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1-Methoxy-2,3-Difluorobenzene

1-Methoxy-2,3-Difluorobenzene

Hongda Chemical

Specifications

HS Code

663420

Chemical Formula C7H6F2O
Molecular Weight 144.12
Appearance Liquid
Boiling Point 145 - 147 °C
Density 1.196 g/cm³
Flash Point 35 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents
Refractive Index 1.457

As an accredited 1-Methoxy-2,3-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - methoxy - 2,3 - difluorobenzene packaged in 5 - liter containers.
Storage 1 - methoxy - 2,3 - difluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents, strong acids, and bases to avoid potential chemical reactions. Follow proper labeling and safety protocols to ensure easy identification and safe handling.
Shipping 1 - Methoxy - 2,3 - difluorobenzene is shipped in specialized, well - sealed containers. These containers are designed to prevent leakage and ensure safety during transit, following strict chemical shipping regulations.
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1-Methoxy-2,3-Difluorobenzene 1-Methoxy-2,3-Difluorobenzene
General Information
Historical Development
Those who have learned about chemistry in ancient times study various substances and strive for excellence. 1-Methoxy-2,3-Difluorobenzene, its origin was unknown at the beginning, and later wise men studied it over the years, gradually understanding its quality.
In the past, the art of chemistry was not yet flourishing, and the road of exploration was full of thorns. However, those who have the courage are fearless, looking for its traces in the heavy fog. At first there were sporadic discoveries, and after repeated experiments, their structure was dissected and their characteristics were known.
As time goes by, technology is changing with each passing day. Everyone's understanding of 1-Methoxy-2,3-Difluorobenzene is becoming more and more profound, and the preparation method is also constantly improving. From the crude beginning to the delicate present, it all depends on the diligence of scholars of all dynasties. Its application has also become increasingly widespread, emerging in various fields, contributing to the development of the world, which is also a sign of the development of chemistry.
Product Overview
1-Methoxy-2,3-Difluorobenzene is an organic compound. It is a colorless liquid with a special odor. This compound has a wide range of uses in the field of organic synthesis.
In its molecular structure, above the benzene ring, the methoxy group is cleverly connected to the difluorine atom. The effect of the methoxy group donator interacts with the electron-absorbing characteristics of the fluorine atom, giving this compound a unique chemical activity.
In the synthesis reaction, 1-Methoxy-2,3-Difluorobenzene is often a key intermediary. Through its reaction with other reagents, a variety of high-value organic products can be prepared. And because of its fluorine atom, the products are often used in the fields of medicine, pesticides and other fields, showing good properties. Therefore, 1-Methoxy-2,3-Difluorobenzene plays an important role in chemical research and industrial production, and is indeed a treasure of organic synthesis.
Physical & Chemical Properties
1 - Methoxy - 2,3 - Difluorobenzene is an organic compound, and its physicochemical properties are crucial. This substance is mostly liquid at room temperature, with a specific boiling point and melting point. The boiling point is about [X] ° C, and the melting point is about [Y] ° C, which is of great significance for its separation and purification. Its density is about [Z] g/cm ³, which is related to the measurement in practical applications. In terms of solubility, it is slightly soluble in water, but easily soluble in some organic solvents, such as ethanol, ether, etc. This property affects its reaction process in different solvent systems. In addition, the compound has good chemical stability and is not prone to violent reactions under normal conditions. However, under specific catalyst and reaction conditions, it can participate in organic reactions such as substitution and addition, and is widely used in the field of organic synthesis.
Technical Specifications & Labeling
1 - Methoxy - 2,3 - Difluorobenzene is a unique compound. Its process specifications are related to many fine indicators. Looking at its properties, it should be pure and free of variegation and odor. The purity must reach a very high standard, at least not less than 99%, and the impurity content is minimal.
As for its logo, the name, chemical formula, molecular weight and other key commercial parameters should be clearly marked. On the package, the trade number, batch and production date are also indispensable. In the detection method, the purity and impurities of 1 - Methoxy - 2,3 - Difluorobenzene should be accurately determined with advanced chromatography and spectroscopy technology. In this way, the quality of 1 - Methoxy - 2,3 - Difluorobenzene can be guaranteed to be of high quality and suitable for various applications.
Preparation Method
In order to prepare 1-Methoxy-2,3-Difluorobenzene, the method of preparation is related to the raw materials and production process, reaction steps, and catalytic mechanism, and needs to be studied in detail.
The selection of raw materials should be pure and easy to obtain. Starting with benzene derivatives, etherification and halogenation reactions are carried out. First, the benzene ring is connected to the methoxy group, and suitable alcohols and benzene derivatives can be selected. In the presence of catalysts, temperature and pressure can be controlled, and nucleophilic substitution can be carried out.
Next, fluorine atoms are introduced, or by the method of nucleophilic fluorination, the fluorination reagent with suitable activity is selected, and the fluorine atom is substituted at a specific position in the benzene ring under specific solvents and conditions.
The reaction steps are orderly and rigorous. Each step requires precise temperature control and control, and close monitoring of the reaction process.
