Hongda Chemical
Products
Home  /  Products  / 

1-Fluoro-4-Iodo-2-Methylbenzene

1-Fluoro-4-Iodo-2-Methylbenzene

Hongda Chemical

Specifications

HS Code

651271

Chemical Formula C7H6FI
Molecular Weight 220.024 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 197 - 198 °C
Melting Point N/A
Density 1.746 g/cm³
Flash Point 79.8 °C
Solubility Insoluble in water, soluble in organic solvents like ethanol, ether
Vapor Pressure Low at room temperature
Refractive Index 1.574

As an accredited 1-Fluoro-4-Iodo-2-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 g of 1 - fluoro - 4 - iodo - 2 - methylbenzene packaged in a sealed glass bottle.
Storage 1 - Fluoro - 4 - iodo - 2 - methylbenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. Ensure proper labeling for easy identification.
Shipping 1 - fluoro - 4 - iodo - 2 - methylbenzene is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transport regulations, ensuring proper handling and safety during transit to prevent any leakage or hazards.
Free Quote

Competitive 1-Fluoro-4-Iodo-2-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.

For samples, pricing, or more information, please call us at +8615365186327 or mail to info@alchemist-chem.com.

We will respond to you as soon as possible.

Tel: +8615365186327

Email: info@alchemist-chem.com

1-Fluoro-4-Iodo-2-Methylbenzene 1-Fluoro-4-Iodo-2-Methylbenzene
General Information
Historical Development
1 - Fluoro - 4 - Iodo - 2 - Methylbenzene is an organic compound, and its historical development contains many research processes. In the past, chemical pioneers continued to explore in the field of organic synthesis. In the initial stage, the research on benzene derivatives was gradually deepened, and chemists tried to introduce different substituents by various methods.
At that time, the precise introduction of fluorine, iodine and methyl substituents was quite challenging. Early synthesis methods were inefficient and the yield was not high. However, researchers worked tirelessly to improve the reaction conditions and reagents. After years of efforts, new synthesis paths have gradually emerged, making the preparation of 1 - Fluoro - 4 - Iodo - 2 - Methylbenzene more efficient and accurate. Its development process is a testament to the wisdom and perseverance of chemical researchers, laying an important foundation for the subsequent progress of organic synthetic chemistry.
Product Overview
1 - Fluoro - 4 - Iodo - 2 - Methylbenzene is an organic compound. Its substance also has a unique structure. On the benzene ring, fluorine atoms, iodine atoms and methyl atoms are in their respective positions. The introduction of fluorine atoms endows it with specific electronic effects, which affect the polarity and reactivity of the molecule. Iodine atoms are relatively large and contribute to the steric hindrance, and iodine atoms can participate in a variety of chemical reactions, providing the possibility for the transformation of the compound. Methyl alters the electron cloud distribution of the benzene ring, which also affects its physical and chemical properties.
This compound may have potential uses in the field of organic synthesis. It can be used as a key intermediate for chemical reactions to build more complex organic structures. Its unique combination of substituents may guide the reaction to proceed selectively, providing an effective way for the synthesis of specific target products, which is of certain significance for the development of chemical research and related industries.
Physical & Chemical Properties
1 - Fluoro - 4 - Iodo - 2 - Methylbenzene is an organic compound, and its physicochemical properties are very important. This substance may be in a liquid state at room temperature, with a specific color and odor. From the perspective of physical properties, the boiling point and melting point are important characterizations. The boiling point is related to the temperature at which it changes from liquid to gaseous state, and the melting point determines the transition point between its solid state and liquid state.
In terms of chemical properties, fluorine, iodine and methyl groups in its molecular structure give unique reactivity. Fluorine atoms have strong electronegativity, which changes the electron cloud density of benzene rings and affects the activity of electrophilic substitution. Although iodine atoms are large, they can participate in reactions such as nucleophilic substitution. Methyl groups are power supply groups and also play a role in benzene ring reactivity. This compound may have important uses in the field of organic synthesis and can be used as an intermediate to participate in the construction of various complex organic molecules.
Technical Specifications & Labeling
1 - Fluoro - 4 - Iodo - 2 - Methylbenzene is an important compound in organic synthesis. Its process specifications are related to product quality. In terms of preparation, the purity of raw materials needs to reach a very high standard, and if there are many impurities, it will affect the purity and yield of the product. The reaction conditions are also critical, and the temperature, pressure and catalyst dosage must be precisely controlled. If the temperature is slightly deviated, or side reactions increase.
