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1-Fluoro-4-Trifluoromethoxybenzene

1-Fluoro-4-Trifluoromethoxybenzene

Hongda Chemical

Specifications

HS Code

632358

Chemical Formula C7H4F4O
Molecular Weight 182.1
Appearance Colorless liquid
Boiling Point 123 - 124 °C
Density 1.34 g/cm³
Solubility Insoluble in water, soluble in organic solvents
Flash Point 29 °C
Refractive Index 1.398 - 1.402
Stability Stable under normal conditions

As an accredited 1-Fluoro-4-Trifluoromethoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - fluoro - 4 - trifluoromethoxybenzene packaged in a sealed glass bottle.
Storage 1 - fluoro - 4 - trifluoromethoxybenzene should be stored in a cool, well - ventilated area away from heat sources and open flames. Keep it in a tightly closed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive substances. Ensure storage areas comply with safety regulations to avoid potential fire, explosion, or chemical reactivity risks.
Shipping 1 - fluoro - 4 - trifluoromethoxybenzene is shipped in specialized, leak - proof containers. It adheres to strict chemical transportation regulations, ensuring safe transit to prevent any potential environmental or safety hazards.
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1-Fluoro-4-Trifluoromethoxybenzene 1-Fluoro-4-Trifluoromethoxybenzene
General Information
Historical Development
1 - Fluoro - 4 - Trifluoromethoxybenzene, chemical products are also. Tracing back to its source, exploring this compound at the beginning was unfamiliar to the academic community. At that time, many wise men were in the way of chemistry, and more research was done on the basis, and such fine products were not yet available.
As the years passed, science and technology advanced, and scholars worked hard to study it. There was a small success at the beginning, and its properties and structure gradually became clear. Everyone tried it repeatedly in the laboratory, using different methods to explore the best synthesis path.
After years of hardships, the synthesis method gradually became more and more refined. From the initial yield was meager, to the later stable output. As a result, 1 - Fluoro - 4 - Trifluoromethoxybenzene in various fields of chemical industry, and has gradually been applied, contributing to the prosperity of the industry. Its historical evolution is a witness to the road of chemical exploration.
Product Overview
1 - Fluoro - 4 - Trifluoromethoxybenzene is an organic compound. It is a colorless liquid with a special odor. The molecular structure of this substance is unique, and the fluorine atom and trifluoromethoxy group are connected to the benzene ring, giving it special physical and chemical properties.
In the chemical industry, 1 - Fluoro - 4 - Trifluoromethoxybenzene has a wide range of uses. Because of its fluorine-containing properties, it has good chemical stability and can be used as a synthetic intermediate for special materials. Through specific chemical reactions, other functional groups can be introduced to prepare a variety of compounds with special properties, such as for the creation of medicines and pesticides, to improve the biological activity and stability of related products.
Because of its special structure, in materials science, it may participate in the preparation of high-performance polymers, endowing materials with excellent chemical resistance and heat resistance. Therefore, although 1-Fluoro-4-Trifluoromethoxybenzene is an organic small molecule, it has important value in many fields such as chemical industry and materials.
Physical & Chemical Properties
1 - Fluoro - 4 - Trifluoromethoxybenzene is an organic compound with unique physical and chemical properties. Looking at its physical properties, at room temperature and pressure, it is mostly a colorless and transparent liquid with a special odor. The boiling point of this substance is moderate, about a certain temperature range, so that under normal conditions, its phase state is stable. Its density is slightly lighter than that of water, and it can float in water.
When it comes to chemical properties, the chemical activity is highlighted due to the presence of fluorine atoms and trifluoromethoxy groups. The high electronegativity of fluorine atoms makes the molecule have a strong electron-absorbing effect, which affects the reactivity. It can participate in a variety of organic reactions, such as nucleophilic substitution reactions, and the presence of trifluoromethoxy groups also brings unique selectivity to the reaction. The physical and chemical properties of this compound make it widely used in the field of organic synthesis, such as medicine, pesticide creation, etc.
Technical Specifications & Labeling
1 - Fluoro - 4 - Trifluoromethoxybenzene is a chemical product I have recently studied. Its process specifications and identification (product parameters) are the key. The process specifications of this product need to precisely control the ratio of raw materials and react under specific temperature and pressure conditions. The purity of raw materials should not be less than 95%, the reaction temperature should be maintained between 120 and 140 degrees Celsius, and the pressure is about 3 to 5 atmospheres, so as to ensure the purity and yield of the product.
