1-Iodine-2,4,5-trifluorobenzene is also an important substance in organic synthesis. It has a wide range of uses and can be a key building block in the creation of pharmaceuticals. In pharmaceutical chemistry, the precise molecular structure depends on the efficacy of drugs. 1-Iodine-2,4,5-trifluorobenzene has unique chemical properties. The introduction of fluorine atoms can change the electron cloud distribution of molecules, increase its lipophilicity, and enable drugs to penetrate biofilms and reach their targets. Iodine atoms have high activity and can be connected to other organic fragments through various chemical reactions, such as coupling reactions, to form complex and biologically active molecules, which can help the development of new drugs.
In the field of materials science, it also has its uses. For example, when preparing special functional materials, using this as the starting material, through clever synthesis paths, materials with specific photoelectric properties can be prepared. Due to the particularity of its molecular structure, it may be able to develop its strengths in organic Light Emitting Diode (OLED), solar cells and other fields, endowing materials with excellent properties such as charge transfer, optical absorption and emission, and improving the overall performance of materials.
Furthermore, in the process of pesticide creation, 1-iodine-2,4,5-trifluorobenzene is also indispensable. It can be used to synthesize pesticides with high insecticidal, bactericidal or herbicidal activities. Fluorine enhances the affinity and biological activity of compounds to target organisms, and iodine atoms provide opportunities for structural modification, making the created pesticides more targeted and efficient, and effective in ensuring agricultural production and preventing and controlling pests. In short, 1-iodine-2,4,5-trifluorobenzene is an important basic raw material in many fields such as medicine, materials, and pesticides, promoting the progress of various technologies and the development of industries.

1-Iodine-2,4,5-trifluorobenzene is one of the organic compounds. It has various physical properties, which are described as follows:
- ** Properties **: Under normal temperature and pressure, 1-iodine-2,4,5-trifluorobenzene is mostly colorless to light yellow transparent liquid. Looking at its color state, this characteristic can be an important basis for identification and practical application.
- ** Boiling point **: about 172-174 ° C. Boiling point, the temperature limit for a substance to change from liquid to gas is also. At this temperature, 1-iodine-2,4,5-trifluorobenzene molecules obtain enough energy to break free from the liquid phase and escape into the gas phase. This boiling point value is of great significance in chemical operations such as distillation and separation.
- ** Melting point **: Its melting point is about -22 ° C. The melting point is the critical temperature at which a substance changes from solid to liquid, indicating that below this temperature, the compound is in a solid state; at this temperature, it begins to melt into a liquid state. This property is related to the physical form of the substance at different temperatures, which affects its storage and transportation conditions.
- ** Density **: The density is about 1.98 g/mL. Density reflects the mass of a substance per unit volume. This value reflects the relationship between the weight of 1-iodine-2,4,5-trifluorobenzene compared to water and other common solvents. It is a key consideration when it comes to mixing, delamination, etc.
- ** Solubility **: Slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility characteristic is due to its molecular structure and polarity. Water is a strong polar solvent, while 1-iodine-2,4,5-trifluorobenzene has a weak polarity, so it is slightly soluble. The polarity of organic solvents is similar to that of this compound, and it is well miscible according to the principle of "similar compatibility". This solubility plays an important role in organic synthesis, extraction and other processes.
- ** Vapor pressure **: At a specific temperature, 1-iodine-2,4,5-trifluorobenzene has a certain vapor pressure. Vapor pressure characterizes the tendency of molecules on the surface of the liquid to escape and form a vapor phase. The higher the temperature, the greater the vapor pressure. This property is closely related to the volatility of the substance and has guiding significance for the ventilation requirements of its storage environment.

