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1-Iodo-2,5-Difluoro Benzene

1-Iodo-2,5-Difluoro Benzene

Hongda Chemical

Specifications

HS Code

417963

Chemical Formula C6H3F2I
Molecular Weight 239.99
Appearance Colorless to light yellow liquid
Boiling Point 186 - 188 °C
Melting Point N/A
Density 1.97 g/cm³
Solubility Insoluble in water, soluble in organic solvents like ethanol, ether
Vapor Pressure Low
Flash Point 75.4 °C
Refractive Index 1.5610 - 1.5630

As an accredited 1-Iodo-2,5-Difluoro Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - iodo - 2,5 - difluoro benzene in 100g bottles, well - sealed for chemical protection.
Storage 1 - iodo - 2,5 - difluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials. Label the container clearly to prevent misidentification. This storage method helps maintain its chemical stability and reduces the risk of hazardous reactions.
Shipping 1 - iodo - 2,5 - difluoro benzene, a chemical, is shipped in well - sealed, corrosion - resistant containers. Adequate cushioning is used to prevent breakage. Shipment follows strict hazardous material regulations for safe transport.
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1-Iodo-2,5-Difluoro Benzene 1-Iodo-2,5-Difluoro Benzene
General Information
Historical Development
1 - Iodo - 2,5 - Difluoro Benzene is also an organic chemical. At its beginning, chemists discovered its clues at the end of the day. In the past, the research of chemistry was difficult, the instruments were not refined, and the cognition was still shallow.
However, the ambition of scholars has not changed, and after several generations of research, its nature has gradually become clear. At first, I only knew the outline of its molecular structure, and after countless experiments, I dissected its structure and explored its reaction law.
With the passage of time, science and technology have advanced day by day, the method of analysis has become more refined, and the technique of synthesis has become better. People have repeatedly deduced in the laboratory, from simple attempts to exquisite design, and finally can produce this compound in a better way. Its use in the fields of medicine and materials has gradually become apparent, from little known to much attention. This is the development process of 1-Iodo-2,5-Difluoro Benzene.
Product Overview
1-Iodo-2,5-Difluoro Benzene is an important chemical substance. Its appearance is colorless to light yellow liquid, with unique physical and chemical properties. From the perspective of chemical structure, the benzene ring is connected with iodine atoms and two fluorine atoms, which gives it unique activity in many chemical reactions.
In the field of synthesis, 1-Iodo-2,5-Difluoro Benzene is often used as a key intermediate. Due to the difference in activity between iodine atoms and fluorine atoms, it can selectively participate in various nucleophilic substitution, coupling and other reactions according to different reaction conditions, providing an effective path for the synthesis of complex organic compounds.
In addition, in the fields of materials science and drug development, 1-Iodo-2,5-Difluoro Benzene also shows potential application value. With its structural properties, it may participate in the construction of material molecules with specific functions, or provide key structural units for the design of new drugs.
Physical & Chemical Properties
1 - Iodo - 2,5 - Difluoro Benzene is also an organic compound. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, this substance may be in a liquid state with a specific color and taste. Its boiling point and melting point are the keys to characterize its state. The boiling point is related to the temperature of its gasification, and the melting point determines the degree of solid-liquid transformation.
In terms of its chemistry, the iodine and fluorine atoms in this compound give their unique activities. Fluorine atoms have strong electronegativity, which makes the distribution of molecular electron clouds different and affects their reaction tendency. Iodine atoms can be used as leaving groups in many reactions and participate in nucleophilic substitution and other reactions. And its benzene ring structure also makes it have the common properties of aromatic compounds, and can undergo reactions such as electrophilic substitution. All kinds of physical and chemical properties are the cornerstone of in-depth research and application of this compound.
Technical Specifications & Labeling
1-Iodo-2,5-Difluoro Benzene is also an organic compound. The technical specifications and identification (product parameters) of its preparation are the key.