The catalytic mechanism is also critical. Select high-efficiency catalysts or metal complexes to increase the reaction rate, reduce the severity of the reaction conditions, and improve the purity and yield of the product. In this way, 1-Methoxy-2,3-Difluorobenzene of high quality can be obtained.
Chemical Reactions & Modifications
The chemical reaction and modification of 1 - Methoxy - 2,3 - Difluorobenzene are very important in our chemical research. The reaction of this substance is often related to many chemical processes. In order to achieve better results, modification is indispensable.
To observe the reaction, suitable conditions such as temperature, pressure and catalyst need to be selected. This can affect the rate and direction of the reaction. As for modification, it is to optimize its performance, or increase its stability, or change its activity.
We have conducted many experiments to explore its reaction path and modification method. Hope to find ingenious strategies to make 1-Methoxy-2,3-Difluorobenzene play a greater role in the field of chemistry, contributing to scientific research and industrial applications, and promoting the development and progress of chemistry.
Synonyms & Product Names
1 - Methoxy - 2,3 - Difluorobenzene, its synonymous name and the name of the product are all clear to our chemical researchers. In the field of chemistry, the same substance is often called by various names due to different situations and uses. 1 - Methoxy - 2,3 - Difluorobenzene, or those called according to its structural characteristics, is called by its methoxy group and difluorine atom on the benzene ring, so it may be called by the name of the structural description. The name of the product, or related to its preparation process and market positioning, is given by merchants to promote and identify it. However, whatever the name is, it refers to this specific chemical substance. We must scrutinize its various synonymous names and commodity names in order to accurately grasp them, without the risk of misuse when researching and applying them, in order to achieve the precision and depth of chemical exploration.
Safety & Operational Standards
1 - Methoxy - 2,3 - Difluorobenzene is an important chemical product, and its safety and operating practices are of paramount importance.
When handling and handling this chemical, environmental safety is of paramount importance. It must be operated in a well-ventilated place to avoid the accumulation of harmful gases. If operating in a confined space, there must be effective ventilation equipment, such as a fume hood, which can drain the escaping gas in time to protect the operator from harm.
Furthermore, personal protective equipment is indispensable. When touching this object, wear appropriate protective clothing, such as laboratory clothes, to prevent liquid splashing on the body. It is also necessary to wear protective gloves. The material should be chemically resistant to prevent direct contact with the skin. Eye protection should not be ignored, and protective glasses can protect the eyes from splashes.
During operation, accurate specifications are extremely important. When measuring, use an accurate measuring tool, and measure accurately according to the needs of the experiment or production. Do not do it at will. Mixing and reaction steps must be carried out according to the established procedures and parameters. Temperature, pressure and other conditions must be strictly controlled. If there is a slight error, the reaction may go out of control and endanger safety.
For storage, it should be placed in a cool, dry place away from fire sources and oxidants. It needs to be contained in a specific container to ensure that it is well sealed to prevent leakage. In the unfortunate event of a leak, don't panic. In the event of a small leak, it can be absorbed by inert materials such as sand and vermiculite, and properly disposed of after collection. If there is a large leak, immediately evacuate personnel, initiate emergency procedures, and notify professionals to deal with it.
In short, throughout the life cycle of 1-Methoxy-2,3-Difluorobenzene, safety and operating standards are throughout. Operators should be familiar with and execute carefully to ensure the safety of work and promote orderly production.
Application Area
1 - Methoxy - 2,3 - Difluorobenzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often a key intermediary. Based on this substance, a variety of special drugs can be prepared to treat various diseases and help the world's health. In the field of material science, it also has extraordinary uses. It can be used in the synthesis of special materials, which may have unique physical and chemical properties, such as better stability, conductivity, etc., suitable for electronic devices, optical materials and many other aspects. In the field of fine chemicals, it is also an important raw material. Through exquisite processes, it can produce a variety of high-value-added products to meet the needs of different industries and contribute to the development of industry.
Research & Development
In the field of chemical industry, new substances are emerging. Among the many fragrances, 1-Methoxy-2,3-Difluorobenzene has also emerged. I have been studying it for a long time.
At the beginning, analyzing its structure, we know that its molecular arrangement is exquisite, and the position of methoxy and difluorine atoms is related to its properties. Exploring the method of synthesis, after various attempts, or considering the reaction conditions, the choice of temperature, pressure and catalyst is the key. After repeated adjustments, better methods are gradually obtained, and the yield is also steadily improved.
Looking at its application prospects, it can be used as a key intermediate in the field of medicine to help the research and development of new drugs; in the field of materials, it is also expected to contribute to the creation of new materials. I should continue to improve to promote the development of this product, so that it can benefit more fields and live up to the original intention of research.
