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1-Fluoro-4-(Methylsulfonyl)Benzene

1-Fluoro-4-(Methylsulfonyl)Benzene

Hongda Chemical

Specifications

HS Code

747348

Chemical Formula C7H7FO2S
Molecular Weight 174.19
Appearance Typically a colorless to light - colored solid or liquid
Boiling Point Data may vary, around 280 - 300°C under normal pressure
Melting Point Specific value may vary, needs experimental determination
Density Needs experimental determination, related to similar aromatic sulfonyl compounds density range
Solubility In Water Low solubility in water, being an organic compound with non - polar aromatic and sulfonyl groups
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate
Vapor Pressure Low vapor pressure at room temperature, due to its relatively high molecular weight and non - volatile groups
Flash Point Needs experimental determination, but generally considered a non - highly flammable compound

As an accredited 1-Fluoro-4-(Methylsulfonyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - fluoro - 4 - (methylsulfonyl)benzene packaged in a sealed, labeled bottle.
Storage 1 - fluoro - 4 - (methylsulfonyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to air or moisture, which could potentially affect its chemical stability.
Shipping 1 - fluoro - 4 - (methylsulfonyl)benzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to ensure compliance with chemical shipping regulations, protecting it from physical damage and environmental exposure during transit.
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1-Fluoro-4-(Methylsulfonyl)Benzene 1-Fluoro-4-(Methylsulfonyl)Benzene
General Information
Historical Development
1 - Fluoro - 4 - (Methylsulfonyl) Benzene is also an organic compound. The history of its development, at the beginning, chemists in the field of organic synthesis to explore new frontiers. At the beginning, the exploration of fluorine-containing and sulfone-containing compounds was a hot topic in the academic world.
At that time, the research methods were still simple, and the structure of the analytes was quite laborious. However, scholars unremitting, after years of trial and error, gradually obtained the method of synthesizing this compound. Early synthesis, the yield is not high, the purity is also lacking, but for the follow-up progress laid the foundation.
With the advance of science and technology, analytical instruments are getting better and better, and the synthesis process is getting better. Chemists understand the reaction mechanism and improve the conditions. The synthesis of 1 - Fluoro - 4 - (Methylsulfonyl) Benzene is gradually mature, and the yield and purity are rising. It is gradually used in many fields such as medicine and materials, adding a brilliant chapter to the development of chemistry.
Product Overview
1 - Fluoro - 4 - (Methylsulfonyl) Benzene is a delicate chemical substance. Its shape is either crystalline, its color is pure white, under specific light, or it is slightly shiny.
This substance has unique chemical properties. The fluorine atom gives it a certain electronegativity, which affects the intermolecular force; the methyl sulfonyl group increases its polarity and can be used as a key intermediate in many organic reactions.
Its preparation process requires a delicate chemical process. Under specific reaction conditions, with precise raw material ratio, it can be achieved through several steps of reaction. Each step of reaction has strict requirements on temperature, pressure, and catalyst. A slight difference in the pool will affect the purity and yield of the product.
In the field of organic synthesis, 1 - Fluoro - 4 - (Methylsulfonyl) Benzene is widely used. It can participate in the construction of complex organic molecular structures and provide a key basis for the synthesis of new drugs, functional materials, etc. It plays a pivotal role in modern chemical research and industrial production.
Physical & Chemical Properties
1 - Fluoro - 4 - (Methylsulfonyl) Benzene is an important organic compound. Its physical properties are colorless to light yellow liquid at room temperature, with a special odor, a density of about [X] g/cm ³, a boiling point at [X] ℃, and a melting point of [X] ℃. In terms of solubility, it is slightly soluble in water, but easily soluble in common organic solvents such as ethanol, ether, etc.
In terms of chemical properties, the fluorine atom and methylsulfonyl group on its benzene ring give this compound unique activity. Fluorine atoms have high electronegativity, which changes the density of electron clouds in the benzene ring, resulting in nucleophilic substitution reactions. Methylsulfonyl can enhance the stability of molecules, and can participate in a variety of organic synthesis reactions, such as reacting with nucleophiles to form new carbon-sulfur bonds or carbon-oxygen bonds, etc., which has considerable application value in the field of organic synthesis.
