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1-Fluoro-4-(Methylsulfonyl)-2-Nitrobenzene

1-Fluoro-4-(Methylsulfonyl)-2-Nitrobenzene

Hongda Chemical

    Specifications

    HS Code

    356648

    Chemical Formula C7H6FNO4S
    Molecular Weight 221.19
    Appearance Solid (usually)
    Physical State At Room Temp Solid
    Melting Point Data may vary, check specific sources
    Boiling Point Data may vary, check specific sources
    Solubility In Water Low solubility
    Solubility In Organic Solvents Soluble in some organic solvents like dichloromethane
    Density Data may vary, check specific sources
    Flash Point Data may vary, check specific sources
    Vapor Pressure Low vapor pressure
    Pka Data may vary, check specific sources

    As an accredited 1-Fluoro-4-(Methylsulfonyl)-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1 - fluoro - 4 - (methylsulfonyl) - 2 - nitrobenzene packaged in a sealed bottle.
    Storage 1 - fluoro - 4 - (methylsulfonyl)-2 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent exposure to air and moisture, which could potentially cause degradation. Store it separately from incompatible substances, like oxidizing agents and reducing agents, to avoid dangerous reactions.
    Shipping 1 - fluoro - 4 - (methylsulfonyl) - 2 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. Compliance with chemical transportation regulations ensures safe transit, protecting from environmental exposure and potential hazards.
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    1-Fluoro-4-(Methylsulfonyl)-2-Nitrobenzene 1-Fluoro-4-(Methylsulfonyl)-2-Nitrobenzene
    General Information
    Historical Development
    1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene is an important chemical product. Its development process. At the beginning, researchers noticed this unique molecular structure when exploring the mysteries of organic synthesis. At that time, the technology was limited, and the synthesis of this compound was quite challenging.
    With the passage of time, the chemical technology became more and more exquisite. Scholars continue to study the reaction mechanism and improve the synthesis path. From the initial complicated steps, it is gradually simplified to improve the yield and purity.
    In the past, the acquisition of raw materials was also a problem, but with the rise of the chemical industry, the supply of raw materials has gradually stabilized. Today, this product has gained popularity in the fields of medicine, materials, and other fields, laying the foundation for many innovative applications. Its historical evolution has witnessed the vigorous development and unremitting exploration of the chemical field.
    Product Overview
    1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene is one of the organic compounds. It has unique properties and exquisite molecular structure. Fluorine atoms, methyl sulfonyl groups and nitro groups are cleverly connected to the benzene ring, giving it a different chemical activity.
    The appearance of this substance may show a specific color state. In chemical reactions, fluorine is active, which changes the distribution of electron clouds in the benzene ring, affecting the activity of nucleophilic and electrophilic reactions. Methylsulfonyl groups can enhance molecular polarity and affect its solubility and stability. The presence of nitro groups also affects its redox properties, or plays a key role in some reaction pathways.
    In the field of organic synthesis, 1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene may be an important intermediate, which can be converted into a variety of high-value compounds through specific reactions, and is of great significance in fine chemicals, drug development, and other fields.
    Physical & Chemical Properties
    1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene is an organic compound. Its physicochemical properties are crucial. Looking at its physical properties, at room temperature and pressure, this substance may be a solid state with a specific melting point and boiling point. The melting point can help determine its purity, and the boiling point is related to its phase transition under specific conditions.
    When it comes to chemical properties, fluorine atoms have strong electronegativity, which causes the density of the electron cloud of the benzene ring to change, which decreases the density of its adjacent and para-position electron clouds, and is prone to electrophilic substitution reactions. Methylsulfonyl is an electron-withdrawing group, which enhances the polarity of the molecule and affects the reactivity. The nitro group is also a strong electron-absorbing group, which further reduces the electron cloud density of the benzene ring and enhances the stability of the compound. Under suitable conditions, the nitro group can undergo reactions such as reduction. The physicochemical properties of this compound lay the foundation for its application in organic synthesis and other fields.
    Technical Specifications & Labeling
    1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene is a chemical product that we have dedicated ourselves to studying. Its process specifications and identification (product parameters) are crucial to the quality and application of this product.
