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1-Fluoro-4-[(4-Fluorophenyl)Sulfonyl]Benzene

1-Fluoro-4-[(4-Fluorophenyl)Sulfonyl]Benzene

Hongda Chemical

Specifications

HS Code

678703

Chemical Formula C12H7F3O2S
Molecular Weight 274.24
Appearance Solid (usually white to off - white powder)
Melting Point Typically in a certain range (exact value may vary based on purity)
Solubility In Water Low solubility in water
Solubility In Organic Solvents Soluble in some organic solvents like dichloromethane, chloroform
Density Calculated density based on structure (value depends on crystal form)
Purity Can be produced in different purity levels (e.g., 95%, 98%, 99% etc.)
Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents
Packing & Storage
Packing 100g of 1 - fluoro - 4 - [(4 - fluorophenyl)sulfonyl]benzene in sealed chemical - grade packaging.
Storage 1 - fluoro - 4 - [(4 - fluorophenyl)sulfonyl]benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption and evaporation. Avoid storing near incompatible substances to prevent chemical reactions.
Shipping 1 - fluoro - 4 - [(4 - fluorophenyl)sulfonyl]benzene is shipped in sealed, corrosion - resistant containers. They are carefully packed to prevent breakage, with proper labeling for chemical identification and safety instructions during transit.
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1-Fluoro-4-[(4-Fluorophenyl)Sulfonyl]Benzene 1-Fluoro-4-[(4-Fluorophenyl)Sulfonyl]Benzene
General Information
Historical Development
1 - Fluoro - 4 - [ (4 - Fluorophenyl) sulfonyl] Benzene is a chemical substance. The historical development of its substance, at the beginning, scholars first involved in related explorations in the laboratory, and at that time only a little glimpse of its properties.
After years have passed, many researchers have worked hard to understand its structure. In the synthesis method, it has also been continuously refined. First, it is a complicated method, which requires multiple steps of reaction, which is time-consuming and laborious. However, scientific researchers have worked tirelessly to improve the path, making the synthesis easier and more efficient.
With the passage of time, this compound has emerged in many fields, or used in material creation, or to assist in pharmaceutical research and development. Its development process is like a long road, with researchers moving forward step by step, making it more widely used and shining in the field of chemistry.
Product Overview
1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene is a chemical substance that I have been researching recently. It has unique properties and an exquisite molecular structure. It contains fluorine atoms and benzenesulfonyl groups, and the two co-form this novel substance.
The appearance of this substance is crystalline, with pure and bright color. It shimmers under light, imitating the essence of condensation. It dissolves very well in specific organic solvents and can interact with many reagents, resulting in wonderful transformation.
The process of research has gone through complicated steps, from the selection of raw materials to the control of reaction conditions, all of which need to be done with caution. Each step is related to the quality of the final product. Our scientific researchers maintain a rigorous heart, explore its mysteries, and hope to use this object as a foundation to expand the new realm of chemical research and add useful materials to the world.
Physical & Chemical Properties
1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene is also an organic compound. Its physical and chemical properties are quite important in the academic community. The state of this substance is either solid at room temperature, or nearly white in color, with a certain crystal form. The number of melting points can be obtained by fine measurement, which is related to the transformation of its phase state. Its solubility varies in various solvents, with a certain solubility in polar solvents such as alcohols, and a certain solubility in non-polar solvents such as alkanes.
Chemically, the presence of fluorine atoms and sulfonyl groups gives the molecule a unique reactivity. Fluorine atoms have high electronegativity, which changes the density of electron clouds at ortho sites, and is easy to induce nucleophilic or electrophilic reactions. Sulfonyl groups are also active check points and can participate in many organic synthesis reactions, which are key parts of building complex organic structures. In experiments, scholars often explore the reaction paths and products of various reagents to clarify the full picture of their chemical properties, hoping to expand their applications in the field of organic synthesis.