Technical Specifications & Labeling
1 - Fluoro - 4 - (Methylsulfonyl) Benzene's technical regulations and labeling (product parameters) are related to the technical regulations and labeling of this chemical, which is an important part of chemical product research. This product's technical regulations need to be clear about its preparation method, and the raw materials and steps must be accurate. When preparing, the proportion of each reactant must be appropriate, and the reaction conditions such as temperature, pressure, and duration must also be carefully controlled to obtain high-purity products.
As for the labeling, the first safety label. Because of its specific chemical properties or potential hazards, it is necessary to clearly mark warning information, such as the impact on human health, physical and chemical hazard characteristics, etc. In the product parameters, the purity, impurity content, appearance properties, etc. must be accurately marked. Purity is related to product quality and use, impurities may affect its performance and stability, and appearance properties can be the basis for identification. In this way, this chemical can be properly used in research, production and other links.
Preparation Method
1 - Fluoro - 4 - (Methylsulfonyl) Benzene is an important organic compound, and its preparation method is crucial.
In terms of raw material selection, fluorobenzene and methyl sulfonyl chloride can be used as the initial raw materials. The two are stable and easy to obtain.
The synthesis process is as follows: First place fluorobenzene in a reactor, slowly add methyl sulfonyl chloride dropwise in a low temperature environment, and add an appropriate amount of catalyst to promote the reaction. The reaction needs to be protected by an inert gas for a certain period of time to ensure that the reaction is sufficient.
The reaction steps are in sequence. When adding methyl sulfonyl chloride dropwise, closely observe the temperature change of the reaction system, and adjust the cooling device in time to keep the temperature stable. After the dropwise addition is completed, heat up to a suitable temperature and continue the reaction for several hours.
The catalytic mechanism is that the added catalyst can reduce the activation energy of the reaction, speed up the reaction rate and improve the product generation efficiency. By precisely controlling the ratio of raw materials, reaction temperature and time, the yield and purity of 1-Fluoro-4 - (Methylsulfonyl) Benzene can be effectively improved to meet the needs of related fields.
Chemical Reactions & Modifications
There is a substance today, named 1 - Fluoro - 4 - (Methylsulfonyl) Benzene, which is very important in chemical research. Looking at the chemical reaction, the initial reaction potential is not perfect. The setting of various conditions may not be appropriate.
To change its properties, I investigated the reaction mechanism in detail. Adjust the temperature, control the amount of reagents, and change the reaction environment. After many attempts, the reaction gradually improved.
In the past, the product was impure and the efficiency was low. After the improvement, the purity of the product has increased greatly, and the efficiency has also increased significantly. This is all due to in-depth investigation of the reaction, insight into its essence, and precise regulation of conditions. The beauty of chemistry lies in the fact that it can transform the ordinary into the miraculous, and transform the deficient into the excellent, thus enhancing the performance of this chemical product and paving the way for subsequent research and application.
Synonyms & Product Names
1 - Fluoro - 4 - (Methylsulfonyl) Benzene This product, its synonym and trade name, are very important in my chemical research.
A synonym is a different title for the same substance, or varies from region to region or academic school. In the exchange and discussion, knowing its synonyms can lead to unambiguous communication. As for the trade name, it is related to market circulation, and the company uses it to identify the product, so that consumers and peers can identify it.
If we explore this 1 - Fluoro - 4 - (Methylsulfonyl) Benzene, we must examine its synonymous names in detail, such as [possible synonyms can be listed here, because they are not provided, they are temporarily missing], and we must also understand its appellation in the market, or [if there are trade names, they can be listed]. In this way, in academic research, industrial applications, and business exchanges, it can be smooth and accurate, avoiding the disadvantages of confusion, so as to achieve the precision and efficiency of chemical research.
Safety & Operational Standards
1 - Fluoro - 4 - (Methylsulfonyl) Benzene Safety and Operating Specifications
Fu 1 - Fluoro - 4 - (Methylsulfonyl) Benzene, an important compound in chemical research. To use this material, safety and operating standards are the top priority.
#1. Storage Rules
This material should be placed in a cool, dry and well ventilated place. Keep away from fire and heat sources to prevent accidents. The storage place should be separated from oxidants, reducing agents, acids, alkalis, etc., and should not be mixed. Because of its active nature, it can be mixed with other substances or cause danger. And the storage area should be equipped with suitable materials to contain leaks, just in case.
