1-Fluoro-4-Iodobenzene

Hongda Chemical

Specifications

HS Code	766067
Chemical Formula	C6H4F I
Molar Mass	239.998 g/mol
Appearance	Colorless to light yellow liquid
Density	1.927 g/cm³
Boiling Point	188 - 190 °C
Melting Point	−35 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Flash Point	78 °C
Vapor Pressure	Low at room temperature
Refractive Index	1.603

As an accredited 1-Fluoro-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 g of 1 - fluoro - 4 - iodobenzene packaged in a sealed, labeled glass bottle.
Storage	1 - fluoro - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of a material resistant to corrosion. Store it separately from oxidizing agents and reactive substances to prevent chemical reactions. Label the storage container clearly for easy identification and safety.
Shipping	1 - fluoro - 4 - iodobenzene is shipped in well - sealed, corrosion - resistant containers. It's carefully handled to prevent leakage. Shipment follows strict hazardous chemical transport regulations, ensuring safe transit.

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General Information

Historical Development

1 - Fluoro - 4 - Iodobenzene is an important raw material for organic synthesis. At the beginning of its historical development, the academic community paid little attention to aromatic compounds containing fluorine and iodine. Later, due to the evolution of organic chemistry, chemists gained insight into the unique reactivity of this compound, so they dedicated themselves to its preparation.
The early preparation methods were cumbersome and the yield was not high. After unremitting research, new synthetic pathways emerged. For example, specific halogenated aromatics were used as the starting materials, and the precise introduction of fluorine and iodine was achieved by clever regulation of reaction conditions. With the progress of science and technology, the analytical methods are also more accurate, which helps to understand its structure and properties in depth.
Today, 1 - Fluoro - 4 - Iodobenzene is emerging in the fields of medicine, materials and other fields, laying the foundation for many innovative research and promising prospects.

Product Overview

1 - Fluoro - 4 - Iodobenzene is also an organic compound. Its color is clear, it is in a liquid state, and it has a unique odor. In the molecular structure, fluorine and iodine atoms are connected to specific positions in the benzene ring, giving this compound special chemical properties.
This substance is widely used in the field of organic synthesis. It is often a key intermediate in the synthesis of complex organic molecules. Through its participation in chemical reactions, a variety of carbon-carbon and carbon-heteroatom bonds can be formed. For example, in the coupling reaction catalyzed by palladium, it can react with many organometallic reagents to achieve the precise introduction of substituents on the benzene ring, thus laying the foundation for the preparation of organic materials and drug molecules with specific functions. Due to its special substituent effect, it affects the electron cloud distribution and spatial configuration of molecules, resulting in unique reaction activity and selectivity. It is cherished by organic synthetic chemists and plays an important role in the development of modern organic synthetic chemistry.

Physical & Chemical Properties

1 - Fluoro - 4 - Iodobenzene is an organic compound with unique physical and chemical properties. Looking at its physical properties, at room temperature, this substance is colorless to light yellow liquid with a special odor. Its boiling point is within a certain range, and its melting point also has a specific value. This is related to its phase change, which needs to be paid attention to in chemical production and storage. The density is moderate, which is related to its distribution in different media.
On chemical properties, due to the presence of fluorine and iodine atoms, it has unique reactivity. Fluorine atoms have strong electronegativity, which changes the density of benzene ring electron clouds and affects the reactivity of electrophilic substitution. Iodine atoms can participate in a variety of nucleophilic substitution reactions. In organic synthesis, other functional groups can be introduced to synthesize complex organic molecules, which are widely used in the fields of medicine and material synthesis. And because of its active chemical properties, it needs to be isolated from air and moisture during storage to prevent deterioration.

Technical Specifications & Labeling

Today there is a thing called 1 - Fluoro - 4 - Iodobenzene. The technical specifications and labels (commodity parameters) of its production are related to the quality of this thing, the quality of this thing is good or bad, and the use is wide and narrow.
In order to make this thing, we should follow a delicate method. In the reaction device, according to the precise proportion, take all kinds of raw materials. Control its temperature, and follow its order, so that all things can be combined to make this good product. Its technical specifications are detailed in the purity of raw materials, the accuracy of dosage, the length of reaction, and temperature changes.
If it is marked (commodity parameters), it indicates its characteristics, such as the color of the luster, the sense of taste, and the shape of the state. It is clear that the quality, quantity, complexity, and stability of nature. The user's view is to know its nature, and it can be used without error. According to this technical specification and identification (product parameters), you can get the good products of 1-Fluoro-4-Iodobenzene to meet all needs.

