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What are the main uses of 1-Iodo-2-Fluoro-4-Chloro-6-Bromobenzene?
1-Iodine-2-fluoro-4-chloro-6-bromobenzene is a compound that has attracted much attention in the field of organic synthetic chemistry. Its main use can probably be found in the field of organic synthesis.
First, in the field of pharmaceutical chemistry, this compound may serve as a key intermediate. Drug development often requires the construction of molecules with specific structures and activities. The diverse halogen atoms of 1-iodine-2-fluoro-4-chloro-6-bromobenzene can introduce various functional groups through many organic reactions, such as nucleophilic substitution reactions, and then build complex molecular structures that fit drug targets. Taking the development of anti-cancer drugs as an example, it may be possible to use this intermediate to create new drug molecules with specific inhibitory effects on cancer cells through delicate reaction design.
Second, in the field of materials science, it also has potential uses. The development of organic electronic materials is on the rise, and halogenated aromatics are often the cornerstone of high-performance organic semiconductor materials. 1-Iodine-2-fluoro-4-chloro-6-bromobenzene can be reacted with other conjugated systems to form materials with unique electrical and optical properties, or can be applied to the manufacture of organic Light Emitting Diodes (OLEDs), organic field effect transistors (OFETs) and other devices to improve their performance.
Third, this compound may also play a role in pesticide chemistry. The creation of pesticides requires precise design of molecular structures to achieve high-efficiency insecticidal and weeding effects. 1-Iodine-2-fluoro-4-chloro-6-bromobenzene can be used as a starting material and chemically modified to synthesize pesticide products with high selectivity and activity to specific pests or weeds, which can help agricultural production of pest control.
In short, 1-iodine-2-fluoro-4-chloro-6-bromobenzene has potential uses in many fields such as drugs, materials, and pesticides, providing important support for the development of organic synthetic chemistry and the progress of related industries.
What are the physical properties of 1-Iodo-2-Fluoro-4-Chloro-6-Bromobenzene?
1-Iodine-2-fluoro-4-chloro-6-bromobenzene is an organohalogenated aromatic hydrocarbon compound. Its physical properties are quite elusive.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow liquid, but it also depends on its purity. If it contains impurities, or a slightly darker color. Looking at its smell, it often has a special smell unique to aromatic hydrocarbons. Although it is not a bad smell, it also has a distinct smell.
When it comes to boiling point, due to the large number of halogen atoms in the molecule, the intermolecular force increases, resulting in a high boiling point. It is approximately between 250 and 300 degrees Celsius, and the specific value will vary slightly depending on the measurement environment and method. This higher boiling point is due to the increase in molecular polarity of halogen atoms and the enhancement of intermolecular van der Waals forces.
In terms of melting point, the melting point of this compound is about -10 ° C to 10 ° C, which is relatively low. This is because the molecular structure contains halogen atoms, but the planar structure of the benzene ring and the distribution of halogen atoms do not make the molecules closely arranged to form a strong lattice energy, so the melting point does not reach a very high degree.
In terms of solubility, the substance is insoluble in water, because water is a polar solvent, and although 1-iodine-2-fluorine-4-chloro-6-bromobenzene contains a slightly polar halogen atom, the non-polar part of the benzene ring dominates, resulting in a large difference in polarity from water. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, in organic solvents such as dichloromethane, chloroform, ether, etc., it has good solubility, because these organic solvents are similar to the polarity of the compound.
The density is heavier than that of water, usually between 2.0 and 2.2 g/cm ³. The relative weight of halogen atoms is relatively large, resulting in an increase in molecular weight, while the molecular volume is not excessive expansion, so the density is higher than that of water.
Its vapor pressure is low, and it is difficult for molecules to escape from the liquid surface due to strong intermolecular forces. This characteristic also affects its volatilization rate in the environment. For volatile organic compounds, volatilization is slower.
In summary, the physical properties of 1-iodine-2-fluoro-4-chloro-6-bromobenzene are different from those of common organic compounds due to the interaction of benzene ring and halogen atoms in the molecular structure.
Is 1-Iodo-2-Fluoro-4-Chloro-6-Bromobenzene chemically stable?
1-Iodine-2-fluoro-4-chloro-6-bromobenzene, the stability of its chemical properties is related to the interaction and bond energy of atoms in the molecule. This compound contains iodine, fluorine, chlorine, and bromine halogen atoms on the benzene ring.