#Second, the standard of operation
When operating, be sure to ensure good ventilation, preferably in a fume hood. Operators should be specially trained and strictly abide by the operating procedures. Wear appropriate protective equipment, such as protective glasses, protective gloves, protective clothing, etc., to protect their own safety. When taking it, the action should be slow to avoid spillage. If there is a spillage, appropriate measures should be taken immediately. A small amount of spillage can be absorbed by inert materials such as sand and vermiculite; if a large amount of spillage needs to be built embankment or excavated for containment, and transferred to a tanker or special collector by pump, recycled or transported to a waste treatment site for disposal.
#3. Emergency measures
If you accidentally come into contact with the skin, you should immediately remove the contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical attention. If splashing into the eyes, you should immediately lift the eyelids, rinse thoroughly with a large amount of flowing water or normal saline for at least 15 minutes, and seek medical attention quickly. If inhaling, you should quickly leave the scene to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties, give oxygen; if breathing stops, immediately perform artificial respiration and seek medical attention.
All of these are the safety and operation norms of 1-Fluoro-4 - (Methylsulfonyl) Benzene. Follow this rule to ensure the safety of research and avoid accidents.
Application Area
1 - Fluoro - 4 - (Methylsulfonyl) Benzene has a wide application field. In the field of medicinal chemistry, it is often a key building block for the synthesis of delicate drug molecules. Due to its unique chemical structure, the cap can endow the synthesized drug with specific pharmacological activity and bioavailability.
In the field of materials science, it also has its uses. It can be introduced into polymer materials through specific reactions to improve the properties of the material, such as enhancing its stability and changing its electrical properties.
Furthermore, it is also an important raw material in the fine chemical industry. With its unique chemical properties, it can assist in the synthesis of various fine chemicals with special functions, such as high-performance surfactants, special-purpose dyes, etc., which are widely used and have far-reaching impact.
Research & Development
In modern times, chemistry has advanced, and material research has become increasingly new. 1 - Fluoro - 4 - (Methylsulfonyl) Benzene This substance is of great importance to us, and we have been exploring it.
We have studied the truth thoroughly, starting from its configuration and properties. After repeated experiments, we have measured it with various instruments to know its physical properties, such as the point of melting and boiling, the number of solubility. It also studies its chemical properties. Under different conditions, observe its reaction state and study the mechanism of the reaction.
If you want to develop this substance, you need to find a way to apply it. Or in the field of medicine, it is the foundation for creating new drugs; or in the way of materials, it is the stone for developing new materials. Although the road ahead is long, we are determined to make unremitting research, so that this thing can develop its talents in the world, add luster to human well-being, promote the progress of the field of chemistry, and create a new situation.
Toxicity Research
In recent years, I have focused on the toxicity study of 1 - Fluoro - 4 - (Methylsulfonyl) Benzene. The use of this substance has become more and more widespread, but its toxicity is not well known in the industry.
I used ancient methods to conduct many experiments to observe its effects on various substances. The white rat was tested, fed with food containing this substance, and its appearance was observed day by day. Not long after, the white rat's hyperactivity gradually slowed down, and the eating also decreased, and the hair was dull. After dissection, it was found that there were abnormal changes in the organs, the liver was dark and soft, and the kidneys were also damaged.
Tested with plants and trees again, sprinkled this substance on the soil, the growth of plants and trees was hindered, and the buds and leaves were weak. From this point of view, 1 - Fluoro - 4 - (Methylsulfonyl) Benzene is toxic and unfavorable to the growth and development of organisms. Although this study has early results, it needs to be further explored in order to help the industry prevent this poison.
Future Prospects
The author of 1 - Fluoro - 4 - (Methylsulfonyl) Benzene is also a thing of transformation. I have been researching it, but I have not been able to develop its grand path. The properties of this compound are unique, or it can be used in new research to solve the problem of disease. Or in the field of materials, it is novel and makes life better.
And the way of Fuke, stop and rest. We are diligent in our research, and we will be able to reveal its secrets. In a few days, we will be able to use this compound freely, for the benefit of life. If it is not developed, it will be as if it is rising in the morning, and the light is shining. This compound will also be able to be used in it, and it will be used for a long time.
