1-Fluoro-4-Bromobenzene

Hongda Chemical

Specifications

HS Code	825089
Chemical Formula	C6H4BrF
Appearance	Colorless to light yellow liquid
Boiling Point	153 - 155 °C
Melting Point	-28 °C
Density	1.57 g/cm³ at 25 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Flash Point	48 °C
Vapor Pressure	1.33 kPa at 31.8 °C
Refractive Index	1.5340 - 1.5360 at 20 °C

As an accredited 1-Fluoro-4-Bromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 1 - fluoro - 4 - bromobenzene packaged in a sealed, chemical - resistant bottle.
Storage	1 - fluoro - 4 - bromobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reactive substances to avoid potential chemical reactions. Label the storage container clearly with its name and relevant safety information.
Shipping	1 - fluoro - 4 - bromobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous material shipping regulations. Temperature - controlled transport may be required to prevent degradation during transit.

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General Information

Historical Development

1 - Fluoro - 4 - Bromobenzene is an important compound in organic chemistry. Looking at the development of chemistry, its discovery and evolution are also of far-reaching significance. In the past, chemists gradually noticed compounds with this special structure when exploring the properties and synthesis of organohalides.
In the early days, limited by technology and cognition, its research progress was slightly delayed. However, with the advancement of chemical analysis methods and the rise of spectroscopic technology, researchers can gain more accurate insight into its molecular structure and properties. After repeated experiments, chemists tried a variety of synthesis paths, from the initial complex and inefficient method to developing a simpler and more efficient preparation process. The application of this compound in the field of organic synthesis has also continued to expand, providing key raw materials for the preparation of various fine chemicals and pharmaceutical intermediates. Its historical development has witnessed the process of continuous exploration and breakthrough innovation in the field of chemistry, driving organic chemistry to new heights.

Product Overview

1 - Fluoro - 4 - Bromobenzene is also an organic compound. Its color is clear, the shape is like a liquid, and it has a special odor. In the molecular structure, fluorine atoms and bromine atoms are respectively connected to the benzene ring, giving this compound unique chemical properties.
Preparation method, often using benzene as the starting material, through halogenation reaction, fluorine and bromine atoms are precisely introduced, but the reaction conditions need to be carefully controlled to achieve high yield and high purity.
In the field of organic synthesis, this compound has a wide range of uses. It can be used as an intermediate to prepare a variety of drugs, pesticides and functional materials. Due to the stability of the benzene ring and the reactivity of the halogen atom, it can participate in many organic reactions, such as nucleophilic substitution, coupling reactions, etc., laying the foundation for the construction of complex organic molecular structures. It is an indispensable raw material in organic chemistry research and industrial production.

Physical & Chemical Properties

1 - Fluoro - 4 - Bromobenzene is an organic compound with unique physical and chemical properties. Its physical properties are mostly colorless to light yellow liquid at room temperature, with a special odor, boiling point about 150 - 155 ° C, melting point about - 20 ° C, density greater than water, insoluble in water, but can be miscible with most organic solvents, such as ethanol, ether, etc.
In terms of chemical properties, fluorine atoms and bromine atoms in this compound are highly active. Fluorine atoms have strong electronegativity, which changes the electron cloud density of the benzene ring, resulting in relatively high density of adjacent and para-potential electron clouds, and are more prone to electrophilic substitution reactions. Although bromine atoms are less active than fluorine atoms, they can also participate in many chemical reactions, such as nucleophilic substitution reactions. Under suitable conditions, 1-Fluoro-4-Bromobenzene can react with various reagents to generate various derivatives, which are widely used in the field of organic synthesis.

Technical Specifications & Labeling

1 - Fluoro - 4 - Bromobenzene is an organic compound, and the technical specifications and labeling (product parameters) of this compound are extremely important. Its preparation depends on a specific chemical process. During the reaction process, there are strict requirements for parameters such as temperature, pressure, and reactant ratio. For example, selecting a suitable catalyst can improve the reaction rate and yield.
In terms of technical specifications, purity should be a key indicator, and extremely high purity is required to meet the application requirements of many fields. The impurity content must be strictly controlled to prevent adverse effects on subsequent reactions or applications.
In terms of labeling, product labels should clearly label the name, chemical formula, purity, and hazardous characteristics. In this way, users can take appropriate safety measures based on accurate information during storage, transportation, and use to ensure safe operation and product quality and application.

