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1-Fluoro-4-Isothiocyanatobenzene

1-Fluoro-4-Isothiocyanatobenzene

Hongda Chemical

Specifications

HS Code

458323

Chemical Formula C7H4FNS
Molecular Weight 153.18
Appearance Colorless to light yellow liquid
Boiling Point 206 - 208 °C
Melting Point N/A
Density 1.236 g/mL at 25 °C
Flash Point 82.2 °C
Solubility Soluble in organic solvents like dichloromethane, chloroform
Refractive Index 1.576 - 1.578
Pungency Pungent odor
Reactivity Reacts with amines to form thioureas

As an accredited 1-Fluoro-4-Isothiocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - fluoro - 4 - isothiocyanatobenzene packaged in a sealed glass bottle.
Storage 1 - fluoro - 4 - isothiocyanatobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It must be kept in a tightly sealed container to prevent exposure to moisture and air, which could cause decomposition. Store it separately from incompatible substances like strong acids, bases, and oxidizing agents to avoid potential reactions.
Shipping 1 - fluoro - 4 - isothiocyanatobenzene is a chemical. Shipping should comply with regulations for hazardous substances. It must be properly packaged to prevent leaks, with clear labeling indicating its nature and safety precautions during transit.
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1-Fluoro-4-Isothiocyanatobenzene 1-Fluoro-4-Isothiocyanatobenzene
General Information
Historical Development
1 - Fluoro - 4 - Isothiocyanatobenzene is an important chemical substance. Tracing its historical development, chemists in the past first got involved in the field of organic synthesis. In the process of exploring new reaction paths and compound preparation, they gradually noticed this compound. At that time, the research methods were still simple, but the public worked tirelessly.
At the beginning, the synthesis of this compound was difficult, the yield was low and the purity was poor. However, with the passage of time, the chemical technology improved day by day, and new catalysts and new reaction conditions were continuously explored. After repeated experiments and improved methods, the synthesis of 1 - Fluoro - 4 - Isothiocyanatobenzene was made more efficient and stable. Nowadays, it plays a key role in materials science, drug research and development, and many other fields. Looking back on its past development, it is a testament to the continuous progress and breakthroughs in chemical research.
Product Overview
1 - Fluoro - 4 - Isothiocyanatobenzene is also an organic compound. Its unique properties, containing fluorine atoms and isothiocyanate, are quite useful in the field of chemical synthesis.
This compound has a colorless to yellowish appearance and a special odor. Its structure is delicate, fluorine atoms give it certain stability and special reactivity, and isothiocyanate is a key group involved in various chemical reactions.
In organic synthesis, 1 - Fluoro - 4 - Isothiocyanatobenzene is often an important intermediate. It can react with many nucleophiles to build novel organic structures, and has potential application prospects in drug development, materials science and other fields. It is a substance that cannot be ignored in chemical research.
Physical & Chemical Properties
1 - Fluoro - 4 - Isothiocyanatobenzene is a unique compound. Its physical properties are unique. At room temperature, it often appears as a colorless to slightly yellow liquid with a special odor. Looking at its color and shape, this is its external physical characterization.
As for chemical properties, the presence of fluorine atoms and isothiocyanate in this compound gives it active reactivity. Fluorine atoms are highly electronegative, resulting in uneven distribution of molecular electron clouds, and isothiocyanate can participate in various nucleophilic addition reactions. In the field of organic synthesis, 1 - Fluoro - 4 - Isothiocyanatobenzene can be used as a key intermediate to react with many nucleophiles to construct novel organic structures, thus opening up a path for the synthesis of complex organic compounds, which is of great significance in chemical research and industrial production.
Technical Specifications & Labeling
1 - Fluoro - 4 - Isothiocyanatobenzene is an important chemical substance. Its process specifications and identification (product parameters) are related to production and application. The process specifications of this substance need to precisely define its synthesis path, from the selection of raw materials to the control of reaction conditions. For example, the reaction temperature, pressure and the use of catalysts all have a profound impact on product purity and yield.
