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1-Fluoro-4-Methylbenzene

1-Fluoro-4-Methylbenzene

Hongda Chemical

Specifications

HS Code

634881

Chemical Formula C7H7F
Molecular Weight 110.13
Appearance Colorless liquid
Odor Aromatic odor
Boiling Point 117 - 119 °C
Melting Point -43 °C
Density 1.009 g/mL at 25 °C
Solubility In Water Insoluble
Flash Point 15 °C
Vapor Pressure 2.67 kPa at 25 °C
Refractive Index 1.472 - 1.474

As an accredited 1-Fluoro-4-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - fluoro - 4 - methylbenzene in 500 - mL glass bottle, tightly sealed.
Storage 1 - fluoro - 4 - methylbenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents and incompatible substances. Ensure proper labeling for easy identification and to prevent mis - handling.
Shipping 1 - fluoro - 4 - methylbenzene is shipped in tightly - sealed, corrosion - resistant containers. It's transported in accordance with hazardous chemical regulations, ensuring proper handling to prevent leakage and maintain safety during transit.
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1-Fluoro-4-Methylbenzene 1-Fluoro-4-Methylbenzene
General Information
Historical Development
1 - Fluoro - 4 - Methylbenzene, the development of this thing is traced back to the past, and its initial discovery originated from the study of various sages. At that time, the chemical technology was not as sophisticated as it is today, but the ancestors made unremitting efforts.
At the beginning, only a glimpse of its clues, groping in limited cognition. After years, the ingenuity and practice of the craftsmen were superimposed. With the gradual enrichment of chemical theory and the evolution of experimental methods, the insight into its properties deepened.
The method of preparation has also changed from crude to exquisite. In the past, the steps were cumbersome and ineffective, but now they are efficient and pure. The field of application has also expanded from narrow to broad. From its inception, it has been indispensable in many fields such as chemical engineering and materials. Its historical development is a microcosm of chemical progress.
Product Overview
1 - Fluoro - 4 - Methylbenzene is an organic compound. Its color is clear and transparent, its shape is like a liquid, and it has a special odor. In its molecular structure, fluorine atoms and methyl groups are respectively connected to the benzene ring, resulting in its unique properties.
This substance is widely used in the field of organic synthesis. It is often a key raw material for the preparation of complex organic compounds. With its special structure, it can be derived from a variety of chemical reactions with specific functions. For example, in pharmaceutical chemistry, this is used as a starting material, and through delicate reaction design, it may be possible to obtain pharmaceutical ingredients with unique pharmacological activities.
However, it also has certain dangers. Flammable, under certain conditions, in case of open flame, hot topic, or risk of combustion. And it may be harmful to the human body, if it accidentally touches the skin, or irritates; if it inhales its volatile gas, or damages the respiratory tract. Therefore, when researching and using, safety procedures should be strictly followed to prevent accidents.
Physical & Chemical Properties
1 - Fluoro - 4 - Methylbenzene is also an organic compound. It has special physical and chemical properties. Looking at its physical properties, at room temperature, it is liquid, colorless and aromatic, lighter in density than water, and can float on water. Its boiling point is moderate, making it easy to separate and purify. As for chemical properties, the structure of the benzene ring gives it certain stability, but the substitution of fluorine and methyl gives it unique reactivity. The high electronegativity of fluorine atoms can affect the distribution of the electron cloud of the molecule, causing the reaction activity of the neighbor to be different. Methyl can also affect the electron cloud of the benzene ring through the superconjugation effect. In the field of organic synthesis, this compound can be used as a key intermediate, participating in various reactions to prepare a variety of organic products, and is widely used in the chemical industry.
Technical Specifications & Labeling
1 - Fluoro - 4 - Methylbenzene is an organic compound with a wide range of uses in the chemical industry. Its preparation process requires specific raw materials and follows precise processes and conditions.
First, take a suitable aromatic hydrocarbon raw material, add a fluorine-containing reagent, and under the action of a catalyst, under a specific temperature and pressure environment, through a substitution reaction, the fluorine atom and methyl group precisely replace the corresponding position of the aromatic hydrocarbon to obtain a crude product. After that, high purity 1 - Fluoro - 4 - Methylbenzene can be obtained by distillation, extraction, recrystallization and other purification methods.
The label of the product should be detailed with the name, chemical formula C H F, molecular weight 98.13, clear physical and chemical properties, such as appearance as colorless liquid, special odor, boiling point, melting point, density and other data. Storage conditions should also be marked, suitable for a cool and ventilated warehouse, away from fire and heat sources. And safety precautions should be clearly stated, because it has certain toxicity and flammability, protection is required during operation, fire and explosion protection.