Technical Specifications & Labeling
1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene is also a material for melting. Its technology is very important (commercial quality). If you want to make this thing, you must follow the method of refining. The first and most suitable raw materials, the quality and quantity must be suitable. For the reverse equipment, control the quality and quality of the product, so that the product can be properly processed.
After the reaction is completed, the essence of the product can be improved to improve its quality. Or use crystallization, or use the method of extraction, so that the product can be removed. As for the product, it is clear that its chemical formula, molecular weight, quality and other requirements are required, so that the product can be used for its properties and quality. In this way, the 1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene is guaranteed to be used in a general way.
Preparation Method
1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene is prepared as a raw material. Fluorobenzene, p-fluorobenzene sulfonyl chloride, etc. are taken as the base materials.
The preparation process is as follows: In a clean reactor, the temperature is moderately controlled, starting with fluorobenzene and p-fluorobenzene sulfonyl chloride, and a catalyst is added to promote the reaction. This reaction goes through several steps. The first step is to mix the two, and with the help of a catalyst, the molecules are attached to the phase and gradually form an intermediate product.
The reaction process requires careful observation of temperature and pressure. If the temperature is too high, side reactions will occur, and if it is too low, the reaction will be slow. After the reaction is completed, the impurities are removed by separation and purification to obtain pure 1-Fluoro-4- [ (4-Fluorophenyl) Sulfonyl] Benzene. At the time of separation, extraction and distillation are used, depending on the boiling point and solubility of each substance. After purification, the purity of the product meets the industrial standard for other uses.
Chemical Reactions & Modifications
1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene is an important chemical synthesis product. In its synthesis reaction, chemical reaction and modification are extremely critical.
In the past, the reaction conditions for synthesizing this product were quite harsh, and the yield was not ideal. In order to improve, many chemists worked hard to optimize the reaction.
In view of this, chemists focused on the selection and ratio of reaction raw materials. After multiple experiments, it was found that adjusting the ratio of specific reactants can increase the reaction rate and improve the purity of the product.
At the same time, the temperature and pressure conditions of the reaction were also optimized. Appropriate regulation of temperature and pressure can not only promote the progress of the reaction, but also effectively inhibit the occurrence of side reactions, thereby improving the yield and quality of the product.
In addition, the improvement of the catalytic system is also the focus. The introduction of a new catalytic system greatly reduces the activation energy of the reaction, making the reaction easier to occur and the chemical properties of the product more stable, laying a solid foundation for the large-scale production and application of the product.
Synonyms & Product Names
1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene This product, its trade name, has an important value. In the field of chemical research, the same is an important way to express the characteristics of the product. For example, if it is the same, it can be used more often, all of which come from different research backgrounds. Naming.
Trade names are often tested in terms of market acceptance and product characteristics. Analyzing the trade name of this product can determine its positioning in the commercial field.
Or some people take the trade name because of its unique characteristics and the characteristics of the product. Both of them are useful, but they both refer to this chemical product more accurately and effectively. Exploring the same product name can help researchers understand this product more comprehensively and help businesses grasp the market.
Safety & Operational Standards
1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene is an important chemical. During its production and application, safety and operating standards are of paramount importance.
This chemical has certain characteristics and is related to safety. It needs to be treated with caution. When storing, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources to prevent accidents. Due to its potential hazards, if it is not stored properly, it may cause serious consequences such as combustion and explosion.
Operators must be professionally trained and familiar with the operation process. When operating, be sure to wear suitable protective equipment, such as protective gloves, goggles and gas masks, to avoid contact with the skin, eyes and inhalation of harmful substances. In the operation site, complete ventilation facilities should be equipped to discharge possible harmful gases in time.
When performing relevant reaction operations, it is necessary to strictly control the reaction conditions, such as temperature, pressure and reaction time. Precise control of these parameters is not only related to product quality, but also closely related to operation safety. A slight deviation may cause the reaction to go out of control and cause dangerous conditions.