Preparation Method

1 - Fluoro - 4 - Bromobenzene is an important compound in organic synthesis. 4 - bromoaniline and fluoroboronic acid can be used as raw materials for its preparation. The reaction step of the preparation process is to mix 4 - bromoaniline with fluoroboronic acid to generate 4 - bromobenzene diazofluoroborate, which is the key intermediate product.
The reaction conditions need to be strictly controlled, and the temperature and reaction time are required. The diazotization reaction in a low temperature environment can improve the purity and yield of the product. Subsequent decomposition of 4 - bromobenzene diazofluoroborate can obtain 1 - Fluoro - 4 - Bromobenzene.
As for the catalytic mechanism, a suitable catalyst can be selected to accelerate the reaction process, reduce the activation energy of the reaction, and make the reaction more efficient in the direction of generating the target product. By optimizing each link, it is expected to improve the preparation efficiency and quality of 1-Fluoro-4-Bromobenzene.

Chemical Reactions & Modifications

1 - Fluoro - 4 - Bromobenzene is also an organic compound. In chemical research, its reaction and modification are of great importance to us.
Looking at its reaction, the way of nucleophilic substitution can introduce different groups into its structure. The different activities of fluorine and bromine make the reaction direction different. Fluorine has strong electronegativity, and the density of ortho-electron clouds changes, which affects the attack of nucleophilic reagents.
On its modification, with different reagents and conditions, its physical and chemical properties can be changed. Or change its boiling point, or change its solubility, for different purposes.
is a chemical researcher, and its reaction mechanism should be carefully investigated to explore modification methods, so that this compound can be used in the fields of medicine and materials to develop its growth and be used by the world.

Synonyms & Product Names

1 - Fluoro - 4 - Bromobenzene, the synonym and trade name of this thing, is quite important. Its synonyms are either named according to its chemical structure characteristics, or derived from its reaction characteristics, uses, etc. The trade name is mostly determined by the manufacturer according to market demand, product positioning and other factors.
In the chemical industry, many practitioners often call it by a specific name, which is not only convenient for communication, but also forms a consensus in the industry. Just like the ancient alchemists, they have specific names for all kinds of medicinal materials, and the peers know what they mean when they hear it. 1 - Fluoro - 4 - Bromobenzene's synonyms and trade names are like a key in chemical trade, research and other links, accurately opening the door to related communication and research, so that all parties can efficiently connect and deeply explore its characteristics, applications, etc., which are indispensable for the development of the chemical industry.

Safety & Operational Standards

1 - Fluoro - 4 - Bromobenzene, it is also necessary to transform things. Its use must be subject to safe operation before it can be used.
If you want to reduce this thing, the general equipment must be damaged. The quantity of the product needs to be refined to the millimeter, and the difference is thousands of miles. The cost of the product, the cost, the force, and the cost are all essential. If the cost is high, it may cause the reaction to lose control, and there is a risk of explosion; if the cost is low, the reaction will be high, and the quality will be good. The power also needs to be determined, and the high and low will be low, for fear of accidents. And the control of the system should not be neglected. The problem may be decomposed, and the short-term reaction will not be completed.
In the operation, it is necessary to take precautions. Anti-corrosive clothing, gloves, and eyes are all indispensable. This product may be corrosive and toxic, and if it is not careful, it will cause great harm to the skin or enter the eyes. And the operation should be carried out in good conditions. If the poison is concentrated, it will be inhaled and life-threatening.
If it exists, it should be placed in a dry place, such as a source of ignition and oxidation. Because of its activity, it is easy to cause strong reactions in case of fire or oxidized substances.
Use it, and do not pour it out. It needs to be handled properly in accordance with the relevant laws to avoid polluting the environment and health.
Of course, 1 - Fluoro - 4 - Bromobenzene's safe operation is essential. Those who work hard at this task should focus on their hearts and make unremitting efforts to ensure peace and achieve good results.

