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1-Methoxy-2-Nitro-4-(Trifluoromethyl)Benzene

1-Methoxy-2-Nitro-4-(Trifluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

227000

Chemical Formula C8H6F3NO3
Molar Mass 221.13 g/mol
Appearance Solid (usually)
Melting Point Data may vary, check specific references
Boiling Point Data may vary, check specific references
Solubility In Water Low solubility, likely hydrophobic
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Density Data may vary, check specific references
Vapor Pressure Low vapor pressure, as it is often a solid
Packing & Storage
Packing 1 - methoxy - 2 - nitro - 4 - (trifluoromethyl)benzene packaged in 1 - kg bottles.
Storage 1 - Methoxy - 2 - nitro - 4 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames due to its potential flammability. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reducing substances to avoid chemical reactions.
Shipping 1 - methoxy - 2 - nitro - 4 - (trifluoromethyl)benzene is shipped in well - sealed containers, following strict hazardous chemical shipping regulations. Containers are secured to prevent leakage during transport.
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1-Methoxy-2-Nitro-4-(Trifluoromethyl)Benzene 1-Methoxy-2-Nitro-4-(Trifluoromethyl)Benzene
General Information
Historical Development
1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene, the development of this product has a long history. In the past, various sages studied in the field of chemistry, hoping to obtain this delicate compound. At the beginning, the road of exploration was full of thorns, and everyone searched for suitable methods to make it.
After years, the public has repeatedly speculated in the experiment, and the technique has gradually matured. From simple utensils to exquisite devices; from ignorant temptations to clear steps. Every step has gathered countless efforts.
Today, this compound has been widely used in various fields, or as the cornerstone of pharmaceutical research and development, or as a means of material innovation. Looking back on its historical evolution, it is like a magnificent picture, witnessing the glorious course of chemical development, and inspiring our generation to move forward unremittingly on the road of scientific research.
Product Overview
Today there is a substance called 1-Methoxy-2-Nitro-4- (Trifluoromethyl) Benzene. It is an organic compound with a unique chemical structure. In this compound, methoxy, nitro and trifluoromethyl are respectively attached to the benzene ring, which gives it specific chemical properties.
In the field of organic synthesis, 1-Methoxy-2-Nitro-4- (Trifluoromethyl) Benzene may be used as a key intermediate. Because methoxy has a electron-absorbing effect, nitro and trifluoromethyl have an electron-absorbing effect. The difference in this electronic effect can change the electron cloud density distribution on the benzene ring, which in turn affects its reactivity and selectivity.
In addition, the introduction of trifluoromethyl makes the compound have better stability, lipophilicity and biological activity. In medicine, pesticide research and development, etc., it may have potential application value, which can help chemists create new active molecules with unique properties.
Physical & Chemical Properties
1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene is also an organic compound. Its physical and chemical properties are worth studying. Looking at its properties, at room temperature, it is either a solid or a liquid, depending on the environment. Its melting point and boiling point are the keys to characterize the physical properties. For the melting point, the specific temperature at which a substance changes from a solid state to a liquid state, and the boiling point is the critical temperature at which the liquid is converted to a gas state.
In terms of its chemical properties, it contains groups such as methoxy, nitro and trifluoromethyl, and its activity is unique. Nitro has strong electron absorption, which affects the distribution of electron clouds in molecules, causing it to exhibit special reactivity in many chemical reactions. Although the methoxy group is a power supply group, it interacts with other groups in the compound system to plasticize chemical properties. This compound may be used as a key intermediate in the field of organic synthesis, participating in various reactions, and is of great significance to the expansion of organic synthesis.
Technical Specifications & Labeling
There is a product today, named 1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene. In terms of the technical regulations and labels (commodity parameters) of the product, our generation should study it in detail.
Looking at the technical regulations, starting from the selection of materials, the materials need to be fit and impurities should be removed. The method of its synthesis, temperature, pressure and time are all important. The reaction device must be clean and suitable to ensure a smooth reaction. The steps in between should be careful and orderly, not disordered.
As for the logo (commodity parameters), its color, taste and state should be clear, and the purity geometry should also be confirmed. The point of melting and the number of densities are all key. These various parameters can be evaluated for their quality, and it is a good way to use this item for conclusive evidence and make it correct.
