the meta-electron cloud is slightly higher relative to the adjacent and para-position.
And because of its silicon atom, the silicon-carbon bond has a certain stability, and the carbon-fluorine bond energy in the trifluoromethyl is also high, and the interaction of various parts in the molecular structure makes the overall chemical properties tend to be stable. Under common conditions, without specific reagents or severe reaction conditions, chemical reactions are less likely to occur, and the chemical properties are relatively stable, capable of maintaining structural stability in a certain environment.
What are the synthesis methods of 1- (methylthio) -4- (trifluoromethyl) benzene?
To prepare 1- (methylphenyl) -4- (trifluoromethyl) naphthalene, the following ancient methods can be used.
First, use suitable aromatic hydrocarbons as starting materials. First, the aromatic hydrocarbon and the halogenated methyl phenyl reagent are reacted with a suitable catalyst, such as a metal catalyst, according to the mechanism of the alkylation reaction of Fu Ke, to form an intermediate with methyl phenyl. This process requires careful control of the reaction conditions, such as temperature and catalyst dosage, to prevent the growth of side reactions. Then, for the obtained intermediate, trifluoromethyl is introduced. A reagent containing trifluoromethyl can be selected. Under specific reaction conditions, the trifluoromethyl group can be substituted for the hydrogen atom at a specific position in the intermediate to obtain the target product 1- (methylphenyl) -4- (trifluoromethyl) naphthalene.
Second, it can also start from naphthalene derivatives. The naphthalene ring is modified first, and a suitable functional group is introduced at a specific position in one of the naphthalene rings, which can be converted into methylphenyl. It can be gradually achieved through a series of substitution reactions, addition reactions, etc. After the group that can be converted into methylphenyl is successfully introduced, the conversion step is carried out to make it a methylphenyl structure. Subsequently, using a suitable method, trifluoromethyl is introduced into another designated position of the naphthalene ring. This approach requires careful consideration of the sequence and reaction conditions of each step to ensure that the reaction can proceed in the expected direction, effectively avoid unnecessary by-products, and smoothly obtain 1- (methylphenyl) -4- (trifluoromethyl) naphthalene.
What should be paid attention to when storing and transporting 1- (methylthio) -4- (trifluoromethyl) benzene?
If you want to store and transport methyl ethyl ether, you need to pay attention to many matters. The first thing to check is its physical properties. Methyl is flammable and volatile, and its steam and air can form an explosive mixture, which can cause ignition and explosion in case of open flame and high heat. Therefore, when storing and transporting, fire and explosion prevention is the top priority.
Store in a cool and ventilated warehouse, away from fire and heat sources. The warehouse temperature should not exceed 29 ° C. It should be stored separately from oxidants and acids, and should not be mixed. The warehouse must be equipped with suitable materials to contain leaks.
When transporting, be sure to drive according to the specified route and do not stop in residential areas and densely populated areas. Transportation vehicles should be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment. It is best to transport in the morning and evening in summer to prevent excessive temperature from causing its volatilization and increasing the risk factor.
When loading and unloading, it should be handled lightly to prevent damage to packaging and containers. During transportation, it should be protected from exposure to the sun, rain, and high temperature. If it is road transportation, drive according to the specified route, and do not stop in residential areas and densely populated areas; during railway transportation, it is strictly forbidden to slip.
For trimethyl basic benzene, it is also flammable and irritating. When storing, it should also be stored in a cool and ventilated place, away from fire and heat sources, and stored separately from oxidants. During transportation, attention should also be paid to fire prevention, sun protection, and rain protection. Be careful in loading and unloading to ensure safety. Therefore, the storage and transportation of paraben ethyl ether are safe.