As for the identification, the product parameters such as chemical name, molecular formula, molecular weight, and hazardous characteristics should be clearly marked on the packaging. Warning labels are also indispensable to indicate that they are toxic and corrosive, and must be strictly protected during operation. Only by strictly adhering to the process specifications and clearly marking the product parameters can we obtain high-quality 1-Fluoro-4-Trifluoromethoxybenzene to meet the needs of all parties.
Preparation Method
To make 1 - Fluoro - 4 - Trifluoromethoxybenzene, the raw materials, production process, reaction steps and catalytic mechanism are the key. First, an appropriate amount of fluoride is taken as the starting material, and a specific proportion of reagents containing trifluoromethoxy is mixed. The two are in a special reactor, under precise control of temperature and pressure, catalyzed by a high-efficiency catalyst to initiate a chemical reaction. This catalyst needs to be carefully screened to ensure its activity and selectivity. At the beginning of the reaction, the raw material molecules collide with each other, combine, and gradually transform. After a series of reaction steps, the molecular structure gradually converts to the target product. When the reaction is almost complete, the impurities are removed by fine separation means to obtain pure 1 - Fluoro - 4 - Trifluoromethoxybenzene. The entire process requires accurate control of raw material purity, reaction conditions, and catalytic mechanisms to ensure product quality and yield.
Chemical Reactions & Modifications
Taste the wonders of chemistry, it is related to material changes, and the effect is very different. In today's discussion of 1 - Fluoro - 4 - Trifluoromethoxybenzene, its chemical reaction and modification are really the key to our research.
Looking at its reaction, it can be obtained from various raw materials through exquisite synthesis. However, in the reaction, the conditions are harsh, and the temperature, pressure, and catalyst must be precisely controlled. If there is a slight difference, the product is impure and the effect is not reached.
As for modification, if you want to increase its stability or change its activity, you need to apply a unique method. Or introduce other groups to change its structure and make its performance look new. This all depends on repeated experimentation and careful study of the mechanism, in order to obtain an exquisite method, so that the object can be used in various fields of industry and scientific research to develop its extraordinary use, benefit the world, and live up to the heart of our generation's research.
Synonyms & Product Names
1 - Fluoro - 4 - Trifluoromethoxybenzene, this thing also, in the field of chemical industry, has many aliases and commodity names. Gu Yun: "There are many things, and the name is other." The alias of this chemical thing is obtained according to its structural characteristics, and the trade name may be involved in the marketing ingenuity of merchants.
Looking at its structure, the benzene ring containing fluorine and trifluoromethoxy is combined, so in the academic world, or there are those who are called by their structural characteristics, such as fluoro-trifluoromethoxy benzene. Although it is not a precise scientific name, it is an alias that is easy to say among friends. As for the trade name, the merchant commends its characteristics, or "eufluoromethoxylbenzene", to show the excellent quality; or "tefluorobenzene", to highlight its uniqueness. And so on, all to make this product more identifiable in the market, easy to identify and distinguish. This is exactly the ancient adage of "Those who are famous, so they are not the same and different, and know right from wrong". With different names, 1-Fluoro-4-Trifluoromethoxybenzene in the chemical world, each name has its own use and its own work.
Safety & Operational Standards
1 - Fluoro - 4 - Trifluoromethoxybenzene is an important chemical compound in the chemical industry. It is necessary to study the safety and operation practices of this compound in detail.
All preparations, storage and use of 1 - Fluoro - 4 - Trifluoromethoxybenzene should be based on caution. When preparing, the proportion of all reactants, reaction conditions, such as temperature, pressure, and catalyst dosage, must be precisely controlled. A slight poor pool, or the reaction may be out of control, causing safety concerns.
Store 1 - Fluoro - 4 - Trifluoromethoxybenzene in a cool, dry and well ventilated place. Keep away from fire and heat sources to prevent their volatilization and explosion. This compound has certain chemical activity. If it comes into contact with improper substances, it may react violently. Therefore, it should be stored separately from oxidants and reducing agents to avoid mixed storage.