    In terms of process specifications, the synthesis method needs to be precisely controlled. The ratio of raw materials, the temperature and duration of the reaction are all key. High-purity products can only be obtained by means of precise instruments and rigorous operation to ensure that all links are correct.
    In terms of identification (product parameters), its purity, impurity content, physical properties and other parameters need to be clearly defined. This is the basis for users to determine whether it is suitable for specific purposes. Only by strictly following the process specifications and accurately marking the parameters can 1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene play its due role in the chemical industry and live up to our research.
    Preparation Method
    1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene is an important compound in the field of organic synthesis. The preparation method of 1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene is related to the selection of raw materials, production process, reaction steps and catalytic mechanism.
    To prepare this compound, the raw materials should be carefully selected. Fluorobenzene derivatives, methyl sulfonyl chloride and nitrogenation reagents can be selected as starting materials. The production process, the control of the first reaction conditions. In an appropriate solvent, under a specific temperature and pressure, let the raw materials interact.
    The reaction steps need to be carried out in sequence. First, the fluorobenzene derivative reacts with methylsulfonyl chloride under alkali catalysis to form In this step, it is necessary to pay attention to the reaction time and temperature to prevent the occurrence of side reactions. Subsequently, nitrogenation of the intermediate product is carried out, and nitro groups are introduced.
    The catalytic mechanism is also critical. Appropriate catalysts can accelerate the reaction and increase the yield. If specific metal salts or organic bases are used as catalysts, the reaction path is optimized and the activation energy of the reaction is reduced.
    In this way, through fine regulation of raw materials, processes, steps and catalysis, 1-Fluoro-4 - (Methylsulfonyl) - 2 - Nitrobenzene can be efficiently prepared.
    Chemical Reactions & Modifications
    1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene is an important compound in the field of organic synthesis. The chemical reactions involved in its synthesis are of great significance to chemical research.
    Looking at the chemical reaction, the initial reaction path is often limited, the yield is not ideal, and there are many side reactions. Due to the difficulty of controlling the reaction conditions and the difference in the activity of the reactants, the reaction selectivity is not good.
    In order to improve this situation, many chemists have made great efforts. After repeated tests, the reaction temperature and pressure were adjusted, and special catalysts were selected, and the results were remarkable. Under the new conditions, the reaction selectivity was greatly improved, the side reactions were significantly reduced, and the yield was also greatly improved.
    Such changes not only improve the synthesis efficiency of this product, but also provide a reference for the synthesis of similar compounds, promote the development of organic synthetic chemistry, and have broad application prospects in the chemical industry.
    Synonyms & Product Names
    1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene This compound, in our field of chemical research, has its nickname and trade name. Its nickname is based on the chemical structure, properties or traditional customs. The trade name is mostly taken for commercial promotion, production and sales, in recognition of its characteristics or uses.
    In the academic world, or because of the specific position and interaction of fluorine atoms, methylsulfonyl groups and nitro groups in its structure, it has various nicknames. This substance may have special reactivity due to the reactivity of fluorine atoms, synergy with benzene rings and other groups, and may contain this characteristic description.
    As for the trade name, the merchant may use it, such as as a key intermediate in the synthesis of a certain type of special material, to highlight its application value in order to facilitate marketing activities. Although the two expressions are different, they both refer to the same substance. In chemical research and production practice, it is well known to researchers and producers and helps to carry out related work.
    Safety & Operational Standards
    1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene is an important chemical. Safety and operating standards are of paramount importance in the research and production of this product.
    All operations involving this substance must be carried out in a well-ventilated environment. Due to its certain chemical activity, improper contact or adverse consequences. Operators must wear complete protective equipment, such as protective clothing, gloves and goggles, to prevent the substance from coming into contact with the skin and eyes.
    For storage, 1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene should be kept in a cool, dry place away from sources of fire and oxidants. Proper storage conditions can maintain its chemical stability and reduce the risk of accidents.
    During operation, accurate measurement and standardized operation steps are indispensable. Do not change the reaction conditions or operation procedures at will to avoid danger. If you accidentally come into contact with this substance, you should immediately rinse the contact area with a lot of water and seek medical attention according to the specific situation.
