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1-Fluoro-4-Iodo-3-Nitrobenzene

1-Fluoro-4-Iodo-3-Nitrobenzene

Hongda Chemical

Specifications

HS Code

587314

Chemical Formula C6H3FINO2
Molar Mass 267.00 g/mol
Appearance Solid (likely a yellow - colored solid due to nitro group)
Melting Point Data needed from literature
Boiling Point Data needed from literature
Density Data needed from literature
Solubility In Water Insoluble (aromatic nitro - halo compounds are generally insoluble in water)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Flash Point Data needed from literature
Hazard Class May be harmful if swallowed, inhaled or in contact with skin; potential irritant

As an accredited 1-Fluoro-4-Iodo-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - fluoro - 4 - iodo - 3 - nitrobenzene packaged in a sealed glass bottle.
Storage 1 - Fluoro - 4 - iodo - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent exposure to air and moisture. Store it separately from incompatible substances like oxidizing agents, reducing agents, and bases to avoid potential chemical reactions.
Shipping 1 - fluoro - 4 - iodo - 3 - nitrobenzene is shipped in properly sealed, corrosion - resistant containers. It's labeled clearly with hazard warnings. Shipment follows strict regulations for hazardous chemicals, ensuring safe transport.
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1-Fluoro-4-Iodo-3-Nitrobenzene 1-Fluoro-4-Iodo-3-Nitrobenzene
General Information
Historical Development
1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene is an important compound in the field of organic synthesis. Looking back in the past, the research and development process of this compound is of great significance.
At the beginning, the scientific community began to explore halogenated nitrobenzene compounds, and many scholars participated in it. At that time, the synthesis method was still simple and the yield was not satisfactory.
With the passage of time, the chemical skills became more and more exquisite. Researchers worked tirelessly to improve the synthesis path, making the synthesis of 1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene more efficient. The optimization of reaction conditions and the application of new catalysts have all contributed to the development of this compound.
Today, 1-Fluoro-4-Iodo-3-Nitrobenzene has emerged in many fields such as medicine and materials science. Its historical development has witnessed the vigorous progress of chemistry, and it is expected to open up a wider application field in the future.
Product Overview
1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene is a unique chemical substance. It has a unique molecular structure, with fluorine, iodine, nitro and other functional groups cleverly connected to the benzene ring.
The properties of this compound are determined by its structure. Fluorine atoms have high electronegativity, which can affect the electron cloud distribution of molecules, resulting in their unique chemical activity. Although iodine atoms have a large atomic radius, they also play an important role in the reaction. The existence of nitro groups gives them specific chemical properties. For example, in reactions such as nucleophilic substitution, nitro can activate benzene rings, making the reaction more prone to occur.
During synthesis, the reaction conditions, such as temperature, solvent, catalyst, etc., need to be carefully regulated. Accurately grasping various factors can effectively obtain this compound and improve its yield and purity. It can be used as a key intermediate in the field of organic synthesis to build more complex organic molecular structures, with potential application value, and may play an important role in drug development, materials science, and other fields.
Physical & Chemical Properties
1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene is an organic compound. Its physical properties are mostly solid at room temperature, with a specific melting point. Due to intermolecular forces, the melting point value is within a certain range. Appearance may be crystalline, color may be white or slightly yellowish.
In terms of chemical properties, fluorine atoms change the electron cloud density of benzene ring, resulting in its adjacent para-position electrophilic substitution activity different from benzene. Nitro strongly absorbs electrons, which greatly reduces the electron cloud density of benzene ring. Electrophilic substitution is difficult, but nucleophilic substitution is easy. Iodine atoms can participate in a variety of nucleophilic substitution reactions, because carbon-iodine bonds are relatively active. It is widely used in the field of organic synthesis, and can introduce various functional groups through nucleophilic substitution, laying the foundation for the construction of complex organic molecules.
Technical Specifications & Labeling
1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene is also a chemical substance. Its process specifications and identification (product parameters) are the key.