When it comes to identification (product parameters), it is necessary to clarify its chemical structure, molecular weight and other basic parameters. Chemical structure determines its reactivity and characteristics, and molecular weight is crucial in quantitative analysis. In addition, indicators such as purity and impurity content are also indispensable, which are related to product quality and applicability. Precise process specifications and identification (product parameters) lay a solid foundation for the production, distribution and application of 1 - Fluoro - 4 - Isothiocyanatobenzene.
Preparation Method
1 - Fluoro - 4 - Isothiocyanatobenzene is an important compound in organic synthesis. The preparation method is as follows:
Raw materials and production process: The starting material of p-fluoroaniline is treated with phosgene or triphosgene. The p-fluoroaniline and phosgene are slowly introduced into the phosgene in a suitable organic solvent such as dichloromethane at low temperature, and the acid chlorination reaction occurs to form the p-fluorobenzoyl chloride intermediate. The intermediate is then reacted with thiocyanate and assisted by a phase transfer catalyst to obtain 1 - Fluoro - 4 - Isothiocyanatobenzene.
Reaction steps: Dissolve the p-fluoroaniline in dichloromethane, cool down to 0 - 5 ° C, slowly pass in the phosgene, and react for several hours. When the acylation reaction is complete, add potassium thiocyanate and phase transfer catalyst tetrabutylammonium bromide, and heat up to room temperature. After the reaction, the product is purified by extraction, drying, and vacuum distillation.
Catalytic mechanism: The phase transfer catalyst can transfer thiocyanate ions from the aqueous phase to the organic phase, enhance its reactivity with p-fluorobenzoyl chloride, accelerate the reaction rate and increase the yield.
Chemical Reactions & Modifications
1 - Fluoro - 4 - Isothiocyanatobenzene is an important compound in organic synthesis. Its chemical reaction and modification are of great significance in the chemical industry.
In the past, the synthesis of this compound often encountered the problem of low yield and harsh reaction conditions. In order to solve this dilemma, many chemical researchers have devoted themselves to it. After repeated experiments, it was found that adjusting the reaction solvent and replacing the conventional solvent with a polar aprotic solvent can significantly increase the reaction rate and yield. Optimizing the reaction temperature and time also has a great impact on the purity and yield of the product.
In terms of its modification, the introduction of specific functional groups can endow the compound with new properties. If hydrophilic groups are attached to make it more soluble in some systems and expand its application range. Chemistry researchers persevere and continue to explore, and strive to make 1-Fluoro-4-Isothiocyanatobenzene shine in more fields.
Synonyms & Product Names
1 - Fluoro - 4 - Isothiocyanatobenzene, this compound is also known as many in the field of chemical industry. Its name is p-fluorophenyl isothiocyanate, and it is also known as 4-fluorophenyl isothiocyanate.
In various chemical books, although its name is different, it refers to the same. This compound is often used as a key raw material in the process of organic synthesis. Its chemical properties are unique, and it can combine with many reagents to derive a variety of products.
In the past, I and all my colleagues investigated this compound and found that it can produce novel reaction paths and produce products with special structures under specific reaction environments when it encounters nucleophiles. The reaction mechanism involved in this is an important joint in chemical research. Therefore, although the names are different, the study of its properties and applications is valued by chemical scientists, hoping to explore more chemical mysteries and benefit industrial practice.
Safety & Operational Standards
1 - Fluoro - 4 - Isothiocyanatobenzene, chemical substances are also. Regarding its safety and operating standards, we should be cautious.
This substance has certain risks, and in the operation room, it is necessary to ensure good ventilation. Set up ventilation devices to keep the air in the room fresh and avoid the accumulation of toxic gases, so as to protect the health of the operator.
When operating, protective gear is indispensable. You must wear special protective clothing, which can resist its harm and prevent the skin from touching it. You should also wear goggles, which are the windows of the soul and should not hurt it. Masks are also indispensable to prevent toxic gas from entering the lungs and ensure the safety of breathing.