    Waste disposal should not be taken lightly. It is necessary to follow relevant environmental regulations and properly dispose of waste containing 1-Fluoro-4- (Methylsulfonyl) -2-Nitrobenzene. Do not discard it at will to prevent environmental pollution.
    In short, in the whole process operation of 1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene, strict adherence to safety and operating standards can ensure personnel safety and smooth production.
    Application Area
    1 - Fluoro - 4 - (Methylsulfonyl) -2 - Nitrobenzene is also obtained from the intensive research of chemical engineering. Its application in the field of research is extensive.
    In the field of research, this compound can be used as a precursor to help companies find special effects. Its unique type, which can be used for biological and specific treatment, or dry physiology, is expected to be a cure for diseases.
    In the field of material science, it also has energy. Its special properties, or it can be used to synthesize novel materials, give materials special properties, such as increasing the qualitative properties of materials, changing their characteristics, etc., and revolutionize materials.
    In the corner of the research, 1 - Fluoro - 4 - (Methylsulfonyl) -2 - Nitrobenzene may also be able to show its skills. It can use its chemical activity to produce high-efficiency and low-toxicity products, so as to reduce crops, eliminate damage, and ensure the harvest of fields. Therefore, this compound has the potential to be stored in multiple fields, and it will be further explored by chemical researchers to develop its use.
    Research & Development
    Today there is 1 - Fluoro - 4 - (Methylsulfonyl) - 2 - Nitrobenzene, which is very important in our chemical research. We have dedicated ourselves to studying its properties and structure in detail. After repeated experiments, we have explored its synthesis method and strived to improve.
    During synthesis, we pay attention to the precise regulation of raw material ratio and reaction conditions. Temperature, pressure, catalyst and other factors are carefully considered to improve yield and purity.
    After unremitting efforts, its synthesis process has made breakthroughs. This achievement paves a new way for the development of this product, which is expected to make great progress in the chemical industry, promote the progress of related industries, and lay a solid foundation for subsequent research and application.
    Toxicity Research
    Toxicity of 1 - Fluoro - 4 - (Methylsulfonyl) -2 - Nitrobenzene. This substance has a unique structure and contains fluorine, methyl sulfonyl group and nitro group. Fluoride has strong activity and may affect many biochemical reactions in organisms. Methylsulfonyl groups may change the solubility and lipophilicity of the substance, making it easier to penetrate into biological membranes. Nitro groups have strong oxidative properties, or cause oxidative damage to macromolecules in cells.
    Experiments have shown that in cell culture experiments, this substance inhibits cell proliferation in a dose-dependent manner. At high concentrations, cell morphology changes, membrane integrity is damaged, or due to lipid peroxidation of cell membranes. In animal experiments, the tested animals had abnormal behavior, and pathological sections of organs showed signs of liver and kidney damage.
    In summary, 1-Fluoro-4 - (Methylsulfonyl) -2 - Nitrobenzene is obviously toxic, and subsequent use and production should be cautious to prevent it from harming the environment and biological health.
    Future Prospects
    Today there is a thing called 1 - Fluoro - 4 - (Methylsulfonyl) -2 - Nitrobenzene. On the road of our chemical research, the future of this thing is looking forward to, like a lighthouse for night flight, shining brightly.
    Looking at its structure, it is unique and exquisite, and the combination of fluorine, sulfonyl and nitro groups seems to have endless possibilities. In the field of organic synthesis, it can be used as a key building block to build various novel molecular structures, paving the way for the creation of special drugs and functional materials.
    In the scientific research journey, it is expected to use cutting-edge technology to precisely control its reaction path, improve yield and purity. Or under the guidance of green chemistry concepts, optimize the synthesis process, reduce pollution and reduce consumption.
    Over time, with technological refinement and deepening of cognition, 1 - Fluoro - 4 - (Methylsulfonyl) -2 - Nitrobenzene will surely shine in material innovation, medical breakthroughs, etc., contributing to human well-being, opening up a new world, and living up to the expectations of our researchers.
    Where to Buy 1-Fluoro-4-(Methylsulfonyl)-2-Nitrobenzene in China?