In terms of process specifications, the preparation method needs to be rigorous. The selection of raw materials must be pure, and the reaction conditions such as temperature, pressure, catalyst, etc. must be precisely controlled. If the temperature is too high or too low, the reaction may be biased and the product is impure. The same is true for pressure. Improper pressure affects the reaction rate and yield. The amount of catalyst is also related to the reaction process, and the amount should not be appropriate.
As for the identification (product parameters), its chemical structure should be clearly marked to help identify its essence. Purity is crucial, and high purity shows quality. Physical parameters such as melting point and boiling point also need to be detailed to provide a basis for application. In this way, this product can be properly applied in chemical research and industrial production and play its due role.
Preparation Method
1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene is an important compound in organic synthesis, and its preparation method is crucial.
Raw materials and production process:
The starting material can be selected from specific nitrobenzene derivatives, and fluorine and iodine atoms are introduced through halogenation reaction. First, the nitrobenzene derivative undergoes a nucleophilic substitution reaction under specific reaction conditions with a fluorine-containing reagent, and fluorine atoms are introduced. Subsequently, the reaction system is replaced, and a suitable iodine-containing reagent is used. After similar nucleophilic substitution, iodine atoms are introduced. The whole process requires precise control of the reaction temperature, time and reagent dosage.
Reaction steps:
In the first step, the nitrobenzene derivative and the fluorine-containing reagent are placed in a reaction kettle in a specific ratio, an appropriate amount of catalyst is added, and the reaction is reacted under heating and stirring for several hours. This step requires close monitoring of the reaction process, and the completion of the fluorination reaction is confirmed by chromatographic analysis and other means. In the second step, after treating the reaction product, an iodine-containing reagent is added, and the reaction conditions are adjusted to rereact again. When the reaction is sufficient, the product is separated and purified by extraction, distillation and other means.
Activation mechanism: The strong electron-absorbing effect of the nitro group decreases the electron cloud density of the benzene ring, which is conducive to In the process of introducing fluorine and iodine atoms, the nitro group plays a significant role in locating the reaction check point, guiding the halogen atom to replace at a specific position, thus realizing the efficient preparation of 1-Fluoro-4-Iodo-3-Nitrobenzene.
Chemical Reactions & Modifications
1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene is also an organic compound. Its chemical reaction and modification are the top priority of our chemical research.
Looking at this compound, fluorine, iodine and nitro are connected to the benzene ring. Fluorine atoms have electron-absorbing properties, which can affect the electron cloud density of the benzene ring, reduce the electron cloud density of the adjacent and para-position, and change the activity of electrophilic substitution reactions. Although iodine atoms are large in size, they can be introduced through specific reactions to expand the reaction path of the compound. Nitro is a strong electron-absorbing group, which greatly reduces the electron cloud density of the benzene ring, giving the compound unique properties in reactions such as nucleophilic substitution.
To modify this compound, the fluorine atom can be replaced by a suitable nucleophilic reagent by a nucleophilic substitution reaction, and its substituent group can be changed, or its electronic structure and reactivity can be adjusted by reducing the nitro group. This is all for exploring the path of its chemical change and performance optimization, and has potential important applications in the fields of organic synthesis and material research and development.
Synonyms & Product Names
1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene is also a chemical product. The same trade name is important for my research.
The husband is the same, so help us understand the properties of this compound. For example, the chemical industry may be named because of its characteristics, so that researchers can express it differently. As for the trade name, it is the name used for business and circulation. Merchants often take the name of the special.
We need to understand the same trade name in our research, so that we can check the text, business and other things. Not because of the name, but not the same thing. In this way, in the research and application of chemistry, we can use 1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene to explore in a general way.
Safety & Operational Standards
1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene is an important chemical and needs to be clarified in detail in terms of its safety and operating practices.
This chemical is dangerous. When storing, it must be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Do not mix with oxidizing agents, reducing agents, etc. to prevent dangerous chemical reactions.
