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What are the main uses of 1-Fluoro-3- (Phenoxymethyl) Benzene?
1-Fluoro-3- (phenoxy methyl) benzene, this substance has a wide range of uses and has important applications in the chemical and pharmaceutical fields.
In the chemical industry, it is often used as an intermediate in organic synthesis. The delicacy of organic synthesis is just like building a tall building with masonry, and the preparation of intermediates is fine, so that complex organic compounds can be achieved. Using this substance as masonry can build a variety of organic molecular structures. For example, in the development of new materials, it imparts special properties to the material. Due to its fluorine atom, the characteristics of fluorine give synthetic materials unique physical and chemical properties, or increase material stability, or change their surface activity, opening up new paths for the development of new chemical materials.
In the field of medicine, its role cannot be ignored. It can be used as a pharmaceutical intermediate to participate in the synthesis of drug molecules. Drug synthesis is as accurate as a doctor's surgery. 1-Fluoro-3- (phenoxy methyl) benzene can provide a specific structural fragment, combined with other groups, and reacted delicately to obtain drugs with specific pharmacological activities. Or as an antibacterial drug to kill bacteria and protect human health; or as a drug to regulate physiological functions, relieve pain and help patients recover.
In summary, although 1-fluoro-3- (phenoxy methyl) benzene is an organic compound, it plays a key role in the chemical and pharmaceutical fields, promoting the development of the industry and bringing many benefits to human life.
What are the physical properties of 1-Fluoro-3- (Phenoxymethyl) Benzene?
1-Fluoro-3- (phenoxy methyl) benzene, this is an organic compound. Its physical properties are as follows:
Looking at its appearance, under normal conditions, it may be a colorless to light yellow transparent liquid, and those that are pure are rarely solid. Due to the molecular structure, the benzene ring is connected to fluorine atoms and phenoxy methyl groups. This structure results in moderate intermolecular force, so it exists in a liquid state at room temperature and pressure.
Smell its smell, often aromatic, due to the characteristics of the benzene ring. The benzene ring is a typical conjugated system, giving the compound a unique aroma. However, the smell is not single and pure, or varies slightly due to the influence of substituents, but generally does not leave the category of aromatics.
Measure its melting boiling point, the melting point is low, usually in the range of -20 ° C to -10 ° C. This is due to the van der Waals force between molecules. Although the benzene ring can increase the intermolecular force, the steric resistance and electronic effect of fluorine atoms and phenoxy methyl groups to a certain extent weaken the close arrangement of molecules, resulting in a high melting point. The boiling point is relatively high, about 230 ° C to 240 ° C. Due to the large molecular mass and the conjugated structure of the benzene ring, the molecular polarizability is increased, and the van der Waals force is enhanced. High energy is required to overcome the intermolecular attractive force and achieve gas-liquid conversion.
Measure its density, which is slightly greater than that of water, about 1.1-1.2 g/cm ³. The reason is that the benzene ring, fluorine atoms and phenoxy methyl group in the molecule have a tight structure, the atomic mass is concentrated, and the spatial arrangement is compact, so the density is higher than that of water.
Looking at its solubility, it is difficult to dissolve in water. Because water is a polar molecule, and the polarity of 1-fluoro-3- (phenoxy methyl) benzene molecule is weak, according to the principle of "similarity and miscibility", the two are insoluble. However, it is soluble in many organic solvents, such as ethanol, ether, chloroform, etc., because these organic solvents have similar forces with the molecules of the compound, and can be miscible with each other.
In addition, the volatility of this compound is relatively low. Due to the intermolecular force and relatively large molecular mass, it is more difficult for its molecules to escape from the liquid surface, so the volatilization rate is slow at room temperature.
Is 1-Fluoro-3- (Phenoxymethyl) Benzene Chemically Stable?
1-Fluoro-3- (phenoxy methyl) benzene, this is an organic compound. The stability of its chemical properties requires multiple considerations.
Check its chemical bond first. The carbon-fluorine bond is quite strong, and the fluorine atom has strong electronegativity. It tightly pulls the bonding electron pair, which makes the bond energy quite high. To break it, more energy is required. This improves the stability of the compound to a certain extent. Looking at the structure of the benzene ring, the benzene ring has a conjugated large π bond, and this conjugated system gives it special stability. The electron cloud is delocalized on the benzene ring, which reduces the molecular energy and stabilizes the structure.