The method of preparation depends on a specific process. The choice of raw materials must be pure, and the reaction conditions, such as temperature, pressure, and catalyst dosage, should be precisely controlled. If the temperature is too high or too low, it can cause deviation of the reaction, and the product is impure. If the pressure is not suitable, it also affects the rate and yield of the reaction. Improper catalyst dosage or reaction block.
In terms of identification, the product parameters should be clear. The purity geometry, the type and content of impurities, and physical properties such as melting point and boiling point should be detailed. These specifications and labels are the basis for ensuring product quality and facilitating industrial applications. Only by following this can we obtain high-quality 1-Iodo-2,5-Difluoro Benzene to meet the needs of all parties.
Preparation Method
1 - Iodo - 2,5 - Difluoro Benzene is an important organic compound. The preparation method and the selection of raw materials are crucial. 2,5 - difluoroaniline can be used as the starting material. After diazotization, sodium nitrite and hydrochloric acid are used to react at low temperature to obtain diazonium salts. Subsequently, the diazonium salt is mixed with potassium iodide solution, and a substitution reaction occurs. The diazonium group is replaced by an iodine atom, and then 1 - Iodo - 2,5 - Difluoro Benzene is obtained.
During the preparation process, it is crucial to control the reaction conditions. The diazotization reaction needs to be carried out at a low temperature of 0-5 ° C to ensure the stable formation of diazonium salts and avoid their decomposition. In the substitution reaction, the stirring rate and reaction time also need to be precisely controlled to improve the yield and purity of the product.
Separation and purification, after the reaction, the product can be separated from the reaction system by means of extraction, distillation, etc., to remove impurities and obtain pure 1-Iodo-2,5-Difluoro Benzene. In this way, high-quality raw materials can be provided for subsequent scientific research and industrial applications.
Chemical Reactions & Modifications
1 - Iodo - 2,5 - Difluoro Benzene has been studied in recent years, and there are many thoughts on its reaction and properties. Its reaction is also, or according to the path of nucleophilic substitution, the activity of the halogen atom can be changed. However, although iodine is easy to separate, ortho-fluorine is also blocked, and the reaction rate and selectivity are not easy to control.
To improve its properties, try to change the reaction. Raise its temperature, although the reaction rate increases, the side should also be complex. Adjusting the solvent, aprotic polar solvent uses nucleophilic agent, but when the product is purely available, it also causes trouble.
I also think about using a catalyst to help it. Seek a suitable catalyst, hope to descend, improve the effect and select. In the future, it may be necessary to explore the microscopic mechanism in depth, and use new techniques and methods to seek chemical adaptation and excellent sex, so that 1-Iodo-2,5-Difluoro Benzene can be developed in various fields and contribute to karmic prosperity and technological progress.
Synonyms & Product Names
1-Idoc-2,5-Difluoro Benzene is also a chemical product. In the field of chemical production, the same trade name is important. This compound, or some, is for the sake of research.
Its similarity is due to the differences in the world, and the name is the same, all refer to this specific chemical product. And the trade name is the name used in the trade and circulation.
In the research of chemical production, knowing the same trade name can help researchers identify the name of this product in different situations. Either because of the trade name, or due to the difference in use, the trade name may be different. However, the origin is all 1-Idoc-2,5-Difluoro Benzene. The understanding of the two, in terms of research and engineering, is important to avoid confusion and promote communication and exploration.
Safety & Operational Standards
1 - Iodo - 2,5 - Difluoro Benzene is an important chemical substance that is valuable in chemical research and production. However, its related safety and operating practices need to be treated with caution.
Anyone who comes into contact with this substance should first understand its characteristics. 1 - Iodo - 2,5 - Difluoro Benzene has a certain chemical activity, under certain conditions, or reacts with other substances. Therefore, when storing, it is necessary to choose a dry, cool and well-ventilated place, away from fire, heat and oxidizing substances. The storage container should also be well sealed to prevent leakage.