When operating, operators must strictly follow the specifications. Appropriate protective clothing, protective gloves and goggles are required to prevent contact with skin and eyes. If working in a poorly ventilated area, effective ventilation equipment must be equipped to avoid inhalation of harmful gases.
If you accidentally come into contact with this chemical and splash it on the skin, you should immediately rinse it with a large amount of flowing water for at least 15 minutes, and then seek medical treatment. If it splashes into the eyes, you should also immediately lift the eyelids, rinse it with flowing water or normal saline, and seek medical attention quickly.
During transportation, ensure that the container is sealed to prevent leakage. Choose the appropriate means of transportation and follow the relevant transportation regulations to ensure the safety of transportation.
In short, the safety and operation regulations for 1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene need to be treated with caution and strictly followed by all parties, so as to ensure that the safety of personnel and the environment are not endangered and avoid accidents.
Application Area
1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene is a unique chemical substance with a wide range of application fields. In the field of pharmaceutical research and development, this substance can be used as a key intermediate to help synthesize specific drugs or have significant effects on the treatment of specific diseases. In the field of materials science, its unique chemical structure may endow materials with novel properties, such as improving the stability and conductivity of materials, providing opportunities for the creation of new materials. And in the fine chemical industry, with its characteristics, it can participate in the preparation of a variety of fine chemicals to optimize product quality and performance. Looking back on the past, the application of chemical substances continues to expand, and this 1-Fluoro-4-Iodo-3-Nitrobenzene will also emerge in more fields with in-depth research, making extraordinary contributions to human life and technological progress.
Research & Development
In recent years, Yu has dedicated himself to the research of organic compound 1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene. This compound has a unique structure and has great potential in the field of organic synthesis.
Initially, its synthesis path was explored, and many problems were encountered after repeated experiments. The ratio of raw materials and the control of reaction conditions all need to be fine-tuned. After repeated attempts, a better synthesis method was finally obtained, and the yield gradually increased.
In the study, its reaction characteristics were also concerned. It was found that under specific conditions, it can selectively react with a variety of reagents, providing the possibility for the derivation of new compounds.
Looking to the future, we hope to use this compound to develop more high-value-added products and expand its application in medicine, materials and other fields. Continue to optimize the synthesis process, reduce costs and increase efficiency, and promote its industrialization process to promote the development of organic chemistry.
Toxicity Research
Recently, the toxicity of 1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene was studied. This substance contains fluoride, iodine, and nitro groups, and its properties may be strong. After various experiments, its effects on various substances were observed. Take white mice as a test, and feed them food containing this substance. Not long after, the white mice gradually withered, their diet was sluggish, and their fur color was dry, showing its harm. And flowers and plants were planted in the soil containing this substance, and the vitality of flowers and plants suddenly decreased, and the leaves gradually wilted. From this point of view, 1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene is highly toxic, which is very harmful to the growth and development of organisms. When using it in the future, one must be cautious and study its prevention methods in detail, so as not to leave behind disasters and endanger the surrounding environment.
Future Prospects
1 - Fluoro - 4 - Iodo - 3 - Nitrobenzene is also an organic compound. Looking at its structure, fluorine, iodine, nitro are combined with benzene ring, which is very unique.
My generation will study in the future, hoping to gain something new. First, I want to explore its reaction characteristics, and find out under what conditions it can combine with other things smoothly to create new substances, which can be used in medicine and materials. Second, I hope to study its synthesis method carefully, seeking a simpler and purer way, reducing costs and improving benefits. Third, study its impact on the environment and human body, and ensure its safe and good use.
Although the road ahead is long, with enthusiasm and perseverance, our generation will be able to explore new frontiers and open new chapters in the research of 1-Fluoro-4-Iodo-3-Nitrobenzene, and contribute to the progress of science, waiting for the future.
Where to Buy 1-Fluoro-4-Iodo-3-Nitrobenzene in China?