However, the phenoxy methyl part on its side chain may have a certain active check point. Oxygen atoms have lone pair electrons and can participate in chemical reactions or reactions such as nucleophilic substitution. In case of strong nucleophilic reagents, or the carbon-oxygen bond at the phenoxy methyl group is broken. However, under generally mild conditions, if there is no specific reagent to interact with it, this part is relatively stable.
In common temperature, pressure and ordinary chemical environment, if there is no strong oxidant, strong reducing agent or special catalyst interference, the chemical properties of 1-fluoro-3 - (phenoxy methyl) benzene are relatively stable. However, under extreme conditions, such as high temperature, high pressure, or specific active reagents, their chemical stability may be challenged, or various chemical reactions may occur, causing molecular structure changes.
What are the synthesis methods of 1-Fluoro-3- (Phenoxymethyl) Benzene?
The synthesis method of 1-fluoro-3- (phenoxy methyl) benzene, although the synthesis method of this specific compound is not directly described in books such as Tiangongkai, it can be deduced from the general principles of chemical synthesis and the synthesis of similar compounds.
To synthesize this compound, one can first consider constructing a benzene ring structure. The benzene ring is the basic structure of many aromatic compounds and can be obtained by the reaction of aromatic hydrocarbons. For example, using benzene as the starting material, through the Fu-gram alkylation reaction, benzene and a suitable halogenated hydrocarbon are catalyzed by Lewis acid to introduce a carbon chain containing a specific substituent. The halogenated hydrocarbon needs to contain a structure that can be subsequently converted into phenoxy methyl.
Second, for the introduction of fluorine atoms. There are various methods for the introduction of fluorine atoms. If the benzene ring has been constructed, a nucleophilic substitution reaction can be used. Select suitable fluorine-containing reagents, such as potassium fluoride, etc., and replace the specific position of the benzene ring in the presence of appropriate solvents and catalysts. However, it should be noted that the positioning effect of the original substituents on the benzene ring will affect the substitution position of fluorine atoms, and the reaction sequence needs to be reasonably designed.
Third, the access of phenoxy methyl. Phenoxy negative ions can be prepared first, which can be obtained by the reaction of phenol and base. Then the negative ion is reacted with the halogenated hydrocarbon. The halogenated hydrocarbon should echo the structure introduced in the previous construction of the benzene ring, and a nucleophilic substitution reaction occurs, so that the phenoxy methyl is connected to a specific position in the benzene ring.
During the synthesis process, the control of the conditions of each step of the reaction is extremely critical. Temperature, reaction time, and the proportion of reactants all affect the yield and selectivity of the reaction. After many experiments, the reaction conditions need to be optimized to achieve the purpose of efficient synthesis of 1-fluoro-3- (phenoxy methyl) benzene.
What is the price range of 1-Fluoro-3- (Phenoxymethyl) Benzene in the market?
The price range of 1-fluoro-3- (phenoxymethyl) benzene in the market is difficult to determine. This is due to the unpredictable market conditions and is influenced by various factors.
The first to bear the brunt is the situation of supply and demand. If the demand for this product is high and the supply is scarce, the price will increase; conversely, if the supply is abundant and the demand is low, the price will decrease. And the cost of producing this product is also the key. The price of raw materials, the preparation process, energy consumption and labor costs all affect the cost. If the cost is high, the price will also rise.
Furthermore, the market competition situation also has an impact. If there are many merchants producing this product, the competition is fierce, and in order to compete for market share, the price may be reduced and promoted; however, if the market is almost monopolized, the price may be high due to control.
Multiple, the price varies from region to region. In different places, due to differences in transportation costs, tax differences, market consumption levels, etc., the price will vary. In places with developed economies and strong consumption power, the price may be slightly higher; in places with underdeveloped economies and weak consumption power, the price may be slightly lower.
View "Tiangong Kaiwu", although it is an ancient scientific and technological masterpiece in our country, it contains many process technologies in detail, but the book does not involve 1-fluoro-3- (phenoxymethyl) benzene, so it is difficult to find the price according to it.
In short, in order to know the exact price range of 1-fluoro-3- (phenoxymethyl) benzene, it is necessary to investigate the chemical raw material market in real time, consult suppliers, distributors, or refer to professional chemical product quotation platforms to obtain more accurate numbers.