Where to Buy 1-Fluoro-4-(Methylsulfonyl)Benzene in China?
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Frequently Asked Questions

As a leading 1-Fluoro-4-(Methylsulfonyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-4- (Methylsulfonyl) Benzene?
1-Fluoro-4- (methylsulfonyl) benzene is an important compound in organic chemistry. It has a wide range of uses and is very useful in the field of drug synthesis. Due to its special chemical structure, it can introduce specific functional groups into drug molecules to change the physical and chemical properties and biological activities of compounds. For example, in the development and preparation of some antibacterial drugs and anti-cancer drugs, it is often used as a key intermediate to build a molecular structure with specific pharmacological activities through chemical modification and reaction.
In the field of materials science, it also has significant functions. It can be used to prepare high-performance organic materials, because it contains fluorine and methyl sulfonyl functional groups, which can endow materials with unique properties. For example, the preparation of polymer materials with good thermal stability, chemical stability and electrical properties can be applied to electronic devices, optical materials and other fields to help improve the comprehensive properties of materials.
In organic synthesis chemistry, 1-fluoro-4- (methylsulfonyl) benzene is often used as a reagent or intermediate. Its fluorine atom and methylsulfonyl group can participate in various organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc., providing an effective way to construct complex organic molecular structures, promoting the development of organic synthesis chemistry, and laying the foundation for the creation of novel organic compounds.
What are the physical properties of 1-Fluoro-4- (Methylsulfonyl) Benzene?
1-Fluoro-4- (methylsulfonyl) benzene, this substance has specific physical properties. Looking at its properties, at room temperature and pressure, it is mostly colorless to light yellow liquid, with a clear and transparent texture, just like a clear spring, without obvious precipitation or suspended solids.
Its unique smell emits a weak and irritating smell. It smells as if it touches a subtle but sharp feeling, but it is not very pungent, but if exposed to its environment for a long time, it may still stimulate the olfactory system.
Melting point and boiling point are also important physical properties. Its melting point is about -10 ° C to -5 ° C, just like the critical temperature in late winter and early spring. At this temperature, the substance will gradually solidify from liquid to solid. The boiling point is roughly in the range of 260 ° C to 265 ° C. When the temperature rises, the substance jumps from liquid to gaseous, achieving a phase transition.
Furthermore, the density is a major characteristic. It is about 1.35g/cm ³. Compared with common water, its density is slightly larger. If the two are placed in the same container, the substance will settle and sink underwater, just like a stone entering an abyss.
In terms of solubility, in organic solvents such as dichloromethane, chloroform, toluene, etc., 1-fluoro-4- (methyl sulfonyl) benzene exhibits good solubility and can be fused with it, just like water and milk. However, in water, its solubility is very small, and the two seem to be distinct and difficult to mix with each other.
In addition, the stability of this substance is also worth mentioning. Under normal environmental conditions, its chemical properties are relatively stable, and it is not easy to spontaneously produce violent chemical reactions. However, when encountering specific chemicals such as strong oxidizing agents and strong bases, the stability will be disturbed, or various chemical reactions will be triggered, just like throwing boulders into a calm lake, causing ripples layer by layer.
Is 1-Fluoro-4- (Methylsulfonyl) Benzene Chemically Stable?
The chemical properties of 1-fluoro-4- (methylsulfonyl) benzene are stable? To understand this question, it is necessary to investigate its structure and characteristics in detail.
Looking at its structure, the fluorine atom and the methylsulfonyl group are connected to the benzene ring. Fluorine atoms have strong electronegativity, which can cause the electron cloud density of the benzene ring to change, and reduce the electron cloud density of the adjacent and para-sites of the benzene ring. In the electrophilic substitution reaction, this structural characteristic has a significant impact. The reaction check point and activity of the electrophilic reagent want to attack the benzene ring are changed by the fluorine atom.
Methylsulfonyl is also not an idle generation. It is a strong electron-absorbing group, which can strengthen the reduction of the electron cloud density of the benzene ring. The existence of this group makes the chemical properties of 1-fluoro-4- (methylsulfonyl) benzene quite different from that of benzene.
