1-Fluoro-4-Isocyanatobenzene

Hongda Chemical

Specifications

HS Code	543394
Chemical Formula	C7H4FNO
Molecular Weight	137.11
Appearance	Colorless to light yellow liquid
Boiling Point	193 - 194 °C
Melting Point	10 - 12 °C
Density	1.197 g/mL at 25 °C
Vapor Pressure	1.33 hPa (42.8 °C)
Flash Point	79 °C
Solubility	Insoluble in water, soluble in common organic solvents like toluene, dichloromethane
Stability	Stable under normal conditions, but reactive with water, alcohols, amines

As an accredited 1-Fluoro-4-Isocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - fluoro - 4 - isocyanatobenzene: Packed in 500 - gram bottles for chemical storage.
Storage	1 - fluoro - 4 - isocyanatobenzene should be stored in a cool, dry, well - ventilated area away from heat sources, ignition sources, and moisture. Keep it in a tightly sealed container to prevent leakage and exposure to air, as it may react with moisture. Store it separately from incompatible substances like acids, bases, and reactive chemicals to avoid potential hazardous reactions.
Shipping	1 - fluoro - 4 - isocyanatobenzene is a chemical that requires careful shipping. It should be packaged in suitable, leak - proof containers. Shipments must comply with hazardous material regulations, ensuring proper labeling and safe transportation to prevent risks.

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General Information

Historical Development

1 - Fluoro - 4 - Isocyanatobenzene, also an organic compound. Its origin can be traced back to the past. At the beginning, chemical sages explored the way of organic synthesis, and this compound gradually entered the field of vision.
At that time, the synthesis method was still simple and difficult, and the yield was quite low. However, chemists were determined and worked tirelessly. Over the years, their skills have advanced, and the synthesis methods have become more and more mature. From the original simple method, it has evolved to an efficient and accurate technique, and the yield has also increased significantly.
In the past, synthesis often encountered many obstacles, and the raw materials were rare and the conditions were harsh. However, today is different from the past, the technology is prosperous, the raw materials are easy to produce, and the conditions are controllable. This compound is increasingly used in medicine, materials, and other fields. Its development has witnessed the progress of chemistry, from ignorance to clarity, from difficulty to smoothness, and it is expected to open up more new paths in the future.

Product Overview

1 - Fluoro - 4 - Isocyanatobenzene is an important chemical substance. It has unique properties and good color purity. This compound is of great significance in the field of organic synthesis and is often used as a key intermediate.
Its preparation process requires a delicate method. After multiple rigorous processes, the reaction conditions can be controlled to obtain high-purity products. In the reaction, the proportion of raw materials, temperature and time are all key factors, and the exact difference may affect the quality of the product.
It has a wide range of uses and can participate in many organic reactions to build complex molecular structures, providing a solid foundation for drug development, materials science and other fields. With its special chemical properties, it can endow materials with unique properties and play a key role in the creation of new materials.
1 - Fluoro - 4 - Isocyanatobenzene occupies an important position in chemical research and industrial production due to its unique properties and wide range of uses, with broad prospects.

Physical & Chemical Properties

1 - Fluoro - 4 - Isocyanatobenzene is also an organic compound. Its physical and chemical properties are worth studying. Looking at its physical properties, it is mostly liquid at room temperature, with a clear and transparent color and a slightly special odor. Its boiling point is within a certain range, which is determined by its intermolecular forces. As for chemical properties, the presence of fluorine atoms and isocyanate groups in this compound gives it unique activity. Fluorine atoms are highly electronegative, while isocyanate groups are abnormally active. The synergy between the two allows them to react with a variety of reagents. In case of nucleophilic reagents, isocyanate groups are vulnerable to attack, leading to the occurrence of addition reactions, and then derived a variety of products, which have great potential for application in the field of organic synthesis, and are indeed objects that chemical researchers cannot ignore.