Application Area

1 - Fluoro - 4 - Bromobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, this compound is often the key raw material for the synthesis of specific drugs. Due to the unique chemistry of fluorine and bromine, it can help the drug to act precisely on the target and improve the efficacy. For example, when developing new antimalarial drugs, 1 - Fluoro - 4 - Bromobenzene participates in the construction of molecular structures, which can enhance the inhibitory power of the drug against malaria parasites.
In the field of materials science, it is also indispensable. Based on it, materials with special photoelectric properties can be synthesized. Such materials are used in the manufacture of advanced display devices, which can optimize the luminous efficiency and color performance of the screen, making the picture clearer and more vivid. From this point of view, 1 - Fluoro - 4 - Bromobenzene is of great value in the application fields of medicine and materials, and is a key factor in promoting related scientific and technological progress.

Research & Development

In recent years, I have been in the field of chemistry, specializing in the products of 1 - Fluoro - 4 - Bromobenzene. This substance has unique properties and has great potential in organic synthesis.
At the beginning, I explored the method of its preparation, and after various attempts, a stable process was obtained. The ratio of raw materials, reaction temperature and time are long, all of which need to be precisely controlled. If there is a slight difference in the pool, the yield will not be good, or impurities will be generated.
Then, study its application. In pharmaceutical synthesis, it can be used as a key intermediate to help form several kinds of special drugs. In the research and development of materials, adding this substance also significantly improves the material properties.
I often think, the road of science is long, and only by maintaining perseverance and research can we make progress. 1 - Fluoro - 4 - Bromobenzene's research has been achieved, but there is still a wide space for future application. We must make unremitting efforts to contribute to the development of chemistry and benefit the world.

Toxicity Research

The chemical industry is related to people's livelihood, but the study of poisons in it should not be careless. Today, in terms of 1-Fluoro-4-Bromobenzene, the study of its toxicity is crucial.
1-Fluoro-4-Bromobenzene may be potentially harmful. In experimental research, observe its impact on various organisms. If you try it with insects, you will see that its action is gradually slowing down, and even its vitality is disappearing. It is also tested with green plants, and the leaf color turns yellow and growth is blocked.
And this substance is in the environment, or difficult to degrade, accumulating in water and soil, causing ecological changes. If a person touches it, the skin will be uncomfortable in light cases, and the viscera will be damaged in severe cases, endangering life.
Therefore, the study of its toxicity is not only to clarify its harm, but also to prevent problems before they occur, and to determine proper methods to avoid its scourge, ensure the well-being of all beings, and protect the peace of the environment. Make the chemical industry prosperous and long-term prosperous.

Future Prospects

1 - Fluoro - 4 - Bromobenzene is also a chemical product. There is no way to find out the future prospects of this product.
This product is used in the field of chemical research, and its use is not limited. Its characteristics can be mixed with multiple and reverse raw materials to produce various novel compounds. If it is not developed, it can be used for research and development, or it can be used to expand the color. The completion of the product, the characteristics of this compound, may be able to help researchers obtain special effects, so as to generate.
And in the field of materials, 1 - Fluoro - 4 - Bromobenzene is also expected to be built. Or the properties of the material can be improved, such as increasing its strength and qualitative. In this way, all kinds of projects such as construction and development can be extraordinary.
In the future, 1 - Fluoro - 4 - Bromobenzene has not been developed, and it can be expected that it will be developed in multiple domains, creating a new situation.

Where to Buy 1-Fluoro-4-Bromobenzene in China?

As a trusted 1-Fluoro-4-Bromobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Fluoro-4-Bromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Fluoro-4-Bromobenzene?