Preparation Method
To prepare 1 - Fluoro - 4 - Methylbenzene, the method is as follows:
Raw material and production process: Take p-toluidine as the initial raw material, undergo diazotization reaction, and then react with fluoroborate acid to obtain p-toluene diazofluoroborate. This salt has acceptable stability and is convenient for subsequent processing.
Reaction steps: First dissolve p-toluidine in an appropriate amount of inorganic acid, and add sodium nitrite solution dropwise at low temperature to complete the diazotization. Then add fluoroborate acid to form a precipitation, filter and separate. Finally, the resulting p-toluene diazofluoroborate is heated and decomposed to obtain 1 - Fluoro - 4 - Methylbenzene. Catalytic mechanism: In the diazotization step, nitrous acid reacts with p-toluidine to form a diazonium salt, which is the key intermediate. When heating p-toluene diazonium fluoroborate, fluorine ions replace the diazonium group to form the target product. The whole process conditions are mild and the operation is relatively simple, and the pure 1-Fluoro-4-Methylbenzene can be obtained.
Chemical Reactions & Modifications
1 - Fluoro - 4 - Methylbenzene is an organic compound, and there are many studies related to its chemical reaction and modification.
Looking at the reaction, in the electrophilic substitution reaction, because methyl is an ortho-para localization group, fluorine atoms also have a certain localization effect, and the two cooperate to make the reaction check point have a specific selectivity. If brominated with bromine, bromine atoms will mostly introduce ortho or para-sites of methyl. This is due to the influence of methyl and fluorine atoms on the electron cloud density distribution of the benzene ring. The electron cloud density of the benzene ring can be increased by the superconjugation effect of methyl group, especially in the ortho-para position; although the fluorine atom has strong electronegativity and obvious electron-withdrawing induction effect, its lone pair electrons can form p-π conjugate with the benzene ring, and the electron cloud density of the ortho-para position also increases to a certain extent, so the reaction check point is inclined to this.
Regarding modification, other functional groups can be introduced into its benzene ring to expand its application. For example, the introduction of carboxyl groups can make it acidic and serve as a key intermediate in some organic synthesis. This can be achieved by a specific chemical reaction, such as by first oxidizing 1-Fluoro-4-Methylbenzene side chain methyl, and through appropriate steps, a carboxyl-containing derivative can be obtained, thus endowing the compound with new chemical properties and application possibilities.
Synonyms & Product Names
1 - Fluoro - 4 - Methylbenzene is also a chemical product. It has the same trade name, and there is no way to investigate it. In the field of chemical production, it may have a name.
In the past, the name of chemical production, the depth of research, and one. However, in the early days, due to the difference between the research regions and the people who studied it, the same thing was not named. 1 - Fluoro - 4 - Methylbenzene is no exception, or it is called by the name, or according to its characteristics and characteristics, or according to the name of the product, etc.
As for the name of the product, the merchants sold it, and often took the name of easy and special. This name may contain a business connotation, or it is intended to show its characteristics, so that it can be used for other things. Therefore, the same trade names as 1 - Fluoro - 4 - Methylbenzene are all part of the research and business activities that cannot be ignored, waiting for me to investigate.
Safety & Operational Standards
1 - Fluoro - 4 - Methylbenzene, this substance is an organic compound. It is related to its safety and operation specifications. It needs to be explained in detail to ensure that everything goes smoothly and is harmless.
At the safe end, 1 - Fluoro - 4 - Methylbenzene has certain flammability and is easy to burn in case of open flames and hot topics. Therefore, when storing, it must be kept away from fire and heat sources and placed in a cool and ventilated warehouse. The warehouse temperature should not exceed 37 ° C, and the container should be kept sealed. And it should be stored separately from oxidizing agents, acids and alkalis, and should not be mixed. Be careful during handling to prevent damage to packaging and containers, so as not to cause leakage and cause danger.
Furthermore, its vapor or mist is irritating to the eyes, mucous membranes and upper respiratory tract, and irritating to the skin. During operation, the operator must wear a self-priming filter gas mask (half mask), wear chemical safety protective glasses, wear anti-poison penetration overalls, and wear rubber oil-resistant gloves to protect their own safety. If you accidentally come into contact with the skin, you should immediately take off the contaminated clothes and rinse the skin thoroughly with soapy water and water; if you come into contact with the eyes, you need to lift the eyelids, rinse with flowing water or normal saline, and seek medical attention in time.