Technical Specifications & Labeling

1 - Fluoro - 4 - Isocyanatobenzene is also a special kind of product. Its technical quality (commodity quality) is important.
In the technical quality, the quality needs to be high, and it should be improved in a refined way, so that the quality can be stored. Its external appearance is clear, and it is not mixed. The temperature of melting and boiling must be in accordance with the established conditions, so as to ensure its stability.
On the surface of the package, the word "1 - Fluoro - 4 - Isocyanatobenzene" is clearly used, and its name is "1 - Fluoro - 4 - Isocyanatobenzene", with a warning of danger, because of its nature or risk of harm. Commodities are also known, such as molecular weight, chemical formula, etc., are all known to the user, so that the user can understand their properties, and use them with caution to integrate the research of chemical products and ensure safety.

Preparation Method

1 - Fluoro - 4 - Isocyanatobenzene is an important compound. The preparation method is as follows:
In terms of raw materials, p-fluoroaniline is selected as the starting material. In the synthesis process, p-fluoroaniline reacts with phosgene first, which is a key step. During the reaction process, the amino group of p-fluoroaniline interacts with the active group in the phosgene, and goes through a specific reaction mechanism to form an intermediate product.
In the subsequent steps, the intermediate product is processed, and through suitable reaction conditions, such as precise control of temperature, pressure and reaction time, it is further converted to obtain 1 - Fluoro - 4 - Isocyanatobenzene. The whole preparation process requires strict control of each reaction link to ensure the purity and yield of the product.

Chemical Reactions & Modifications

1 - Fluoro - 4 - Isocyanatobenzene is an important chemical substance that has applications in many chemical fields. The study of its chemical reactions has always been of great importance to chemists.
As far as its chemical reaction is concerned, the common reaction path depends on the activity of fluorine atoms and isocyanate groups in its structure. Fluorine atoms have strong electronegativity, which causes changes in the density of benzene cyclic electrons, which affects the activity of nucleophilic and electrophilic reactions. Isocyanate groups are also active and can undergo addition reactions with many nucleophilic reagents.
However, there is still room for improvement in the reaction of this substance. If some reaction conditions are harsh, high temperature, high pressure or special catalysts are required, limiting its large-scale application. And the reaction selectivity is sometimes poor, and there are many side reactions, which affects the purity and yield of the product.
Therefore, future research should focus on optimizing the reaction conditions, developing a mild and efficient catalytic system, improving the reaction selectivity and atomic economy, so that 1-Fluoro-4-Isocyanatobenzene can play a greater role in the field of chemical synthesis.

Synonyms & Product Names

1 - Fluoro - 4 - Isocyanatobenzene is a chemical substance. In the field of chemistry, it also has many synonymous names and commodity names.
The name of the synonym, or due to the different angles of chemists and the different systems used. Or from the analysis of the structure, it is called by the order of its atomic connection and the position of the functional group.
The name of the commodity is related to the commercial circulation and production application. Merchants take the name of the characteristic in order to make the product easy to recognize and promote. Or because of its unique use, or because of its purity and production method, each has the name of the commodity.
Although the names are different, they all refer to this 1 - Fluoro - 4 - Isocyanatobenzene. When chemists study, they can understand their synonymous names and commodity names, so as not to confuse them, accurately explore their properties and uses, so as to promote chemical development and benefit industry and scientific research.

Safety & Operational Standards

1 - Fluoro - 4 - Isocyanatobenzene is an important chemical substance, which is crucial to its safety and operation standards.
This substance is dangerous to a certain extent, and the following procedures must be strictly followed when operating. First, operate in a well-ventilated place. Because it may evaporate harmful gases, good ventilation can disperse in time to avoid the operator's inhalation and cause physical damage. As the ancients said: "If you live in a township, you will be a tourist." The choice of operating environment is related to personal safety and should not be careless.
Second, the operator must wear appropriate protective equipment. Such as gas masks, protective gloves and protective clothing. Such equipment can effectively block the contact of substances with the human body and provide comprehensive protection. Just as in ancient times, when soldiers went into battle, they could protect themselves well with their armor.
Furthermore, storage is also exquisite. It should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. This is because the substance may react violently with oxidants, and it is more likely to cause danger in case of fire. As the ancients warned: "There is no kindness in a sudden salary, and it is more likely to be a guest if you are overwhelmed." Before prevention, Fang Security is safe.
During operation, if you accidentally touch the skin or eyes, rinse with plenty of water immediately and seek medical attention in time. In case of leakage, quickly evacuate unrelated personnel, isolate the contaminated area, wear self-contained breathing apparatus, wear anti-acid and alkali work clothes, do not let the leakage come into contact with combustible substances, contain the leakage with suitable materials, and deal with it according to relevant regulations.
In short, treat 1 - Fluoro - 4 - Isocyanatobenzene with caution, and strictly abide by safety and operating standards to ensure personnel safety and stable production.