1-Fluoro-4-bromobenzene is a crucial raw material in the field of organic synthesis, and is widely used in many chemical production and scientific research fields.
First, it plays a pivotal role in the field of pharmaceutical synthesis. The construction of many drug molecules requires 1-fluoro-4-bromobenzene as a starting material. Due to the unique chemical properties of fluorine atoms and bromine atoms, it can participate in many chemical reactions to construct structural fragments with specific biological activities. For example, in the synthesis of some antibacterial drugs and nervous system drugs, 1-fluoro-4-bromobenzene is often the key starting material. After a series of chemical reactions, complex molecular structures that meet pharmacological requirements can be accurately constructed, laying the foundation for drug development.
Second, in the field of materials science, 1-fluoro-4-bromobenzene also has extraordinary performance. For example, in the preparation of organic optoelectronic materials, it can be used to participate in polymerization reactions, introduce fluorine and bromine elements, and then adjust the electronic structure and optical properties of materials. Organic materials containing fluorine and bromine often have unique electrical and optical properties, such as high charge mobility, good fluorescence properties, etc., which make them show broad application prospects in the fields of organic Light Emitting Diode (OLED) and organic solar cells, and help to develop photoelectric materials with better performance.
Third, in the synthesis of pesticides, 1-fluoro-4-bromobenzene is also an indispensable component. With its chemical structure characteristics, pesticide molecules with high killing or inhibitory effects on specific pests can be constructed through chemical reactions. The introduction of fluorine and bromine can enhance the interaction between pesticide molecules and target check points in pests, improve the biological activity and selectivity of pesticides, and provide more effective means for agricultural pest control.
In summary, 1-fluoro-4-bromobenzene, with its unique chemical structure and properties, plays a crucial role in many fields such as medicine, materials, and pesticides, promoting technological development and innovation in various fields.

What are the physical properties of 1-Fluoro-4-Bromobenzene?

1-Fluoro-4-bromobenzene is an organic compound. It has specific physical properties, let me tell you one by one.
Looking at its properties, under normal temperature and pressure, 1-fluoro-4-bromobenzene is in a colorless to light yellow liquid state. This state is easy to flow, its texture is uniform, and it can be seen under light that it is clear and slightly shiny.
When talking about the boiling point, it is about 154 ° C. When the temperature rises to this value, 1-fluoro-4-bromobenzene changes from the liquid state to the gaseous state, and the intermolecular forces are overcome. The molecules break free from the liquid phase and escape in space.
In terms of melting point, it is about -27 ° C. Below this temperature, 1-fluoro-4-bromobenzene will solidify from liquid to solid, and the molecular arrangement will gradually become regular, forming a lattice structure.
In density, it is about 1.57 g/cm ³. It is heavier than water. If placed in water, it will sink to the bottom. Because 1-fluoro-4-bromobenzene contains more substances per unit volume than water.
In terms of solubility, 1-fluoro-4-bromobenzene is insoluble in water. Water is a polar molecule, while the polarity of 1-fluoro-4-bromobenzene is weaker. According to the principle of "similarity and miscibility", the two are difficult to miscible. However, it is soluble in organic solvents such as ethanol and ether, because the polarity of these organic solvents is similar to that of 1-fluoro-4-bromobenzene, the intermolecular force is suitable, and it can be miscible with each other.
The vapor pressure of 1-fluoro-4-bromobenzene is relatively low at room temperature, which means that its volatilization degree is limited. However, with the increase of temperature, the vapor pressure increases and the volatilization rate accelerates.
And it has a certain smell, although it is difficult to describe accurately, it has a special aromatic smell, but if this smell is inhaled in excess, it may be harmful to the human body.
This is a rough outline of the physical properties of 1-fluoro-4-bromobenzene, which are of great significance in chemical research, industrial production and other fields.

Is 1-Fluoro-4-Bromobenzene chemically stable?