As a trusted 1-Fluoro-4-Iodo-3-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Fluoro-4-Iodo-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-4-Iodo-3-Nitrobenzene?
1-Fluoro-4-iodine-3-nitrobenzene is a crucial chemical substance in the field of organic synthesis. It has a wide range of uses, first in the field of medicinal chemistry. The structure of fluorine, iodine and nitro groups can endow compounds with unique biological activities and pharmacological properties. For example, when developing new antibacterial and anticancer drugs, this substance is often a key intermediate. Through ingenious chemical reactions, specific groups are introduced to construct drug molecular structures with targeting and high efficiency.
Furthermore, in the field of materials science, 1-fluoro-4-iodine-3-nitrobenzene also has important applications. Due to its special functional groups, it can participate in the synthesis of functional polymer materials. For example, in the synthesis of optoelectronic materials, fluorine atoms in the structure can adjust the electron cloud distribution of the material and affect the photoelectric properties of the material; iodine atoms and nitro groups can cooperate to optimize the charge transport properties of the material, thus laying the foundation for the preparation of high-performance organic Light Emitting Diodes, solar cells and other materials.
In addition, 1-fluoro-4-iodine-3-nitrobenzene also plays an important role in the study of the reaction mechanism of organic synthesis chemistry. Because it contains many different active functional groups, various reactions such as nucleophilic substitution and electrophilic substitution can occur. By studying the reaction process, scholars can further explore the mechanism of various reactions, providing theoretical support and practical experience for the development of organic synthesis methodologies. In short, 1-fluoro-4-iodine-3-nitrobenzene has important uses in many fields that cannot be ignored.
What are the physical properties of 1-Fluoro-4-Iodo-3-Nitrobenzene?
1-Fluoro-4-iodine-3-nitrobenzene is a kind of organic compound. Its physical properties are worth exploring.
First of all, its appearance, at room temperature, is mostly solid, usually white to light yellow crystalline powder. The appearance of this color state is related to the arrangement of atoms in its molecular structure and the distribution of electron clouds.
As for the melting point, it is within a certain range. Due to the force between molecules, molecules attract each other, and a specific energy is required to disintegrate their lattice structure, causing it to change from solid to liquid. The temperature corresponding to this energy is the melting point.
Its solubility is also characteristic. In organic solvents, such as some common polar organic solvents, it has a certain solubility. Due to the principle of similarity and miscibility, the compound molecule has a certain polarity and can form interactions such as hydrogen bonds and van der Waals forces with polar organic solvent molecules, so it is soluble. However, in water, the solubility is relatively small, and the polarity of its molecules is not enough to form a strong interaction with water molecules, and structures such as benzene rings are hydrophobic, which hinders their dispersion in water.
Its density is also an important physical property. Because the type and number of atoms in the molecule are determined, the sum of atomic weights is certain, and the molecular stacking method is relatively fixed, it has a specific density value. This density is one of the key factors to consider in the process of chemical operation, separation and purification.
The physical properties of 1-fluoro-4-iodine-3-nitrobenzene are of great significance in the fields of organic synthesis and chemical production. The setting of many reaction conditions and the selection of product separation methods need to be based on the accurate grasp of their physical properties.
1-Fluoro-4-Iodo-3-Nitrobenzene chemical synthesis methods
There are various methods for the synthesis of 1-fluoro-4-iodine-3-nitrobenzene. First, nitrobenzene can be started. First, nitrobenzene is halogenated, and fluorine atoms are introduced with a specific halogenated reagent at a suitable temperature, pressure and catalyst to obtain fluorine-containing nitrobenzene. This process requires precise temperature control, pressure and reagent dosage, otherwise the product is impure. Then, through iodine substitution reaction, suitable iodine substitution reagents are selected, such as iodine elemental substance combined with a specific oxidant. Under appropriate reaction conditions, iodine atoms are introduced at a specific position in the benzene ring to obtain 1-fluoro-4-iodine-3-nitrobenzene.