Preparation Method
To make 1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene, the raw materials and production process, reaction steps, and catalytic mechanism are essential. The raw materials should be selected and pure and suitable. The production process should be refined, and careful consideration should be given from the reaction conditions to the process. The reaction step is to mix the raw materials at the beginning, control the temperature and pressure appropriately, so that they can be fully integrated. Then catalyze, select a good catalyst, adjust the dosage and time machine, and promote the reaction speed and efficiency. In this process, the control of temperature, pressure, and time all affect the product. Such as the ancient alchemy, the temperature must not be wrong, so that this delicate chemical product can be obtained. In the fine regulation, the required product can be obtained to meet the needs of chemical diversity.
Chemical Reactions & Modifications
The transformation and transformation of 1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene is an important part of chemical investigation. Its transformation is also related to nucleophilic substitution, or to the transformation of electron clouds. At the position of nitro and trifluoromethyl, the density of the electron cloud is different from usual, resulting in the activity of the ortho-methoxy group.
In the past, all the sages observed the rules of chemical reaction, and there were many things to be gained. If you can make good use of this mechanism, or you can change its properties and increase its effectiveness. If you adjust the regulation of the reaction by appropriate law, the temperature, pressure, and catalytic agent should be expected. Those who change their nature can seek to change their solubility and stability, or make them more useful in special circumstances.
However, if you want to achieve a wonderful state, you must study it diligently. Only by carefully observing the subtleties of the chemical response, understanding the disconnection of its bonds, and the change of quality can you control its transformation, improve its nature, and contribute to the progress of chemistry.
Synonyms & Product Names
1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene, the synonym and trade name of this substance, is of great research value. In the process of my chemical research, the different names of each substance have profound meanings.
Its synonyms can help us recognize this compound from different perspectives. Or due to differences in the analytical perspective of the structure, or due to the uniqueness of the synthetic path, many synonyms are generated. This is a manifestation of the richness of the chemical knowledge system.
As for the trade name, in the circulation of the industry, its trade name may highlight its unique use or highlight its quality characteristics. In ancient Chinese, the names of chemical substances, such as human characters, synonyms like aliases, and trade names like Ruoya, are all used to identify their characteristics and facilitate identification and use by all parties. This 1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene, through the study of synonyms and trade names, can more thoroughly clarify its position and value in the field of chemistry.
Safety & Operational Standards
1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene is an important chemical substance, and safety and operating standards are of paramount importance during its production and use.
Many chemical experiments and production cases in the past have caused frequent accidents due to careless operation. Therefore, the related operations of 1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene must abide by certain rules.
The first to bear the brunt is the qualification and training of the operator. Anyone involved in the handling of this substance must be familiar with chemical knowledge and understand its characteristics and latent risks. After professional training and detailed knowledge of various operating procedures, you can join the work.
As for the operating environment, it is necessary to ensure good ventilation. This substance may be volatile, and if harmful gases gather in the room, it will endanger the health of the operator. In addition, it is necessary to maintain a clean environment, away from fire and heat sources, to prevent accidents.
During operation, various protective measures are indispensable. In front of professional protective clothing, wear protective gloves, goggles, and if necessary, a gas mask to prevent harmful substances from invading the human body.
The storage of substances should not be underestimated. It should be stored in a cool, dry and ventilated place, and stored separately from oxidants and reducing agents to prevent chemical reactions.
The handling process should be handled with care to avoid damage to the container and material leakage. In the event of a leak, do not panic, and take prompt measures according to the established emergency plan, such as evacuating people, sealing off the site, and properly cleaning up.
In this way, strict adherence to safety and operating standards can ensure personnel safety and promote smooth work in the research and production of 1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene.
Application Area
1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene is also a chemical substance. Its application field can be studied. In the field of research, or it can be used to synthesize the raw materials of special effects, and its special molecules can be used to create more and more reactions, to help the development of new technologies, in order to solve the suffering of diseases. In the context of material science, it can also develop its capabilities, or it can improve the characteristics of materials, such as increasing their quality and corrosion resistance, etc., so that the material can be used in more special combinations. And in the process of chemical production, it can be used in research to achieve high efficiency and low toxicity, to ensure the flourishing of crops and the harvest of fields. All these things show that they are in many domains and have a hidden value. It is up to us to explore them in depth, so as to develop them and benefit the world.
