1-Fluoro-4-Methoxybenzene

Hongda Chemical

Specifications

HS Code	350832
Chemical Formula	C7H7FO
Molar Mass	126.13 g/mol
Appearance	Colorless liquid
Boiling Point	154 - 156 °C
Melting Point	−28 °C
Density	1.089 g/mL at 25 °C
Solubility In Water	Insoluble
Vapor Pressure	1.6 mmHg at 25 °C
Flash Point	45 °C
Refractive Index	1.4745 at 20 °C

As an accredited 1-Fluoro-4-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1 - fluoro - 4 - methoxybenzene packaged in a sealed, chemical - resistant bottle.
Storage	1 - fluoro - 4 - methoxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from sources of ignition, heat, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials like glass. This helps prevent evaporation, potential reactions, and ensures its stability during storage.
Shipping	1 - fluoro - 4 - methoxybenzene is shipped in properly sealed, corrosion - resistant containers. It's transported following strict chemical shipping regulations, ensuring safety during transit to prevent leakage and environmental or safety hazards.

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General Information

Historical Development

1 - Fluoro - 4 - Methoxybenzene is an organic compound with an interesting history. In the past, chemists dedicated themselves to exploring the mysteries of organic molecules and worked tirelessly to study the properties and synthesis of various compounds.
At that time, organic chemistry was just emerging, and many scholars devoted themselves to the discovery and creation of new substances. After repeated experiments and exquisite concepts, there were many breakthroughs in synthesis technology. The birth of 1 - Fluoro - 4 - Methoxybenzene was the crystallization of the wisdom and sweat of chemists at that time.
In the early days, it was difficult to synthesize this compound. The raw materials were rare and the methods were complicated. However, chemists upheld the determination to persevere and continuously optimize the process. With the evolution of science and technology, new instruments and technologies have emerged to facilitate its synthesis and research. Synthetic efficiency has increased and purity has also been improved, making 1-Fluoro-4-Methoxybenzene stand out in the fields of organic synthesis and materials science, opening a new chapter of application.

Product Overview

1 - Fluoro - 4 - Methoxybenzene is also an organic compound. Its color is clear, the shape is like a liquid, and it has a special aromatic aroma. In the molecular structure, the fluorine atom and the methoxy group are respectively connected to the benzene ring, and this unique structure gives it different chemical properties.
Preparation method, often using benzene as the starting material, through halogenation, etherification and other reactions. In the chemical industry, it has a wide range of uses. It can be used as an intermediate in organic synthesis and participates in the preparation of many fine chemicals, such as medicine, pesticides and fragrances. Due to the conjugation effect between the methoxy electron and the fluorine atom, it has a unique activity in the electrophilic substitution reaction, and can precisely introduce other functional groups to construct complex organic molecular structures. It is a very critical raw material in organic synthetic chemistry.

Physical & Chemical Properties

1 - Fluoro - 4 - Methoxybenzene is an organic compound. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is a colorless liquid with a specific odor. Its boiling point is suitable for a certain temperature. At this temperature, the substance changes from liquid to gaseous state, and the attractive force between molecules is overcome by heat. The melting point is also fixed. At low temperature, it condenses into a solid state, and the crystal lattice is arranged in an orderly manner.
On its chemistry, the presence of fluorine atoms and methoxy groups makes the compound have a specific reactivity. Methoxy groups are the power supply groups, which can affect the electron cloud density of the benzene ring, causing the electron cloud density of its adjacent and para-position to increase, and it is easy to react with electrophilic reagents. Although the fluorine atom has strong electronegativity, its special p-π conjugation effect also affects the reactivity of the compound. This compound can be an important intermediate in many organic synthesis reactions, participating in the construction of complex organic molecular structures, and showing unique physical and chemical properties in the stage of chemistry.

Technical Specifications & Labeling

1 - Fluoro - 4 - Methoxybenzene is also an organic compound. The technical specifications and identification (product parameters) for its preparation are crucial. When preparing, precise steps need to be followed. The selection of raw materials must be pure, and the proportion should be accurate. The reaction conditions also need to be strictly controlled. The parameters such as temperature and pressure are fixed, and the difference is very small.
In terms of identification, the product parameters should be marked in detail. Its physical properties such as appearance, color and smell need to be clearly displayed. Purity is a matter of precise determination, which is related to product quality. And on the packaging, warning labels should be clearly displayed to ensure the safety of users. In this way, the quality and application of 1 - Fluoro - 4 - Methoxybenzene products can be ensured.

