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1-Methyl-3-(Trifluoromethoxy)Benzene

1-Methyl-3-(Trifluoromethoxy)Benzene

Hongda Chemical

    Specifications

    HS Code

    717346

    Chemical Formula C8H7F3O
    Molar Mass 180.135 g/mol
    Appearance Liquid (usually)
    Boiling Point Approximately 153 - 155 °C
    Density Around 1.22 - 1.24 g/cm³
    Solubility In Water Poorly soluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
    Vapor Pressure Low vapor pressure at room temperature
    Flash Point Relatively low, around 42 - 45 °C

    As an accredited 1-Methyl-3-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100 - gram bottle packaging for 1 - methyl - 3 - (trifluoromethoxy)benzene chemical.
    Storage 1 - methyl - 3 - (trifluoromethoxy)benzene should be stored in a cool, well - ventilated area, away from heat and ignition sources. Keep it in a tightly - sealed container to prevent evaporation. Store it separately from oxidizing agents and reactive chemicals. Use a storage facility compliant with safety regulations to ensure its stability and prevent potential hazards.
    Shipping 1 - methyl - 3 - (trifluoromethoxy)benzene is a chemical. Shipping should be in well - sealed, corrosion - resistant containers. It must comply with hazardous chemical transport regulations, ensuring proper labeling and handling to prevent spills and ensure safety during transit.
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    1-Methyl-3-(Trifluoromethoxy)Benzene 1-Methyl-3-(Trifluoromethoxy)Benzene
    General Information
    Historical Development
    1 - Methyl - 3 - (Trifluoromethoxy) Benzene is an organic compound with an interesting history. In the past, chemists worked diligently in the field of organic synthesis to explore the preparation path of new compounds. At that time, many chemists were dedicated to exploring fluorinated organic compounds, which attracted attention due to their unique properties.
    During this exploration process, through repeated experiments and exquisite design of reactions, chemists gradually mastered the synthesis of compounds containing specific functional groups. For 1 - Methyl - 3 - (Trifluoromethoxy) Benzene, chemists have successfully synthesized this compound after countless attempts to prepare different reactant proportions and optimize reaction conditions. After setbacks and failures, they finally succeeded in synthesizing this compound.
    Its birth adds new members to the field of organic chemistry, and subsequent research continues to expand the understanding of its properties, laying the foundation for its application in materials science, medicinal chemistry and other fields, opening up new directions in organic synthesis, and promoting the continuous development of chemistry.
    Product Overview
    1 - Methyl - 3 - (Trifluoromethoxy) Benzene is a chemical I have been working on recently. This substance has a colorless and transparent liquid appearance, a unique smell, and a slight irritation. Its boiling point is suitable, and it volatilizes and stabilizes under specific conditions.
    In terms of chemical properties, it has a certain chemical activity due to the presence of methyl and trifluoromethoxy groups. Methyl changes the electron cloud density of the benzene ring, which affects its reactivity; the strong electron-absorbing properties of the trifluoromethoxy group make the compound exhibit unique selectivity in the electrophilic substitution reaction.
    In the application field, with its special structure and properties, it can be used as a key intermediate in pharmaceutical synthesis to help develop new special drugs; in the field of materials science, it is also expected to participate in the preparation of high-performance materials and improve the specific properties of materials. I will continue to explore its potential applications and reaction mechanisms, hoping to contribute to the development of the chemical field.
    Physical & Chemical Properties
    1 - Methyl - 3 - (Trifluoromethoxy) Benzene is an organic compound. Its physical and chemical properties are unique. Looking at its physical properties, it is mostly liquid at room temperature, has a special odor, and is highly volatile. In terms of solubility, it has good solubility in organic solvents such as ethanol and ether, but it is difficult to dissolve in water. In terms of chemical properties, its phenyl ring structure makes it stable to a certain extent. However, the presence of methyl and trifluoromethoxy groups also endows the compound with unique reactivity. Methyl can undergo reactions such as oxidation, while trifluoromethoxy affects the electron cloud distribution of the benzene ring, making it more prone to substitution reactions at specific locations of the benzene ring, and is widely used in the field of organic synthesis. The physical and chemical properties of this compound determine its important position and application prospects in chemical, pharmaceutical and other industries.
    Technical Specifications & Labeling
    1 - Methyl - 3 - (Trifluoromethoxy) Benzene is an organic compound, and its preparation process depends on specific scientific laws. To make this product, the characteristics of the raw material and the mechanism of the reaction should be known first.