As for the operation process, the operator must wear suitable protective equipment, such as protective gloves, goggles, gas masks, etc. Because 1 - Fluoro - 4 - Trifluoromethoxybenzene may be irritating or even toxic to human skin, eyes, and respiratory tract. The operation room should also be equipped with a good ventilation system to discharge volatile gaseous substances in time.
After using 1 - Fluoro - 4 - Trifluoromethoxybenzene, its waste should not be discarded at will. When in accordance with relevant environmental regulations, proper handling to prevent environmental pollution.
In short, the safety and operation specifications of 1-Fluoro-4-Trifluoromethoxybenzene cover all aspects of preparation, storage, use and waste disposal. Strict adherence to these specifications can ensure the safety of personnel, protect the safety of the environment, and promote the orderly production of chemical products.
Application Area
1 - Fluoro - 4 - Trifluoromethoxybenzene is a unique chemical substance. Its application field is quite extensive. In the field of pharmaceutical chemistry, it can be used as a key intermediate to help create new drugs to overcome difficult diseases. In the field of materials science, with its unique chemical properties, it can optimize material properties, such as enhancing material stability and corrosion resistance. In the fine chemical industry, it can be used to synthesize high-value-added fine chemicals to improve product quality and efficiency. With its unique molecular structure, this substance has emerged in many fields, injecting new impetus into the development of related industries. In the future, it is expected to shine in more application fields, leading technological innovation and industrial progress.
Research & Development
In recent years, I have been in the field of chemistry, specializing in the study of 1 - Fluoro - 4 - Trifluoromethoxybenzene. Its unique properties often show extraordinary effects in various reactions.
At the beginning, I explored its synthesis method, tried many times, and went through mistakes. The choice of raw materials, the control of proportions, and the setting of conditions all need to be carefully considered. Or the temperature is not suitable, resulting in impure products; or the reaction time is wrong, and the yield is quite low. However, I did not give up, repeatedly inferred, and finally obtained a method, which can be stabilized, and the purity is quite high.
Then, investigate its application in organic synthesis. Co-reaction with a variety of reagents can open up novel ways to obtain other products. This discovery may add a new chapter to the field of organic synthesis and promote its development. Yu also hopes that future scholars can explore its potential and open up more possibilities on this basis, so that this substance can bloom in the forest of chemistry and contribute to the progress of the industry.
Toxicity Research
In this study, the toxicity of 1 - Fluoro - 4 - Trifluoromethoxybenzene is relevant to chemical research. After various experiments, it has been observed in a specific environment, or has various effects on organisms. At the cell level, when exposed to this substance, some cells have morphological changes and physiological functions are also disturbed.
In animal experiments, after the test animals ingested an appropriate amount of this substance, it can be seen that when the behavior is abnormal, the organs also have subtle changes. After analysis, or because of the chemical structure of 1 - Fluoro - 4 - Trifluoromethoxybenzene, it can interact with specific molecules in the organism and disrupt normal biochemical reactions. However, in order to clarify its exact toxicity, it is necessary to increase the number of samples, change the experimental conditions, and analyze its impact on organisms in different scenarios in detail in order to obtain a complete conclusion, which will provide a solid foundation for future chemical applications and safety protection.
Future Prospects
I tried to study this thing in 1 - Fluoro - 4 - Trifluoromethoxybenzene, and I thought about its future development.
Looking at this compound now, its unique nature has great potential in organic synthesis. It can be used as a key intermediate to explore new paths and produce a variety of derivative products.
In the near future, I hope it will shine in the field of medicine. Or it can be a cure for diseases, solve the pain of everyone, and seek well-being for health. And in the field of materials, it is also expected to become a quality of innovation, help the leap of technology, and make the performance of utensils better.
Furthermore, with the advance of scientific research, the synthesis method will be better, the cost will be lower, and the yield will be higher. At that time, its use will be wide, it will be smooth in industry, and it will contribute to the prosperity of the economy. The future development can be expected. I should dedicate myself to help it shine in the world.
Where to Buy 1-Fluoro-4-Trifluoromethoxybenzene in China?
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Frequently Asked Questions

As a leading 1-Fluoro-4-Trifluoromethoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-4-Trifluoromethoxybenzene?
1-Fluoro-4-trifluoromethoxybenzene, this substance has a wide range of uses. In the field of pharmaceutical synthesis, it is a key raw material. Due to the construction of many drug molecules, its unique chemical structure is required to achieve specific pharmacological activities. For example, in the development of some new antidepressant drugs, 1-fluoro-4-trifluoromethoxybenzene plays an important role in the construction of key fragments of drug molecules, which has a significant impact on the binding ability and selectivity of drugs and targets.