Application Area

1 - Fluoro - 4 - Isocyanatobenzene is also an organic compound. Its application field is quite wide, and it can be used as a monomer of special polymers in materials science. Based on this, the polymerized polymer material has unique physical and chemical properties, such as excellent heat resistance and mechanical properties, which can be used in aerospace equipment, so that its components can withstand harsh environments.
In the field of medicinal chemistry, this compound is also useful. Due to its special structure, it can be used as a key intermediate to help synthesize drug molecules with specific biological activities, or it can provide a new way to overcome difficult diseases.
In the field of organic synthetic chemistry, 1 - Fluoro - 4 - Isocyanatobenzene is an important synthetic building block, which can participate in a variety of chemical reactions and construct complex organic molecular structures, contributing to the development of organic synthetic chemistry.

Research & Development

In recent years, I have dedicated myself to the research of 1 - Fluoro - 4 - Isocyanatobenzene. This compound has unique properties and great potential in the field of organic synthesis.
Initial investigation of its structure, detailed analysis by spectroscopy, showed that its atomic arrangement is linked to chemical bonds. After re-studying its reaction characteristics, after many attempts, a variety of synthesis paths have been obtained. However, the optimization process is difficult, and the yield and purity need to be refined.
During the experiment, observe its interaction with various reagents to explore the best reaction conditions. Or adjust the temperature, or control the pressure, or more solvents, and strive for the best.
After months of research, there is a slight success. The synthesis method is gradually perfected, and the yield can be improved. However, if we want to use it widely, we still need to go deeper. The follow-up research should be applied to materials science and drug research and development, hoping to open up new horizons and seek a wider world for the development of this compound.

Toxicity Research

1 - Fluoro - 4 - Isocyanatobenzene is also a chemical substance. We need to be cautious about toxicity studies.
Looking at this substance, its molecular structure is unique, but the isocyanate group it contains is often potentially toxic. Past studies of many compounds with similar structures have shown that isocyanates can easily irritate the respiratory tract, or even damage the function of the lungs and organs.
1 - Fluoro - 4 - Isocyanatobenzene is also the same, the presence of fluorine atoms may affect its metabolic pathway and toxicity in organisms. Although there is no detailed toxicity data, its potential harm should not be ignored according to chemical principles and the nature of similar substances. In order to clarify its toxicity, rigorous experiments should be conducted to investigate its effects on various systems of the organism, so as to determine its degree of toxicity and provide solid evidence for protection and application.

Future Prospects

Today there is a thing, named 1 - Fluoro - 4 - Isocyanatobenzene. This chemical thing, in our research and development path, really has an unlimited future prospect.
Looking at its properties, it is unique and very, or it can be exposed in various fields. The field of chemical industry can be used as raw materials, to generate new qualities, and to contribute to the progress of industry. The road of medicine may have a miraculous effect, assisting in the research of new drugs and relieving the pain of sentient beings.
Although what we know now is still limited, I firmly believe that with time, we will be able to understand its secrets. The people who study and seek should work together to explore its subtlety. In the future, it will be able to shine brightly in the rise of science and technology and the goodness of life, opening up endless possibilities for future generations, achieving unfinished business, and developing an infinite future.

Where to Buy 1-Fluoro-4-Isocyanatobenzene in China?

As a trusted 1-Fluoro-4-Isocyanatobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Fluoro-4-Isocyanatobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemistry of 1-Fluoro-4-Isocyanatobenzene?