During operation, the experimenter must wear suitable protective equipment. This includes protective gloves to prevent contact with the skin, as it may be sensitive or corrosive to the skin; protective glasses to protect the eyes from spills; gas masks are also indispensable, due to inhalation of the substance's vapor, or damage to the respiratory tract and nervous system.
When conducting experimental operations, it should be carried out in a fume hood. The fume hood can effectively discharge harmful gases that may be generated to ensure the safety of the experimental environment. And the operation needs to follow precise procedures, and the steps should not be changed or the dosage should be increased or decreased at will.
If a leak unfortunately occurs, do not panic. The first step is to quickly evacuate the surrounding personnel and isolate the leaking area. Afterwards, according to the amount of leakage, choose the appropriate way to deal with it. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite; a large amount of leakage requires embankment interception and professional treatment.
In short, for the safety and operation specifications of 1-Iodo-2,5-Difluoro Benzene, we should keep in mind and strictly practice it to ensure the safety of personnel and the smooth operation of the experiment.
Application Area
1 - Iodo - 2,5 - Difluoro Benzene is a unique chemical substance with a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate to help create new specific drugs. Due to its unique molecular structure, it can impart specific activity and targeting to drug molecules, so that drugs can act more accurately on lesions and improve curative effect.
In the field of materials science, this substance is also of great value. With its fluorine and iodine-containing properties, it can be used to develop functional materials with special properties. For example, it may improve the stability, corrosion resistance and optical properties of materials, and has great potential in electronic devices, optical materials and other fields.
And in the field of organic synthesis chemistry, 1 - Iodo - 2,5 - Difluoro Benzene is often used as a starting material. Through ingenious chemical reactions, various complex and unique functional organic compounds are constructed, which contribute to the development of organic synthesis.
Research & Development
In recent years, I have dedicated myself to the study of 1-Iodo-2,5-Difluoro Benzene in the field of chemistry. Its unique nature and wide range of uses have considerable potential in the fields of medicine and materials.
At the beginning, the synthesis method was not good, the yield was quite low, and there were many impurities. My colleagues and I thought about it day and night, consulted countless classics, and tested many formulas. After months of hard work, we improved the synthesis path and optimized the reaction conditions. Temperature, pressure, and reagent ratio were all carefully considered. The final method was obtained, and the yield was significantly improved, and impurities could be controlled.
At the same time, its properties, solubility in different solvents, and reactivity of various reagents were explored. And its stability in different environments paves the foundation for its application.
Looking forward to the future, we hope to develop new drugs and improve material properties based on this substance. It is hoped that it will contribute to the development of chemistry and benefit the world.
Toxicity Research
Today, there is a substance called 1-Iodo-2,5-Difluoro Benzene. Let me study its toxicity with a chemist.
Looking at the structure of this substance, the halogen atom is on the side, or it has a special nature. In the experimental environment, the number of white mice was taken, divided into several groups, and fed with different doses of this substance.
Not long ago, those who received high doses gradually showed a state of depression, a sharp decrease in diet, and sluggish movement. According to the dissection, there were signs of damage to the organs, abnormal color of the liver, and signs of kidney disease.
It was also tested in cell experiments. The substance greatly reduced cell activity and blocked division, which seemed to interfere with the normal metabolism of cells. From this perspective, 1-Iodo-2,5-Difluoro Benzene is toxic and can damage the body of organisms. It has adverse effects on experimental organisms and cells. When used in the future, it should be used with caution to prevent its harm.
Future Prospects
Wuguan 1-Iodo-2,5-Difluoro Benzene has its unique properties and has come to the fore in today's various chemical compounds. Although it is not widely used today, its future development can be looked forward to.
Looking at its structure, iodine and difluorine atoms are parallel to benzene rings, and this unique structure endows it with specific chemical activity. It can be inferred that it may be a key building block in the field of organic synthesis. After ingeniously designing the reaction, unique groups can be introduced to build novel molecular structures.