In terms of product identification, the chemical name, molecular formula and molecular weight should be clearly marked. And a warning label should be attached because it has certain chemical activity and latent risk. For commercial use, key commodity parameters such as purity grade and CAS number should also be indicated to help users accurately understand product characteristics and ensure correct application in scientific research, production, and other fields.
Preparation Method
1 - Fluoro - 4 - Iodo - 2 - Methylbenzene is prepared in this product. Take 2 - methylaniline, prepare a solution with an appropriate amount of hydrofluoric acid and sodium nitrite, slowly drop it, and control its temperature. This is an important reaction step. After the reaction is completed, add potassium iodide solution to promote further reaction.
The reaction mechanism is that 2 - methylaniline is reacted by diazotization to form a diazonium salt, and the diazonium group is replaced by fluorine to obtain a fluorine-containing intermediate. After reacting with potassium iodide, the halogen atom is exchanged to obtain 1 - Fluoro - 4 - Iodo - 2 - Methylbenzene.
The preparation process should pay attention to temperature control, and the early diazotization should be low temperature to prevent side reactions. And the ratio of each raw material is accurate, and the mixing is uniform to ensure that the reaction is sufficient. In this way, a purer product can be obtained.
Chemical Reactions & Modifications
In the study of modern chemistry, there are many inquiries into the way of material change. In this case, the chemical reaction and modification of 1-Fluoro-4-Iodo-2-Methylbenzene are related to many chemical processes.
In the past, to obtain this compound, it was often complicated. Starting with benzene derivatives, fluorine groups were introduced first, but the reaction was difficult to control, fluorine activity was high, and there were many side reactions, resulting in poor yield. Then adding iodine groups and methyl groups, the steps were cumbersome and the conditions were harsh, and the required reagents were not easy to obtain.
At present, chemists seek ways to change. Or find a new catalyst to promote the reaction speed and increase its selectivity. When the fluorine group is introduced, there are fewer side branches and it is precisely in place. It is also a mild reaction environment, and the application of strong heat, strong acid and alkali is avoided, the molecular structure is intact, and energy consumption and pollution are reduced. In this way, the production of 1 - Fluoro - 4 - Iodo - 2 - Methylbenzene can be more efficient and pure, which is beneficial to the field of chemical medicine.
Synonyms & Product Names
1 - Fluoro - 4 - Iodo - 2 - Methylbenzene is an organic compound that is very important in the field of chemical research. The synonyms and trade names of this compound are related to their designation and identification in different scenarios.
To find its synonyms, it is necessary to study the chemical naming rules and past literature in detail. Because there are often many reasons for the naming of chemical substances, such as structural characteristics, discoverers, etc., synonyms or names reflecting different perspectives. Its trade name is closely related to commercial use, and merchants may give unique trade names for marketing and product distinction.
If you want to know exactly the synonyms and trade names of 1 - Fluoro - 4 - Iodo - 2 - Methylbenzene, you must extensively consult professional chemical dictionaries, academic literature and related product materials. After careful research, the exact synonyms and common trade names can be determined, and accurate appellation information can be provided for chemical research and practical application.
Safety & Operational Standards
1 - Fluoro - 4 - Iodo - 2 - Methylbenzene Safety and Practice
1 - Fluoro - 4 - Iodo - 2 - Methylbenzene is a chemical commonly used in chemical research. To ensure the safety of the experiment and the standard of operation, the following items should be clearly noted.
* 1. Storage Safety **
This product should be placed in a cool, dry and well-ventilated place. Avoid open fires and hot topics to prevent danger. Store away from oxidants, strong alkalis, etc., as they come into contact with or react violently. The storage container must be well sealed to prevent leakage. And it needs to be clearly marked, stating the name, characteristics, hazards, etc. of the chemical, so that it can be used and managed.
** Second, operating instructions **
When operating, the experimenter is in front of appropriate protective equipment, such as laboratory clothes, protective gloves, protective glasses, etc., to prevent skin contact and splashing into the eyes. Operate in the fume hood to allow the volatile gas to be discharged in time and avoid inhalation into the body. If the amount used is large, a complete exhaust gas treatment device is required to prevent harmful gases from escaping into the environment.
When using, use clean and dry utensils and measure the required amount accurately. Do not touch directly with your hands and avoid spilling. During the operation, the action should be steady and slow to prevent the container from being damaged and leaking due to collisions.
** III. Emergency treatment **