    In terms of process specifications, the purity of the raw material is the key, and high-quality starting materials must be selected to ensure a smooth reaction. The temperature, pressure and time parameters of the reaction must also be precisely controlled. If the reaction temperature is high or low, the product can be impure or the yield can be low.
    The label of the product (commodity parameters) should specify its chemical structure, purity index, physical properties, etc. The purity must meet the specified standards, and the physical properties such as appearance, melting point, boiling point, etc. should also be clearly marked so that the user can know its characteristics and be suitable for different uses. In this way, a high-quality 1-Methyl-3 - (Trifluoromethoxy) Benzene product can be obtained.
    Preparation Method
    To prepare 1-methyl-3- (trifluoromethoxy) benzene, the raw materials and production process, reaction steps, and catalytic mechanism are very critical.
    First take an appropriate amount of benzene, add an appropriate amount of methylation reagent in a specific reactor, and carry out a methylation reaction according to the appropriate temperature and pressure, so that methyl groups are introduced into the benzene ring to obtain 1-methylbenzene.
    Then, mix 1-methylbenzene with a reagent containing trifluoromethoxy, and under the action of a catalyst, adjust the reaction conditions, so that the trifluoromethoxy group is connected to the No. 3 position of 1-methylbenzene. The catalyst used needs to be carefully selected to improve the reaction rate and product selectivity. During the reaction, pay close attention to factors such as temperature, pressure and reaction time, and adjust it in time to ensure the smooth progress of the reaction, and finally obtain 1-methyl-3- (trifluoromethoxy) benzene. In this way, it is necessary to strictly control each step to obtain high-quality products.
    Chemical Reactions & Modifications
    Modern chemistry has advanced, and the research of various compounds has been deepened. 1 - Methyl - 3 - (Trifluoromethoxy) Benzene is a compound whose chemical reaction and modification are particularly important in the academic community.
    Looking at the reaction, it is combined with a specific reagent, and under suitable temperature and pressure, the intermolecular bonding rearrangement results in the generation of new substances. However, the initial reaction rate is slow, and impurities are easy to produce, which is an obstacle to synthesis.
    To change its properties, chemists are exhausted. After many tests, with a new type of catalyst, the reaction rate rises sharply, and the purity of the product increases greatly. The disturbance of impurities is also greatly reduced. From this, it can be seen that in the way of chemistry, continuous exploration can make the reaction and modification of compounds reach a delicate state, opening up a smooth path for various applications.
    Synonyms & Product Names
    1 - Methyl - 3 - (Trifluoromethoxy) Benzene is a synonymous name and a commodity, which is quite important. In the process of my chemical investigation, we can get accurate cognition by knowing the situation of more than one thing.
    Consider its synonymous name, or it is called according to its structural characteristics, or because of past customs. The name of the product is designed by merchants for the market, who want to be easy to remember and show its characteristics.
    1 - Methyl - 3 - (Trifluoromethoxy) Benzene, or it is called by another name because of its similar chemical composition, or it is called by different common names in different regions and industries. As for the name of the product, when it fits the market demand, it not only shows its unique attributes, but also is easy to identify.
    In the field of chemical research, understanding its synonymous name and the name of the product can avoid confusion and promote academic and application. Therefore, exploring the name of this thing is actually an indispensable move for chemical research.
    Safety & Operational Standards
    1 - Methyl - 3 - (Trifluoromethoxy) Benzene is a special chemical. Safety and operating practices are of paramount importance during its experimentation and production.
    Where this substance is involved in the operation, the experimenter must wear appropriate protective equipment, such as protective clothing, gloves and goggles, to prevent contact with the skin and eyes. Due to its specific chemical properties, if inadvertent contact, it may cause skin irritation, burns, and serious damage to the eyes.
    The operating environment must be well ventilated, which is the key. The gaseous substances evaporated by this substance may accumulate under specific conditions. If the ventilation is not smooth, or the concentration of poisons in the air increases, endangering the health of the operator. The laboratory should be equipped with effective ventilation equipment to continuously update the air and reduce the concentration of harmful gases.
    When taking 1-Methyl-3- (Trifluoromethoxy) Benzene, follow a precise operation procedure. Use special equipment and take it in the specified dose. It is strictly forbidden to dump or waste it at will. And the operation process should be cautious to avoid spilling. If there is a spill, it should be cleaned up immediately according to the established procedures to prevent further harm caused by proliferation.
    In terms of storage, it should be placed in a cool, dry place away from fire sources and oxidants. Due to its chemical properties, improper storage may cause serious accidents such as fire and explosion. The storage container must be well sealed to prevent leakage, and the integrity of the container should be checked regularly.