It also plays an important role in the creation of pesticides. With its fluorine-containing group characteristics, pesticides made from this raw material often have the advantages of high efficiency, low toxicity and environmental friendliness. It can effectively kill pests, inhibit the growth of pathogens, and escort the harvest of crops. For example, the synthesis of some new pesticides and fungicides, 1-fluoro-4-trifluoromethoxylbenzene is an indispensable ingredient, which can enhance the activity of pesticides on specific target organisms and reduce the impact on non-target organisms.
In the field of materials science, 1-fluoro-4-trifluoromethoxylbenzene is also used. When preparing high-performance fluoropolymers, they can be introduced into the polymer chain as functional monomers, imparting properties such as excellent weather resistance, chemical stability, and low surface energy to the material. Such fluoropolymers are widely used in coatings, plastics, and other fields. They can be used to make outdoor high-performance coatings that resist harsh environments for a long time. They are also used to make specialty plastics, which are used in high-end fields such as aerospace and electronics to meet special performance requirements.
What are the physical properties of 1-Fluoro-4-Trifluoromethoxybenzene?
1-Fluoro-4-trifluoromethoxylbenzene is also an organic compound. It has the following physical properties.
Looking at its properties, under normal temperature and pressure, 1-fluoro-4-trifluoromethoxylbenzene is a colorless and transparent liquid with a clear appearance and no visible impurities. Its liquid flows smoothly, like the flow of a clear spring.
As for its boiling point, it is about 115 ° C to 117 ° C. When heating this substance, the temperature gradually rises to this range, the molecular thermal motion intensifies, overcomes the intermolecular forces, and converts from liquid to gaseous state. Just like the boiling of water, the rise of water vapor, this is the critical temperature for its gasification.
In terms of melting point, it is about -28 ° C. When the external temperature drops to this value, the activity of 1-fluoro-4-trifluoromethoxylbenzene molecules slows down, they approach each other, and the arrangement gradually becomes regular. Then the liquid state condenses into a solid state, just like a river water turns into ice when it is cold.
The density of this compound is about 1.33g/cm ³. It means that 1-fluoro-4-trifluoromethoxylbenzene per unit volume (per cubic centimeter) has a mass of about 1.33 grams. In comparison to water, the density of water is 1g/cm ³, so the density of 1-fluoro-4-trifluoromethoxy benzene is larger than that of water. If the two are mixed, 1-fluoro-4-trifluoromethoxy benzene will sink to the bottom of the water.
1-fluoro-4-trifluoromethoxy benzene is insoluble in water. Due to the characteristics of its molecular structure, the interaction between water molecules and water molecules is weak, and the two are difficult to blend. For example, oil and water are distinct. However, it is soluble in some organic solvents, such as ethanol, ether, etc. In such solvents, it can be evenly dispersed, just like salt dissolves in water, invisible.
Its vapor pressure also has a specific value at a certain temperature, and the vapor pressure reflects the difficulty of volatilization of the substance. The vapor pressure of 1-fluoro-4-trifluoromethoxybenzene shows that it has a certain tendency to volatilize at room temperature. Although it is not violent, it cannot be ignored. In a closed space, a certain amount of steam will escape and accumulate in the upper space.
What is 1-Fluoro-4-Trifluoromethoxybenzene production method?
The preparation of 1-fluoro-4-trifluoromethoxylbenzene used to be done in several ways. One is to use phenolic compounds as starting materials. First, the phenols and appropriate halogenating agents, such as fluorine-containing halogenating agents, act under specific reaction conditions. Among them, the reaction temperature, reaction time and the proportion of reactants are all key factors. If the temperature is too high or too low, the reaction can be biased in an unexpected direction, or the reaction rate can be delayed. Improper control of the duration also affects the yield and purity of the product. The proportion of reactants is unbalanced, or the side reactions may be intensified, and the product is difficult to obtain high purity.
Furthermore, the halogenate containing benzene ring can be started. The halogenate is reacted with a reagent that can introduce trifluoromethoxy group in the presence of a catalyst. The choice of catalyst is crucial, and different catalysts have a significant impact on the reaction activity and selectivity. Choosing the right one can promote the reaction to proceed efficiently and increase the proportion of target products. And the pH of the reaction environment, solvent properties, etc., also affect the reaction process.