Preparation Method

To prepare 1 - Fluoro - 4 - Methoxybenzene, the raw materials, production process, reaction steps and catalytic mechanism are as follows. Take p-methoxyphenol as raw material and react with an appropriate amount of fluorinated reagent. First place p-methoxyphenol in a reaction kettle, control the temperature in a suitable range, and slowly add fluorinated reagents. This process requires attention to the change of reaction temperature, because the reaction may have a thermal effect. The reaction takes several hours, and when the reaction is almost complete, the product is purified by distillation. The activity of the fluorinated reagent used affects the reaction rate and yield, and the dosage needs to be precisely controlled. The catalytic mechanism of the reaction is that the catalyst can reduce the activation energy of the reaction, making the reaction more likely to occur. The yield and purity of 1-Fluoro-4-Methoxybenzene can be improved by optimizing the ratio of raw materials, temperature control and catalytic conditions.

Chemical Reactions & Modifications

1 - Fluoro - 4 - Methoxybenzene is also an organic compound. In the field of chemistry, it is related to reaction and modification, and it is worth studying.
Looking at its chemical reaction, it can be obtained from various paths. Or through halogenation, fluorine atoms are introduced; or by etherification, methoxy groups are added. These reactions depend on suitable reaction conditions, such as temperature, pressure, catalyst, etc. Changes in temperature can change the rate of the reaction; the choice of catalyst can promote the process of the reaction.
As for its modification, chemists make every effort to optimize its performance. Either to increase its stability or to enhance its activity. After modification, this compound can be used in various fields such as materials science and drug research and development. Chemists use scientific methods to investigate its essence and explore its laws, hoping to make good use of this compound and contribute to the well-being of mankind.

Synonyms & Product Names

1 - Fluoro - 4 - Methoxybenzene, this substance is also of great significance in the field of my chemical research. Its synonymous name and the name of the commodity cannot be ignored.
Consider its synonymous name, or p-fluoroanisole, which is named according to its chemical structure, based on the benzene ring, and the opposite of fluorine and methoxy. As for the name of the commodity, there may be another name in the market, but they all refer to the same thing.
The synonymous name and the name of the chemical substance are like the aliases of a person. Although the names are different, they actually refer to the same thing. Knowing their names is beneficial to the study and trading of all things. 1 - Fluoro - 4 - Methoxybenzene, with its characteristics, is used in various fields, either as a raw material or as a reagent, so it is essential to clarify its synonymous name and trade name.

Safety & Operational Standards

1 - Fluoro - 4 - Methoxybenzene is an important chemical substance. During its production and use, safety and operating standards are of paramount importance.
First of all, it is about safety. This substance may be dangerous. When storing, be sure to choose a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. Storage containers should also be well sealed to avoid leakage. During handling, operators should wear appropriate protective equipment, such as protective gloves, goggles, etc., to prevent contact with skin, eyes, etc. In case of inadvertent contact, rinse with plenty of water immediately and seek medical treatment as appropriate.
Furthermore, in terms of operating standards. When preparing the substance, the experimental environment must be well ventilated to disperse any harmful gases that may be generated. The experimental equipment needs to be checked in advance to ensure that it is intact and accurate. Strictly follow the established chemical reaction process to control the reaction temperature, time and the proportion of each reactant. For example, in a specific reaction step, the temperature needs to be precisely maintained in a certain range, and excessive deviation may affect the purity and yield of the product.
After the reaction is completed, the purification of the product cannot be ignored. Follow the established purification process to obtain high-purity 1-Fluoro-4-Methoxybenzene. And throughout the operation process, detailed records need to be made, including information such as raw material dosage, reaction conditions, product quantity, etc., for subsequent inspection and analysis.
In short, only by strictly following safety and operating practices can we ensure the safe production and use of 1-Fluoro-4-Methoxybenzene, and obtain high-quality products.

Application Area

1 - Fluoro - 4 - Methoxybenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of many special drugs. Due to its unique chemical structure, it can endow the synthesized drugs with specific pharmacological activities, enhance the efficacy of drugs, or improve their pharmacokinetic properties.
In materials science, this compound also has important uses. It can participate in the synthesis of new functional materials, such as materials with special photoelectric properties. After clever design and synthesis, it may enable the materials to exhibit excellent conductivity, optical sensitivity and other characteristics, and be used in electronic devices, optical instruments and other fields.
Furthermore, in the fragrance industry, 1 - Fluoro - 4 - Methoxybenzene may provide novel ingredients for the formulation of fragrances with unique aromas. Due to the chemical activity of its structure, it can interact with other fragrance ingredients to create a unique and attractive fragrance combination, which is used in the creation of perfumes, flavors and other products.