Second, fluorobenzene is used as raw material. First, fluorobenzene is nitrified, and nitrifying reagents, such as mixed acid (concentrated sulfuric acid mixed with concentrated nitric acid), are used to introduce nitro groups into the benzene ring under suitable reaction conditions to obtain fluorinated nitrobenzene. Then the product is iodized. According to the above iodization reaction method, iodine atoms are successfully introduced to complete the synthesis of 1-fluoro-4-iodine-3-nitrobenzene.
Third, iodobenzene can also be used as the starting material. Nitro groups are introduced through nitrification reaction first, and then fluorine atoms are introduced through fluorination reaction. The target product 1-fluoro-4-iodine-3-nitrobenzene can be obtained by selecting high-efficiency fluorinated reagents and paying attention to the reaction conditions. All synthesis methods have their own advantages and disadvantages, and the appropriate synthesis path should be carefully selected according to the actual demand, raw material availability, cost and other factors.
What 1-Fluoro-4-Iodo-3-Nitrobenzene need to pay attention to when storing and transporting
1-Fluoro-4-iodine-3-nitrobenzene is also an organic compound. When storing and transporting it, all matters must be paid attention to.
First words storage, this compound is active or active, and it should be placed in a cool, dry and well-ventilated place. Because of heat or moisture, it is easy to cause chemical changes, damage the quality, or even cause danger. Therefore, the storage place, the temperature should be controlled in the appropriate range, and the humidity should not be too high.
In addition, this compound may be toxic and irritating, and it should be stored away from food, beverages and daily necessities to prevent inadvertent contact or ingestion. At the same time, it must be stored separately from oxidizing agents, reducing agents, etc. Due to its mixing with them, or triggering violent chemical reactions, the risk of ignition and explosion increases sharply.
As for transportation, tight packaging is essential. Suitable packaging materials must be used to ensure that there is no leakage during transportation. Transportation vehicles must also be clean, dry, and free of other substances that may react with them. During transportation, avoid high temperatures, open flames and severe vibrations to avoid safety accidents. Escort personnel should also be familiar with the properties of this compound and emergency treatment methods to prepare for emergencies.
In conclusion, the storage and transportation of 1-fluoro-4-iodine-3-nitrobenzene requires strict compliance with regulations and careful handling according to its chemical characteristics to ensure safety.
What is the market price of 1-Fluoro-4-Iodo-3-Nitrobenzene?
The market price of 1-fluoro-4-iodine-3-nitrobenzene is difficult to say exactly. Because the market situation is unpredictable, its price often changes due to various factors.
Looking at the trading conditions of chemical materials in the past, the abundance of raw materials has a great impact on their prices. If fluorine, iodine, nitro and other related raw materials are abundant, easy to mine and low cost, the production cost of 1-fluoro-4-iodine-3-nitrobenzene may be reduced, and its market price may also be reduced. Conversely, if raw materials are scarce, difficult to obtain, and costs soar, the price of this compound will rise.
Furthermore, the quality of the production process is also related to the price. Exquisite and advanced technology can improve output efficiency, reduce energy consumption and waste, thereby lowering unit costs and making prices more competitive. If the process is crude, inefficient, and the cost is high, the price will be higher.
The amount of market demand also determines the price. For example, in the fields of medicine and electronics, the demand for 1-fluoro-4-iodine-3-nitrobenzene is strong, and the supply is in short supply, so the price must be high; if the demand is low and the supply exceeds the demand, the merchant may reduce the price in order to destock.
There is market competition. When there are many merchants producing this compound in the market, the competition is fierce, and each merchant is competing for a share, or the price may be used as a weapon, resulting in a downward price. If the market is almost monopolized and only a few merchants control the supply, they can dominate the price.
Overall consideration, the price may fluctuate between tens of yuan and hundreds of yuan per gram, but this is only a rough guess. The actual price must be determined according to the current market conditions.