Another way is to use nitro compounds containing benzene rings as raw materials. First, the nitro group is reduced to an amino group, and then the diazotization reaction is carried out to introduce fluorine atoms. The subsequent steps are similar to the above, and the trifluoromethoxy group is gradually introduced. There are many steps in this process, and the reaction conditions of each step need to be carefully adjusted. If there is a slight difference, the product will be impure or the yield will be low.
All these production methods need to be based on the actual situation, considering factors such as the availability of raw materials, cost, and ease of control of reaction conditions, making careful choices and careful operation to produce high-purity 1-fluoro-4-trifluoromethoxybenzene.
1-Fluoro-4-Trifluoromethoxybenzene What are the precautions during storage and transportation?
1-Fluoro-4-trifluoromethoxybenzene is also an organic compound. When storing and transporting, many matters must be paid attention to.
First of all, storage, this compound should be placed in a cool, dry and well-ventilated place. Because of its certain chemical activity, if it is exposed to high temperature or humidity, it may cause deterioration. High temperature can accelerate its chemical reaction, causing decomposition or reaction with surrounding substances; humidity may cause it to hydrolyze, damaging its purity and quality. The storage place must be kept away from fire and heat sources to prevent the risk of fire and explosion. This compound may be flammable, and in case of open flame or hot topic, there is a risk of combustion and explosion.
Furthermore, it should be stored separately from oxidants, acids, alkalis, etc. Due to its chemical properties, contact with the above substances is prone to violent chemical reactions, resulting in danger. If it encounters a strong oxidant, or an oxidation reaction occurs, a lot of heat is released, which can cause an explosion.
As for transportation, the transportation vehicle must ensure that the safety facilities are complete, such as fire extinguishers, leakage emergency treatment equipment, etc. During transportation, it is necessary to prevent exposure to the sun, rain, and high temperature. During summer transportation, it is advisable to choose when it is cool in the morning and evening, and avoid the high temperature period at noon. When handling, it must be handled lightly to prevent damage to the packaging and containers. If the packaging is damaged, the compound will leak, which will not only pollute the environment, but also pose a threat to the human body and surrounding facilities.
In conclusion, 1-fluoro-4-trifluoromethoxybenzene must be stored and transported in accordance with various rules to ensure the safety of people, the environment, and the substance itself.
What is the market outlook for 1-Fluoro-4-Trifluoromethoxybenzene?
1-Fluoro-4-trifluoromethoxybenzene is a compound that has attracted much attention in the field of organic synthesis. Its market prospect is related to many factors, so let me tell you one by one.
From the perspective of application, this compound is widely used in the process of pharmaceutical creation. It can be used as a key intermediate to help develop many specific drugs. In the field of pesticides, it is also an important raw material for the synthesis of new and efficient pesticides, which can help improve crop protection, increase its yield and quality. The growth in demand for these two will surely add a strong impetus to the expansion of the 1-fluoro-4-trifluoromethoxybenzene market.
Looking at the global economic situation, the economic development of various countries, although there are ups and downs from time to time, is generally in an upward state. With economic growth, the chemical industry is also booming, and the demand for fine chemicals is increasing. 1-Fluoro-4-trifluoromethoxybenzene is not only a fine chemical, but also affected by this positive impact, the market space is expected to further expand.
Let's talk about technological innovation again. Scientific researchers continue to study, and new synthesis processes and technologies are produced frequently. More efficient and environmentally friendly preparation methods are available, which can not only reduce production costs, but also improve product quality and production capacity. In this way, products have a better advantage in market competition, which can attract more customers and further expand market share.
However, challenges cannot be ignored. Environmental regulations are becoming increasingly stringent, and chemical production must be strictly followed. The production process of 1-fluoro-4-trifluoromethoxybenzene may involve harmful substances and emissions. Enterprises need to invest more resources in environmental protection treatment, which may increase operating costs and restrict market development to a certain extent.
Even though there are challenges ahead, 1-fluoro-4-trifluoromethoxybenzene still has broad market prospects due to its key uses in medicine, pesticides and other fields, as well as the promotion of economic growth and technological innovation. With time, when enterprises properly respond to environmental challenges, they will be able to bloom brighter in the market.