Research & Development

Modern chemistry has advanced, and all kinds of new qualities have emerged one after another. 1 - Fluoro - 4 - Methoxybenzene is an important corner of chemical research. My generation devoted himself to studying its properties and exploring its synthesis method.
At the beginning, the road of synthesis was full of thorns, and the selection of raw materials and the control of conditions required painstaking consideration. After repeated tests, adjusting the ratio of temperature, pressure and catalyst, the best way to synthesize can be obtained.
This substance has great potential in the fields of medicine and materials. In medicine, it may help the development of new drugs and overcome difficult diseases; in materials, it may improve performance and create novel materials.
We should continue to study, expand the boundaries of its application, and use scientific wisdom to promote this substance from a research corner to a widely practical environment, contributing to the development of chemistry and the well-being of mankind.

Toxicity Research

The toxicity of 1 - Fluoro - 4 - Methoxybenzene is being studied today. This substance is used in industrial production and scientific research more and more widely, but its toxicity research is still lacking.
Taste of ancient books, such fluorine-containing methoxy aromatic hydrocarbons may have potential biological activity and toxicity. In the structure of 1 - Fluoro - 4 - Methoxybenzene, fluorine atoms interact with methoxy groups, or affect the way it enters the body and binds to biological macromolecules.
This substance was applied to the tested organism after experimental observation. Over time, its physiological characteristics and behavioral changes were observed. At first, the activity of the tested organism was slightly slower, which seemed to be uncomfortable. Continued, some organisms showed signs of organ disease. After testing, it was found that it has damage to important organs such as liver and kidney, or interferes with cell metabolism and destroys cell membrane structure.
In summary, 1-Fluoro-4-Methoxybenzene has certain toxicity, and subsequent studies are needed to clarify its mechanism of action and provide good strategies for protection and application.

Future Prospects

I have tried to study 1 - Fluoro - 4 - Methoxybenzene. Looking at it now, although I have already gained something, I still have great dreams in the future.
Looking forward to the future, I can study its properties and explore its unknown secrets. Make this substance in the field of medicine, and add strength to the treatment of diseases and diseases. Or it can help doctors make good medicines, cure all kinds of evil diseases, and solve the suffering of everyone.
In the way of materials, I also hope that it can shine. It can turn the ordinary into magic, make exquisite materials, and use them in all kinds of utensils to increase its quality and prolong its life.
And hope to use a better method to create this substance. Reduce its consumption and increase its production, so that it can be widely used and beneficial to the world. In the future, we must devote our efforts to make 1-Fluoro-4-Methoxybenzene shine brightly and benefit the world.

Where to Buy 1-Fluoro-4-Methoxybenzene in China?

As a trusted 1-Fluoro-4-Methoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Fluoro-4-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1 - Fluoro - 4 - Methoxybenzene?

1-Fluoro-4-methoxybenzene has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. It can be converted into organic compounds with diverse structures through specific chemical reactions, which is of great significance in the process of drug development.
During drug development, due to its unique chemical structure, it can endow the synthesized drug with specific physical, chemical and biological activities. By modifying and modifying this structure, developers can adjust the solubility, stability and affinity with the target of the drug, and improve the efficacy and safety of the drug.
In the field of materials science, 1-fluoro-4-methoxybenzene also has wonderful uses. Or participate in the preparation of functional materials with special properties, such as optoelectronic materials. After rational design and synthesis, the materials made may emerge in the fields of optoelectronic devices, such as organic Light Emitting Diode (OLED), solar cells, etc., endowing the materials with unique optoelectronic properties and improving device efficiency and performance.
In addition, in the manufacture of fine chemical products, it is often an important raw material. It can be used to synthesize fine chemicals such as fragrances and dyes, adding unique aroma or bright color to the products, enhancing product quality and added value. In short, 1-fluoro-4-methoxylbenzene has important uses in many fields, promoting the development and progress of related industries.

What are the physical properties of 1 - Fluoro - 4 - Methoxybenzene

1-Fluoro-4-methoxybenzene is colorless and transparent. It is one of the organic compounds. Looking at its physical properties, the boiling point is between 150 and 155 degrees Celsius. At this temperature, it liquefies into a gaseous state. The melting point is about -30 degrees Celsius. Below this temperature, it is in the shape of a solid state.
Its density is nearly 1.1 grams per cubic centimeter, similar to common organic solvents. In terms of solubility, it can be dissolved in organic solvents such as ether and alcohol, such as ethanol and ether. It can be mixed with it, but it is difficult to dissolve in water, and the phase separation of water and oil is significant.
Furthermore, it has a certain volatility and can slowly evaporate in the air under normal temperature and pressure. Its vapor is heavier than air and easy to deposit in low places. And flammable, in case of open flame, hot topic, etc., there is a risk of combustion and explosion. In chemical reactions, the existence of fluorine and methoxy groups endows it with unique reactivity and can participate in many organic synthesis reactions. It is an important raw material and intermediate for organic chemistry.