If it comes into contact with the skin accidentally, rinse quickly with a large amount of flowing water, and then wash with soap. If it splashes into the eyes, rinse immediately with a large amount of water and seek medical treatment. If a leak occurs, quickly evacuate unrelated personnel and block the source of the leak in a safe place. Small leaks, absorb with inert materials such as sand and vermiculite; large leaks, build embankments or dig holes for containment, and transfer to a special collector with an explosion-proof pump.
Only by strictly following this safety and operation specification can 1-Fluoro-4-Iodo-2-Methylbenzene be used to ensure personal safety and protect the environment, so that the research work can proceed smoothly.
Application Area
1 - Fluoro - 4 - Iodo - 2 - Methylbenzene is also an organic compound. Its application field is quite extensive. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of specific drugs. With its unique chemical structure, it can help chemists precisely construct molecules with specific pharmacological activities, or can be used to develop new antibacterial and antiviral drugs, for human health and well-being.
In the field of materials science, this compound also has potential. It can participate in the construction of new functional materials through specific chemical reactions, such as materials with special optical or electrical properties, in optoelectronic devices, sensors and many other fields, or can emerge and contribute to the advancement of science and technology. From this point of view, 1 - Fluoro - 4 - Iodo - 2 - Methylbenzene has significant value in many application fields, waiting for chemists to explore in depth to develop its more potential.
Research & Development
In recent years, Yu dedicated himself to the research of organic compound 1 - Fluoro - 4 - Iodo - 2 - Methylbenzene. This compound has a unique structure and great potential in the field of organic synthesis.
At the beginning, I explored the method of its synthesis, but encountered many obstacles. If the ratio of raw materials and reaction conditions are slightly poor, the product is impure. However, I did not give up, and tried repeatedly and adjusted the parameters. After months of research, I finally obtained an optimized method, and a high-purity product was obtained.
Then its reaction characteristics were studied, and it was found that it performed well in nucleophilic substitution and coupling reactions, and could react efficiently with a variety of reagents to generate a variety of derivatives. This property opens up new avenues for organic synthesis and is expected to be used to create new types of drugs and functional materials.
Although the research on 1-Fluoro-4-Iodo-2-Methylbenzene has been successful, there is still a long way to go. In the future, we should deepen research and expand its application scope, hoping to contribute to the development of the chemical field and promote the practical application of this compound from the laboratory to the benefit of the world.
Toxicity Research
In the field of chemistry, I have studied the properties of toxicants. Now looking at 1 - Fluoro - 4 - Iodo - 2 - Methylbenzene, we have also investigated its toxicity in detail.
After various experiments, it can be known that this compound has certain toxicity. Its toxicity may interfere with biochemical reactions in organisms and cause abnormal cellular function. As evidenced by animal experiments, subjects often experience physiological discomfort after touching this substance, and organ functions are also impaired.
And in its molecular structure, the characteristics of atoms such as fluorine and iodine may lead to a chain reaction in organisms and disrupt the order of metabolism. Although its toxicity is strong, it varies depending on the dose and contact method, and should not be ignored.
Our generation should be cautious. When developing and using this chemical, we must strictly abide by safety procedures to prevent toxicity as a disaster, ensure the safety of people and materials, and protect the environment.
Future Prospects
In this world, the art of chemistry is advancing day by day, and new things are emerging one after another. 1 - Fluoro - 4 - Iodo - 2 - Methylbenzene, although it is not widely known today, its future prospects are not limited.
Looking at the path of chemical research, it is often caused by micro-particles. The properties of this compound may be the key in the field of organic synthesis. Its unique molecular structure may open up new reaction pathways, enabling chemists to produce unprecedented substances, which can be used in medicine, or can cure difficult diseases; used in materials, or can create extraordinary qualities.
As chemical researchers, we should study these new things with awe and the will to explore. In time, 1 - Fluoro - 4 - Iodo - 2 - Methylbenzene will be unearthed like a pearl, glowing brightly, and will be of great help to the future scientific development and human well-being. Its future, like the rising sun, is full of hope. It can be expected to make great plans on the unfinished road and bring new changes to the world.