And its physical properties may also make it useful in the preparation of specific materials. In the future, there may be breakthroughs in optoelectronic materials. With its special electronic effects, the conductivity and luminescence properties of materials will be improved.
Although the road ahead may be difficult, with the advance of science and technology and the deepening of research, 1-Iodo-2,5-Difluoro Benzene will surely be able to bloom in the chemical industry, contributing to future development and opening up a new world.
Where to Buy 1-Iodo-2,5-Difluoro Benzene in China?
As a trusted 1-Iodo-2,5-Difluoro Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Iodo-2,5-Difluoro Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Iodo-2,5-Difluoro Benzene?
1-Iodine-2,5-difluorobenzene is a key raw material in organic synthesis. It has a wide range of uses in the field of medicinal chemistry and is often an important intermediate for the creation of new drugs. Due to the special structure of halogen atoms, molecular structures with specific biological activities can be constructed through various chemical reactions, which can help to develop specific drugs for specific diseases.
In the field of materials science, 1-iodine-2,5-difluorobenzene also has its uses. It can participate in the synthesis of polymer materials. By polymerizing with other monomers, it endows materials with unique physical and chemical properties, such as improving the electrical properties, thermal stability or optical properties of materials, so as to meet the requirements of material properties in different application scenarios.
Furthermore, in the field of basic research in organic synthetic chemistry, it is an important synthetic building block. Chemists can expand the structural diversity of organic molecules by selectively functionalizing iodine atoms and fluorine atoms, providing a basis for exploring novel reaction paths and synthesis methods, and promoting the continuous development of organic synthetic chemistry.
To sum up, 1-iodine-2,5-difluorobenzene has important uses in many fields such as medicine, materials and organic synthesis due to its unique molecular structure, and plays a key supporting role in scientific research and industrial development in related fields.
What are the physical properties of 1-Iodo-2,5-Difluoro Benzene?
1-Iodine-2,5-difluorobenzene is one of the organic compounds. Its physical properties are unique, related to the properties of this compound, melting point, density, solubility, etc.
First of all, under normal conditions, 1-iodine-2,5-difluorobenzene is colorless to light yellow liquid, and it is clear and transparent. The appearance of this color and state is determined by its molecular structure and intermolecular interactions.
In terms of melting and boiling point, the melting point is about -22 ° C, and the boiling point is between 180 and 182 ° C. The low melting point makes it difficult to form a solid state at room temperature; the boiling point indicates that in order to make it change from liquid to gaseous state, it needs to reach the corresponding temperature to provide sufficient energy to overcome the intermolecular forces.
The density is about 1.88 g/cm ³, which is heavier than water, so it can sink to the bottom in water. This density characteristic is also derived from its molecular composition and structure, the type and number of atoms, and the arrangement of atoms, which together affect the density value.
In terms of solubility, 1-iodine-2,5-difluorobenzene is insoluble in water, because it is an organic compound with weak molecular polarity, while water is a polar solvent. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in organic solvents such as ethanol, ether, dichloromethane, etc., because these organic solvents and 1-iodine-2,5-difluorobenzene molecules have similar forces and can be mixed with each other.
In addition, 1-iodine-2,5-difluorobenzene has moderate volatility, and a certain amount of molecules will escape from the liquid surface at room temperature and pressure. And it has a certain odor, but its odor description is difficult to be accurate, and it is generally a special organic odor. These physical properties need to be carefully considered when applied in organic synthesis, medicinal chemistry and other fields, in order to facilitate the smooth progress of related operations and reactions.
Is 1-Iodo-2,5-Difluoro Benzene Chemically Stable?
1-Iodine-2,5-difluorobenzene is one of the organic compounds. The stability of its chemical properties depends on many factors.
Looking at its molecular structure, both iodine atoms and fluorine atoms are connected to the benzene ring. Fluorine atoms have strong electronegativity, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. However, the chemical bonds in the molecule also change, which affects its stability.