Waste disposal should not be ignored. Relevant environmental regulations should be followed, and appropriate methods should be used to dispose of them. They should not be discarded at will to avoid pollution to the environment.
Only by strictly adhering to safety and operating standards can we ensure the smooth and safe production and use of 1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene, while taking into account environmental protection and achieving sustainable development.
Application Area
1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene is also a chemical substance. Its application field is worth studying. In the field of medicine, it may be able to use its unique structure to get involved in drug synthesis. The fluorine atom and sulfonyl group of its molecular structure may give drugs special activity and help overcome difficult diseases.
In the field of materials science, it is also possible. It may participate in the creation of high-performance materials, such as improving the properties of polymer materials to make them more stable and weather-resistant. Because of its structural properties, it may be able to build special interactions inside the material to improve the overall quality of the material.
Furthermore, in the field of fine chemicals, this substance may be a key intermediate. Through ingenious chemical reactions, a variety of fine chemicals can be derived to meet the special needs of various industries, contribute to industrial development, and are widely used in various application fields.
Research & Development
Recently, the research on 1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene has been quite successful. Its characteristics are different, and the preparation method requires careful observation of all conditions. Temperature and the proportion of reagents are all about success or failure.
At the beginning, it was tried by the usual method, but no good results were obtained. Later, the classics were studied in detail and the improvement steps were taken. First, fluorobenzene and sulfonyl chloride should be used as the response, and the temperature should be controlled at a moderate level. After other agents, the reaction gradually became smooth.
Looking at the product, the purity still needs to be refined. Therefore, the purification technique was studied again, and after several attempts, it was relatively pure. This substance may be of great use in many fields, and its application should be explored in the future, hoping to promote it and add new achievements to the industry, so as to promote the development of this science and live up to the intention of research.
Toxicity Research
Toxicity Study of 1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene
To investigate the toxicity of 1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene. This substance is related to many fields, and toxicity research is extremely important.
The first observation of its effects on organisms. Taking various organisms as samples, it has been tested by many methods. In experimental animals, observe their physiological changes after ingestion. See it or cause damage to organs, such as liver and kidney dysfunction, cell structure is also damaged.
Furthermore, observe its effect on the environment. In the ecosystem, this substance may accumulate. If it is contained in soil and water, it may affect plant growth or interfere with the survival and reproduction of aquatic organisms.
From this perspective, 1-Fluoro-4- [ (4-Fluorophenyl) Sulfonyl] Benzene has certain toxicity. It is necessary to study the prevention and control measures in detail to reduce the harm between organisms and the environment in order to maintain ecological balance and biosafety.
Future Prospects
I have tried to research 1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene. This product is unique in nature and has a wide range of uses. Although the research is not deep at present, I am looking forward to the future.
Thinking about the future, it is expected to shine in the field of medicine. Or it can make special drugs to treat serious diseases and relieve the suffering of patients. In materials science, or it can be the foundation of new materials, creating something with extraordinary performance.
Although the road ahead is long and the geometry is unknown, I firmly believe that with time and diligent research, it will be able to uncover its mysteries and develop its grand path. Make this material available to the world, benefit all people, and become a bright future.
Frequently Asked Questions
What is the use of 1-Fluoro-4- [ (4-Fluorophenyl) Sulfonyl] Benzene?
1-Fluoro-4- [ (4-fluorophenyl) sulfonyl] benzene is widely used in today's chemical industry. In the field of organic synthesis, it is often used as a key intermediate.
Looking at the records of the past, organic synthesis is like a wonderful show of skills, and 1-fluoro-4- [ (4-fluorophenyl) sulfonyl] benzene seems to play an indispensable role. It can interact with many organic compounds through specific reaction pathways to form more complex and diverse organic molecules. For example, when preparing some aromatic compounds with special functions, they can undergo condensation and substitution reactions with other substances containing active groups by virtue of their unique chemical structure, thus laying the foundation for the birth of new compounds.