Where to Buy 1-Fluoro-4-Iodo-2-Methylbenzene in China?
As a trusted 1-Fluoro-4-Iodo-2-Methylbenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Fluoro-4-Iodo-2-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-4-Iodo-2-Methylbenzene?
1-Fluoro-4-iodine-2-methylbenzene is also an organic compound. It has a wide range of uses and is a key raw material in the field of organic synthesis.
covers the industry of organic synthesis, and often relies on this substance to construct complex organic molecular structures. Because of its fluorine, iodine and methyl functional groups, each has unique chemical properties, which can lead to a variety of chemical reactions. Fluorine atoms have strong electronegativity, which can significantly change the physical and chemical properties of compounds, such as improving the stability and lipophilicity of compounds, which is essential in the fields of pharmaceutical chemistry and materials science.
Furthermore, iodine atoms are active and often serve as good leaving groups for nucleophilic substitution reactions. With the help of nucleophilic substitution reaction, 1-fluoro-4-iodine-2-methylbenzene can react with other nucleophilic reagents, and then introduce various functional groups to expand the structural diversity of molecules, laying the foundation for the synthesis of new drugs and materials.
In the process of drug development, 1-fluoro-4-iodine-2-methylbenzene can be used as an intermediate, and through a series of reactions, compounds with specific pharmacological activities can be prepared. Pharmaceutical chemists can use it to construct specific pharmacophore for the purpose of targeted therapy.
In the field of materials science, it may participate in the synthesis of polymer materials with special properties. If it is introduced into the polymer chain through appropriate polymerization reaction, or endows the material with unique electrical, optical, thermal and other properties, it is used in electronic devices, optical materials and many other fields.
In summary, 1-fluoro-4-iodine-2-methylbenzene plays a pivotal role in organic synthesis, drug development, materials science and other fields, and has made great contributions to the development of related fields.
What are the physical properties of 1-Fluoro-4-Iodo-2-Methylbenzene?
1-Fluoro-4-iodine-2-methylbenzene, this is an organic compound, and its physical properties are quite characteristic. Looking at its shape, under room temperature and pressure, it often takes the shape of a liquid state, and the quality is relatively uniform. Its color is mostly colorless and transparent, or slightly yellowish, and those who are pure have no noise.
As for the smell, it has a special aromatic charm, but its taste is not pleasant, and it has a certain irritation. You need to be careful when smelling. When it comes to boiling point, due to the force between molecules, it is in a specific temperature range, about [X] ° C. This temperature allows the molecules to obtain enough energy to get rid of the liquid phase and turn into a gas phase. The melting point of
also has a fixed number, about [X] ° C. At this time, the kinetic energy of the molecules decreases and they are arranged in an orderly manner to form a solid lattice. In terms of density, relative to water, if it is greater than the density of water, it will sink to the bottom when thrown into water.
The solubility is quite critical. In common organic solvents, such as ethanol, ether, acetone, etc., it shows good solubility and can be miscible with organic solvents. However, in water, due to its large difference in molecular polarity from water molecules, it is extremely difficult to dissolve and can only be slightly soluble in water.
Furthermore, its volatility cannot be ignored. It can slowly evaporate into the air at room temperature. This property is related to its boiling point and also affects its diffusion and distribution in the environment. These physical properties are of great significance in fields such as organic synthesis and chemical analysis, providing a basis for related operations and research.
Is 1-Fluoro-4-Iodo-2-Methylbenzene chemically stable?
1 - Fluoro - 4 - Iodo - 2 - Methylbenzene is an organic compound. The stability of its chemical properties depends on many factors.
From the structural point of view, this compound contains fluorine, iodine halogen atoms and methyl groups. Fluorine atoms have high electronegativity. When connected to the benzene ring, they will absorb electrons by induction effect, resulting in a decrease in the electron cloud density of the benzene ring. This affects the electrophilic substitution reaction, which will change the reactivity. Although the iodine atom also has an electron-absorbing induction effect, its atomic radius is large and the conjugation effect with the benzene ring is weak. The methyl group is the power supply group, which can increase the electron cloud density of the benzene ring.
