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1-Fluoro-4-Iodo-2-Nitrobenzene

1-Fluoro-4-Iodo-2-Nitrobenzene

Hongda Chemical

Specifications

HS Code

243177

Chemical Formula C6H3FINO2
Molar Mass 267.00 g/mol
Appearance Yellow solid
Boiling Point Approx. 255 - 257 °C
Melting Point 57 - 61 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Stability Stable under normal conditions, but may react with strong oxidizing agents

As an accredited 1-Fluoro-4-Iodo-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - fluoro - 4 - iodo - 2 - nitrobenzene packaged in a sealed glass bottle.
Storage 1 - fluoro - 4 - iodo - 2 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and exposure to air or moisture, which could potentially cause decomposition or unwanted reactions. Label the storage container clearly with the chemical name and relevant hazard information.
Shipping 1 - fluoro - 4 - iodo - 2 - nitrobenzene is shipped in sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical regulations, ensuring proper labeling, secure packaging to prevent leakage during transit.
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1-Fluoro-4-Iodo-2-Nitrobenzene 1-Fluoro-4-Iodo-2-Nitrobenzene
General Information
Historical Development
I heard that there was a strange thing in the past, called 1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene. Its quality began to appear, and chemists were curious about it. At the beginning, when studying its properties and exploring its methods, everyone tried their best.
At that time, the technique was not refined, and the method was not good, so it was difficult to make this thing. The wise men were poor for years and months, or in dark rooms, or in remote places, they used various utensils, and tried them repeatedly. Although there are many mistakes, the determination is stronger.
Over the years, the technique is progressive, and the method is gradually improving. Everyone is united, and they study the wonder of preparation. Finally, the best method was obtained, and the production of this thing increased.
Looking at it today, since its initial appearance, through the unremitting research of various sages, the preparation method has become more and more complete, and its use has become wider. This is the work of predecessors, and it has made great contributions to the progress of chemistry.
Product Overview
1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene is also a chemical compound. Its shape, often solid, color or light, with a specific physical reason. Melting and boiling are all fixed, which can be distinguished.
Autochemical properties, its molecules are special. Fluorine, iodine, nitro and other groups coexist, resulting in their chemical activity. It can be reversed like a chemical reaction, such as the nuclear substitution reaction, due to the absorption effect of nitro, the density of benzene is changed, and it is more susceptible to nuclear attack.
The method of synthesis requires a specific process. Or from benzene, multiple steps are reversed, and fluorine, iodine, nitro and other groups are introduced in sequence. Every step needs to control the reaction components, such as efficiency and catalysis, in order to achieve high efficiency and high efficiency. It has many uses in the field of synthesis, and can be used in many bioactive compounds.
Physical & Chemical Properties
1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene is an organic compound. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is a solid state, color or yellowish, with a certain melting point and boiling point. The melting point is about [X] ° C, and the boiling point is around [X] ° C. These two are the keys to identification. Its density is about [X] g/cm ³, which is related to the weight of the substance.
On its chemical properties, the functional groups of fluorine, iodine and nitro give it active properties. Nitro has strong electron absorption, which reduces the density of the electron cloud of the benzene ring, making the electrophilic substitution reaction difficult, but it is easy to cause nucleophilic substitution. Although fluorine atoms are small and highly electronegative, they affect the polarity and reactivity of molecules. Iodine atoms can participate in coupling reactions, etc., to increase the diversity of their reactions. This compound has a wide range of uses in the field of organic synthesis, or is the cornerstone of building complex molecules.
Technical Specifications & Labeling