Furthermore, in the field of materials science, 1-fluoro-4- [ (4-fluorophenyl) sulfonyl] benzene has also emerged. The research and development of materials has always pursued excellent performance, and this compound can impart different characteristics to the material. For example, when synthesizing some high-performance polymer materials, introducing them into the molecular chain of the polymer can change the electron cloud distribution of the polymer, which in turn affects the electrical, optical and thermal stability of the material. Although the concept of materials science is not mentioned in detail in ancient books, by analogy with current principles, it can be known that in the process of creating new materials, if it can be used properly, it will definitely lead to the generation of novel and excellent materials.
In addition, in the exploration of pharmaceutical chemistry, 1-fluoro-4- [ (4-fluorophenyl) sulfonyl] benzene also has its uses. The development of drugs aims to find molecules with specific biological activities. The structural characteristics of this compound make it possible to become a key building block for the synthesis of new drug molecules. Through reasonable design and modification, it is expected to develop high-efficiency and low-toxicity drugs targeting specific disease targets, contributing to human health and well-being. Although there is no complete system of modern medicinal chemistry in ancient times, the concept of curing diseases and saving people is in the same vein. The drug research and development of this compound in today's world is just like a new path to find good medicines in ancient times, with infinite potential.
What are the physical properties of 1-Fluoro-4- [ (4-Fluorophenyl) Sulfonyl] Benzene
1-Fluoro-4- [ (4-fluorophenyl) sulfonyl] benzene, this is an organic compound. Its physical properties, with a unique appearance, odor and melting boiling point. Usually solid, the appearance may be white to light yellow crystalline powder, which is solid due to the regular molecular structure and intermolecular forces.
In terms of odor, it contains fluorine atoms and sulfonyl groups, or emits a weak and specific odor, but the specific odor varies according to purity and environment.
The melting boiling point is affected by intermolecular forces. Molecules contain fluorine atoms, fluorine electronegativity is large, causing intermolecular forces to increase, and the melting boiling point is relatively high. Specifically, the melting point may be within a certain range, such as [X] ° C to [X] ° C, and the boiling point may reach [X] ° C under certain conditions.
In terms of solubility, according to the principle of similar miscibility, because it is an organic compound, it has good solubility in organic solvents, such as in common organic solvents such as dichloromethane, chloroform, and toluene. In water, because of its dominant hydrophobic groups, its solubility is poor, and it is difficult to dissolve in water.
The density may be different from that of water, and its density may be greater than that of water due to molecular composition and structure. The specific value is subject to accurate measurement.
The physical properties of 1-fluoro-4- [ (4-fluorophenyl) sulfonyl] benzene are crucial for their applications in organic synthesis and materials science. In organic synthesis, depending on its solubility and stability, suitable solvents and reaction conditions can be selected. In materials science, properties such as melting point and density are related to the processing and properties of materials.
What are the chemical properties of 1-Fluoro-4- [ (4-Fluorophenyl) Sulfonyl] Benzene
1-Fluoro-4- [ (4-fluorophenyl) sulfonyl] benzene, this is an organic compound. Its chemical properties are unique, containing fluorine atoms and sulfonyl structures, which are of great significance in the fields of organic synthesis.
As far as its stability is concerned, due to the fluorine atom, its carbon-fluorine bond energy is quite high, so that the compound has a certain stability and is not easy to decompose under common conditions.
When it comes to reactivity, the sulfur atom in the sulfonyl group is in a high valence state and has strong electron absorption, which can reduce the electron cloud density of the benzene ring. As a result, in the electrophilic substitution reaction, the reactivity of this compound is reduced compared with that of benzene. However, under certain conditions, nucleophilic substitution reactions can occur, such as when interacting with nucleophiles, fluorine atoms or sulfonyl groups on the benzene ring can be substituted.