Talking about the operating specifications, the operating environment should have good ventilation conditions. During use, the process parameters should be strictly controlled to avoid danger caused by runaway temperature, pressure and other conditions. For the amount used, it should be taken as needed to avoid waste. After use, the remaining materials should not be discarded at will, and should be properly disposed of according to regulations. And the operating equipment should be regularly checked and maintained to ensure its normal operation and prevent accidents such as leakage due to equipment failure. Only by strictly observing safety and operating standards can we ensure the safety of personnel, protect the tranquility of the environment, and promote the orderly progress of experiments and production in the research and application of 1-Fluoro-4-Methylbenzene.
Application Area
1 - Fluoro - 4 - Methylbenzene is also an organic compound. Its application field is quite wide. In the chemical industry, it is often used as a raw material for the synthesis of other fine chemicals. Due to the special structure of fluorine and methyl, it is endowed with unique chemical properties, and materials with special properties can be prepared through specific reaction paths.
In the field of materials science, based on this, it may be able to synthesize new polymer materials to improve the stability and corrosion resistance of materials. In the field of pharmaceutical research and development, it also has its uses. Its structural characteristics may help drug molecules to precisely combine with targets, providing the possibility to create new drugs with high efficiency and low toxicity.
The unique structure of this compound makes it potentially valuable in many fields, and researchers need to explore it in depth to expand its application boundaries and benefit the world.
Research & Development
The rise of modern chemistry is due to the deepening of material exploration. 1 - Fluoro - 4 - Methylbenzene is a substance that chemists have paid much attention to.
At the beginning of the investigation, various sages wanted to clarify its structure. After repeated experiments, they used spectroscopy and diffraction to analyze its atomic arrangement in detail, so as to obtain a precise structure.
The study of its properties is related to the reactivity. In the context of electrophilic substitution, due to the effect of fluorine and methyl, the reaction check points are different. Fluorine has strong electronegativity, and the distribution of electron clouds in the benzene ring is changed. In the experiment, it was observed that it reacted with halogenating reagents, nitrifying reagents, etc., and the rate and product ratio were all regular.
As for development, this compound has made its mark in the field of material synthesis. Based on it, polymer materials with special properties can be made, which can be used in electronic and optical devices. The craftsmen constantly optimize the synthesis path, hoping to increase the yield, reduce the cost, and hope that it can be widely used in the world, benefiting everyone, making the wonders of chemistry used for people's livelihood, and promoting the progress of science and technology. This is the ambition of our generation of chemists.
Toxicity Research
In recent years, I have been studying the toxicity of "1-Fluoro-4-Methylbenzene" and I have made great efforts to study it. This substance has appeared frequently in various chemical processes, but its toxic effects are still poorly known to the world.
The first research, consulting the classics, is rarely described in detail. So I set up various experiments to explore its properties. Take all kinds of creatures, such as insects and rats, and feed them with different doses of "1-Fluoro-4-Methylbenzene" to observe their path and physiological changes.
Over time and months, the fruit has been gained. At low doses, the subjects occasionally showed fatigue; with increasing doses, they saw a sharp decrease in diet, sluggish movement, and even hair loss. From an anatomical perspective, the organs also showed abnormalities, or discoloration, or qualitative abnormalities.
From this, it can be seen that the toxicity of "1-Fluoro-4-Methylbenzene" should not be underestimated. In the future, it should be widely publicized, so that workers should be cautious. During production and use, they should strictly abide by the procedures to prevent poisoning, protect everyone's health, and protect the environment.
Future Prospects
1 - Fluoro - 4 - Methylbenzene is also an organic compound. In today's chemical research, it shows many specific properties. Looking at its future development, the future is quite promising.
On the road of self-synthesis, new techniques are gradually emerging, which can make the preparation simpler and purer, and the yield will also increase. For industrial use, due to its unique chemistry, it may be able to emerge in the fields of material creation, pharmaceutical research and other fields.
For example, in the field of materials, or as a key component of new polymeric materials, endowing materials with new properties, such as better heat resistance, corrosion resistance, etc. In the field of medicine, it may become the basic structure of new pharmaceuticals, opening up new paths for the treatment of various diseases.
Future researchers should exhaust their wisdom, explore its properties, and expand its applications. Make 1-Fluoro-4-Methylbenzene great in various fields, add brilliance to human well-being, promote the progress of science and technology, and the prosperity of society.
Where to Buy 1-Fluoro-4-Methylbenzene in China?