Today there is a product called 1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene. The technical specifications and identification (product parameters) of this product should be reviewed in detail.
To clarify this product, first check its chemical composition, fluorine, iodine, nitro and benzene ring combination, to determine its physical and chemical characteristics. In the technical specifications, the purity must be high, and the impurity content must be fine before it can meet the user's requirements.
In terms of identification, the product parameters should be presented in detail, such as molecular weight, melting point, boiling point and other data, which must be accurate. On the packaging, the name and key parameters should be marked with prominent words, so that the user can see it at a glance and will not be wrong. In this way, the essence of the technical specifications and labels of this object can be used to the best of its ability in scientific research and production.
Preparation Method
To prepare 1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene, prepare the raw materials, take fluoride, iodide and nitrobenzene as the base. The preparation method is as follows:
First, take a specific reaction apparatus and add the raw materials in proportion. First, the nitrobenzene derivative and the iodide are co-placed in the reactor, the temperature is moderately controlled, and a catalyst is added to make the two react. After a few hours, the intermediate product is obtained.
times, the intermediate product is mixed with fluoride, the reaction environment is adjusted, or the temperature is controlled, or the pressure is adjusted, and the reaction is promoted again. After appropriate time, the product is gradually formed. After
, the product is purified by separation methods, such as distillation, extraction, etc., to obtain pure 1-Fluoro-4-Iodo-2-Nitrobenzene. The whole process needs to abide by the rules of operation and control the conditions of the reaction to achieve good results.
Chemical Reactions & Modifications
1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene is an important compound in organic synthesis. In the field of chemistry, the reaction and modification of this compound are quite critical.
In the past, this compound was synthesized under harsh reaction conditions and the yield was not very high. However, today's research has achieved remarkable results by modifying the reaction path. Chemists have selected other reagents to fine-tune the reaction temperature and duration to improve the reaction environment. In this way, the reactivity is greatly increased and the yield is also greatly improved.
After this chemical modification, the reaction of 1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene is more controllable. It can not only precisely control the structure and purity of the product, but also effectively avoid the occurrence of side reactions. This has made great contributions to the synthesis of higher purity and more specific properties derivatives, and has broad prospects in the fields of medicinal chemistry and materials science.
Synonyms & Product Names
1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene, in the field of my chemical research, its synonymous name and trade name are quite elegant. The name of the chemical substance covers, either according to its structure, or according to its characteristics, or according to the meaning of the discoverer.
1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene, in terms of structure, "1 - fluoro - 4 - iodine - 2 - nitrobenzene" is its common name, depending on the position of the atom and the functional group. However, in different books, research places, or aliases. The trade name of this substance may vary by the manufacturer according to its use and market positioning.
In various research records, although the synonymous name refers to this substance, it changes according to the era, region, and researcher's preference. And the trade name is carefully conceived by the manufacturer in order to recognize its characteristics and gain market benefits. It is to explore the synonymous name and trade name of 1-Fluoro-4-Iodo-2-Nitrobenzene, which are important in chemical research and industrial applications. It can clarify its development context and help to communicate between different fields without barriers.
Safety & Operational Standards
1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene is an organic compound. The following describes its safety and operation specifications in ancient classical form:

Fu 1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene is also a chemical product. Its unique nature is related to safety and operation rules, and cannot be ignored.
In terms of safety, this compound has certain risks. The genus of nitro may be explosive, and the properties of fluorine and iodine elements may also play a role in other things. Therefore, when storing, it must choose a cool, dry and well-ventilated place, away from fire and heat sources, and avoid co-location with strong oxidants, reducing agents, etc., to prevent unexpected changes.
When it comes to the rules of operation, where this thing is involved, the operator must first wear appropriate protective equipment, such as gloves, goggles, gas masks, etc., to protect the body from its harm. In the place of operation, the ventilation should be complete, so that the foul gas will dissipate quickly and will not stay in the room. Weighing and mixing all kinds of movements should be done with caution, according to the precise method, so as not to make a slight mistake. If you accidentally touch it, or enter your eyes or mouth, rinse it with water as soon as possible and seek medical treatment immediately.
After use, the remnants should not be disposed of at will, but must be disposed of in accordance with the prescribed laws to prevent pollution of the environment and harm to life. In short, the safety and operation of 1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene must be strictly followed to ensure that everything goes smoothly and without worry.
Application Area
1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene is a unique chemical substance. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create specific drugs, or used to develop targeted drugs for specific diseases, bringing good news to patients. In the field of materials science, because of its unique chemical structure, it may be able to participate in the preparation of materials with special optoelectronic properties, used in new display technologies, optoelectronic devices, etc., to promote the development of science and technology. In the field of organic synthetic chemistry, this compound, with its unique substituent, can be used as an important building block to help build complex organic molecular structures, expand the boundaries of organic synthesis, and lay the foundation for innovative development in many fields. It is a widely used and crucial chemical substance.
Research & Development
In recent research, fluoroiodine and nitrobenzene have been widely used. 1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene is also an important material for organic synthesis.
My generation studied it and explored its craftsmanship. With the ancient method, its yield was not good, but now it is seeking a new way. After repeated trials, I have obtained a method. With a certain agent, the temperature control is timely, and the yield can be increased.
Looking at its properties, it shows specificity in various reactions. The position of fluorine, iodine, and nitro affects the direction of the reaction. This characteristic opens the door for the creation of new substances.
And it has great potential in fields such as pharmaceutical research and development, material preparation, etc. With time, the intensive research method will surely be able to be widely used, benefit all industries, and become better in research and progress.
Toxicity Research
Chemical refinement in modern times, the study of toxicants is becoming more and more detailed. On 1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene today, its toxicity should not be ignored.
Study its toxicity, in the body of living things, or disrupt their physiological order. Entering the human body, it is afraid of damaging the internal organs and meridians. Looking at various experiments, when exposed to this substance, the changes of cells can be seen, the vitality is gradually lost, and the metabolism is perverse.
Its toxicity is due to the structure, and the interaction of fluorine, iodine, and nitro groups produces this toxicity. The reactivity of fluorine and the strong oxidation of nitro groups are all sources of toxicity.
In the environment, this substance is not a good kind. Or sewage and soil, harming plants, insects and fish. Make the ecological balance gradually decline.
Therefore, the study of the toxicity of this substance is the basis for protection. Workers should work with a foolproof strategy to avoid its harm. In ecological conservation, we must also be careful to deal with it, not to let the poison flow everywhere, so as to ensure the harmony of all kinds and the tranquility of the world.
Future Prospects
1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene is a chemical I have dedicated myself to researching. Looking forward to the future, this substance may emerge in the field of pharmaceutical synthesis. Its unique chemical structure may become a key cornerstone for the creation of new specific drugs. In the field of materials science, it is also expected to shine, and improve the photoelectric properties of materials with its own characteristics, and open up new frontiers of material applications.
Furthermore, with the deepening of the concept of green chemistry, the development of more environmentally friendly and efficient 1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene synthesis process is the trend of the times. Our scientific researchers should uphold the spirit of research, make unremitting explorations, and strive for breakthroughs, paving the way for its future wide application, enabling them to contribute extraordinary power in various fields, lead the trend of scientific and technological progress, and seek well-being for future generations.
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Frequently Asked Questions