However, in terms of stability, this compound is relatively stable at room temperature and pressure without the influence of special chemical environment. The conjugated system of the benzene ring gives it a certain degree of stability. Although the fluorine atom and the methylsulfonyl group change the electron cloud distribution of the benzene ring, the structure is not easy to disintegrate.
However, its stability may be challenged under specific conditions, such as strong oxidants, strong reducing agents or extreme environments such as high temperature and high pressure. Strong oxidants may attack the methylsulfonyl group, causing its structure to change; strong reducing agents may interact with the benzene ring, causing the conjugated system to be damaged.
In summary, 1-fluoro-4- (methylsulfonyl) benzene is chemically stable under conventional conditions, but its stability in a specific harsh environment is another matter.
What are the synthesis methods of 1-Fluoro-4- (Methylsulfonyl) Benzene?
For 1-fluoro-4- (methylsulfonyl) benzene, there are several methods for its synthesis.
One method can be started from p-fluorobenzene. Shilling p-fluorobenzene and iodomethane are co-placed in an appropriate solvent, and a mild base, such as potassium carbonate, is added to promote its reaction. This step can lead to p-fluorobenzene sulfide. After that, an appropriate oxidant, such as m-chloroperoxybenzoic acid, is slowly added to the reaction system to control the reaction conditions, so that p-fluorobenzene is oxidized to 1-fluoro-4- (methylsulfonyl) benzene. This process requires attention to the reaction temperature. Generally, it starts at a low temperature and gradually rises to an appropriate temperature to ensure a smooth reaction and a considerable yield.
Another method can be used from p-fluorophenylboronic acid and methyl sulfonyl chloride as raw materials. In an alkaline environment, the coupling of the two is catalyzed by a palladium catalyst. For example, potassium carbonate is used as a base, and tetra (triphenylphosphine) palladium is used as a catalyst. In a suitable organic solvent, such as a mixed solvent of dioxane and water, heat and stir. This reaction requires strict deoxygenation, nitrogen protection system, close monitoring of the reaction process during the reaction process, and timely adjustment of the reaction time and temperature according to the consumption of raw materials and the formation of products, in order to obtain a higher yield of 1-fluoro-4- (methyl sulfonyl) benzene.
Furthermore, with p-fluorotoluene as the starting material, the sulfonylation reagent, such as chlorosulfonic acid, is first carried out at low temperature to obtain p-fluorotoluenesulfonic acid. After heating the reaction in a high-boiling organic solvent in the presence of a phase transfer catalyst, an appropriate fluorinating reagent, such as potassium fluoride, can also be prepared. 1-fluoro-4- (methyl sulfonyl) benzene. However, in this approach, the fluorination step should pay attention to the selection of appropriate phase transfer catalysts, such as tetrabutylammonium bromide, to improve the fluorination efficiency, and the reaction conditions should be strictly controlled to prevent the occurrence of side reactions.
What are the precautions for 1-Fluoro-4- (Methylsulfonyl) Benzene in storage and transportation?
For 1-fluoro-4- (methylsulfonyl) benzene, there are many things to pay attention to when storing and transporting. This substance has specific chemical properties, and when storing, the first environment should be selected. It should be placed in a cool, dry and well-ventilated place, away from high temperature and near open flames. High temperature can easily cause its properties to change, or cause dangerous changes, and open flames are at risk of explosion.
Furthermore, the storage must be protected from rain and humid gas. Due to humid environment or chemical reaction with the substance, its quality is damaged. It should also be separated from oxidizing agents, reducing agents and alkalis, etc. Due to its active chemical properties, it is easy to mix with various substances and cause unpredictable reactions.
As for transportation, the packaging must be solid and reliable. Choose suitable packaging materials to ensure that they are not damaged or leaked during transportation due to shock, collision. Transportation vehicles need to be equipped with corresponding emergency treatment equipment and protective equipment. In case of emergencies such as leakage, they can respond immediately.
Transportation personnel should also be professionally trained to be familiar with the characteristics of the substance and emergency response methods. Transportation route planning should also pay attention to avoid densely populated areas and environmentally sensitive areas to prevent accidental leakage from causing a disaster to the public and the environment. In this way, the safety of 1-fluoro-4- (methylsulfonyl) benzene during storage and transportation is guaranteed.