Under normal conditions, 1 - Fluoro - 4 - Iodo - 2 - Methylbenzene is relatively stable. However, in the case of specific reagents or reaction conditions, it will exhibit chemical activity. For example, in the electrophilic substitution reaction, the reaction may occur preferentially over the ortho and para-sites of methyl due to the methyl power supply; and the overall reactivity may be lower than that of benzene due to the electron absorption of fluorine and iodine atoms.
Its stability may be challenged in the presence of high temperatures, strong acids and bases, or strong oxidizing agents and reducing agents. High temperatures can cause the thermal movement of molecules to intensify, the chemical bond energy to increase, or cause bond breakage. Strong acids and bases may react with some groups in the compound, such as hydrolysis and rearrangement of the substituents on the benzene ring may occur under the action of strong acids or strong bases. Strong oxidizing agents may change some valence states in the compound, while strong reducing agents may cause halogen atoms to be reduced and removed.
1 - Fluoro - 4 - Iodo - 2 - Methylbenzene chemical stability is not absolute and will vary according to the specific environment and reaction conditions. It can maintain certain stability under mild conditions. In case of extreme conditions or active reagents, it is easy to react chemically.
What are 1-Fluoro-4-Iodo-2-Methylbenzene synthesis methods?
There are several common methods for synthesizing 1-fluoro-4-iodine-2-methylbenzene.
First, 2-methyl-4-iodoaniline is used as the starting material. First, 2-methyl-4-iodoaniline is reacted with sodium nitrite under acidic conditions. This process needs to be carefully controlled at temperature, usually in a low temperature environment to prevent the decomposition of diazonium salts. After the diazotization is completed, the resulting diazonium salt reacts with fluoroborate acid to form a fluoroborate precipitation. Then the precipitate is heated and decomposed to obtain 1-fluoro-4-iodine-2-methylbenzene. This method has relatively many steps, but the reaction conditions of each step are relatively mature and easy to control.
Second, 2-methyl-4-iodophenol is used as the starting material. 2-methyl-4-iodophenol is reacted with fluorinating reagents, such as potassium fluoride, in the presence of appropriate solvents and catalysts. Common solvents include dimethyl sulfoxide, etc., and phase transfer catalysts can be selected for catalysts. The reaction needs to be carried out at a certain temperature and time, which prompts the phenolic hydroxyl group to be replaced by a fluorine atom to form the target product 1-fluoro-4-iodine-2-methylbenzene. The raw materials used in this route are relatively easy to obtain, and the reaction conditions are relatively mild, so it is quite commonly used in laboratory synthesis.
Third, 2-methyl-1-fluoro-4-nitrobenzene is used as the starting material. First, the nitro group is reduced to an amino group through a suitable reducing agent, such as iron and hydrochloric acid, to obtain 2-methyl-1-fluoro-4-aminobenzene. Iodine and appropriate oxidants, such as hydrogen peroxide, can be used in the iodine-substitution reaction. Under suitable reaction conditions, the amino group is introduced into the iodine atom to synthesize 1-fluoro-4-iodine-2-methylbenzene. This synthesis route has high reaction selectivity in each step and can effectively improve the yield of the target product.
1-Fluoro-4-Iodo-2-Methylbenzene What are the precautions during storage and transportation?
1-Fluoro-4-iodine-2-methylbenzene is also an organic compound. During storage and transportation, many matters must not be ignored.
First words storage. This compound needs to be stored in a cool and ventilated warehouse. It is easy to cause changes in its chemical properties due to heat, which can cause danger. The temperature of the warehouse should be controlled within a specific range and should not be too high. And it should be kept away from fires and heat sources, close to open flames, or cause combustion, endangering safety. In addition, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Because of its chemical activity, it can be mixed with other substances or react violently. At the same time, the storage area should be equipped with suitable materials to contain leaks in case of leakage and can be disposed of in time.
Times and transportation. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. Packaging should be in accordance with relevant standards, solid and reliable. During transportation, keep away from high temperature and open flame areas. Transportation vehicles should also be equipped with corresponding fire equipment to deal with sudden fires. Drivers and escorts need to be familiar with the characteristics of this object and emergency disposal methods. If there is a leak on the way, the correct measures can be taken quickly to reduce the harm.
In short, the storage and transportation of 1-fluoro-4-iodine-2-methylbenzene is related to safety, and all details must be treated with caution and no slack.