Research & Development
Today there is a product called 1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene, and we are exploring its development as researchers. This product is in the field of chemical industry and has potential to be tapped. At first, its understanding was still shallow, and only a little bit of its basic nature was known. However, after repeated research, its structure and characteristics were measured by various methods.
Between experiments, the reaction under different conditions, or temperature change, or agent change, was recorded in detail. From this, the reaction mechanism was gradually clarified, and it was used for subsequent paving. And think about how to optimize the production method, hoping to increase its yield and reduce its cost. After various attempts, it has been slightly effective, and the yield has gradually increased.
The road to scientific research is long. Although the research of 1-Methoxy-2-Nitro-4- (Trifluoromethyl) Benzene has been advanced, it still needs to be unremitting in the future. It is expected to be more widely used and contribute to the development of chemical industry.
Toxicity Research
The taste of substances is related to human use, and the study of toxicity is particularly important. Today there are 1-Methoxy-2-Nitro-4- (Trifluoromethyl) Benzene, and we should investigate its toxicity in detail.
Looking at its structure, methoxy, nitro and trifluoromethyl coexist. Nitro has strong oxidative properties, or can cause oxidative damage to cells. The introduction of trifluoromethyl increases the hydrophobicity of molecules and easily penetrates biofilms.
From an experimental point of view, this substance is applied to the test organism. At first, it can be seen that the behavior of the test organism is slightly different, and then the physiological function may change. It may interfere with the cell metabolic pathway, affect the activity of enzymes, and cause abnormalities in biochemical indicators.
The study of toxicity still needs multiple methods and factors such as dose and time. Only by careful investigation can we obtain the full picture of the toxicity of this substance, so as to avoid harm and profit when used by people, preserve the safety of life and spirits, and protect the environment.
Future Prospects
Wuguanfu 1 - Methoxy - 2 - Nitro - 4 - (Trifluoromethyl) Benzene is unique and has a wide range of uses. Although it has been explored now, the future prospects still have a broad range.
In the chemical industry, it may be possible to develop various new agents by virtue of its characteristics to meet the diverse needs of the industry. In pharmaceutical research and development, it is also expected to find new paths, and by virtue of its structure, create a good medicine for treating difficulties.
With the increasing technology and improved analytical methods, we will be able to learn more about the subtleties of this substance and explore its unseen capabilities. In the coming days, we may emerge in the field of new energy and new materials, contributing to the prosperity of various industries, developing infinite possibilities, and becoming a brilliant future. This will lead our generation to explore the unknown and open a new chapter.
Frequently Asked Questions
What are the main uses of 1-methoxy-2-nitro-4- (trifluoromethyl) benzene?
The main uses of methoxy, acetyl, and (triethoxy) silicon are related to many fields, and each has its own wonders.
Methoxy groups are often key structural units in the field of organic synthesis. It can affect the electron cloud distribution of compounds, thereby changing the reactivity and physical properties of compounds. For example, in drug synthesis, the introduction of methoxy groups may adjust the ability of drug molecules to bind to targets, enhance drug efficacy, or improve the solubility and stability of drugs, making drugs easier to absorb and utilize by the human body. In the field of materials science, compounds containing methoxy groups can be used as precursors to prepare materials with specific structures and properties through reactions such as hydrolysis and polycondensation, such as some functional coatings, ceramic precursors, etc.
Acetyl is also a commonly used group in organic synthesis. In the fragrance industry, many compounds containing acetyl groups emit unique aromas, which can be used to prepare various flavors and add aroma charm to products. In the field of biochemistry, acetylation modification widely exists on biological macromolecules such as proteins. This modification can regulate the function, localization and interaction of proteins, and has a crucial impact on cell physiological processes, such as gene expression and metabolic regulation.