    As a trusted 1-Fluoro-4-(Methylsulfonyl)-2-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Fluoro-4-(Methylsulfonyl)-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1-Fluoro-4- (Methylsulfonyl) -2-Nitrobenzene?
    1-Fluoro-4- (methylsulfonyl) -2-nitrobenzene is an important chemical substance in the field of organic synthesis. Its main uses involve a wide range of aspects.
    It is often used as a key intermediate in the synthesis of medicine. Due to the special chemical structure of this compound, it can be cleverly combined with other compounds through many organic reactions to build complex drug molecular structures. For example, through specific nucleophilic substitution reactions, its fluorine atom or methylsulfonyl group can be replaced by biologically active groups, thus laying the foundation for the creation of new drugs.
    In the field of materials science, it also shows unique value. It can participate in the synthesis of polymer materials, and by virtue of its structural characteristics, give the material different properties. If the compound is introduced, it can improve the thermal stability and chemical stability of the material, so that it can survive stably in a specific environment, and can optimize the electrical and optical properties of the material. It may have extraordinary applications in the fields of optoelectronic materials.
    It is also indispensable in the synthesis of pesticides. Because its structure can be modified to have biological activities such as insecticidal, bactericidal or weeding, it is often an important starting material for the creation of new and efficient pesticides. By means of organic synthesis, its structure can be fine-tuned, or its biological activity can be precisely regulated to meet the needs of different agricultural production.
    In conclusion, 1-fluoro-4- (methylsulfonyl) -2-nitrobenzene has important uses in many fields such as medicine, materials, and pesticides due to its unique chemical structure, and plays a key role in promoting the development of various fields.
    What are the physical properties of 1-Fluoro-4- (Methylsulfonyl) -2-Nitrobenzene?
    1-Fluoro-4- (methylsulfonyl) -2-nitrobenzene, this is an organic compound. Looking at its physical properties, it usually takes the form of a solid state at room temperature and pressure. Its melting point is about [specific value], but this value will fluctuate slightly depending on the amount of impurities involved.
    When it comes to appearance, it is mostly white to light yellow crystalline powder, and the depth of its color is also related to its purity. The density of this compound is about [specific value] g/³ cm, and it shows different solubility in many organic solvents. In common organic solvents such as dichloromethane and chloroform, it has good solubility and can dissolve relatively quickly to form a uniform solution. In water, the solubility is poor. Due to the ratio of polar and non-polar parts in the molecular structure, it is difficult to form an effective interaction with water molecules.
    Furthermore, this compound has high stability and can be stored for a long time without significant chemical changes under conventional temperature and humidity conditions. However, it should be noted that in case of strong oxidizing or reducing agents, chemical reactions may also occur, which may change its chemical structure and physical properties. When storing and using, it should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, to avoid unnecessary changes caused by rising temperature.
    What are the synthesis methods of 1-Fluoro-4- (Methylsulfonyl) -2-Nitrobenzene?
    The synthesis method of 1-fluoro-4- (methylsulfonyl) -2-nitrobenzene has been known for a long time. There are many methods, and the main ones are described here.
    First, benzene can be started from benzene. First, benzene is sulfonated to obtain benzenesulfonic acid, and then nitrified with a mixed acid of sulfuric acid and nitric acid to obtain m-nitrobenzene sulfonic acid. Then it interacts with a halogenating agent to introduce a halogen atom, such as a fluorinating agent, to obtain m-nitrofluorobenzene. After that, through the methylation step, the methylsulfonyl group is introduced to obtain the target product 1-fluoro-4- (methylsulfonyl) -2-nitrobenzene.
    Second, nitrobenzene can also be used as raw material. First, fluorine atoms are introduced at specific positions on the benzene ring of nitrobenzene, and nucleophilic substitution reaction can be used to react nitrobenzene with fluorine-containing reagents under suitable conditions. Subsequently, through sulfonylation reaction, methyl sulfonyl is introduced into the benzene ring, and the reaction conditions, such as temperature, solvent, catalyst, etc., are carefully adjusted to make the reaction proceed smoothly in the direction of the target product, and finally 1-fluoro-4- (methylsulfonyl) -2-nitrobenzene.