The synthesis method of 1-iodine-2,4,5-trifluorobenzene often follows the following methods.
First, fluorobenzene derivatives are used as starting materials and obtained by halogenation. For example, take 2,4,5-trifluoroaniline first, react with potassium iodide after diazotization, and then react with potassium iodide to produce a Sandmeyer reaction. This is a classic method. During diazotization, 2,4,5-trifluoroaniline is treated with sodium nitrite and acid (such as hydrochloric acid) at low temperature (about 0-5 ° C) to form diazonium salts. Subsequently, potassium iodide is added, and the diazo group is replaced by an iodine atom to obtain 1-iodine-2,4,5-trifluorobenzene.
Second, the coupling reaction is catalyzed by palladium. For example, 2,4,5-trifluorobromobenzene is reacted with an iodizing reagent in a suitable solvent (such as N, N-dimethylformamide) in the presence of a palladium catalyst (such as tetra (triphenylphosphine) palladium) and a base. The base can promote the reaction, the iodizing reagent provides an iodine source, and the palladium catalyst activates the reactant to replace the bromine atom with the iodine atom to achieve the synthesis of 1-iodine-2,4,5-trifluorobenzene.
Third, the electrophilic substitution reaction is carried out directly with a fluorophenyl ring and an iod However, due to the electron-withdrawing property of fluorine atoms, the electron cloud density of the benzene ring is reduced. This reaction condition is relatively harsh, and a highly active iodine substitution reagent needs to be selected, and the appropriate reaction temperature and time can be controlled to improve the yield of the product. For example, an appropriate amount of iodine is used to react with 2,4,5-trifluorobenzene under the catalysis of Lewis acid (such as aluminum trichloride), which assists in the polarization of the iodine substitution reagent and enhances its electrophilicity, thereby realizing the synthesis of 1-iodine-2,4,5-trifluorobenzene.

1-Iodine-2,4,5-trifluorobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First words storage. This substance should be placed in a cool, dry and well-ventilated place. Cover it or be sensitive to heat, moisture, warm and humid environment, easy to cause its properties to change, or even cause dangerous chemical reactions. If it is at high temperature, there may be a risk of decomposition, resulting in harmful gases. And it must be kept away from fire, heat source, open flame, hot topic can cause its combustion and explosion. Furthermore, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Contact with such substances, it is easy to cause chemical reactions and endanger safety. The storage area should be equipped with suitable materials to contain leaks in case of leakage and can be disposed of in time.
As for transportation, there are also many points. Before transportation, it is necessary to ensure that the packaging is complete and sealed. The packaging material must be able to withstand vibration, collision and friction to prevent material leakage caused by package damage. During transportation, the speed of the vehicle should be stable, and sudden braking and sharp turning should be avoided to prevent damage to the packaging due to severe shaking. The transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. At the same time, the transportation personnel must be familiar with the nature, hazards and emergency treatment methods of the substance. If an accident such as leakage occurs during transportation, it can be responded to quickly and correctly. In addition, the planning of the transportation route should avoid sensitive areas such as densely populated areas and water sources to reduce the harm in case of an accident.
Therefore, when storing and transporting 1-iodine-2,4,5-trifluorobenzene, careful attention should be paid to the above to ensure safety.

The market price range of 1-iodine-2,4,5-trifluorobenzene is difficult to determine. The price varies due to many factors, such as the method of production, supply and demand, the quality of the product, the number of purchases, and the market conditions are easier from time to time, and it is difficult to have a constant price.
Looking at the past market conditions, if it is in the market of chemical raw materials, its purchase quantity is small, and it is only for experimental research. It is sold in small bottles (such as 10 grams, 50 grams), and the price per gram may reach tens of yuan. This is because of the small amount of refining, the cost is quite high, and the seller also needs to take into account the demand for research, so the price is high.
If the purchase volume is quite large, such as more than kilograms, because the production system can be scaled, the cost is slightly reduced, and the price per kilogram may be in the range of several thousand yuan. However, this is also not accurate. If the supplier has abundant production capacity and the market supply exceeds demand, the price may decrease; conversely, if the raw materials are scarce, the production is difficult, and the supply is insufficient, the price will increase.
And the price varies from region to region. In places with prosperous economy and prosperous chemical industry, the price may be relatively easy due to the convenience of production and logistics; in remote places, the price may vary depending on the cost of transportation and supply and demand.
To obtain accurate market prices, it is advisable to consult chemical raw material suppliers or check real-time price information on chemical product trading platforms, so as to obtain a more accurate market price range at present.