1-Iodine-4- (trifluoromethoxy) benzene is also an important agent in organic synthesis. It is widely used in various chemical synthesis industries.
First, it is often a key raw material in the synthesis of fluoroaromatic compounds. Due to the good activity of iodine atoms in molecules, different functional groups can be introduced through various nucleophilic substitution reactions, and then fluoroaromatics with diverse structures can be constructed. If reacted with nucleophilic reagents, such as phenols and thiols, iodine atoms can be replaced to form fluorophenyl ethers or fluorophenyl sulfides with different substituents. These products have potential application value in the fields of medicine and pesticides.
Second, 1-iodine-4- (trifluoromethoxy) benzene can also play an important role in building the skeleton of complex organic molecules. With the help of transition metal-catalyzed coupling reactions, such as Suzuki coupling and Heck coupling, iodine atoms can be coupled with various olefins and aromatics to grow carbon chains or build polycyclic aromatic systems. This is an important strategy for synthesizing complex natural products and functional materials.
Furthermore, in the field of materials science, fluorine-containing materials derived from this compound can endow materials with unique physical and chemical properties due to the special electronic effects and hydrophobic properties of trifluoromethoxy, such as improving the thermal stability, chemical stability and surface hydrophobicity of materials. Therefore, it may be applied in high-performance coatings, electronic materials, etc.
In summary, 1-iodine-4 - (trifluoromethoxy) benzene, with its unique structure and reactivity, is an indispensable substance in many fields such as organic synthesis and materials science, promoting the development and progress of related fields.

1-Iodine-4- (trifluoromethoxy) benzene, its physical properties are as follows.
Looking at it, this substance is often a colorless to light yellow liquid with a clear appearance. Smell it, or have a specific smell, but the exact description of its taste depends on actual perception.
In terms of melting point and boiling point, the melting point is very low, and it is a liquid at room temperature. The boiling point varies according to the ambient pressure. At standard atmospheric pressure, the boiling point is about a specific value. This value may vary slightly due to differences in precise measurement conditions. Its density is heavier than that of water. If placed in water, it will sink to the bottom of the water.
In terms of solubility, it has good solubility in organic solvents such as ethanol, ether, dichloromethane, etc., and can be mutually soluble with it. However, in water, the solubility is extremely small and almost insoluble. This is because the molecular structure contains iodine atoms and trifluoromethoxy groups, making it highly hydrophobic.
Refractive index is also one of its important physical properties. When light of a specific wavelength is emitted in it, the refractive index presented has a certain value, which can be used for the identification and purity judgment of substances.
In addition, the vapor pressure of this substance has a specific value at a certain temperature, indicating the degree of volatility. Although it is not very volatile, under appropriate conditions, some molecules will still escape into the vapor phase.

The stability of the chemical properties of 1-iodine-4- (trifluoromethoxy) benzene is related to many aspects. In this compound, the iodine atom has a certain activity. Due to the large covalent radius of the iodine atom and the relatively small C-I bond energy, the iodine atom is prone to substitution reaction under suitable conditions, or is attacked and left by nucleophiles, which is one end of its instability.
However, it also contains trifluoromethoxy, which has strong electron absorption, which can reduce the electron cloud density of the benzene ring and affect the reactivity of the benzene ring to a certain extent. However, from another perspective, the trifluoromethoxy group forms a conjugated system with the benzene ring, which makes the molecular structure more stable.
Under normal circumstances, in the absence of specific reagents or conditions, 1-iodine-4- (trifluoromethoxy) benzene can remain relatively stable for a certain period of time in a normal temperature and pressure, dark and dry environment. However, in case of high temperature, light or strong nucleophiles, its chemical properties will show an active state, or the substitution of iodine atoms, or other reactions on the benzene ring.
In summary, the chemical stability of 1-iodine-4- (trifluoromethoxy) benzene depends on the specific environment and the reaction conditions encountered, and cannot be generalized.

The preparation method of 1-iodine-4- (trifluoromethoxy) benzene is as follows:
4- (trifluoromethoxy) phenol is often used as the starting material. First, 4- (trifluoromethoxy) phenol is co-placed in a suitable organic solvent, such as N, N-dimethylformamide (DMF), with an appropriate base, such as potassium carbonate. The base deprotonates the phenolic hydroxyl group and enhances its nucleophilicity.
Subsequently, iodine substitutes, such as halogenated hydrocarbons such as iodomethane or iodoethane, are added. In this nucleophilic substitution reaction, the phenoxy anion attacks the carbon atom of the halogenated hydrocarbon, and the halogen ion leaves, thereby generating 1-iodine-4- (trifluoromethoxy) benzene. The reaction needs to be carried out at an appropriate temperature, generally between room temperature and 60 ° C, adjusted according to the specific reaction situation. In this process, stirring is also very important, so that the reactants can be fully contacted and the reaction rate can be accelerated.
Another possible way is to use 4- (trifluoromethoxy) aniline as a raw material. First, 4- (trifluoromethoxy) aniline is diazotized. Sodium nitrite and hydrochloric acid are used at low temperature (0-5 ° C) to convert the amino group into a diazonium salt. Then, an iodine source such as potassium iodide is added, and the diazo group is replaced by an iodine atom to form the target product 1-iodine-4- (trifluoromethoxy) benzene. This reaction requires strict temperature control to prevent the decomposition of diazo salts.
Preparation of 1-iodine-4- (trifluoromethoxy) benzene can be prepared by the above-mentioned method of using 4- (trifluoromethoxy) phenol or 4- (trifluoromethoxy) aniline as starting materials, through rational selection of reagents and control of reaction conditions, in order to achieve the purpose of preparation.

1-Iodine-4- (trifluoromethoxy) benzene is on the market, and its price range is difficult to determine. The price of this compound often varies for many reasons.
First, the purity of the material is extremely critical. If the purity is very high, it is almost flawless, and it is suitable for fine experiments or high-end industrial uses, its price will be high. And if the purity is slightly lower, it can only be used for general experiments or scenes that are not demanding, the price is slightly lower. High purity may reach tens of gold per gram, or even hundreds of gold; low purity, per gram or only a few gold.
Second, the supply and demand of the market also affects its price. If there are many people who need it for a while, but there are few people who supply it, the price will rise; on the contrary, if the supply is full and the demand is sparse, the price will drop. When there is a sudden increase in research and development in a certain field, the demand for this product will increase greatly, and the price will rise; if the development of related industries is stagnant and the demand decreases, the price will also fall.
Third, the cost of making this product is also the main reason for pricing. The price of raw materials, the difficulty of preparation, and the amount of energy consumption all affect its cost. If raw materials are rare and difficult to find, the preparation process is complicated, and the energy consumption is huge, the cost will be high and the price will be high; if raw materials are easy to obtain, the preparation is simple, the cost is low, and the price is also low.
Fourth, the difference between sellers also results in price differences. Well-known large factories, due to their emphasis on quality and compliance with standards, have high product quality, and the price may be higher; while small factories or suppliers compete for the market, the price may be slightly lower.
To sum up, the price of 1-iodine-4- (trifluoromethoxy) benzene can be as low as gold per gram, and as high as more than 100 gold per gram. The specific number needs to be carefully investigated according to the above factors.