    Furthermore, the personnel involved in the relevant operation need to be professionally trained and familiar with the characteristics of this object, safety operation specifications and emergency treatment methods. In the event of an accident, such as leakage or fire, the operator can quickly and accurately take emergency measures to ensure the safety of personnel and reduce losses.
    In short, the safety and operation specifications of 1 - Methyl - 3 - (Trifluoromethoxy) Benzene need to be strictly controlled in terms of protection, ventilation, access, storage and personnel training to ensure the safety of the experimental and production process.
    Application Area
    1 - Methyl - 3 - (Trifluoromethoxy) Benzene is also a chemical substance. It is used in the field of production, and can be used as raw materials to assist in research and development, so as to improve disease. And in the field of materials, it can be made of special materials, so that the material has good properties and increases its use. And in the field of production, it can be the basis of synthesis, so that the crops can be protected from harm. These uses are all unique. Its ability to phase other substances, generate new materials, and meet the needs of all parties. Therefore, 1 - Methyl - 3 - (Trifluoromethoxy) Benzene is used in many fields, and it has an important position, which is also important for scientific research and application.
    Research & Development
    A Brief Introduction to the Study of 1-Methyl-3- (Trifluoromethoxy) Benzene
    Recent Chemical Progress, 1-Methyl-3- (Trifluoromethoxy) Benzene has emerged in various fields of chemical industry. Our generation devoted himself to research, aiming to expand its use and improve its quality.
    At first, analyze its structure, demonstrate chemical bonding, explore the properties of physicochemistry. During experiments, adjust the temperature, pressure and agent ratio of the reaction, and hope to obtain the best method. After repeated trials and errors, a synthetic path was obtained, and the yield and purity were improved.
    It also examines its application. In the synthesis of materials, it can add special properties to materials, such as increasing stability and improving optics. In pharmaceutical research and development, or as a key intermediate, it is expected to develop new drugs.
    Looking forward to the future, we should continue to cultivate deeply. Optimize the process, reduce costs and improve efficiency, in line with the purpose of green chemistry. Explore the application widely, and find new machines in the fields of new energy and electronics. Expect the research and creation of this product to add bricks to the chemical industry and benefit the world.
    Toxicity Research
    Since the modern era, chemical refinement has been advanced, and all kinds of new things have competed. Today, there is 1-Methyl-3 - (Trifluoromethoxy) Benzene, which is gradually useful in the field of chemical industry. However, the study of its toxicity has not yet been detailed.
    Yu and others have tried their best to explore the signs of its toxicity. After repeated experiments, they took all kinds of creatures as test bodies to observe their states of being affected by this substance. Observe the changes in their diet, movement, and physiology, and record and analyze them in detail.
    At the beginning, no significant difference was seen. However, after a little longer, some of the test bodies gradually showed fatigue, and the diet was also impaired. And physiological signs, such as the ability of organs, are also slightly abnormal. From this point of view, 1 - Methyl - 3 - (Trifluoromethoxy) Benzene is toxic, although its toxicity is not strong, it should not be ignored. In the future, it should be used with caution, and the protective measures should be carefully studied to avoid damage to living beings and environmental pollution.
    Future Prospects
    In today's world, science and technology are advancing day by day, and chemical substances have infinite potential. 1 - Methyl - 3 - (Trifluoromethoxy) Benzene is expected to develop in the future.
    In the field of Guanfu chemistry, this compound has unique properties. Its structure is exquisite and contains fluoromethoxy groups, which makes the physical and chemical properties unique. In material science, it can make new functional materials. Due to its stability and special reactivity, it can increase the weathering and corrosion resistance of materials. It is used in aerospace, construction, etc., to make equipment and buildings durable.
    In pharmaceutical research and development, it may be a key raw material for innovative drugs. With its special structure, it can precisely act on biological targets, treat difficult diseases, and bring good news to patients.
    And in chemical synthesis, it can be the cornerstone of a new synthesis path, leading the development of green and efficient synthesis methods, reducing energy consumption and pollution, in line with today's environmental protection trend.
    In the future, 1-Methyl-3 - (Trifluoromethoxy) Benzene will surely shine, bringing many innovations and benefits to the world.
    Where to Buy 1-Methyl-3-(Trifluoromethoxy)Benzene in China?
    As a trusted 1-Methyl-3-(Trifluoromethoxy)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Methyl-3-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 1-Methyl-3- (Trifluoromethoxy) Benzene?
    1-Methyl-3- (trifluoromethoxy) benzene, an organic compound, is widely used in the field of chemical synthesis.