As a leading 1-Fluoro-4-Iodo-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-4-Iodo-2-Nitrobenzene?
1-Fluoro-4-iodine-2-nitrobenzene is also an organic compound. Its main uses cover the following ends.
In the field of organic synthesis, this compound is really important. Due to the unique combination of fluorine, iodine and nitro in its structure, it can be used as a key synthesis intermediate. Fluorine atoms have special electronic and spatial effects, which can significantly affect the selectivity and activity of the reaction; iodine atoms have good activity and can often participate in many nucleophilic substitution reactions, providing a convenient way to construct the structure of complex organic molecules; nitro groups are also not idle, not only can be converted into other functional groups under appropriate conditions, but also have a great effect on the regulation of electron cloud density of the benzene ring, which in turn affects the activity of the surrounding reaction check points.
For example, in the field of medicinal chemistry, 1-fluoro-4-iodine-2-nitrobenzene can be used as the starting material, and a series of carefully designed reaction steps can be used to construct a molecular skeleton with specific pharmacological activities. Chemists can skillfully use the characteristics of its functional groups to gradually introduce other key structural fragments to achieve the desired drug activity and selectivity.
Furthermore, in the field of materials science, this compound is also useful. Its special structure may endow the prepared materials with some unique physical and chemical properties. For example, in the research and development of optoelectronic materials, through reasonable modification and polymerization of this compound, new materials with specific optical and electrical properties may be prepared, providing possibilities for the innovative development of optoelectronic devices.
To sum up, 1-fluoro-4-iodine-2-nitrobenzene has shown considerable application potential in many fields such as organic synthesis, drug development and materials science due to its unique structure, providing strong support for the development of related scientific research and industrial production.
What are the physical properties of 1-Fluoro-4-Iodo-2-Nitrobenzene?
1-Fluoro-4-iodine-2-nitrobenzene is one of the organic compounds. Its physical properties are worth exploring.
First of all, its appearance, under normal temperature and pressure, is mostly solid, but it also varies slightly according to the specific environment. Looking at its color, it often shows a light yellow luster, pure color, and no variegated colors are mixed in between.
As for the melting point, it is about a specific temperature range. This temperature varies slightly due to the fineness of the measurement conditions, but the approximate interval can be tested. The characteristics of the melting point are related to the transformation of its physical state during the heating process. The critical temperature at which it melts from a solid state to a liquid state is the melting point, which is the key to its physical properties.
The boiling point is also an important physical property. Under appropriate pressure, 1-fluoro-4-iodine-2-nitrobenzene will transform from liquid to gaseous state, and the temperature of this transition is the boiling point. Its boiling point value can provide a key reference for industrial applications and laboratory operations.
In terms of solubility, it has a certain solubility in organic solvents, such as common ethanol and ether. However, in water, its solubility is very small. The difference in solubility is due to the characteristics of its molecular structure, and the interaction of groups in the molecule with water molecules and organic solvent molecules is different.
Density is also one of its physical properties. Its density has a specific value, which is heavier than water. This characteristic can be reflected in separation and other operations. Mixing it with water, because of its high density, will sink to the bottom of the water. This phenomenon can often be observed in chemical separation and related experimental operations.
The physical properties of 1-fluoro-4-iodine-2-nitrobenzene, such as appearance, melting point, boiling point, solubility, density, etc., have their own characteristics. They are of great significance in the research of organic chemistry, industrial production and related experimental operations, providing a basic basis for people to understand and use this compound.
What is the chemistry of 1-Fluoro-4-Iodo-2-Nitrobenzene?
1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene is an organic compound with unique chemical properties. Its molecule contains fluorine, iodine, nitro and benzene ring structures, which endow it with specific reactivity and characteristics.
From the perspective of nucleophilic substitution reaction, due to the nitro group attached to the benzene ring, it is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring, making the carbon atoms on the benzene ring more vulnerable to attack by nucleophilic reagents. Especially in aromatic ring nucleophilic substitution reactions, fluorine atoms or iodine atoms can be replaced by suitable nucleophilic reagents. Although fluorine atoms have strong electronegativity, due to its small atomic radius and large C-F bond energy, nucleophilic substitution can occur under certain conditions; iodine atoms are easier to leave due to their large atomic radius and relatively small C-I bond energy, and nucleophilic substitution activity is quite high.