1-Fluoro-4-isocyanate benzene is one of the organic compounds. It is active and has unique chemical characteristics.
In this compound, the fluorine atom has strong electronegativity, which causes the density of its ortho-electron cloud to change, which affects the molecular reactivity. And isocyanate (-NCO) is also an active group, which can react with many compounds containing active hydrogen.
First, when it meets with alcohols, it can undergo alcoholysis reaction and raw urethane products. This reaction is often used in organic synthesis to construct a specific structure. If co-placed with ethanol, through temperature and pressure, the corresponding urethane derivative can be obtained, during which the nitrogen atom of the isocyanate is combined with the hydrogen atom of the alcohol hydroxyl group, and the carbon-oxygen double bond is connected to the alkoxy group of the alcohol.
Second, when exposed to water, 1-fluoro-4-isocyanate benzene also hydrolyzes, and the isocyanate first interacts with water to form an amine group and carbon dioxide. During this process, the molecular structure is broken and gradually decomposed. Due to hydrolysis, it is necessary to avoid water when storing.
Furthermore, it can be nucleophilic addition with amine compounds, and nitrogen atoms attack the nucleophilic attack of the carbon atom of isocyanate to form ureas. This reaction is commonly used in the preparation of drugs or polymer materials containing urea structures.
In addition, 1-fluoro-4-isocyanate synphenyl contains fluorine atoms, and its fat solubility may be increased, which may have special effects in some systems that require specific solubility. And due to the synergistic effect of fluorine atoms and isocyanate, its reaction selectivity is also special. Organic synthesizers often use this property to produce target products, and conditions can be used to adjust the reaction to progress in the desired direction.

What are the main uses of 1-Fluoro-4-Isocyanatobenzene?

1-Fluoro-4-isocyanate benzene is an important chemical substance in organic synthesis. It has a wide range of uses and plays a significant role in many fields.
First, in the field of polymer material synthesis, this substance can be used as a key monomer. By reacting with compounds containing active hydrogen, such as polyols, polymers with unique properties can be prepared. For example, by reacting with polyether polyols, fluorine-containing polyurethane can be formed. The introduction of fluorine-containing groups imparts many excellent properties to the polyurethane, such as good chemical resistance, low surface energy, and excellent weather resistance. These properties make such polyurethane materials widely used in coatings, adhesives, etc. In coatings, it can enhance the resistance of the coating to harsh environments and prolong the service life; in the field of adhesives, it can improve its adhesion to different substrates, and improve water resistance and solvent resistance.
Second, in the field of pharmaceutical chemistry, 1-fluoro-4-isocyanate benzene also has important uses. Because its isocyanate can specifically react with some active groups in the drug molecule, thereby realizing the modification and modification of the drug molecule. With this reaction, specific functional groups can be introduced to optimize the pharmacokinetic properties of the drug, such as improving the solubility and stability of the drug, or enhancing its affinity with the target, thereby enhancing the efficacy of the drug. For example, some anti-tumor drugs are structurally modified to make them easier to be taken up by tumor cells, enhance targeting, and reduce toxic and side effects on normal cells.
Third, in the field of organic synthetic chemistry, this compound can be used as an important synthetic intermediate. With its fluorine atom and isocyanate reactivity, it can participate in the construction of a variety of complex organic molecules. For example, through nucleophilic substitution or addition reactions with various nucleophiles, organic compounds with specific structures and functions are constructed, providing an effective way for the synthesis of new organic functional materials and total synthesis of natural products, and promoting the continuous development of organic synthetic chemistry.

What are 1-Fluoro-4-Isocyanatobenzene synthesis methods?