    First, it is a key intermediate in pharmaceutical synthesis. When many drug molecules are constructed, the physical and chemical properties and biological activities of the drug need to be adjusted by introducing this structural unit. For example, in the development of some antiviral and anti-tumor drugs, the specific structure derived from 1-methyl-3- (trifluoromethoxy) benzene can enhance the affinity of the drug to the target and improve the efficacy of the drug. Due to the strong electron-absorbing properties of trifluoromethoxy, it can change the electron cloud distribution of molecules and affect the interaction between drugs and receptors, so it is very popular in medicinal chemistry.
    Second, in the field of pesticides, it also plays an important role. As an important raw material for the synthesis of new pesticides, pesticide products with high efficiency, low toxicity and environmentally friendly characteristics can be prepared. For example, the synthesis of some pesticides and fungicides, the compound participates in the structure of reaction generation, which helps to improve the inhibition and killing effect of pesticides on specific pests or pathogens, and because of its special structure, it can make pesticides degrade quickly in the environment and reduce the long-term impact on the ecological environment.
    Third, in the field of materials science, 1-methyl-3- (trifluoromethoxy) benzene can be used to synthesize polymer materials with special properties. By polymerizing with other monomers, the material can impart properties such as chemical resistance and low surface energy. For example, in the preparation of some high-performance coatings, the introduction of monomers containing this structure can make the coatings have better weather resistance and stain resistance, and are widely used in surface protection coatings in construction, automotive and other industries.
    In conclusion, 1-methyl-3- (trifluoromethoxy) benzene, with its unique structure, plays a key role in many fields such as medicine, pesticides, materials, etc., promoting technological progress in various fields and the development of new products.
    What are the physical properties of 1-Methyl-3- (Trifluoromethoxy) Benzene?
    1-Methyl-3- (trifluoromethoxy) benzene is one of the organic compounds. Its physical properties are worth studying, and this is for you to describe in detail.
    First of all, its appearance, at room temperature and pressure, is mostly a colorless and transparent liquid, clear and pure. It looks like smart water, but it has the characteristics of chemical substances. Its smell may have a little special aroma, but this fragrance is not pleasant and rich, but it is the special smell of chemical compounds. Although it is not very pungent, it is enough to attract attention to its chemical essence.
    As for the boiling point, it has been determined by many experiments that it is within a specific temperature range. This boiling point value is one of its important physical constants, which is related to its phase change under different temperature environments. When the temperature gradually rises to the boiling point, the substance converts from liquid to gaseous state, and the intermolecular force is weakened, allowing the molecules to break free and diffuse freely in space.
    The melting point is also a physical property that cannot be ignored. Under certain low temperature conditions, 1-methyl-3- (trifluoromethoxy) benzene will solidify from liquid to solid state. At this time, the molecular arrangement is more orderly, forming a regular lattice structure. The exact value of the melting point is like a key to unlock the mystery of its phase change in the low temperature environment.
    Furthermore, density is also one of its important physical properties. Its density may have a specific proportional relationship with water, which determines its floating or sinking state when mixed with other liquids such as water. In chemical reaction systems, differences in density may affect the distribution and interaction of substances.
    In terms of solubility, 1-methyl-3- (trifluoromethoxy) benzene may exhibit good solubility in organic solvents, such as common organic solvents such as ethanol and ether, which are mutually soluble with it. However, in water, its solubility may be quite limited, due to factors such as molecular polarity.
    These many physical properties are interrelated and together describe the physical properties of 1-methyl-3- (trifluoromethoxy) benzene, which is of great significance in chemical research, industrial production and related application fields.
    What are the chemical properties of 1-Methyl-3- (Trifluoromethoxy) Benzene?
    1-Methyl-3- (trifluoromethoxy) benzene, this is an organic compound. It has unique chemical properties and is of great significance to the field of organic synthesis.
    First talk about its physical properties. Under normal temperature and pressure, it is mostly a colorless and transparent liquid with a special odor. Its boiling point and melting point vary depending on the presence of methyl and trifluoromethoxy groups in the molecular structure. The fluorine atom in the trifluoromethoxy group is extremely electronegative, causing different intermolecular forces, which affect physical parameters such as boiling point. Generally speaking, the boiling point of the compound may be within a certain range, which is convenient for separation and purification under specific conditions.