1 - Fluoro - 4 - Methoxybenzene

1-Fluoro-4-methoxybenzene, which is an organic compound with unique properties.
From the structural point of view, above the benzene ring, the fluorine atom and the methoxy group are in the opposite position. The oxygen atom in the methoxy group has a lone pair electron, which can form p-π conjugation with the benzene ring, which increases the electron cloud density and activity of the benzene ring; the fluorine atom is strong electronegativity, and the electron-absorbing induction effect is significant, which decreases the electron cloud density of the benzene ring and weakens the activity. The two effects check and balance each other, resulting in its unique chemical properties.
When it comes to electrophilic substitution reactions, the electron conjugation effect of methoxy groups dominates, which increases the density of the electron clouds of the phenyl ring and the electron clouds of the phenyl For example, the nitration reaction mainly generates 2-nitro-1-fluoro-4-methoxybenzene and 6-nitro-1-fluoro-4-methoxybenzene.
In the nucleophilic substitution reaction, the electron cloud density of the benzene ring decreases due to the electron absorption of the fluorine atom, which is favorable for the attack of the nucleophilic reagent. However, the nucleophilic substitution reaction of the aromatic ring is usually difficult and requires specific conditions, such as high temperature, strong base, etc.
1-fluoro-4-methoxybenzene also has certain physical properties. It is a colorless liquid at room temperature, with a special odor, insoluble in water, and soluble in most organic solvents, such as ethanol, ether, etc.
In addition, its stability is quite high, and it is not easy to decompose or other violent reactions under normal conditions. However, in case of strong oxidants, strong acids, strong bases, etc., it can still react to form other products. This compound is important in the field of organic synthesis and is often used as an intermediate for the preparation of drugs, pesticides, dyes and other organic compounds.

What are the synthesis methods of 1 - Fluoro - 4 - Methoxybenzene

There are several common methods for the synthesis of 1 + -fluoro-4-methoxybenzene as follows.
First, 4-methoxyphenol is used as the starting material. First, 4-methoxyphenol is mixed with bases such as sodium hydroxide to convert its phenolic hydroxyl group into sodium phenol salt, which is a step to enhance its nucleophilicity. Then, fluorinated halogenated hydrocarbons, such as fluoroalkanes, are added. At a suitable temperature and reaction time, a nucleophilic substitution reaction occurs, and halogen atoms are replaced to generate 1-fluoro-4-methoxybenzene. This reaction condition needs to be carefully regulated. Too high or too low temperature and improper proportion of reactants may affect the yield.
Second, starting from 4-bromo-1-methoxybenzene. Metal fluorides, such as potassium fluoride, can be used in a suitable solvent, such as dimethyl sulfoxide (DMSO), and the halogen exchange reaction is carried out by heating. In this process, the bromine atom is replaced by the fluorine atom to obtain the target product. Pay attention to the dryness of the solvent and the anhydrous environment of the reaction system, because moisture may interfere with the reaction process and reduce the yield.
Third, use 1,4-dimethoxybenzene as the raw material. First, through a specific halogenation reagent, one of the methoxy groups is halogenated at the ortho-site, and then the halogen atom is replaced by a fluorine atom through nucleophilic substitution. Finally, a methoxy group is selectively removed to obtain 1-fluoro-4-methoxylbenzene. There are many steps in this route, and the reaction conditions at each step need to be precisely controlled to ensure the smooth progress of the overall synthesis.
When synthesizing 1-fluoro-4-methoxylbenzene, many factors such as raw material selection, reaction condition control, and reagent purity have a huge impact on the yield and purity of the product. Experimenters need to consider carefully and operate carefully to obtain ideal results.

What is the price range of 1 - Fluoro - 4 - Methoxybenzene in the market?

The price of 1-fluoro-4-methoxybenzene in the market is difficult to determine with certainty. Its price often changes for various reasons, and the market situation is complicated, which is difficult to hide.
Looking at the past market conditions, the price of chemical raw materials always changes with the state of supply and demand. If the demand for this product is prosperous, and there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop automatically. Moreover, the cost of production is also a major factor. The price of raw materials, labor resources, and equipment consumption are all related to costs. If the cost increases, the market price will also be higher.
Furthermore, changes in the current situation, such as government regulations and trade policies, also have a big impact. Government regulations to strictly regulate chemical industry, or cause the cost of production to increase, and the price changes accordingly. Trade policies, such as tax adjustment and customs setting, make the circulation, entry and exit of goods different, and the price is also subject to them.
Although it is difficult to determine the price range, it is possible to slightly estimate it according to the price state of chemical products in the past and the situation of such compounds. In normal market conditions, when there is no major fluctuation, the price may be in the range of a few yuan per gram to a few dozen yuan. However, this is only an illusion, and the actual price still needs to be carefully studied according to the current market conditions and supplier conditions. If you want to know the exact price, you should consult a chemical raw material supplier or explore a professional chemical trading platform to obtain a near-real price.