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Frequently Asked Questions

As a leading 1-Fluoro-4-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 1-Fluoro-4-Methylbenzene?
1 - Fluoro - 4 - Methylbenzene, that is, p-fluorotoluene, is an organic compound. Its chemical properties are unique, with the characteristics of aromatic hydrocarbons and halogenated hydrocarbons.
p-fluorotoluene contains benzene rings, which have typical properties of aromatic hydrocarbons. It can occur electrophilic substitution reaction. The benzene ring is rich in electrons and is easily attacked by electrophilic reagents. Take the halogenation reaction as an example. Under the action of the catalyst, it can react with halogens, and the halogen atom replaces the benzene ring hydrogen atom. For example, under the catalysis of iron or iron tribromide with bromine, the bromine atom will replace the hydrogen on the benzene ring that is in the ortho or para-position with
It can also undergo nitration reaction. Under the action of concentrated sulfuric acid and concentrated nitric acid mixed with acid, nitro (-NO ³) replaces benzene cyclic hydrogen to form nitro compounds. In the sulfonation reaction, under the action of concentrated sulfuric acid, the benzene ring introduces the sulfonic acid group (-SO 🥰 H).
Because of the fluorine atom, it has some properties of halogenated hydrocarbons. Although the fluorine atom is connected to the benzene ring, the C-F bond has high stability, but under certain conditions, the substitution reaction can still occur. In case of strong nucleophilic reagents, the fluorine atom may be replaced by a nucleophilic reagent. However, compared with other halogenated hydrocarbons, this reaction condition is usually
In addition, the methyl of p-fluorotoluene is affected by the benzene ring, and α-hydrogen has a certain activity. Under the action of appropriate oxidants, methyl can be oxidized. For example, oxidized with acidic potassium permanganate solution, methyl can be gradually oxidized to carboxyl group to obtain p-fluorobenzoic acid.
P-fluorotoluene is rich in chemical properties and can be used as a key intermediate in the field of organic synthesis. It is used in the preparation of a variety of organic compounds and is widely used in medicine, pesticides, materials and other industries.
What are the common uses of 1-Fluoro-4-Methylbenzene?
1-Fluoro-4-methylbenzene, also known as p-fluorotoluene, has a wide range of common uses. In the process of chemical synthesis, it is a key raw material. It can be converted into other fluorine-containing compounds through many reactions. In the field of medicine, its significance is extraordinary. Many drug synthesis, with 1-fluoro-4-methylbenzene as the starting material, through multi-step reactions, pharmaceutical ingredients with specific pharmacological activities are prepared for the prevention and treatment of diseases. In the field of pesticides, it also plays an important role. It can be used as an intermediate to synthesize high-efficiency, low-toxicity and environmentally friendly pesticides to help the prevention and control of agricultural pests and diseases, and improve crop yield and quality. In the field of materials science, 1-fluoro-4-methylbenzene can participate in the preparation of functional materials. For example, the synthesis of fluoropolymers, which endow materials with special properties such as chemical resistance, good weather resistance, and low surface energy due to the properties of fluorine atoms, are widely used in the improvement of materials such as coatings, plastics, and fibers, and expand the application scenarios of materials. Furthermore, in the study of organic synthetic chemistry, 1-fluoro-4-methylbenzene is a commonly used reagent for researchers to explore new reaction paths, develop new synthesis methods, and promote the progress and development of organic synthetic chemistry. All of this shows that 1-fluoro-4-methylbenzene has important uses in many fields and is an indispensable substance for industrial production and scientific research.
What are the preparation methods of 1-Fluoro-4-Methylbenzene?
1-Fluoro-4-methylbenzene, also known as p-fluorotoluene, can be prepared by the following methods:
First, the diazotization method using p-toluidine as raw material. The diazotization reaction occurs by first interacting p-toluidine with hydrofluoric acid and sodium nitrite. This process needs to be carefully operated at low temperature to prevent the decomposition of diazonium salts. After the diazonium salt is formed, it is thermally decomposed and nitrogen is released to produce 1-fluoro-4-methylbenzene. The reaction mechanism is clear, but the steps are slightly complicated, and the stability of the diazonium salt is poor, so it needs to be handled carefully.
Second, the halogen exchange method using p-methylchlorobenzene as raw material. In the presence of specific catalysts, such as copper salts, the halogen exchange reaction of methyl chlorobenzene with potassium fluoride is carried out. The reaction conditions are mild and the operation is relatively simple. However, the choice and amount of catalyst are quite critical, which will affect the reaction rate and yield. The potassium fluoride used needs to be dried and pure, otherwise the reaction effect will be affected.