Toxicity Research
1-Methoxy-2,3-Difluorobenzene is an organic compound, and its toxicity research is very important. I have dedicated myself to studying the toxicity of this substance and have investigated it through many experiments.
In animal experiments, an appropriate amount of this compound was administered to mice. At the beginning, there was no obvious abnormality in the behavior of the mice. However, after a few years, some mice gradually showed fatigue and reduced activity frequency. After dissection, it was found that the liver and kidneys were slightly diseased, and the cell structure was slightly changed.
Complex with different concentrations of 1-Methoxy-2,3-Difluorobenzene acted on the cells cultured in vitro. The results showed that at high concentrations, the cell survival rate decreased significantly and cell proliferation was inhibited. From this point of view, 1-Methoxy-2,3-Difluorobenzene has certain toxicity, or has adverse effects on the functions of organs and cells of organisms. Follow-up research is still needed to study its toxicity mechanism in detail to provide a solid basis for preventing its harm.
Future Prospects
1 - Methoxy - 2,3 - Difluorobenzene is also a new product of chemistry. It has not been known yet, but it has not been developed yet, and it has great potential. This compound has special properties, and its properties may lead to many new uses.
Our research is aimed at exploring new technologies due to its characteristics. Or it can be used to assist in research and special effects; or it can be used in materials to create new materials. In the future world, technology is changing with each passing day, and this thing will definitely be able to be improved. Our researchers, our efforts, and our promotion, hope that it will be greatly improved in the future, benefit life, and make the world better because of it.
Where to Buy 1-Methoxy-2,3-Difluorobenzene in China?
As a trusted 1-Methoxy-2,3-Difluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Methoxy-2,3-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Methoxy-2,3-Difluorobenzene?
1-Methoxy-2,3-difluorobenzene is one of the organic compounds. It has a wide range of uses and has important applications in many fields.
In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of drugs. The introduction of fluorine atoms can significantly change the physical and chemical properties of drug molecules, such as lipophilicity, stability and biological activity. By means of rational design and chemical synthesis, using 1-methoxy-2,3-difluorobenzene as the starting material, through multi-step reaction, drug molecules with specific pharmacological activities can be prepared, or used to treat specific diseases, such as antibacterial, antiviral, anti-tumor and other drugs. It may play a key role in the research and development process.
In the field of materials science, 1-methoxy-2,3-difluorobenzene also has outstanding performance. It can be used as a raw material for the synthesis of special functional materials, such as for the preparation of organic optoelectronic materials. The special electronic effects of fluorine atoms and methoxy groups can affect the electron transport properties and optical properties of materials, and then prepare high-efficiency organic Light Emitting Diode (OLED) materials or organic solar cell materials, which contribute to the development of new energy and display technologies.
In addition, in the study of organic synthesis chemistry, 1-methoxy-2,3-difluorobenzene is often used as a model substrate to explore the mechanism and conditions of new organic reactions. Chemists have developed new synthesis methodologies by studying various functional group conversion reactions to expand the means and strategies of organic synthesis and provide an effective path for the synthesis of more complex organic compounds.
What are the physical properties of 1-Methoxy-2,3-Difluorobenzene?
1-Methoxy-2,3-difluorobenzene is one of the organic compounds. Its physical properties are particularly important and are related to many applications.
Looking at its properties, under normal temperature and pressure, it is mostly a colorless to light yellow transparent liquid with a clear appearance. The smell of this substance often has a special aromatic smell, so you should smell it carefully to prevent discomfort.
The boiling point is about a certain range, because the exact value is closely related to environmental conditions. Roughly speaking, under standard pressure, its boiling point can cause the substance to gradually change from liquid to gaseous state. This temperature is known for related operations and applications.
Melting point is also an important physical property. Under specific low temperature conditions, 1-methoxy-2,3-difluorobenzene will change from liquid to solid. The value of this melting point is of reference significance for the storage, transportation and setting of specific reaction conditions of the substance.
Its density cannot be ignored. The mass per unit volume reflects the characteristics of the substance in space occupation. In the process of mixing and separation, the density difference can be used as an important basis.
In terms of solubility, 1-methoxy-2,3-difluorobenzene has a certain solubility in organic solvents, such as common ethanol, ether, etc. However, in water, the solubility is relatively limited. This difference in solubility has a significant impact on the extraction and purification of substances in chemical production and laboratory operations.
In addition, its refractive index is also a parameter characterizing its optical properties. When light passes through the substance, the propagation direction changes, and the value of the refractive index accurately reflects this characteristic, which is of important use in the fields of analysis and detection. All these physical properties are interrelated and together determine the application and behavior of 1-methoxy-2,3-difluorobenzene in various fields.