1-Fluoro-4-bromobenzene is also an organic compound. Its chemical properties depend on the characteristics of fluorine and bromine atoms in its molecular structure and the conjugation system of the benzene ring.
The benzene ring has a stable conjugate structure, which endows the compound with certain stability. Fluorine atoms have strong electronegativity. Although they are connected to the benzene ring, the electron cloud density of the benzene ring is reduced due to the p-π conjugation effect, but because of their small atomic radius, they have little effect on the steric resistance of the benzene ring. Bromine atoms are also electronegativity. After connecting with the benzene ring, the electron cloud density of the benzene ring is also reduced, and its atomic radius is larger, and the steric resistance effect is more obvious than that
In the electrophilic substitution reaction, the electron cloud density of the benzene ring decreases due to the electron-absorbing effect of fluorine and bromine atoms, so the compound is more difficult to undergo electrophilic substitution reaction than benzene. However, because fluorine and bromine atoms are ortho-para-position groups, electrophilic reagents often attack the ortho and para-position of the benzene ring. In case of electrophilic substitution reactions such as halogenation, nitrification, and sulfonation, substituents are mostly introduced into the ortho and para-position.
Under certain conditions, 1-fluoro-4-bromobenzene can also undergo the substitution reaction of halogen atoms. Due to the strong binding force between fluorine atoms and benzene rings, it is difficult to be replaced; while bromine atoms are relatively easy to be replaced by nucleophiles. For example, under appropriate nucleophiles and reaction conditions, bromine atoms can be replaced by hydroxyl groups, amino groups, etc.
In addition, 1-fluoro-4-bromobenzene can also exhibit unique chemical activities in some metal catalytic reactions, participating in the construction of new carbon-carbon bonds or carbon-hetero bonds. Its stability is generally guaranteed due to the existence of the benzene ring conjugate system, but it also shows specific activity and selectivity in chemical reactions due to the electron-absorbing properties of fluorine and bromine atoms.

What are 1-Fluoro-4-Bromobenzene synthesis methods?

There are several methods for the synthesis of 1-fluoro-4-bromobenzene. One is to use p-bromoaniline as the starting material, react with diazotization, then react with fluoroboronic acid, and then pyrolyze it. In this process, p-bromoaniline reacts with sodium nitrite and hydrochloric acid at low temperatures to form diazonium salts, which are then reacted with fluoroboronic acid to obtain p-bromobenzene diazofluoroborate, which is decomposed by heating to obtain 1-fluoro-4-bromobenzene.
Second, it can be started from p-bromophenol. First, p-bromophenol is converted into the corresponding phenate, and then reacts with fluorinating reagents, such as potassium fluoride, under specific conditions. This reaction requires an appropriate solvent and temperature to make the oxygen anion of the phenate attack the fluorine atom of the fluorinating reagent, thereby introducing a fluorine atom. After subsequent treatment, the target product 1-fluoro-4-bromobenzene is obtained.
Furthermore, benzene is used as the initial raw material and bromobenzene is obtained through bromination reaction. Bromobenzene is then nitrified to form p-bromonitrobenzene, and then p-bromonitrobenzene is reduced to p-bromoaniline. After that, the steps are similar to the first method from p-bromoaniline. After diazotization, interaction with fluoroboronic acid and pyrolysis, 1-fluoro-4-bromobenzene can also be obtained. Each method has its advantages and disadvantages. In practical application, it is necessary to weigh and choose according to the availability of raw materials, cost, reaction conditions and many other factors.

What is the price range of 1-Fluoro-4-Bromobenzene in the market?

The price range of 1-fluoro-4-bromobenzene in the market is difficult to determine. Its price often varies due to many factors, such as material sources, preparation methods, supply and demand conditions, and fluctuations in market conditions.
If you look at the past, the abundance of raw materials has a great impact on its price. If the raw materials required for the preparation of 1-fluoro-4-bromobenzene are abundant and easy to obtain, the price may be stable and slightly cheaper; if the raw materials are scarce and need to be purchased, the price will rise.
The method of preparation is also critical. Sophisticated and efficient methods can reduce costs and make prices close to the people; if the preparation is cumbersome, expensive and laborious, the price should be high.
Furthermore, the supply and demand of the market, the price is very huge. If at some point, many industry players compete for 1-fluoro-4-bromobenzene, and the supply is insufficient, the price will soar; conversely, if the supply exceeds the demand, the merchant will sell the goods, or reduce the price to promote.
The change of market conditions cannot be ignored. The economic boom and bust and easier policies can make the price of 1-fluoro-4-bromobenzene fluctuate.
Therefore, in order to know the exact price range, it is necessary to carefully investigate the current market conditions and consult the chemical raw material suppliers or market professionals to obtain a near-real price.