(triethoxy) silicon is widely used in the field of materials. First, it can be used as a coupling agent. Because its molecules contain both ethoxy groups that can react with the surface hydroxyl groups of inorganic materials, and organic groups that can chemically react or physically entangle with organic materials, it can enhance the interfacial bonding force between organic and inorganic materials and improve the properties of composites. For example, in glass fiber reinforced plastics, glass fibers can be better combined with resin matrices, improving the strength and durability of materials. Second, it can be used to prepare silicon-based materials. After hydrolysis and condensation reactions, siloxane polymers with three-dimensional network structures can be formed. Such materials have unique properties in optics, electricity, and heat, and can be used as optically transparent materials, electronic packaging materials, and high temperature resistant materials. From this perspective, although methoxy, acetyl, and (triethoxy) silicon are different chemical groups or compounds, they play an indispensable role in synthetic chemistry, materials science, biochemistry, and other fields, promoting the development and progress of various fields.
What are the physical properties of 1-methoxy-2-nitro-4- (trifluoromethyl) benzene?
The name of something is called methoxy, acetyl, (triethoxy) silicon, which is an organosilicon compound. Its physical properties are particularly important and related to many uses.
Let's talk about its properties first. Under normal circumstances, it may be a clear and transparent liquid. It looks like clear water, but it has its own unique features. Smell it, or it may have a specific smell, not pungent but also distinct and palpable, which can make a deep impression on the smell.
Besides, its boiling point is in a specific range due to the interaction of various groups in the molecular structure. This boiling point value is not only affected by methoxy and acetyl groups, but also closely related to the (triethoxy) silicon structure. Appropriately heated to a specific temperature, the substance will transform from a liquid state to a gaseous state. This temperature is where its boiling point is, and its control of separation, purification and related chemical reactions is crucial.
In terms of melting point, the substance will condense from a liquid state to a solid state under a certain low temperature environment. This transition temperature is the melting point, which is determined by the intermolecular force. Groups such as methoxy and acetyl give molecules a specific shape and interaction mode, so that the melting point presents a corresponding value, which is of great significance for material storage and certain low temperature conditions.
Solubility is also an important physical property. This substance exhibits good solubility in a variety of organic solvents, such as common ethanol, acetone, etc. Due to the specific interactions between some groups in the molecular structure and organic solvent molecules, such as hydrogen bonds, van der Waals forces, etc., it can be uniformly dispersed in the solvent. This solubility property is convenient for mixing it with other ingredients in the preparation process of coatings, adhesives, etc., to achieve the desired performance. The density of
can not be ignored, and the density of this substance may be different from that of water. When participating in various mixing systems, density factors affect their distribution and play a role in delamination, sedimentation and other processes, providing an important reference for practical applications. The above physical properties are of great significance in many fields such as chemical industry and materials, or used in the synthesis of new materials, or as an auxiliary to improve product performance, all rely on their unique physical properties.
What are the chemical properties of 1-methoxy-2-nitro-4- (trifluoromethyl) benzene?
The chemical properties of a compound composed of methoxy, acetyl, and (trifluoromethyl) naphthalene are quite unique.
The methoxy group has the effect of a electron conductor. Because the oxygen atom contains lone pair electrons, it can be conjugated by p-π to bias the electron cloud towards the naphthalene ring, which increases the electron cloud density of the naphthalene ring. This makes the compound exhibit higher activity in the electrophilic substitution reaction. For example, compared with naphthalene itself, it is easier to react with electrophilic reagents such as halogenating agents and nitrifiers, and the substitution check points are mostly in the ortho and para-methoxy groups, because the electron cloud density of the two groups is more significant.
Acetyl groups belong to electron-absorbing groups. The strong electronegativity of the carbon-oxygen double bond in the carbonyl group will pull the electron cloud of the naphthalene ring and reduce the electron cloud density of the naphthalene ring. This makes the compound less active during the electrophilic substitution reaction, and the substitution reaction is more difficult to occur. Moreover, the presence of acetyl groups will make the electrophilic reagents tend to attack the area with relatively high electron cloud density on the naphthalene ring, that is, the meta-position.
And trifluoromethyl has extremely strong electron-absorbing ability. The electronegativity of the three fluorine atoms is extremely high, strongly attracting electrons, which greatly reduces the electron cloud density of the naphthalene ring. This makes the naphthalene compound containing trifluoromethyl extremely inactive in the electrophilic substitution reaction. At the same time, due to the strong influence of trifluoromethyl on the electron cloud, the polarity of the molecule changes, and the physical properties such as solubility are also reflected. The solubility in organic solvents may be different from that of the proto-naphthalene compound.