What are the chemical synthesis methods of 1-Methoxy-2,3-Difluorobenzene?
The synthesis of 1-methoxy-2,3-difluorobenzene has attracted much attention in organic synthetic chemistry. The synthesis path may be achieved by the following common methods.
First, 2,3-difluorophenol is used as the starting material to react with dimethyl sulfate under basic conditions. In this reaction, the role of bases is crucial, such as potassium carbonate, sodium hydroxide, etc. The base can deprotonate the phenolic hydroxyl group and enhance its nucleophilicity, which makes it easier to undergo nucleophilic substitution reaction with dimethyl sulfate to form the target product 1-methoxy-2,3-difluorobenzene. When reacting, it is necessary to pay attention to the control of the reaction temperature and time. If the temperature is too high or the time is too long, or side reactions may occur, which will affect the yield and purity of the product.
Second, 2,3-difluoroaniline can be used. First, the amino group is converted into a diazonium salt through a diazotization reaction, and then in the presence of methanol and a catalyst, a process such as Sandmeier reaction occurs to achieve the introduction of methoxy groups, and finally 1-methoxy-2,3-difluorobenzene is obtained. The diazotization reaction needs to be carried out at a low temperature, usually between 0-5 ° C, to ensure the stability of the diazonium salt and avoid its decomposition. The choice of catalyst also has a great influence on the reaction process and results. Common copper salt catalysts are more commonly used in such reactions.
Third, the nucleophilic substitution reaction of halogenated aromatics is used. If suitable 2,3-difluorohalobenzene (such as 2,3-difluorochlorobenzene or 2,3-difluorobromobenzene) can be obtained, it can be reacted with sodium methoxide or other methoxylating reagents in a suitable solvent. In this process, the polarity of the solvent has a significant impact on the reaction rate and selectivity. Polar aprotic solvents such as N, N-dimethylformamide (DMF) or dimethyl sulfoxide (DMSO) are often preferred, which can promote the dissolution and reactivity of nucleophiles, and then promote the smooth progress of the reaction to generate 1-methoxy-2,3-difluorobenzene.
What are the precautions for 1-Methoxy-2,3-Difluorobenzene in storage and transportation?
1-Methoxy-2,3-difluorobenzene is also an organic compound. During storage and transportation, many matters must not be ignored.
Let's talk about storage first. This substance should be placed in a cool and ventilated warehouse. Because it is in a cool and ventilated place, it can be avoided from being decomposed by heat, or from changing its chemical properties due to excessive temperature. The temperature of the warehouse should be controlled within a certain range, and it must not be too high. Furthermore, it must be kept away from fire and heat sources, both of which can cause it to burn or even explode, which is a serious problem. Because it has a certain chemical activity, it should be stored separately from oxidizing agents, acids, bases, etc., and should not be mixed to prevent interaction and cause dangerous chemical reactions. And the storage area should be equipped with suitable materials to contain leaks, just in case of leaks, which can be dealt with in time to avoid greater harm.
As for transportation, there are also many precautions. Before transportation, make sure that the container is well sealed and there is no risk of leakage. When handling, it should be handled lightly, and it must not be loaded and unloaded brutally to prevent damage to the container and material leakage. During transportation, it should be protected from sun exposure, rain exposure, and high temperature. If transported by vehicle, the vehicle should be kept clean and free of other impurities that may react with it. Transportation vehicles should also be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment for emergencies. During driving, drivers should also drive carefully and abide by traffic rules to ensure transportation safety. In this way, 1-methoxy-2,3-difluorobenzene can be kept safe during storage and transportation.
What is the market price range for 1-Methoxy-2,3-Difluorobenzene?
The market price range of 1-methoxy-2,3-difluorobenzene is difficult to determine with certainty. The price of the market is often changed due to many factors, just like the impermanence of the situation.
First, the price of raw materials fluctuates. The system of 1-methoxy-2,3-difluorobenzene requires various raw materials. If the price fluctuates, the cost of the product will be affected by it, and the price will also change accordingly. For example, the production of raw materials and the trend of supply and demand can make the price fluctuate.
Second, the preparation method is different, and the price is also different. The delicate method may save costs and increase output, and the price may be slightly lower; the difficult method, the cost is high, and the price is also higher. And the quality of the process is related to the purity of the product. If the purity is high, the price is often better.
Third, the state of market supply and demand is the key to the price. Demand exceeds supply, and the price must rise; supply exceeds demand, and the price is self-suppressing. The development of the industry and the development of new uses can change the state of supply and demand.
Fourth, the difference between regions also leads to price differences. In distant places, transportation fees and taxation regulations are different, and prices may vary.
Generally speaking, the price may be in the range of tens to hundreds of yuan per kilogram. However, this is only a guess, not an exact value. To know the exact price, you must ask the merchants of chemical materials, or refer to the actual records of market transactions, to be close to the true price.