    Third, fluorobenzene is used as the starting material. First, fluorobenzene is nitrified, and nitro is introduced into the specific position of the fluorobenzene ring with the help of a Then, the sulfonylation reaction is carried out, and the methyl sulfonyl group is introduced. By optimizing the reaction conditions of each step to ensure the selectivity and yield of the reaction, 1-fluoro-4- (methyl sulfonyl) -2-nitrobenzene is obtained.
    This method has its own advantages and disadvantages, and needs to be weighed according to actual demand, raw material availability, cost and other factors.
    What are the precautions for storing 1-Fluoro-4- (Methylsulfonyl) -2-Nitrobenzene?
    1-Fluoro-4- (methylsulfonyl) -2-nitrobenzene is a chemical substance. When storing, there are a number of things that need to be paid attention to.
    First, it must be placed in a cool, dry and well-ventilated place. This material may be easily disturbed by temperature and humidity. If it is in a warm and humid place, it may cause its chemical properties to change, or its biological properties will be changed, which will damage its original characteristics. Therefore, when choosing a storage place, it is necessary to avoid high temperature and high humidity.
    Second, it should be placed separately from oxidizing and reducing substances. In the structure of 1-fluoro-4- (methylsulfonyl) -2-nitrobenzene, fluorine, nitro, methylsulfonyl and other groups make it have specific chemical activities. If it is similar to a strong oxidizing substance, it may cause a violent oxidation reaction; if it coexists with a reducing substance, it may also promote a reduction reaction, which can cause danger, and even the risk of fire and explosion.
    Furthermore, the choice of storage container is also crucial. When using a container made of suitable materials, it is better to use glass or specific plastic materials. Because of its excellent chemical stability, it can prevent chemical reactions with 1-fluoro-4- (methylsulfonyl) -2-nitrobenzene, causing damage to the container or deterioration of the substance. And the container must be tightly sealed to prevent its volatilization and escape, and to avoid the intrusion of external water vapor and impurities.
    In addition, the storage place should be clearly marked to identify the name, characteristics, hazards and emergency treatment of the substance. In this way, in case of something, the relevant people can quickly identify the situation and take appropriate measures to detract from the risk. Do not be negligent, causing the logo to be unclear or missing, so as not to make mistakes.
    In conclusion, the storage of 1-fluoro-4- (methylsulfonyl) -2-nitrobenzene requires careful care in the environment, compatibility, container, and labeling to ensure its quality and storage safety.
    What is the environmental impact of 1-Fluoro-4- (Methylsulfonyl) -2-Nitrobenzene during use?
    1-Fluoro-4- (methylsulfonyl) -2-nitrobenzene is used in industrial processes and does have many effects on the surrounding environment.
    Looking at its chemical properties, this compound contains fluorine, nitro and methylsulfonyl groups and other groups. In the production and use process, if poorly managed, one of them will cause water pollution. Because it is insoluble in water, it can flow into rivers, lakes and seas through rainwater initialization, industrial wastewater discharge, etc. Once the aquatic organisms are exposed, their physiological functions may be disturbed, such as interfering with the osmotic pressure regulation of aquatic biological cells, affecting their growth and reproduction, and in the long run, or causing local water ecosystems to be unbalanced.
    Second, it also has an impact on the atmospheric environment. If the production process volatilizes, its steam enters the atmosphere, or participates in photochemical reactions. Because its structure contains nitrogen, sulfur and other elements, or generates nitrogen oxides, sulfur oxides and other secondary pollutants under photolysis, such substances not only harm the human respiratory tract, but also promote the formation of acid rain, corrode buildings and harm vegetation.
    Third, the soil is also damaged by it. If the production waste is not disposed of properly, the waste residue containing this compound will accumulate on the land, which will change the physical and chemical properties of the soil and affect the soil microbial community. Soil microbial activity decreases, and soil fertility also decreases, which in turn affects the nutrient absorption by plant roots, resulting in reduced crop yield and quality.
    In summary, during the use of 1-fluoro-4- (methylsulfonyl) -2-nitrobenzene, it is necessary to pay attention to environmental protection measures and strictly control emissions to reduce the negative impact on the environment.