These three groups coexist on the naphthalene ring and affect each other, making the chemical properties of the compound complex. The methoxy power supplier competes with the acetyl group and the trifluoromethyl group for electron-absorbing effects, and the final chemical properties depend on the comprehensive results of the electronic effects of each group, which affects its reactivity and selectivity.
What are the synthesis methods of 1-methoxy-2-nitro-4- (trifluoromethyl) benzene?
To prepare 1-amino-2-hydroxy-4- (trifluoromethyl) benzene, there are various methods.
First, a suitable halogenated aromatic hydrocarbon can be started. First, the halogenated aromatic hydrocarbon is taken, and it is combined with an amino-containing reagent under appropriate reaction conditions, such as in a suitable base and solvent system. A nucleophilic substitution reaction is performed to introduce an amino group. Then, the obtained product is hydroxylated at a specific position of the benzene ring by a specific hydroxylation reaction, such as under the action of a suitable oxidizing agent and catalyst, and then a hydroxyl group is introduced. As for the introduction of trifluoromethyl, reagents containing trifluoromethyl can be selected. Under suitable conditions, trifluoromethyl can be attached to the designated position of the benzene ring through nucleophilic substitution or free radical reaction.
Second, it can also start from compounds with partial target structures. If the starting material has a benzene ring-like structure with partial substituents, it can be transformed into functional groups in sequence. For example, the existing substituents are suitably modified first to facilitate subsequent reactions. By ingeniously designing the reaction sequence, various organic reactions, such as acylation, reduction, and substitution, can be used to gradually construct the structure of the target molecule. When introducing trifluoromethyl, you can refer to the classic trifluoromethylation method, such as the use of trifluoromethylation reagents, such as trifluoromethyl magnesium halide, etc., to react with the substrate under a suitable catalytic system.
Third, the reaction strategy of transition metal catalysis can also be considered. Using transition metal catalysts, such as palladium, copper and other catalysts, to promote the coupling reaction between substrate molecules. First select small molecular substrates containing different substituents, under the catalysis of transition metals, make them couple and gradually splice into the basic skeleton of the target molecule. Subsequently, for imperfect substituents, targeted conversion and modification are carried out to achieve precise introduction of amino groups, hydroxyl groups and trifluoromethyl groups.
The above methods each have their own advantages and disadvantages, and need to be carefully weighed according to the actual situation, such as the availability of raw materials, the difficulty of reaction, cost considerations, etc. Only by selecting their advantages can 1-amino-2-hydroxy-4- (trifluoromethyl) benzene be synthesized efficiently.
What are the precautions for storing and transporting 1-methoxy-2-nitro-4- (trifluoromethyl) benzene?
There are many things to pay attention to during storage and transportation of methoxy, acetyl, and (triethoxy) silicon.
Methoxy is active and easily reacts with water. Therefore, when storing, it is necessary to ensure that the environment is dry, and the selected container must also have good sealing performance to prevent the intrusion of external water vapor. Otherwise, it will cause a chemical reaction in contact with water, causing it to deteriorate and lose its original function. During transportation, you should also be careful to prevent the container from being damaged. If there is an omission, water vapor will take advantage of the void, and the consequences will be unimaginable.
Acetyl group has a certain volatility and a unique smell. The storage place should be cool and ventilated to avoid high temperature and fire sources. Under high temperature, the volatilization will increase, which will not only lose materials, but also easily cause safety hazards. In case of an open flame, there may be a risk of explosion. During transportation, it should be properly wrapped to prevent it from evaporating and escaping, affecting the surrounding environment and personal safety.
(triethoxy) silicon, in addition to being sensitive to water vapor, its chemical properties are also relatively active. When storing, it needs to be stored separately from oxidizing substances, acids, etc. to prevent chemical reactions. Because it is corrosive to metals, storage containers should not be made of ordinary metals, and corrosion-resistant materials should be selected. During transportation, ensure that the container is stable to avoid collision and vibration that cause damage to the container and cause leakage.
In short, these three have different precautions due to their characteristics when storing and transporting, and must be handled with caution to ensure material safety and prevent accidents.