In terms of solubility, in view of the fact that the molecule contains aromatic rings and polar sulfonyl groups, it may have a certain solubility in polar organic solvents such as dimethyl sulfoxide, N, N-dimethylformamide, while in non-polar solvents such as n-hexane The solubility or poor solubility.
In addition, the fluorine atom of the compound imparts a certain lipid solubility to it, or affects its transport and distribution in vivo. And the sulfonyl group in its structure can participate in a variety of chemical reactions, such as reacting with amine compounds to form sulfonamides, providing the possibility for the construction of new organic compounds.
What is the synthesis method of 1-Fluoro-4- [ (4-Fluorophenyl) Sulfonyl] Benzene
The synthesis method of 1-fluoro-4- [ (4-fluorophenyl) sulfonyl] benzene is a key problem in organic synthetic chemistry. To make this substance, the following path is often followed.
First, fluorobenzene derivatives are used as starting materials. You can first take 4-fluoro-thiophenol and the like, and then oxidize it to convert sulfur atoms into sulfonyl groups. The oxidizing agent can choose hydrogen peroxide oxidant in a suitable solvent, such as glacial acetic acid, to control the temperature. This process requires attention to the reaction temperature and time. If the temperature is too high, it may cause side reactions to multiply and lead to impure products; if the time is too short, the reaction will not be completed and the yield will not be high.
Second, 4-fluorobenzenesulfonyl chloride and 4-fluorophenylboronic acid can also be used as raw materials. The coupling reaction catalyzed by palladium realizes the connection between the two. Palladium catalysts are commonly used in tetra- (triphenylphosphine) palladium, and the choice of ligands is also related to the reaction effect. Ligands such as bipyridine can increase the reactivity. In the reaction system, the choice of base is also very important. Potassium carbonate, sodium carbonate, etc. are commonly used bases. In this reaction, the solvent can be selected from dichloromethane, toluene, etc., and under the protection of inert gas, heat and stir to make the reaction fully proceed.
Furthermore, if 4-fluoroaniline is used as the starting material, the diazonium salt can be prepared by diazotization reaction, and then reacted with fluorothiophenol to form thioether, and then oxidized to obtain the target product. The diazotization reaction requires a low temperature and acidic environment, using sodium nitrite as the reagent to obtain the diazonium salt, and then quickly reacts with thiophenol. The oxidation step follows the method described above to oxidize the thioether to a sulfonyl group.
The methods for synthesizing 1-fluoro-4- [ (4-fluorophenyl) sulfonyl] benzene are diverse, and each method has its advantages and disadvantages. In actual operation, it is necessary to weigh and choose according to the availability of raw materials, the difficulty of controlling reaction conditions, the purity and yield of the product, etc., in order to achieve the ideal synthetic effect.
What is the price range of 1-Fluoro-4- [ (4-Fluorophenyl) Sulfonyl] Benzene in the market?
In today's world, business conditions are ever-changing, and the price of goods also changes accordingly. 1 - Fluoro - 4 - [ (4 - Fluorophenyl) Sulfonyl] Benzene This item is in the market, and its price involves many factors, which are difficult to hide in a single word.
First, the difficulty of its production is related to the price. If the need to make it is very refined, the material is very precious, and the work is complicated and difficult, the price will be high; on the contrary, if the system is easy, the material is often simple, and the price may be slightly lower.
Second, the supply and demand of the market are also heavy. Those who want it are numerous, and those who supply it are few, the price will rise; if the supply exceeds the demand, the price will be self-suppressing.
There are also differences in origin and time, and the price is also different. When the freight increases from a distance, the price may be higher; when there are many goods in the place, the price may drop.
However, it is not easy to determine the range of its price. It is difficult to determine the level of its price because it has not carefully observed the changes and conditions of the market. Generally speaking, if it is an ordinary city, its price may be between [X1] gold and [X2] gold due to its nature and use. However, this is only speculation, not an exact number. The market situation is impermanent, and you must personally observe the business situation and consult the people of Jia before you can get its near-real price.