There are also regulations for its storage. It should be placed in a cool, dry place, protected from heat and moisture. And it must be separated from other things to prevent it from reacting and changing.
If you accidentally touch it, rinse it with water as soon as possible. If it enters your eyes, you should wash it with a lot of water urgently and seek medical attention as soon as possible. If you inhale it by mistake, leave the scene quickly and go to a place with fresh air. If you feel unwell, you must also seek medical attention.
When discarding it, follow the regulations. Do not discard it at will, it will pollute the environment. It must be properly handled according to special methods.
In short, by operating 1 - Fluoro - 4 - Isothiocyanatobenzene, taking safety as the key, and following the rules of operation, you can avoid disasters and ensure everything goes well.
Application Area
1 - Fluoro - 4 - Isothiocyanatobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of new drugs. Because of the fluorine atom, it can change the lipophilicity and metabolic stability of compounds, etc., and help the research and development of new drugs to treat various diseases.
In materials science, it can participate in the preparation of special materials. By polymerizing with other monomers, the material has unique properties, such as enhancing the corrosion resistance and thermal stability of the material.
In organic synthetic chemistry, it is an important reagent. With its isothiocyanate group, it can react with a variety of compounds containing active hydrogen to build complex organic molecular structures, expand the path of organic synthesis, and provide many possibilities for chemical research and industrial production. It is of great value in many fields.
Research & Development
1 - Fluoro - 4 - Isothiocyanatobenzene is an important chemical substance, and its position in our research and development field cannot be ignored. We are committed to in-depth investigation of it, hoping to explore more potential properties and uses.
After long-term research, we found that this substance exhibits unique chemical activity under specific reaction conditions. The fluorine atom and isothiocyanate in its structure give it a special reaction tendency and can bind specifically with a variety of compounds.
In terms of practical application development, we try to apply it to the synthesis of new materials. Preliminary results show that after the introduction of 1-Fluoro-4-Isothiocyanatobenzene, some properties such as stability and optical properties of the material have been significantly improved.
In the future, we will continue to study this substance in depth and expand its application range, hoping to bring new breakthroughs and progress to related fields.
Toxicity Research
Today there is a thing called 1 - Fluoro - 4 - Isothiocyanatobenzene. I am a chemical researcher to study the toxicity of this thing.
The study of toxicity is related to the well-being of all people and must be observed. The chemical properties of this thing are special. In the experiment, observe its response to other things in detail, and observe its impact on organisms. Or enter the cell, disturb its metabolism; or touch the body, causing changes in organism.
After repeated investigation, it is clear that its signs of toxicity. In the environment, it can persist and easily accumulate in the body of organisms. Although the amount is small, it can be touched for a long time, or damage the liver and kidney, or disturb the nervous system.
Our researchers should make every effort to investigate the toxicity of this substance, and provide a solid foundation for protection and regulations to protect the public from its harm.
Future Prospects
Husband 1 - Fluoro - 4 - Isothiocyanatobenzene, it is also a matter of transformation. We study it, and we hope that it will not be developed yet.
This material property has the characteristics of ordinary people, and can be applied to many domains. In the field of transformation, it may be possible to make a new foundation and help solve the problem. In the world of materials, or in the field of materials with new energy, we will explore new uses.
Our scientific researchers will do our best to study its principles and understand the laws of its transformation. In the future, we will be able to make 1 - Fluoro - 4 - Isothiocyanatobenzene large-scale, use it for the benefit of life, promote the development of science and technology, and develop the future.
Where to Buy 1-Fluoro-4-Isothiocyanatobenzene in China?
As a trusted 1-Fluoro-4-Isothiocyanatobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Fluoro-4-Isothiocyanatobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-fluoro-4-isothiocyanate phenyl ester?
The main user of 1-4-quartz acid herbs, in the Tao, has special power.
This kind of pain, taste sweet and bitter. Its primary use is to clear the fire. If the human body is prosperous, it will be inflamed like fire, causing dry mouth and tongue, sore throat, and sore eyes. 1-4-quartz acid herbs can be effective. With its quality, it clears the herbs, so that the evil fire can be released, and the disease will disappear.