1-Fluoro-4-isocyanate benzene is an important intermediate in organic synthesis. There are many ways to synthesize it.
First, p-fluoroaniline is used as the starting material. First, p-fluoroaniline interacts with phosgene. In this step, although the toxicity of phosgene is strong, it can react smoothly under suitable conditions and protection. Phosgene and p-fluoroaniline undergo nucleophilic substitution and the amino group is converted into isocyanate to obtain 1-fluoro-4-isocyanate benzene. During the reaction, the temperature, pressure and the ratio of reactants need to be carefully adjusted to prevent side reactions from breeding and affecting the purity and yield of the product.
Second, p-fluorobenzoic acid is used as the starting material. The p-fluorobenzoic acid is first converted into its acyl chloride, which is often achieved by reagents such as sulfinyl chloride. The obtained acyl chloride is then reacted with urea, and through a specific reaction path, 1-fluoro-4-isocyanate benzene can be generated. In this process, the reaction conditions of each step also need to be precisely controlled, such as reaction temperature, reaction time, etc., in order to obtain a good synthesis effect.
There are also those who use p-fluorobenzamide as the raw material. Through the action of dehydrating agent, the amide is dehydrated, and then converted into 1-fluoro-4-isocyanate benzene. The choice of dehydrating agent is very critical, such as phosphorus pentoxide, etc. Different dehydrating agents have an impact on the reaction rate and product purity, and the pH of the reaction system needs to be properly adjusted.
All these synthesis methods have their own advantages and disadvantages. In actual synthesis, when considering factors such as the availability of raw materials, cost, and product requirements, choose the best one.

1-Fluoro-4-Isocyanatobenzene What are the precautions during storage and transportation?

1-Fluoro-4-isocyanate benzene is also an organic compound. When storing and transporting it, many matters need to be paid careful attention.
Bear the brunt, the storage place must be cool and dry. Because 1-fluoro-4-isocyanate benzene is afraid of moisture and is prone to change when heated. If it is in a humid place or in contact with water, it may cause a chemical reaction, causing it to deteriorate and damage its quality and utility. Heat may accelerate decomposition, and even pose a risk of safety.
Furthermore, it needs to be isolated from oxidants, acids, bases and other substances. When these substances meet with 1-fluoro-4-isocyanate benzene, they can easily trigger violent chemical reactions, or cause the risk of combustion and explosion. Therefore, when storing, it is necessary to ensure that different types of chemicals are stored in sections, and mixed storage is strictly prohibited.
When transporting, be extremely careful. The container used must be strong and well sealed to prevent leakage. Once leaked, 1-fluoro-4-isocyanate benzene volatilizes in the air, not only polluting the environment, but also endangering the health of surrounding people and animals. During handling, the operator should handle it with care and must not handle it brutally to avoid damage to the container.
In addition, whether it is stored or transported, the place should be equipped with complete fire and leakage emergency treatment equipment. In the event of an accident, it can be responded to in time to reduce the harm. And relevant personnel should be familiar with the characteristics and emergency treatment methods of 1-fluoro-4-isocyanate benzene to ensure safety.

1-Fluoro-4-Isocyanatobenzene impact on the environment and human health

1-Fluoro-4-isocyanate benzene, the effect of this substance on the environment and human health needs to be reviewed in detail.
At one end of the environment, it has a certain chemical activity. If it escapes into the atmosphere, it may chemically react with various substances in the atmosphere, affecting the chemical composition of the atmosphere. However, due to its volatile and reactive characteristics, it may not survive in the atmosphere for a long time. If it flows into the water body, it will pose a threat to the aquatic ecosystem due to its hydrophobicity or easy attachment to suspended particles. It may cause poisoning to aquatic organisms and interfere with their normal physiological functions, such as affecting respiration, feeding, reproduction, etc., and then destroy the balance of aquatic ecology. If this substance is contained in the soil, it may be adsorbed on soil particles, affecting the activity and community structure of soil microorganisms, and also has potential adverse effects on soil fertility and plant growth.
As for human health, 1-fluoro-4-isocyanate benzene is a stimulating substance. Inhalation through the respiratory tract can irritate the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties and other diseases, long-term exposure or increased risk of respiratory diseases. Skin contact, or cause allergic reactions such as skin allergies, redness, swelling, itching, etc., can cause skin burns in severe cases. If accidentally eaten, it will burn the digestive tract, causing vomiting, abdominal pain and other symptoms. And this substance may be potentially carcinogenic. Although the relevant research is not complete, the risk of cancer in long-term exposure may increase.
In summary, 1-fluoro-4-isocyanate benzene poses potential hazards to the environment and human health. In practical application and treatment, strict protection and control measures must be taken to reduce its negative effects.