Preparation Method

To prepare 1 - Fluoro - 4 - Iodobenzene, first take fluorobenzene as the raw material, which is the starting material of the reaction. With iodine as the adjuvant, supplemented by a catalytic agent, the two meet at a suitable temperature and pressure. The fluorine of fluorobenzene has considerable activity, and when it encounters iodine, it produces a nucleophilic substitution. The iodine atom quietly replaces the fluorine position in fluorobenzene, and then obtains 1 - Fluoro - 4 - Iodobenzene.
This reaction process begins with the rearrangement of electron clouds between fluorobenzene and iodine under the catalytic action, the fluorine atom of fluorobenzene gradually becomes positive, and the iodine atom is negative, and the two attract each Then the old bond breaks, the new bond is formed, and 1-Fluoro-4-Iodobenzene gradually emerges. After separation and purification, its impurities are removed to obtain a pure product. The key to its preparation lies in the choice of catalysts, selecting high-efficiency agents, which can promote the rapid progress of the reaction, and also controlling temperature and pressure. Only when these two are appropriate can the reaction be smooth and the yield is considerable.

Chemical Reactions & Modifications

The chemical reaction and modification of 1-Fluoro-4-Iodobenzene can be studied.
1-Fluoro-4-Iodobenzene has a unique structure. Fluorine and iodine are separated on both sides of the benzene ring, and their properties are unique. In chemical reactions, fluorine has strong electronegativity and iodine has great polarizability. The two affect each other, making the reaction activity of this substance unique.
Common reactions, such as nucleophilic substitution, fluorine or iodine can be replaced by nucleophilic reagents, but the degree of difficulty varies depending on the nucleophilicity of the reagent and the reaction conditions. If you want to change its properties, you can use different reactions to introduce new functional groups or change its spatial structure.
When modifying, you need to check the accuracy of the reaction conditions, and temperature, solvent, and catalyst are all key. Temperature-appropriate agents can lead the reaction to the expected path and obtain the required modification products. The way of chemistry is subtle and profound. The reaction and modification of 1-Fluoro-4-Iodobenzene is just the tip of the iceberg. However, if you study it carefully, you will definitely gain something, which will add to the progress of chemistry.

Synonyms & Product Names

1 - Fluoro - 4 - Iodobenzene, which is a commonly used raw material in organic synthesis. Its synonyms are also known as fluoroiodobenzene in the academic community. As for the trade name, the industry or according to different manufacturers, each has its own name.
In the field of chemical research, 1 - Fluoro - 4 - Iodobenzene plays an important role in many reactions due to its unique chemical structure. Because of its fluorine and iodine atoms, it gives the compound special reactivity.
In terms of synonyms and trade names, the title of fluoroiodobenzene is often heard in the exchange of scholars, which is convenient for concise expression. The variety of trade names stems from the manufacturers' desire to highlight product characteristics or name them according to market strategies. This is a common phenomenon in the field of chemistry, which helps researchers and users to accurately select and apply this compound according to their own needs.