When it comes to redox properties, nitro groups can be reduced. Under suitable reducing agents and reaction conditions, nitro groups can be gradually reduced to nitroso, hydroxylamine groups, and finally reduced to amino groups. This reduction process is of great significance in organic synthesis, and can be used to introduce important functional groups such as amino groups for the preparation of various nitrogen-containing organic compounds.
Its physical properties are also worthy of attention. The compound is usually a solid, due to the existence of van der Waals force and dipole-dipole interaction between molecules. And because it contains polar group nitro, its solubility in polar solvents is better than that in non-polar solvents. However, the specific solubility is still closely related to the type of solvent and the structure of the compound itself.
In the field of organic synthesis, 1-Fluoro-4-Iodo-2-Nitrobenzene is often used as a key intermediate. Using its fluorine and iodine atomic activities, new carbon-carbon bonds or carbon-heteroatomic bonds can be constructed through nucleophilic substitution reactions to synthesize complex organic molecules; the reducibility of nitro groups provides various possibilities for the introduction of other functional groups, which can help synthesize various organic compounds such as drugs and materials.
What are 1-Fluoro-4-Iodo-2-Nitrobenzene synthesis methods?
The common methods for synthesizing 1-fluoro-4-iodine-2-nitrobenzene are as follows.
First, halogenated aromatics are used as starting materials. A suitable halogenated benzene can be taken first, and the halogen atoms in it can be introduced into the fluorine atom through a nucleophilic substitution reaction. For example, 4-iodine-2-nitrochlorobenzene is used as a substrate, in a specific solvent, with fluorinated reagents, such as potassium fluoride, in the presence of a phase transfer catalyst. The phase transfer catalyst can promote the transfer of anions and cations in the reaction system and speed up the reaction rate. This reaction requires controlling the temperature, reaction time and the amount of reagents to increase the yield of fluorinated products.
Second, starting from nitroaromatic hydrocarbons. First, nitrobenzene is halogenated. Under suitable reaction conditions, iodine atoms are introduced into a specific position in the benzene ring to generate 4-iodine-2-nitrobenzene. Then, fluorine atoms are introduced through suitable fluorination reactions. The fluorination reaction conditions in this step need to be precisely controlled to prevent side reactions from occurring and affecting the purity and yield of the target product.
Third, the coupling reaction catalyzed by transition metals can be carried out with suitable organometallic reagents and halogenated aromatic hydrocarbons under the action of transition metal catalysts such as palladium catalysts. First, the benzene ring structure containing iodine and nitro is constructed through the reaction, and then fluorine atoms are introduced. This method is more demanding on the reaction conditions, and the selection and dosage of catalysts, the use of ligands, etc., all have a great impact on the success or failure of the reaction and the yield of the product.
All synthesis methods have their own advantages and disadvantages, and the appropriate method should be selected according to the actual situation, such as the availability of raw materials, the operability of reaction conditions, and the purity and yield requirements of the target product.
What are the precautions in storage and transportation of 1-Fluoro-4-Iodo-2-Nitrobenzene?
1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene is an organic compound. During storage and transportation, many matters must be paid attention to.
When storing, choose the first environment. It should be placed in a cool, dry and well-ventilated place. Because of its certain chemical activity, high temperature and humidity are prone to deterioration. If this substance is heated, its internal chemical bonds may be unstable, or it may cause reactions such as decomposition. If there are similar nitro-containing compounds in the past, due to improper storage temperature, the nitro group is active, triggering a chain reaction. And the humid environment may cause the substance to absorb moisture, affecting the purity, and even reacting with water, destroying the molecular structure.
Furthermore, keep away from tinder, heat sources and oxidants. 1 - Fluoro - 4 - Iodo - 2 - Nitrobenzene contains nitro groups, which are oxidizing. In case of hot topics, open flames or oxidants, or there is a risk of combustion and explosion. There are many examples in the past. When nitro-containing organic matter encounters oxidants or open flames, it will explode instantly, causing serious disasters.
Packaging is also key. Sealed packaging should be used to prevent leakage. Because it may be volatile, it will leak into the environment, not only polluting the air, but also endangering health if exposed or inhaled by the human body. If there is a leakage of halogenated nitrobenzene substances in the past, the surrounding residents will feel uncomfortable, and the respiratory tract and skin will be affected.
When transporting, be sure to abide by relevant regulations. Because it may be a hazardous chemical, there are strict requirements for transportation qualifications and vehicle equipment. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment, just in case.
The loading and unloading process must be light and light. The substance or nature is unstable, rough handling will cause package damage, or cause danger. And the loading and unloading personnel should be professionally trained, familiar with the operation specifications and emergency disposal methods to ensure the safety of transportation and storage.