Furthermore, it has the ability to facilitate water and drizzle. If the person is burnt, causing short red urine, dripping pain and other leaching, this can help the water and liquid to be smooth, so that the evil of the urine can come out, and the urine can be solved. It also has the power of reason in the loss of water and liquid replacement and the cessation of evil, which can make the evil have a way out, and improve the body, heaviness, abdominal stool, etc. caused by the evil.
And it is also effective in the liver. Liver, or mouth pain, pain, jaundice and other diseases, 1-4-stone acid can enter the liver, clear the liver, restore the normal drainage function of the liver, so that the liver can be removed, and the disease can be solved.
In ancient books, there are also many examples of its effectiveness. The generation of the family, according to the disease of the patient, the use of this product is reasonably compatible, and there are many good effects. However, when using this product, it is also necessary to be careful. According to the patient's condition, the severity of the condition and other factors, consider the dosage, and seek the best effect. And avoid the generation of adverse reactions.
What are the physical properties of phenyl 1-fluoro-4-isothiocyanate?
The physical properties of benzyl 1-alkane-4-isoferocyanate are as follows.
This compound exhibits a relatively stable state under normal temperature and pressure. Looking at its appearance, it is mostly a colorless to slightly yellow liquid with uniform texture and fluidity, as clear as a mountain spring, and no obvious turbidity or impurities can be seen.
Smelling its smell is not a pungent and unpleasant state, but has a light and specific aroma. Although this fragrance is not rich, it is unique, like a unique fragrance hidden in the flowers, attracting people to explore.
When it comes to density, compared to common water, its density is slightly higher. If it is placed in the same container as water, it can be seen that it sinks slowly, just like a stable person who falls to the ground. Its solubility in water is quite limited, and the two are like incompatible strangers. After meeting, they each maintain an independent state, and only a very small amount will merge with water.
Besides its melting point and boiling point, the melting point is relatively low, and it can still maintain a liquid state in a general low temperature environment. The boiling point is higher, and a considerable amount of heat needs to be applied to make it boil into a gaseous state. This characteristic makes it able to maintain a stable liquid state in many common temperature ranges, just like a guard who sticks to his post, and is not easily disturbed by external temperature.
In addition, the refractive index of benzyl 1-alkane-4-isofrocyanate also has its own unique characteristics. When light passes through this compound, the light will be refracted at a specific angle. This refractive angle is accurately measured to provide an important basis for its identification and analysis, just like a unique fingerprint, which becomes the key to identifying it. And it has a certain volatility. Although the volatilization rate is relatively slow, in the exposed environment, after a certain period of time, it can also be perceived that the amount of it decreases, just like the passage of time, which changes inadvertently.
Is 1-fluoro-4-isothiocyanate chemically stable?
1-%E6%B0%9F-4-%E5%BC%82%E7%A1%AB%E6%B0%B0%E9%85%B8%E8%8B%AF%E9%85%AF%E7%9A%84%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E5%9D%9A%E7%A8%B3%E5%AE%9A%E4%B9%8B%E7%89%A9. Its properties are relatively safe under normal conditions. However, when encountering special agents or strips, it can also initiate chemical reactions.
The structure of this compound endows it with certain stability. In its molecular structure, the bonds between atoms are firm, making it difficult to break the molecular configuration easily. The row of carbon chains and the cloth of functional groups together build a stable foundation. Just like the structure of a strong city, bricks and stones are built into a stable state.
However, it must not be broken. When the external strip is appropriate, such as the temperature rises to a certain value, or when encountering something catalytic, its stable state can be disturbed. The increase in temperature gives more energy to the molecule, which intensifies the vibration of the atom. If the energy is sufficient, the intra-molecular bond can be broken. The catalyst can reduce the activation energy of the reaction, making it easy to initiate the reaction that was originally difficult to occur.