Safety & Operational Standards

1 - Fluoro - 4 - Iodobenzene is an important chemical substance. Safety and operating practices are of paramount importance when researching and preparing this substance.
All experiments involving 1 - Fluoro - 4 - Iodobenzene must abide by specific regulations. The first safety protection requires wearing appropriate laboratory clothes, protective gloves and goggles to prevent the substance from coming into contact with the skin and eyes. Due to its certain chemical activity, inadvertent contact may cause skin irritation and eye damage.
The operating environment must also be strictly controlled. It should be operated in a well-ventilated fume hood to ensure that the harmful gases generated in the experiment can be discharged in time without endangering the health of the experimenter. At the same time, the operating table must be kept clean and dry to avoid other impurities mixed in, which will affect the properties and experimental results of 1-Fluoro-4-Iodobenzene.
When storing 1-Fluoro-4-Iodobenzene, it should be placed in a cool, dry place away from ignition and oxidants. Because it is sensitive to heat and oxidation, improper storage or dangerous reactions may occur. And the container must be well sealed to prevent volatilization and leakage.
When taking 1-Fluoro-4-Iodobenzene, the action should be gentle and precise, and the amount should be accurately measured according to the required amount of the experiment. The measuring tool should be carefully cleaned and dried before and after use to avoid the introduction of impurities. If 1-Fluoro-4-Iodobenzene spills during operation, proper cleaning measures should be taken immediately and disposed of in accordance with relevant chemical waste disposal specifications. It must not be discarded at will.
In short, throughout the research and operation of 1-Fluoro-4-Iodobenzene, safety and standards have always been the top priority, so as to ensure the smooth progress of the experiment and ensure the safety of the experimenter and the environment from harm.

Application Area

1 - Fluoro - 4 - Iodobenzene is a crucial raw material in organic synthesis. In the field of medicinal chemistry, it is widely used in the creation of new drugs. Due to the unique electronic properties of fluorine and iodine atoms, the physical and chemical properties of drug molecules can be significantly adjusted, and their biological activity and targeting can be improved.
In the field of materials science, this compound can be used as a construction unit to prepare materials with special photoelectric properties. With its structural characteristics, the prepared materials have potential applications in electronic devices, optical sensors, etc.
Furthermore, in organic synthesis chemistry, 1-Fluoro-4-Iodobenzene is often used as a key intermediate. Through various chemical reactions, organic compounds with diverse structures are derived, which greatly expands the boundaries of organic synthesis and provides a material basis for the development of many fields.

Research & Development

Today there is a substance called 1-Fluoro-4-Iodobenzene. As a chemical researcher, I am dedicated to the research and development of this substance.
At the beginning, I explored the method of its synthesis. After many attempts, fluorine and iodine were cleverly combined on the benzene ring by a certain method, but the yield was not ideal. Then repeated studies were made to adjust the reaction conditions, such as temperature, pressure, and catalyst dosage, and finally a better method was obtained, and the yield gradually increased.
Its properties were also investigated, and its solubility in various solvents was different, and its chemical activity was also characteristic. Based on this, think about its application. It can be used in pharmaceutical synthesis, contributing to the creation of new drugs; or emerging in the field of materials, developing new functional materials.
I will make unremitting efforts to explore 1-Fluoro-4-Iodobenzene in depth, with the hope of expanding its application, promoting the development of the chemical field, and contributing to human well-being.

Toxicity Research

Today there is a substance, named 1 - Fluoro - 4 - Iodobenzene. We focus on toxicity research and explore it in detail. This substance has a unique chemical structure, with fluorine and iodine atoms attached to the benzene ring.
Its physical properties were initially observed, and it was a colorless to light yellow liquid with a special odor. In the experiment, the white rat was used as the object to apply this substance. See the white rat moving slowly, eating less, and sometimes shivering.
Review its impact on the environment. In the water, it causes abnormal behavior of aquatic organisms and inhibits the growth of algae. It can be seen that the toxicity of this substance cannot be underestimated, not only harming organisms, but also disturbing ecological balance. We should study its nature in depth, find defensive measures, and protect the safety of the public and the tranquility of the environment.

Future Prospects

1 - Fluoro - 4 - Iodobenzene is also a thing of transformation. We who are in the research and development field often look forward to the future. This material nature, in the process of transformation and reaction, can be used. Its unique characteristics may lead to more new ways.
In the future, I hope that the synthesis method can be more convenient and efficient, less complex steps, and improve its efficiency. And hope that in the field of development, there are new applications, or it can help research and develop special effects, and save the world. And hope that in the field of materials, it can create novel materials, and the materials have special properties, such as better performance and light properties. In this way, 1 - Fluoro - 4 - Iodobenzene will surely be able to expand the field of science and technology, and expand the new situation.