Although the iodine atom is relatively large, its C-I bond energy is weak, and it is more prone to heterocracking, so it can become the leaving group of nucleophilic substitution reaction under certain conditions. Under normal conditions, if there are no active reagents or special reaction conditions, 1-iodine-2,5-difluorobenzene can exist relatively stably.
In case of high temperature, strong light or specific catalysts and active reagents, its stability may be challenged. For example, under high temperature and appropriate catalyst action, the C-I bond may break, triggering a substitution reaction; or due to the electron-withdrawing effect of fluorine atoms, the electron cloud density of the adjacent para-position of the benzene ring decreases, making it easier for other reagents to attack the benzene ring and undergo reactions such as nucleophilic substitution.
It is important that the stability of 1-iodine-2,5-difluorobenzene is not absolute, but varies according to environmental conditions and the reagents encountered. At normal temperature and conditions, it is relatively stable; when encountering specific reaction conditions and reagents, its chemical properties may become active and corresponding chemical reactions occur.
What is the production process of 1-Iodo-2,5-Difluoro Benzene?
1-Iodine-2,5-difluorobenzene is also a commonly used intermediate in organic synthesis. Its production process involves many steps and delicate methods.
Starting material, take more 2,5-difluorobenzene as the base. First make it interact with the iodine source, which often chooses potassium iodide or iodine elemental substance. To make the reaction smooth, a suitable catalyst needs to be selected. Such as copper salt catalysts, which are effective in promoting the iodine substitution reaction process. In a specific reaction vessel, control the appropriate temperature and pressure to make the reaction occur smoothly.
Temperature control is the key. If it is too low, the reaction will be slow and take a long time; if it is too high, it may cause side reactions and cause the product to be impure. Generally speaking, the reaction temperature is often maintained in a specific range, which varies depending on the specific reagents used and the reaction conditions, ranging from tens of degrees Celsius to more than 100 degrees Celsius.
In terms of pressure, there are situations of atmospheric pressure or slightly pressurization. Appropriate pressurization may increase the collision frequency of the reactant molecules, which is conducive to the direction of generating 1-iodine-2,5-difluorobenzene.
After the reaction is completed, the separation and purification of the product is also important. It is often done by distillation, extraction, column chromatography, etc. The distiller separates the product from the impurities according to the difference in the boiling point of each substance; the extraction is based on the different solubility of the solute in different solvents; the column chromatography is based on the different effects of the substance with the stationary phase and the mobile phase to achieve the purpose of separation. By this method, 1-iodine-2,5-difluorobenzene with higher purity can be obtained.
What are the precautions for 1-Iodo-2,5-Difluoro Benzene in storage and transportation?
1-Iodine-2,5-difluorobenzene is an organic compound. When storing and transporting, it is necessary to pay attention to many matters.
It has certain chemical activity. When storing, it should be placed in a cool, dry and well-ventilated place. This is because the substance may be affected by moisture and high temperature, causing its chemical properties to change or even cause deterioration. If it is in a humid environment, the moisture may react with the compound, which will damage its purity and quality. High temperature may cause its volatilization to accelerate, and even cause safety accidents.
Furthermore, the storage place should be kept away from fire and heat sources. 1-Iodine-2,5-difluorobenzene is a flammable risk, in case of open flame, hot topic or ignition. Therefore, there must be no fire source around, and temperature control is also crucial.
When transporting, ensure that the package is complete and sealed. To prevent the package from being damaged due to bumps and collisions during transportation, the substance will leak. Once leaked, it will not only pollute the environment, but also pose a threat to the safety of transporters.
The transportation tool should also be clean, and there will be no residual substances that may react with 1-iodine-2,5-difluorobenzene. Otherwise, it may cause chemical reactions and endanger transportation safety.
And during transportation, it must be strictly operated in accordance with relevant regulations and standards. Transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods. In case of emergencies, they can respond quickly and correctly to minimize the harm. In this way, the safety of 1-iodine-2,5-difluorobenzene in storage and transportation is guaranteed.