    In terms of chemical properties, the benzene ring is an electron-rich system with aromatic properties and can undergo many electrophilic substitution reactions. The methyl group acts as the donator group, which increases the electron cloud density of the ortho-and para-site of the benzene ring, and the electrophilic reagents are prone to attack the ortho-and para-site. For example, in the presence of a suitable catalyst, a Fu-gram alkylation reaction can occur with halogenated hydrocarbons, introducing new alkyl groups to the benzene ring. Trifluoromethoxy is an electron-withdrawing group, which reduces the electron cloud density of the benzene ring, affecting the reactivity and regioselectivity. In some reactions, the presence of trifluoromethoxy groups may make the reaction more likely to occur in the meta-site.
    This compound can also participate in redox reactions. Methyl groups can be oxidized under the action of specific oxidants and converted into oxygen-containing functional groups such as carboxyl groups. Trifluoromethoxy is relatively stable and is usually not easy to be directly converted in general chemical reactions, but under extreme conditions or the action of special reagents, reactions such as fluorine atom substitution may occur.
    In organic synthesis, 1-methyl-3- (trifluoromethoxy) benzene is often used as a key intermediate. Due to its special chemical properties, complex organic molecular structures can be constructed through various reactions, providing important starting materials for the synthesis of new substances in the fields of drugs, pesticides and materials science.
    What is the production method of 1-Methyl-3- (Trifluoromethoxy) Benzene?
    The preparation method of 1-methyl-3- (trifluoromethoxy) benzene, often using benzene derivatives as the starting material, is obtained through a multi-step reaction.
    First take m-methylphenol, which is a common starting material. In a suitable reaction vessel, m-methylphenol is mixed with strongly basic substances such as sodium hydroxide or potassium hydroxide to deprotonate the phenolic hydroxyl group and generate phenolic salt negative ions. This step of the reaction needs to be carried out under suitable temperature and stirring conditions to ensure sufficient reaction.
    Then, add a reagent containing trifluoromethoxy group, such as trifluoromethylsulfonate compounds. The trifluoromethoxy part of this kind of reagent can undergo nucleophilic substitution reaction with the anion of phenate to form the carbon-oxygen bond of the target product, so as to obtain 1-methyl-3- (trifluoromethoxy) benzene. During the reaction process, the reaction temperature, time and the ratio of reactants need to be controlled to improve the yield and purity of the product.
    Another method can start from m-methyl chlorobenzene. First, m-methyl chlorobenzene is reacted with metal magnesium to make Grignard reagent. Grignard reagent has high activity and can react with trifluoromethyl ether compounds. In this reaction, the carbon-magnesium bond in the Grignard reagent initiates a nucleophilic attack on the carbon-oxygen bond of the trifluoromethyl ether. After a series of transformations, 1-methyl-3- (trifluoromethoxy) benzene is finally generated.
    During the preparation process, precise control of the reaction conditions is extremely critical. If the temperature is too high or too low, side reactions may occur, affecting the quality and yield of the product. At the same time, the purity of the reactants, the choice of solvent, and the cleanliness of the reaction equipment will also affect the reaction results. The best preparation process can be determined after several experiments and optimization to obtain 1-methyl-3- (trifluoromethoxy) benzene with high purity.
    What should be paid attention to when storing and transporting 1-Methyl-3- (Trifluoromethoxy) Benzene?
    1-Methyl-3- (trifluoromethoxy) benzene is an organic compound. When storing and transporting, many aspects need to be carefully paid attention to.
    Let's talk about storage first. Because of its active nature, the storage environment requirements are strict. The first storage location should be a cool and ventilated place, away from fire and heat sources. This compound is exposed to heat or open flame, or the risk of combustion or even explosion. The warehouse temperature should be controlled within a specific range, generally not exceeding 30 ° C, to prevent its volatilization from intensifying due to excessive temperature and increasing the risk factor. And the warehouse humidity should not be ignored, usually should be maintained at 40% - 70%, high humidity or affect its stability.
    Furthermore, the choice of storage container is also critical. Be sure to use a container with good sealing performance, preferably glass or specific plastic materials, which can effectively prevent its volatilization and leakage. When storing, it should be stored separately from oxidants, acids, alkalis, etc. Because of its active chemical properties, contact with these substances may cause severe chemical reactions, endangering safety.
    As for transportation, extreme caution is also required. Transportation vehicles must meet relevant hazardous chemical transportation standards, and be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. During transportation, ensure that the container does not leak, collapse, fall, or damage. Driving routes should avoid sensitive areas such as densely populated areas and water source reserves to prevent leakage during transportation, which could cause serious harm to people's lives and the environment. Transport personnel also need professional training to be familiar with the properties of the compound and emergency treatment methods, so as to ensure the safety of 1-methyl-3- (trifluoromethoxy) benzene during storage and transportation.