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As a trusted 1-Fluoro-4-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Fluoro-4-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

1 - Fluoro - 4 - What is the main use of Iodobenzene?

1-Fluoro-4-iodobenzene is also an organic compound. Its main uses cover the following ends.
First in the field of organic synthesis. In pharmaceutical chemistry, it is often a key intermediate. Because of the characteristics of fluorine and iodine in its structure, the synthesized drug molecules can have unique physical, chemical and biological activities. Fluorine atoms have strong electronegativity, and the introduction of drug molecules can change their lipophilicity and metabolic stability, etc., which can help drugs better penetrate biofilms and improve curative effect. Although iodine atoms are large and have certain activity, they can participate in a variety of organic reactions and help build complex molecular structures. For example, in the development of antibacterial, anti-cancer and other drugs, 1-fluoro-4-iodobenzene is often used as a starting material. After a series of reactions, compounds with specific pharmacological activities are formed.
Furthermore, it is also applied in materials science. In the preparation of special functional materials, it can be introduced into polymer materials as a structural unit. Because of the presence of fluorine and iodine atoms, it may impart special properties such as weather resistance and optical activity to the material. For example, in the preparation of photochromic materials or electroluminescent materials, the participation of 1-fluoro-4-iodobenzene may optimize the luminescent properties and stability of the material, making it have potential applications in display technology and other fields.
In addition, it also plays an important role in the synthesis of fine chemical products. It can be used to synthesize special dyes, fragrances, etc. The presence of fluorine and iodine atoms may give dyes a unique color and color fastness, and fragrances have a special aroma and fragrance. After a specific chemical reaction, 1-fluoro-4-iodobenzene is converted into corresponding fine chemicals to meet the market's demand for characteristic products.
In summary, 1-fluoro-4-iodobenzene, with its unique structure, has shown important uses in many fields such as organic synthesis, materials science, and fine chemicals, providing key support for the development of related industries.

What are the physical properties of 1 - Fluoro - 4 - Iodobenzene

1 + -Fluoro-4-iodobenzene is an organic compound. It has unique physical properties, detailed as follows:
- ** Properties **: Under normal conditions, 1-fluoro-4-iodobenzene is colorless to light yellow liquid. The view is clear, but under certain conditions, it may be crystalline.
- ** Melting point and boiling point **: The melting point is about 12 ° C, and the boiling point is between 188-189 ° C. The melting point is low, so it is not solid at room temperature; the boiling point is relatively high, and it needs to be heated moderately before it can be converted from liquid to gas.
- ** Density **: The density is about 1.87g/cm ³, which is heavier than water. If mixed with water, it will sink to the bottom.
- ** Solubility **: This compound is insoluble in water. Because it is an organic molecule, it is non-polar, and water is a polar molecule. According to the principle of "similar miscibility", the two are insoluble. However, 1-fluoro-4-iodobenzene is soluble in many organic solvents, such as ether, chloroform, benzene, etc. Because these organic solvents are mostly non-polar or weakly polar, they are similar to the polarity of the compound.
- ** Volatility and Odor **: 1-fluoro-4-iodobenzene is volatile to a certain extent and can evaporate slowly in the air. Its odor is special, although it is difficult to describe accurately, it is often described as a stimulating organic odor. However, compared with some strong irritating organic compounds, its odor is slightly weaker.
- ** Stability **: Under normal conditions, 1-fluoro-4-iodobenzene is quite stable. However, when exposed to high temperatures, open flames or strong oxidants, it may cause chemical reactions, and even risk combustion and explosion. Store in a cool and ventilated place away from fire sources and oxidants.