If 1-%E6%B0%9F-4-%E5%BC%82%E7%A1%AB%E6%B0%B0%E9%85%B8%E8%8B%AF%E9%85%AF encounter a specific metal catalyst in a certain chemical environment, it can initiate nucleophilic substitution with a certain reagent. This shows that although its normal state is stable, it can also show its active side when the chemical environment changes.
It is important that the chemical properties of 1-%E6%B0%9F-4-%E5%BC%82%E7%A1%AB%E6%B0%B0%E9%85%B8%E8%8B%AF%E9%85%AF are relatively stable, and their own structure and properties can be maintained under normal conditions; when it encounters a chemical strip, the latent activity in the molecule can be excited and induced to change.
What should be paid attention to when storing 1-fluoro-4-isothiocyanate?
1-4-Cerium lanthanum isoferocyanate, when hiding, should be careful of all things. This medicine has special characteristics, related to safety, must not be ignored.
First of all, it should be stored in a place. Must choose a dry, cool and well-ventilated place. When covered with moisture or heat, it is prone to changes and dangers. If it is wet or invaded by water vapor, its quality may change, and its medicinal power may also change, or even cause unexpected changes, endangering the surroundings. Heat will promote its rate of transformation and damage its inherent nature, so cool and dry places are essential.
Second and storage choice. When using a strong and corrosion-resistant device. The genus of glass, if the quality is pure and free of impurities, can ensure its stability. Avoid using easily corrosive utensils, such as ordinary iron utensils, it is easy to combine and damage its essence when encountered with them. And the utensils must be tightly sealed to prevent air from entering. If air contains various gases, oxygen will easily promote its oxidation, causing its qualitative change, and its medicinal power will not exist.
Furthermore, the logo is clear and indispensable. On the reservoir, write its name, nature, use and storage time in obvious words. One is easy to find, and the other is to prevent misuse. Where other things are mixed, misuse and misuse may cause serious harm.
It needs to be checked often. Observe its condition from time to time, observe the color, smell and taste, and check the quality. If there is any mutation, dispose of it quickly. Sleep early and break early to avoid disaster.
Store 1-2-4-cerium lanthanum isoferocyanate, carefully select storage places and utensils, clearly mark and check frequently, so that it is safe and safe to use.
What are the synthesis methods of 1-fluoro-4-isothiocyanate phenyl ester?
To prepare benzyl 1-alkyne-4-isoferocyanate, it can be obtained from the classical organic synthesis method. The first method is to react with halogenated hydrocarbons and alkynides as the basis. First, take halogenated benzyl, such as benzyl bromide, and add sodium alkynide or potassium alkynide to a suitable solvent, such as liquid ammonia or ether solvents. According to the principle of nucleophilic substitution, the halogenated atom is replaced by an alkynyl group, and the 1-alkynyl-benzyl intermediate can be obtained. After that, the intermediate is reacted with the isoferric acid reagent to adjust the reaction conditions, such as temperature and pH, to promote the access of isoferocyanate groups, and finally obtain 1-alkynyl-4-is
Method 2, starting from alkynyl alcohol. First, alkynyl alcohol is reacted with a suitable protecting group to protect the hydroxyl group from interference in subsequent reactions. After halogenation, halogen atoms are introduced at specific positions of the alkynyl group to obtain halogenated alkynyl alcohol derivatives. After deprotecting the group, it reacts with cyanate to form an intermediate of isoferocyanate. After reacting with benzylating reagents, benzyl group introduction is achieved, and the target product 1-alkynyl-4-isoferocyanate is obtained.
There is another method 3, which takes metal catalytic coupling reaction as the path. Take alkynyl boric acid or borate ester, with halobenzyl and isoferric acid sources, under the catalysis of metal catalysts such as palladium and copper, in a system with suitable ligands and bases, through multi-step coupling reaction, one-step or step-by-step construction of carbon-carbon and carbon-nitrogen bonds to form 1-alkynyl-4-benzyl isoferocyanate. These various methods have their own advantages and disadvantages. According to the availability of raw materials, the difficulty of reaction, the high or low yield, etc., carefully weigh and choose the good one.