Third, the direct fluorination method using toluene as the raw material. Using toluene as the starting material, under suitable catalyst and reaction conditions, it is directly reacted with fluorine gas. This method is theoretically simple in steps and has high atomic utilization. However, fluorine gas is extremely active, the reaction is violent, and it is difficult to control. It is prone to side reactions such as polyfluoride substitution. The reaction conditions, such as temperature, pressure, fluorine gas penetration rate, etc., need to be precisely regulated. The equipment requirements are also high, and it must be able to withstand high pressure and corrosion resistance.
Fourth, the conversion method using p-methylphenol as raw material. First, p-methylphenol reacts with fluorinated reagents, such as boron trifluoride ethyl ether complexes, to achieve the replacement of hydroxyl groups by fluorine atoms, and then produces 1-fluoro-4-methylbenzene. This route requires specific fluorinated reagents, which may be expensive, and the post-reaction treatment needs to be properly arranged to separate and purify the product.
1-Fluoro-4-Methylbenzene what are the precautions during storage and transportation?
1-Fluoro-4-methylbenzene is one of the organic chemicals. When storing and transporting it, you need to pay more attention to the following matters:
The first thing to bear the brunt is the storage environment. This chemical must be stored in a cool and well-ventilated place. Because it is easy to cause internal molecules to become active when heated, or to cause volatilization or even dangerous reactions, a cool environment can stabilize its chemical properties. Good ventilation is essential. If the air in the storage space does not circulate, once the chemical is slightly volatilized, it will cause local concentrations to rise, which not only adds safety hazards, but also is harmful to the health of storage personnel.
Furthermore, the packaging must be rigorous. It is necessary to use suitable packaging materials, such as containers with excellent sealing performance, to effectively prevent the leakage of 1-fluoro-4-methylbenzene. If this chemical leaks outside, it will not only cause pollution to the surrounding environment, but also have certain toxicity and irritation, or endanger human health.
When transporting, there are also many points. Transportation vehicles must have reliable protection and emergency facilities. Protective facilities can reduce the spread and harm of chemicals in the event of an accident; emergency facilities can enable transporters to take timely response measures in the event of an emergency, minimizing losses and hazards.
At the same time, transportation personnel also need to undergo professional training and be familiar with the characteristics, hazards and emergency treatment methods of 1-fluoro-4-methylbenzene. Only in this way can they respond calmly and handle it properly when encountering abnormal conditions during transportation.
In addition, it is necessary to strictly avoid mixing with oxidizers, acids and other substances during transportation. 1-fluoro-4-methylbenzene and these substances are prone to chemical reactions, or cause serious accidents such as combustion and explosion.
In conclusion, the storage and transportation of 1-fluoro-4-methylbenzene requires careful treatment at every step, and no sloppiness is allowed to ensure that personnel safety and the environment are not damaged.
What are the effects of 1-Fluoro-4-Methylbenzene on the environment and human health?
1-Fluoro-4-methylbenzene, also known as p-fluorotoluene, has a significant impact on humans and the environment. This substance is a colorless and transparent liquid at room temperature and has a fragrant odor. It is widely used in industrial fields, such as as as a raw material for the synthesis of fine chemicals such as medicines, pesticides, and dyes.
However, it is significantly harmful to the environment. If released into the atmosphere through photochemical reactions, it can cause ozone and other pollutants to form, damage air quality, and affect regional climate. And because of its volatility, it can be transported over long distances in the atmosphere, causing a wider range of pollution. If it flows into the water body, it is easily adsorbed on suspended particles or sediments due to its hydrophobicity, and enriches through the food chain, endangering aquatic organisms. It is also harmful to the soil, which can inhibit the activity of soil microorganisms and affect the function of soil ecosystem and material circulation.
As for human health, 1-fluoro-4-methylbenzene can be ingested into the human body through respiratory tract, skin contact and digestive tract. Irritates the eyes and respiratory mucosa, causing eye pain, tears, cough, asthma and other diseases. Long-term exposure may damage the nervous system, cause headache, dizziness, fatigue, insomnia, and even affect cognitive and motor functions. Animal experiments have shown that this substance may be potentially carcinogenic. Although there is insufficient definitive evidence about the human body, its risk should not be underestimated. Skin contact can cause skin allergies, itching, and redness. Because of its lipid solubility, it can be absorbed through the skin, increasing the risk of accumulation in the body.