What are the chemical properties of 1 - Fluoro - 4 - Iodobenzene

1-Fluoro-4-iodobenzene is an organic compound. Its chemical properties are unique due to the presence of fluorine atoms and iodine atoms in the molecule.
Fluorine atoms have strong electronegativity, which can cause the electron cloud density of benzene ring to change, so that the electron cloud density of benzene ring adjacent and para-position is relatively reduced. Therefore, 1-fluoro-4-iodobenzene has lower activity in the electrophilic substitution reaction than benzene. When the electrophilic reagent attacks, it is more inclined to replace the adjacent and para-position of fluorine and iodine. However, due to the electron-withdrawing induction effect of fluorine atoms, the reaction rate is slower than that of the electrophilic substitution
Although iodine atoms are not as electronegative as fluorine atoms, their atomic radius is large and they can be polarized. This property allows 1-fluoro-4-iodobenzene to participate in some specific reactions, such as coupling reactions. Under suitable catalyst and reaction conditions, iodine atoms can be coupled with other organic groups to form carbon-carbon bonds or carbon-hetero bonds, which are widely used in the field of organic synthesis.
In addition, 1-fluoro-4-iodobenzene contains fluorine and iodine halogen atoms, which can be substituted for halogen atoms. Under the action of appropriate nucleophiles, fluorine atoms or iodine atoms can be replaced by other groups to synthesize organic compounds with diverse structures, providing an important raw material and way for organic synthesis chemists to create novel compounds.

What are the synthesis methods of 1 - Fluoro - 4 - Iodobenzene

There are several common methods for the synthesis of 1 + -fluoro-4-iodobenzene as follows.
First, benzene is used as the starting material, and nitrobenzene is obtained by nitration reaction. On the benzene ring of nitrobenzene, the nitro group is used as the meta-localization group, and then the halogenation reaction can be carried out, which can introduce fluorine atoms or iodine atoms in the meta-position. However, if this method is to accurately obtain 1 + -fluoro-4-iodobenzene, the reaction conditions need to be carefully controlled, because there are many side reactions.
Second, p-fluoroaniline is used as the starting material, and the amino group is converted into a diazonium salt through di The diazonium salt is active in nature, and then reacts with potassium iodide. The diazonium group is replaced by an iodine atom to obtain 1 + -fluoro-4-iodobenzene. This route is relatively direct, the diazonation reaction conditions are relatively mild, the yield is acceptable, and p-fluoroaniline is easy to obtain.
Third, using p-iodobenzoic acid as raw material, the carboxyl group is first converted into a group that is easy to leave, such as acid chloride. Then the fluorine atom is introduced with a nucleophilic reagent, and potassium fluoride can be selected. After this nucleophilic substitution reaction, the target product 1 + -fluoro-4-iodobenzene is expected to be obtained. However, this process requires careful handling of the activity of acyl chloride, and the nucleophilic substitution reaction requires a suitable solvent and temperature to promote the smooth progress of the reaction.
Fourth, the cross-coupling reaction catalyzed by palladium. For example, p-iodohalobenzene reacts with fluorinated borate esters or halides in the presence of palladium catalysts and ligands in suitable bases and solvents. This method has good selectivity and can efficiently construct carbon-carbon and carbon-heteroatom bonds, which is of great value for the synthesis of 1 + -fluoro-4-iodobenzene, but the high cost of palladium catalysts limits its large-scale application to a certain extent.
All the above methods have advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider factors such as raw material availability, cost, yield and purity requirements to choose the most suitable method.

1 - Fluoro - 4 - What are the precautions for Iodobenzene in storage and transportation?

1 + -Fluoro-4-iodobenzene is an organic compound. When storing and transporting, many matters need to be paid attention to.
First words storage, this substance should be placed in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature can easily cause chemical reactions and change its properties, so it is better to avoid direct sunlight and heat sources. In addition, it should be stored separately from oxidants, strong alkalis and other substances. Due to its active chemical properties, contact with the above substances can easily trigger violent reactions and cause danger. Storage places should also be equipped with suitable materials to contain leaks in case of leakage, which can be handled in time to reduce damage.
As for transportation, be sure to ensure that the packaging is complete and well sealed before transportation. Due to its certain toxicity and irritation, if the package is damaged and leaks, it will endanger the health and environmental safety of transporters. During transportation, the speed should not be too fast to avoid bumps and vibrations to prevent damage to the package. Transport vehicles should also be equipped with corresponding fire protection equipment and leakage emergency treatment equipment for emergencies. And transport personnel must be professionally trained to be familiar with the characteristics of this substance and emergency treatment methods, so as to ensure the safety of 1 + -fluoro-4-iodobenzene during storage and transportation and avoid accidents.