The benzene ring has a conjugated π electron system, which is quite stable. However, the introduction of halogen atoms changes the distribution of electron clouds due to different electronegativity. Fluorine atoms are extremely electronegative and have a strong attraction to the electron cloud of the benzene ring, which decreases the electron cloud density of the benzene ring and changes the reactivity. The electronegativity of chlorine and bromine is slightly weaker than that of fluorine, but it also affects the distribution of electron clouds
Although the electronegativity of the iodine atom is relatively small, its atomic radius is large, and the spatial steric resistance effect is significant. The combined action of various halogen atoms affects the stability of the compound. When encountering electrophilic reagents, the electron cloud density of the benzene ring decreases, and the electrophilic substitution reaction is more difficult than that of benzene. However, under certain conditions, halogen atoms can participate in reactions such as nucleophilic substitution, resulting in structural changes and impaired stability.
In addition, its stability is also influenced by external conditions. Under high temperatures, the thermal motion of molecules intensifies, the vibration of chemical bonds increases, and it is easy to cause bond breakage and reduce stability. When exposed to light, molecules absorb light energy, and electrons transition, triggering chemical reactions and impairing their stability. < br Polar solvents can interact with compounds to change their electron cloud distribution, which in turn affects their stability. Therefore, the stability of 1-iodine-2-fluoro-4-chloro-6-bromobenzene is not absolute, but it maintains a dynamic equilibrium under the combined action of many factors.
What are 1-Iodo-2-Fluoro-4-Chloro-6-Bromobenzene synthesis methods?
The synthesis of 1-iodine-2-fluoro-4-chloro-6-bromobenzene is an important topic in organic synthetic chemistry. There are various synthesis routes, and the following are common methods.
One is the halogenation reaction method. First, benzene can be used as the starting material, and halogen atoms such as fluorine, chlorine, bromine, and iodine can be gradually introduced through halogenation. For example, benzene and chlorine can be obtained under the action of an appropriate catalyst, such as ferric chloride. Then, chlorobenzene reacts with bromine under specific conditions, and bromine atoms can be introduced at specific positions in the benzene ring. Then, through fluorination reaction, fluorine atoms are introduced with suitable fluorine substitutes, such as potassium fluoride, in appropriate solvents and reaction conditions. Finally, the introduction of iodine atoms is achieved through iodine substitution reaction, using iodine elemental substances and suitable oxidizing agents. This process requires precise control of reaction conditions, such as temperature, reaction time, and proportion of reactants, to ensure the selectivity and yield of each step of the reaction.
Second, the reaction of aryl diazonium salts is used. First, aniline compounds are formed into aryl diazonium salts by diazotization reaction, and then fluorine, chlorine, bromine, and iodine atoms are introduced by Sandmeier reaction or other similar reactions with different cuprous halides and other reagents. This method can precisely control the position of the substituents, but the diazotization reaction requires strict control of the reaction conditions to avoid the decomposition of diazonium salts, and the selection and use of reagents are also crucial.
Third, the coupling reaction catalyzed by transition metals. Using aromatic halides containing different halogens as raw materials, with the help of transition metal catalysts, such as palladium catalysts, in the presence of ligands and bases, the coupling reaction occurs. Through rational design of reaction substrates and selection of appropriate reaction conditions, the synthesis of the target product can be achieved. This method has the advantages of high efficiency and good selectivity, but the catalyst cost is high, and the reaction system is relatively complex, so the reaction conditions need to be carefully optimized.
When synthesizing 1-iodine-2-fluoro-4-chloro-6-bromobenzene, the advantages and disadvantages of each method should be comprehensively considered. According to the actual situation, such as the availability of raw materials, cost, reaction equipment and other factors, the most suitable synthesis method should be selected to achieve the purpose of efficient, economical and environmentally friendly synthesis.
What is the price range of 1-Iodo-2-Fluoro-4-Chloro-6-Bromobenzene in the market?
I haven't seen 1 - Iodo - 2 - Fluoro - 4 - Chloro - 6 - Bromobenzene in the market, but if you want to know its price, you can look at it from many places.
The price of materials in the market often varies depending on the purity of quality, quantity, supply and demand, and different producers. If you want to get the exact price of this product, first, you can visit the platform for trading chemical raw materials. Such platforms often collect the prices of various merchants, or you can get an approximate price range. Second, ask chemical raw material suppliers, who often give real-time prices according to market conditions and goods.
However, this compound contains iodine, fluorine, chlorine, bromine and other halogen atoms, and it is difficult to synthesize, so its price is not cheap. Probably due to the difficulty of preparation, special methods and reagents are required, resulting in higher costs. If its purity is high and the dosage is sufficient, its price per gram may be from tens of yuan to more than 100 yuan; if the amount is small, and high purity is required, the price may be even higher, or more than 100 yuan per gram. However, these are all words, and the actual price is still subject to inquiries in the market. You must visit the market in person and ask the merchants before you can get the exact price.